Synthesis and antibacterial activity of novel neamine derivatives

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 24, 2006, Pages 6351-6354

  Minowa, Nobuto ^a   Akiyama, Yoshihisa ^a   Hiraiwa, Yukiko ^a   Maebashi, Kazunori ^a   Usui, Takayuki ^a   Ikeda, Daishiro ^b  

^a MEIJI SEIKA KAISHA LTD   (Japan)

^b INSTITUTE OF MICROBIAL CHEMISTRY   (Japan)

Author keywords

Aminoglycoside; Methicillin resistant Staphylococcus aureus; Neamine

Indexed keywords

AMINOGLYCOSIDE; AMINOGLYCOSIDE ANTIBIOTIC AGENT; ANTIINFECTIVE AGENT; BACTERIAL ENZYME; CARBONYL DERIVATIVE; HABEKACIN; NEAMINE;

ANTIBACTERIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG STRUCTURE; DRUG SYNTHESIS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS; STRUCTURE ACTIVITY RELATION;

AMINOGLYCOSIDES; ANTI-BACTERIAL AGENTS; CARBOHYDRATE CONFORMATION; FRAMYCETIN; METHICILLIN RESISTANCE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; STAPHYLOCOCCUS AUREUS;

METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS AUREUS;

EID: 33750701789     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.09.007     Document Type: Article

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14. 4OH).
15. +. NMR assignments were made by interpretation of COSY experiments.
16. MICs were detemined by the two-fold agar dilution method according to NCCLS.