Xanthine mimetics as potent dipeptidyl peptidase IV inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 24, 2006, Pages 6226-6230

  Kurukulasuriya, Ravi ^a   Rohde, Jeffrey J ^a   Szczepankiewicz, Bruce G ^a   Basha, Fatima ^a   Lai, Chunqui ^a   Jae, Hwan Soo ^a   Winn, Martin ^a   Stewart, Kent D ^a   Longenecker, Kenton L ^a   Lubben, Thomas W ^a   Ballaron, Stephen J ^a   Sham, Hing L ^a   von Geldern, Thomas W ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

Dipeptidyl peptidase IV (DPPIV); SAR; Type 2 diabetes; X ray structure; Xanthines

Indexed keywords

ACETONITRILE; DIPEPTIDYL PEPTIDASE IV INHIBITOR; ENZYME; IMIDAZOLE; NAPHTHOQUINONE; PYRIDAZINONE DERIVATIVE; PYRIDINE 1 OXIDE; XANTHINE;

ARTICLE; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; HIGH THROUGHPUT SCREENING; HUMAN; IC 50; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; RAT; SPECIES DIFFERENCE; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

ANIMALS; ANTIGENS, CD26; IMIDAZOLES; KINETICS; MODELS, MOLECULAR; PROTEASE INHIBITORS; PROTEIN CONFORMATION; RATS; STRUCTURE-ACTIVITY RELATIONSHIP; X-RAY DIFFRACTION; XANTHINES;

EID: 33750741922     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.09.024     Document Type: Article

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