Role of the 5′ untranslated region (UTR) in the tissue-specific regulation of rat tryptophan hydroxylase gene expression by stress

Journal of Neurochemistry

Volumn 82, Issue 3, 2002, Pages 645-654

  Chamas, Firas ^a   Sabban, Esther L ^a  

^a NEW YORK MEDICAL COLLEGE   (United States)

Author keywords

5 untranslated region; Pineal; Raphe nuclei; Serotonin; Stress; Tryptophan hydroxylase

Indexed keywords

SEROTONIN; TRYPTOPHAN HYDROXYLASE; ISOENZYME; MESSENGER RNA;

5' UNTRANSLATED REGION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN STEM; CONTROLLED STUDY; DNA SYNTHESIS; ENZYME INDUCTION; GENE EXPRESSION; GENE EXPRESSION REGULATION; MALE; NONHUMAN; PINEAL BODY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RAPHE NUCLEUS; RAT; RNA ISOLATION; RNA TRANSLATION; SEROTONINERGIC SYSTEM; STRESS; TRANSLATION REGULATION; ANIMAL; ANTIBODY SPECIFICITY; CELL STRAIN; EXERCISE; GENETIC TRANSFECTION; GENETICS; METABOLISM; PHYSIOLOGY; REPORTER GENE; SPRAGUE DAWLEY RAT;

ANIMALIA;

5' UNTRANSLATED REGIONS; ANIMALS; BRAIN STEM; GENE EXPRESSION REGULATION; GENES, REPORTER; ISOENZYMES; MALE; ORGAN SPECIFICITY; PC12 CELLS; PINEAL GLAND; RAPHE NUCLEI; RATS; RATS, SPRAGUE-DAWLEY; RESTRAINT, PHYSICAL; RNA, MESSENGER; STRESS; TRANSFECTION; TRYPTOPHAN HYDROXYLASE;

EID: 0035984396     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2002.00989.x     Document Type: Article

References (38)

1. Increase of tryptophan hydroxylase enzyme protein by dexamethasone in adrenalectomized rat midbrain
2. Serotonin and appetite
3. Regulation of serotonin synthesis
4. The human tryptophan hydroxylase gene. An unusual splicing complexity in the 5′untranslated region
5. Characterization of the human tryptophan hydroxylase gene promoter. Transcriptional regulation by cAMP requires a new motif distinct from the cAMP-responsive element
6. Tryptophan hydroxylase mRNA levels are elevated by repeated immobilization stress in rat raphe nuclei but not in pineal gland
7. Evidence for tryptophan hydroxylase and hydroxy-indol-O-methyl-transferase mRNAs in human blood platelets
8. Circular polysomes predominate on the rough endoplasmic reticulum of somatotropes and mammotropes in the rat anterior pituitary
9. Tissue-specific glucocorticoid regulation of tryptophan hydroxylase mRNA levels
10. Sequence of two mRNAs encoding active rat tryptophan hydroxylase
11. An efficient strategy for cloning 5′ extremities of rare transcripts permits isolation of multiple 5′-untranslated regions of rat tryptophan hydroxylase mRNA
12. Differential control of tryptophan hydroxylase expression in raphe and in pineal gland: Evidence for a role of translation efficiency
13. The enteric nervous system
14. Determination of transcription start sites in the human estrogen receptor gene and identification of a novel, tissuespecific, estrogen receptor-mRNA isoform
15. Post-transcriptional control of tryptophan hydroxylase gene expression in rat brain stem and pineal gland
16. Structure and function of the brain serotonin system
17. Further studies on tryptophan hydroxylase in rat brainstem and beef pineal
18. Features in the 5′ non-coding sequences of rabbit alpha and beta-globin mRNAs that affect translational efficiency
19. Initiation of translation in prokaryotes and eukaryotes
20. Characterization of ribosome-protected fragments from reovirus messenger RNA
21. Determination of some molecular parameters of tryptophan hydroxylase from rat midbrain and murine mast cell
22. Stress and molecular biology of neurotransmitter-related enzymes
23. Tryptophan hydroxylation: Measurement in pineal gland, brainstem, and carcinoid tumor
24. 5′-heterogeneity of glucocorticoid receptor messenger RNA is tissue specific: Differential regulation of variant transcripts by early-life events
25. Involvement of intracellular or extracellular calcium in activation of tyrosine hydroxylase gene expression in PC12 cells
26. NF-Y activates mouse tryptophan hydroxylase transcription
27. Pineal melatonin: Cell biology of its synthesis and of its physiological interactions
28. Translation of the alzheimer amyloid precursor protein mRNA is up-regulated by interleukin-1 through 5′-untranslated region sequences
29. Common themes in translational and transcriptional regulation
30. Characterization of a tryptophan hydroxylating enzyme from malignant mouse mast cell
31. Isolation and structural characterization of the murine tryptophan hydroxylase gene
32. Characterization and chromosomal mapping of a cDNA encoding tryptophan hydroxylase from a mouse mastocytoma cell line
33. Alternative splicing at the 3′-cDNA of human tryptophan hydroxylase
34. Multiple preproenkephalin transcriptional start sites are induced by stress and cholinergic pathways
35. Autoregulation of cell-specific MAP kinase control of the tryptophan hydroxylase promoter
36. A new species of enkephalin precursor mRNA with a distinct 5′-untranslated region in haploid germ cells
37. Evidence for multiple promoters of the human IL-5 receptor alpha subunit gene: A novel 6-base pair element determines cell-specific promoter function