Central nervous system circuitry and peripheral neural sympathetic activity responsible for essential hypertension

Current Neurovascular Research

Volumn 3, Issue 4, 2006, Pages 307-325

  Lechin, Fuad ^a   Van Der Dijs, Bertha ^a  

^a NONE

Author keywords

Acetylcholine; Adrenal system; Adrenaline; Blood pressure; Central neurotransmitters; Locus coeruleus; Monoaminergic system; Noradrenaline; Serotonin

Indexed keywords

SEROTONIN;

ADRENERGIC SYSTEM; CENTRAL NERVOUS SYSTEM; CHOLINERGIC SYSTEM; DORSAL RAPHE NUCLEUS; ESSENTIAL HYPERTENSION; HUMAN; LOCUS CERULEUS; MONOAMINERGIC NERVE; MONOAMINERGIC SYSTEM; NERVE CELL NETWORK; NERVE CONDUCTION; NEUROPHYSIOLOGY; NONHUMAN; NORADRENERGIC NERVE; PATHOPHYSIOLOGY; PERIPHERAL NERVE; PRIORITY JOURNAL; RAPHE NUCLEUS; REVIEW; SEROTONINERGIC NERVE; SYMPATHETIC NERVE;

ACETYLCHOLINE; ANIMALS; AUTONOMIC NERVOUS SYSTEM DISEASES; AUTONOMIC PATHWAYS; CENTRAL NERVOUS SYSTEM; HUMANS; HYPERTENSION; NOREPINEPHRINE; RAPHE NUCLEI; SEROTONIN; SYMPATHETIC FIBERS, POSTGANGLIONIC;

EID: 33750694222     PISSN: 15672026     EISSN: None     Source Type: Journal    
DOI: 10.2174/156720206778792894     Document Type: Review

References (200)

1. Adell, A, Artigas, F. (1999) Regulation of the release of 5-hydroxytryptamine in the median raphe nucleus of the rat by catecholaminergic afferents. Eur J Neurosci 11: 2305-2311.
2. Agren, H, Koulu, M, Saavedra, JM, Potter, WZ, Linnoila, M. (1986) Circadian covariation of norepinephrine and serotonin in the locus coeruleus and dorsal raphe nucleus in the rat. Brain Res 397: 353-358.
3. Amaral, DG, Behniea, H, Kelly, JL. (2003) Topographic organization of projections from the amygdala to the visual cortex in the macaque monkey. Neuroscience 118: 1099-1120.
4. Anderson, DJ, Puttfarcken, PS, Jacobs, I, Faltynek, C. (2000) Assessment of nicotinic acetylcholine receptor-mediated release of [(3)H]-norepinephrine from rat brain slices using a new 96-well format assay. Neuropharmacology 39: 2663-2672.
5. Astier, B, Kitahama, K, Denoroy, L, Berod, A, Jouvet, M, Renaud, B. (1986) Biochemical evidence for an interaction between adrenaline and noradrenaline neurons in the rat brainstem. Brain Res 397: 333-340.
6. Astier, B, Van Bockstaele, EJ, Aston-Jones, G, Pieribone, VA. (1990) Anatomical evidence for multiple pathways leading from the rostral ventrolateral medulla (nucleus paragigantocellularis) to the locus coeruleus in rat. Neurosci Lett 118: 141-146.
7. Baraban, JM, Aghajanian, GK. (1981) Noradrenergic innervation of serotonergic neurons in the dorsal raphe: demonstration by electron microscopic autoradiography. Brain Res 204: 1-11.
8. Basso, N, Kurnjek, ML, Mikulic, L, Ruiz, P, Canata, MA, Taquini, AC. (1989) The central and peripheral renin-angiotensin and noradrenergic systems in the spontaneous hypertensive rats (SHR). Arch Int Physiol Biochim 97: 53-58.
9. Bauman, MD, Amaral, DG (2005) The distribution of serotonergic fibers in the macaque monkey amygdala: an immunohistochemical study using antisera to 5-hydroxytryptamine. Neuroscience 136: 193-203.
10. Beaulieu, S, Di Paolo, T, Barden, N. (1986) Control of ACTH secretion by the central nucleus of the amygdala: implication of the serotoninergic system and its relevance to the glucocorticoid delayed negative feedback mechanism. Neuroendocrinology 44: 247-254.
11. Benarroch, E E, Balda, MS, Finkielman, S, Nahmod, VE. (1983) Neurogenic hypertension after depletion of norepinephrine in anterior hypothalamus induced by 6-hydroxydopamine administration into the ventral pons: role of serotonin. Neuropharmacology 22: 29-34.
12. Benarroch, EE, Pirola, CJ, Alvarez, AL, Nahmod, VE. (1981) Serotonergic and noradrenergic mechanisms involved in the cardiovascular effects of angiotensin II injected into the anterior hypothalamic preoptic region of rats. Neuropharmacology 20: 9-13.
13. Bhaskaran, D, Freed, CR. (1988) Changes in arterial blood pressure lead to baroreceptor-mediated changes in norepinephrine and 5-hydroxyindoleacetic acid in rat nucleus tractus solitarius. J Pharmacol Exp Ther 245: 356-363.
14. Borsody, MK, Weiss, JM (2005) The subdiaphragmatic vagus nerves mediate activation of locus coeruleus neurons by peripherally administered microbial substances. Neuroscience 131: 235-245.
15. Briggs, I. (1977) Excitatory responses of neurones in rat bulbar reticular formation to bulbar raphe stimulation and to iontophoretically applied 5-hydroxytryptamine, and their blockade by LSD 25. J Physiol 265: 327-340.
16. Burchfield, SR (1979) The stress response: a new perspective. Psychosom Med 41: 661-672.
17. Byrum, CE, Guyenet, PG. (1987) Afferent and efferent connections of the A5 noradrenergic cell group in the rat. J Comp Neurol 261: 529-542.
18. Cameron, NM, Carey, P, Erskine, MS. (2004) Medullary noradrenergic neurons release norepinephrine in the medial amygdala in females in response to mating stimulation sufficient for pseudopregnancy. Brain Res 1022: 137-147.
19. Celada, P, Puig, MV, Casanovas, JM, Guillazo, G, Artigas, F. (2001) Control of dorsal raphe serotonergic neurons by the medial prefrontal cortex: Involvement of serotonin-1A, GABA-A, and glutamate receptors. J Neurosci 21: 9917-9929.
20. Christensen, NJ (1983) Catecholamines and essential hypertension. Acta Med Scand Suppl 677: 15-16.
21. Clark, FM, Yeomans, DC, Proudfit, HK. (1991) The noradrenergic innervation of the spinal cord: differences between two substrains of Sprague-Dawley rats determined using retrograde tracers combined with immunocytochemistry. Neurosci Lett 125: 155-158.
22. Consolo, S, Bertorelli, R, Russi, G, Zambelli, M, Ladinsky, H (1994) Serotonergic facilitation of acetylcholine release in vivo from rat dorsal hippocampus via serotonin 5-HT3 receptors. J Neurochem 62: 2254-2261.
23. Conti, LH, Youngblood, KL, Printz, MP, Foote, SL. (1997) Locus coeruleus electrophysiological activity and responsivity to corticotropin-releasing factor in inbred hypertensive and normotensive rats. Brain Res 774: 27-34.
24. Corley, KC, Phan, TH, Daugherty, WP, Boadle-Biber, MC. (2003) Stress-induced activation of median raphe serotonergic neurons in rats is potentiated by the neurotensin antagonist, SR 48692. Neurosci Lett 319: 1-4.
25. Cox, BF, Brody, MJ. (1989) Subregions of rostral ventral medulla control arterial pressure and regional hemodynamics. Am J Physiol 257: R635-R640.
26. Cryan, JF, Page, ME, Lucki, I. (2002) Noradrenergic lesions differentially alter the antidepressant-like effects of reboxetine in a modified forced swim test. Eur J Pharmacol 436: 197-205.
27. Dabsys, SM, Balda, MS, Pirola, CJ, Finkielman, S, Nahmod, VE. (1988) Angiotensin converting enzyme activity in the amygdaloid complex in a neurogenic hypertensive model. Clin Exp Hypertens 10: 605-615.
28. Dampney, RA, Horiuchi, J, Killinger, S, Sheriff, MJ, Tan, PS, McDowall, LM. (2005) Long-term regulation of arterial blood pressure by hypothalamic nuclei: some critical questions. Clin Exp Pharmacol Physiol 32: 419-425.
29. Dampney, RA, Horiuchi, J, Tagawa, T, Fontes, MA, Potts, PD, Polson, JW. (2003) Medullary and supramedullary mechanisms regulating sympathetic vasomotor tone. Acta Physiol Scand 177: 209-218.
30. Dampney, RA. (1994a) Functional organization of central pathways regulating the cardiovascular system. Physiol Rev 74: 323-364.
31. Dampney, RA. (1994b) The subretrofacial vasomotor nucleus: anatomical, chemical and pharmacological properties and role in cardiovascular regulation. Prog Neurobiol 42: 197-227.
32. Dampney, RAL, Czachurski, J, Dembowsky, K, Goodchild, AK, Seller, H. (1987) Afferent connections and spinal projections of the pressor region in the rostral ventrolateral medulla of the cat. J Auton Nerv Syst 20: 73-86.
33. De Souza, EB, van Loon, GR. (1986) Brain serotonin and catecholamine responses to repeated stress in rats. Brain Res 367: 77-86.
34. Dilsaver, SC, Coffman, JA. (1988) Hypertension and depression: question of a causal relationship persists. Psychiatry Res 26: 1115-1157.
35. Dormer, KJ. (1984) Modulation of cardiovascular response to dynamic exercise by fastigial nucleus. J Appl Physiol 56: 1369-1377.
36. Drye, RG, Baisden, RH, Whittington, DL, Woodruff, ML. (1989) The effects of stimulation of the A5 region on blood pressure and heart rate in rabbits. Brain Res Bull 24: 33-39.
37. Dun, NJ, Dun, SL, Shen, E, Tang, H, Huang, R, Chiu, TH. (1995) c-fos expression as a marker of central cardiovascular neurons. Biol Signals 4: 117-123.
38. Egan, TM, North, RA. (1985) Acetylcholine acts on m2-muscarinic receptors to excite rat locus coeruleus neurons. Br J Pharmacol 85: 733-735.
39. Elam, M, Thoren, P, Svensson, TH. (1986) Locus coeruleus neurons and sympathetic nerves: activation by visceral afferents. Brain Res 375: 117-125.
40. Engberg, G, Oreland, L, Thoren, P, Svensson, T. (1987) Locus coeruleus neurons show reduced alpha 2-receptor responsiveness and decreased basal activity in spontaneously hypertensive rats. J Neural Transm 69: 71-83.
41. Ennis, M, Aston-Jones, G. (1987) Two physiologically distinct populations of neurons in the ventrolateral medulla innervate the locus coeruleus. Brain Res 425: 275-282.
42. Fairchild, G, Leitch, MM, Ingram, CD. (2003) Acute and chronic effects of corticosterone on 5-HT1A receptor-mediated autoinhibition in the rat dorsal raphe nucleus. Neuropharmacology 45: 925-934.
43. Farkas, E, Jansen, AS, Loewy, AD. (1998) Periaqueductal gray matter input to cardiac-related sympathetic premotor neurons. Brain Res 792: 179-192.
44. Feldman, S, Conforti, N, Saphier, D. (1990) Adrenal responses and neurotransmitters in posterior hypothalamic deafferentation. Brain Res Bull 25: 75-78.
45. Fenik, V, Marchenko, V, Janssen, P, Davies, RO, Kubin, L. (2002) A5 cells are silenced when REM sleep-like signs are elicited by pontine carbachol. J Appl Physiol 93: 1448-1456.
46. Folkow, B. (1975) Central neurohormonal mechanisms in spontaneously hypertensive rats compared with human essential hypertension. Clin Sci Mol Med Suppl 2: 205s-214s.
47. Folkow, B, Hallback-Nordlander, M, Martner, J, Nordborg, C. (1982) Influence of amygdala lesions on cardiovascular responses to alerting stimuli, on behaviour and on blood pressure development in spontaneously hypertensive rats. Acta Physiol Scand 116: 133-139.
48. Freed, CR, Echizen, H, Bhaskaran, D. (1985) Brain serotonin and blood pressure regulation: studies using in vivo electrochemistry and direct tissue assay. Life Sci 37: 1783-1793.
49. Fritschy, JM, Grzanna, R. (1990) Demonstration of two separate descending noradrenergic pathways to the rat spinal cord: evidence for an intragriseal trajectory of locus coeruleus axons in the superficial layers of the dorsal horn. J Comp Neurol 291: 553-582.
50. Funakoshi, K, Kadota, T, Atobe, Y, Nakano, M, Goris, RC, Kishida, R. (2000) Serotonin-immunoreactive axons in the cell column of sympathetic preganglionic neurons in the spinal cord of the filefish Stephanolepis cirrhifer. Neurosci Lett 280: 115-118.
51. Gauthier, P. (1981) Pressor responses and adrenomedullary catecholamine release during brain stimulation in the rat. Can J Physiol Pharmacol 59: 485-492.
52. Gauthier, P, Reis, DJ, Nathan, MA. (1981) Arterial hypertension elicited either by lesions or by electrical stimulations of the rostral hypothalamus in the rat. Brain Res 211: 91-105.
53. Goldstein, DS, Horwitz, D, Keiser, HR, Polinsky, RJ, Kopin, IJ. (1983) Plasma l-[3H]norepinephrine, d-[14C]norepinephrine, and d,l-[3H]isoproterenol kinetics in essential hypertension. J Clin Invest 72: 1748-1758.
54. Gorea, E, Adrien, J. (1988) Serotonergic regulation of noradrenergic coerulean neurons: electrophysiological evidence for the involvement of 5-HT2 receptors. Eur J Pharmacol 154: 285-291.
55. Grandison, L, Meites, J. (1976) Evidence for adrenergic mediation of cholinergic inhibition of prolactin release. Endocrinology 99: 775-779.
56. Gray, TS, Carney, ME, Magnuson, DJ. (1989) Direct projections from the central amygdaloid nucleus to the hypothalamic paraventricular nucleus: possible role in stress-induced adrenocorticotropin release. Neuroendocrinology 50: 433-446.
57. Groves, DA, Bowman, EM, Brown, VJ. (2005) Recordings from the rat locus coeruleus during acute vagal nerve stimulation in the anaesthetised rat. Neurosci Lett 379: 174-179.
58. Gurtu, S, Pant, KK, Sinha, JN, Bhargava, KP. (1984) An investigation into the mechanism of cardiovascular responses elicited by electrical stimulation of locus coeruleus and subcoeruleus in the cat. Brain Res 301: 59-64.
59. Hagiwara, Y, Ohi, M, Kubo, T. (2005) Cholinergic stimulation in the posterior hypothalamic nucleus activates angiotensin II-sensitive neurons in the anterior hypothalamic area of rats. Brain Res Bull 67: 203-209.
60. Herman, JP, Ostrander, MM, Mueller, NK, Figueiredo, H. (2005) Limbic system mechanisms of stress regulation: hypothalamo-pituitary-adrenocortical axis. Prog Neuropsychopharmacol Biol Psychiatry 29: 1201-1213.
61. Heym, J, Trulson, ME, Jacobs, BL. (1981) Effects of adrenergic drugs on raphe unit activity in freely moving cats. Eur J Pharmacol 74: 117-125.
62. Hilgert, M, Buchholzer, M, Jeltsch, H, Kelche, C, Cassel, JC, Klein, J. (2000) Serotonergic modulation of hippocampal acetylcholine release after long-term neuronal grafting. Neuroreport 11: 3063-3065.
63. Horiuchi, J, Wakabayashi, S, Dampney, RA. (2005) Activation of 5-hydroxytryptamine 1A receptors suppresses the cardiovascular response evoked from the dorsomedial hypothalamic nucleus. Hypertension 46: 173-179.
64. Huether, G, Doering, S, Ruger, U, Ruther, E, Schussler, G. (1996) Psychological stress and neuronal plasticity. An expanded model of the stress reaction process as the basis for understand central nervous system adaptation processes. Z Psychosom Med Psychoanal 42: 107-127.
65. Huether, G. (1996) The central adaptation syndrome: psychosocial stress as a trigger for adaptive modifications of brain structure and brain function. Prog Neurobiol 48: 569-612.
66. Jacobs, BL, Cohen, A. (1976) Differential behavioral effects of lesions of the median or dorsal raphe nuclei in rats: open field and pain-elicited aggression. J Comp Physiol Psychol 90: 102-108.
67. Johnson, PL, Lightman, SL, Lowry, CA. (2004) A functional subset of serotonergic neurons in the rat ventrolateral periaqueductal gray implicated in the inhibition of sympathoexcitation and panic. Ann N Y Acad Sci 1018: 58-64.
68. Kaehler, ST, Salchner, P, Singewald, N, Philippu, A. (2004) Differential amino acid transmission in the locus coeruleus of Wistar Kyoto and spontaneously hypertensive rats. Naunyn Schmiedeberg's Arch Pharmacol 370: 381-387.
69. Kaehler, ST, Singewald, N, Philippu, A. (1999) Release of serotonin in the locus coeruleus of normotensive and spontaneously hypertensive rats (SHR). Naunyn Schmiedeberg's Arch Pharmacol 359: 460-465.
70. Katsu, H. (2001) Selective 5-HT1A receptor agonist, 8-OH-DPAT, locally administered into the dorsal raphe nucleus increased extracellular acetylcholine concentrations in the medial prefrontal cortex of conscious rats. Nihon Shinkei Seishin Yakurigaku Zasshi 21: 121-123.
71. Kawahara, Y, Kawahara, H, Westerink, BH. (1999) Tonic regulation of the activity of noradrenergic neurons in the locus coeruleus of the conscious rat studied by dual-probe microdialysis. Brain Res 823: 42-48.
72. Kawamura, H, Gunn, CG, Frohlich, ED. (1978) Cardiovascular alteration by nucleus locus coeruleus in spontaneously hypertensive rat. Brain Res 140: 137-147.
73. Kjeldsen, SE, Schork, NJ, Leren, P, Eide, IK. (1989) Arterial plasma norepinephrine correlates to blood pressure in middle-aged men with sustained essential hypertension. Am Heart J 118: 775-781.
74. Kobayashi, RM, Palkovits, M, Kizer, JS, Jacobowitz, DM, Kopin, IJ. (1975) Selective alteration of catecholamines and tyrosine hydroxylase activity in the hypothalamus following acute and chronic stress. In: Catecholamines and stress. Usdin, E, Kvetnanky, R, Kopin, IJ, Eds., Pergamon Press: Oxford, pp. 29-38.
75. Korner, PI, Badoer, E, Head, GA. (1987) Cardiovascular role of the major noradrenergic cell groups in the rabbit: analysis based on 6-hydroxydopamine- induced transmitter release. Brain Res 435: 258-272.
76. Kostowski, W. (1979) Two noradrenergic systems in the brain and their interactions with other monoaminergic neurons. Pol J Pharmacol Pharm 31: 425-436.
77. Koulu, M, Saavedra, JM, Bjelogrlic, N, Niwa, M, Agren, H, Linnoila, M. (1986a) Serotonin turnover in discrete hypothalamic nuclei and mesencephalic raphe nuclei of young and adult spontaneously hypertensive rats. Brain Res 379: 257-263.
78. Koulu, M, Saavedra, JM, Niwa, M, Linnoila, M. (1986b) Increased catecholamine metabolism in the locus coeruleus of young spontaneously hypertensive rats. Brain Res 369: 361-364.
79. Krukoff, TL, Mactavish, D, Jhamandas, JH. (1997) Activation by hypotension of neurons in the hypothalamic paraventricular nucleus that project to the brainstem. J Comp Neurol 385: 285-296.
80. Kuhn, DM, Wolf, WA, Lovenberg, W. (1980) Review of the role of the central serotonergic neuronal system in blood pressure regulation. Hypertension 2: 243-255.
81. Kvetnansky, R, Mitro, A, Palkovits, M, Brownstein, M. (1975) Catecholamines in individual hypothalamic muclei in stressed rats. In: Catecholamines and stress. Usdin, E, Kvetnanky, R, Kopin, IJ, Eds., Pergamon Press: Oxford, pp. 39-45.
82. Lai, YY, Strahlendorf, HK, Fung, SJ, Barnes, CD. (1989) The actions of two monoamines on spinal motoneurons from stimulation of the locus coeruleus in the cat. Brain Res 484: 268-272.
83. Lake, CR, Ziegler, MG, Murphy, DL. (1977) Increased norepinephrine levels and decreased dopamine-beta-hydroxylase activity in primary autism. Arch Gen Psychiatry 34: 553-556.
84. Lambas-Senas, L, Chamba, G, Fety, R, Renaud, B. (1986) Comparative responses of the central adrenaline- and noradrenaline-containing neurons after reserpine injections. Biochem Pharmacol 35: 2207-2211.
85. Lawler, JE, Cox, RH, Hubbard, JW, Mitchell, VP, Barker, GF, Trainor, WP, Sanders, BJ. (1985) Blood pressure and heart rate responses to environmental stress in the spontaneously hypertensive rat. Physiol Behav 34: 973-976.
86. Lechin, F, van der Dijs, B, Lechin, E. (1979a) Experimental and clinical bases for the integration of the monoaminergic and cholinergic systems with normal and pathological physiology of the psychic apparatus. In: The Autonomic Nervous System: Physiological basis of psychosomatic therapy. Lechin, F, van der Dijs, B, Lechín, E, Eds., Editorial Científico-Medica: Barcelona, Spain, pp. 1-22.
87. Lechin, F, van der Dijs, B, Lechin, E. (1979b) Experimental bases for outlining and anatomical integration model of the central autonomic nervous system. In: The Autonomic Nervous System: Physiological basis of psychosomatic therapy. Lechin, F, van der Dijs, B, Lechón, E, Eds., Editorial Científico-Medica: Barcelona, Spain, pp. 23-30.
88. Lechin, F, van der Dijs, B, Jakubowicz, D, Camero, RE, Villa, S, Arocha, L, Lechin, A. (1985) Effects of clonidine on blood pressure, noradrenaline, cortisol, growth hormone, and prolactin plasma levels in high and low intestinal tone depressed patients. Neuroendocrinology 41: 156-162.
89. Lechin F, van der Dijs B, Amat J., Lechin S. (1986) Central nervous pathways involved in anxiety behavior. Experimental findings. Res Comm Psychol Psychiat Behav 11: 113-143.
90. Lechin F, van der Dijs B, Jackubowicz D, Camero RE, Lechin S, Villa S, Reinfeld B, Lechin ME. (1987) Role of stress in the exacerbation of chronic illness: effects of clonidine administration on blood pressure and plasma norpeinephrine, cortisol, growth hormone and prolactin concentrations. Psychoneuroendocrinology 12: 117-129.
91. Lechin, F, van der Dijs, B, Amat, J, Lechin, ME. (1989a) Central neuronal pathways involved in depressive syndrome: experimental findings. In: Neurochemistry and clinical disorders: circuitry of some psychiatric and psychosomatic syndromes. Lechin, F, van der Dijs, B, Eds., CRC Press: Boca Raton, FL, pp. 65-90.
92. Lechin, F, van der Dijs, B, Amat, J, Lechin, ME. (1989b) Neuroanatomical basis. In: Neurochemistry and clinical disorders: circuitry of some psychiatric and psychosomatic syndromes. Lechin, F, van der Dijs, B, Eds., CRC Press: Boca Raton, FL, pp. 2-18.
93. Lechin, F, van der Dijs, B, Amat, J, Lechin, S. (1989c) Central neuronal pathways involved in anxiety behavior: experimental findings. In: Neurochemistry and clinical disorders: circuitry of some psychiatric and psychosomatic syndromes. Lechin, F, van der Dijs, B, Eds., CRC Press: Boca Raton, FL, pp. 49-64.
94. Lechin, F, van der Dijs, B, Gomez, F, Lechin, M, Arocha, L, Villa, S. (1989d) Biological markers employed in the assessment of central autonomic nervous system functioning: An approach to the diagnosis of some psychiatric and psychosomatic syndromes. In: Neurochemistry and clinical disorders: circuitry of some psychiatric and psychosomatic syndromes. Lechin, F, van der Dijs, B, Eds., CRC Press: Boca Raton, FL, pp. 151-226.
95. Lechin, F, van der Dijs, B, Villa, S, Lechin, AE. (1989e) Central nervous system circuitry involved in blood pressure regulation. In: Neurochemistry and clinical disorders: circuitry of some psychiatric and psychosomatic syndromes. Lechin, F, van der Dijs, B, Eds., CRC Press: Boca Raton, FL, pp. 121-150.
96. Lechin, F, van der Dijs, B, Lechin, A, Lechin, M, Coll-Garcia, E, Jara, H, Cabrera, A, Jiménez, V, Gómez, F, Tovar, D, Rada, I, Arocha, L. (1991) Doxepin therapy for postprandial symptomatic hypoglycemic patients neurochemical, hormonal and metabolic disturbances. Clin Sci 80: 373-384.
97. Lechin, F, van der Dijs, B, Lechin, M, Jara, H, Lechin, A, Lechin-Báez, S, Orozco, B, Rada, I, Cabrera, A, Arocha, L, Jiménez, V, León, G. (1993) Plasma neurotransmitters throughout an oral glucose tolerance test in essential hypertension. Clin Exp Hypertens 15: 209-240.
98. Lechin, F, van der Dijs, B, Orozco, B, Lechin, M E, Acosta, E, Lechin, A E, Báez, S, Rada, I, Arocha, L, León, G, García, Z. (1995) Plasma neurotransmitters, blood pressure and heart rate during supine-resting, orthostasis and moderate exercise conditions in major depressed patients. Biol Psychiatry 38: 166-173.
99. Lechin, F, van der Dijs, B, Benaim, M. (1996a) Stress versus depression. Prog Neuro Psychopharmacol Biol Psychiatry 20: 899-950.
100. Lechin, F, van der Dijs, B, Lechin, M. (1996b) Plasma neurotransmitters and functional illness. Psychother Psychosom 65: 293-318.
101. Lechin, F, van der Dijs, B, Orozco, B, Báez, S, Rada, I, León, G, García, Z, Jara, H, Lechin, A E, Lechin, M E. (1996c) Plasma neurotransmitters, blood pressure and heart rate during supine-resting, orthostasis and moderate exercise stress test in healthy humans before and after parasympathetic blockade with atropine. Res Comm Biol Psychol Psychiatry 21: 55-72.
102. Lechin, F, van der Dijs, B, Orozco, B, Lechin, A E, Báez, S, Lechin, ME, Benaim, M, Rada, I, Acosta, E, Arocha, L, Jiménez, V, León, G, García, Z. (1996d) Plasma neurotransmitters, blood pressure and heart during supine-resting, orthostasis and moderate exercise in severely ill patients: A model of failing to cope with stress. Psychother Psychosom 65: 129-136.
103. Lechin F, van der Dijs B, Lechin ME, Orozco B, Baez S, Lechin AE, Jahn E, Jimenez V. (1997) Plasma neurotransmitters, blood pressure and heart rate during supine-resting, orthostasis, and moderate exercise conditions in two types of hypertensive patients. Res Comm Biol Psychol Psychiatry 22: 97-112.
104. Lechin, F, Lechin, ME, van der Dijs, B. (2002a) Plasma catecholamines and chronic congestive heart failure. Circulation 106: 222.
105. Lechin, F, van der Dijs, B, Lechin, ME. (2002b) Central neurocircuitry functioning during the wake-sleep cycle. In: Neurocircuitry and Neuroautonomic Disorders Reviews and Therapeutic Strategies. Lechin, F, van der Dijs, B, Lechin, ME, Eds., Karger: Basel, pp. 3-13.
106. Lechin, F, van der Dijs, B, Lechin, ME. (2002c) Neuroautonomic, neuroendocrine and neuroimmune interactions. In: Neurocircuitry and Neuroautonomic Disorders Reviews and Therapeutic Strategies. Lechin, F, van der Dijs, B, Lechón, ME, Eds., Karger: Basel, pp. 57-59.
107. Lechin, F, van der Dijs, B, Lechin, AE. (2004a) Neural sympathetic activity in essential hypertension. Hypertension 44, e3-e4.
108. Lechin, F, van der Dijs, B, Lechin, AE. (2004b) The autonomic nervous system assessment throughout the wake-sleep cycle & stress. Psychosom Med 66: 974-976.
109. Lechin, F, van der Dijs, B, Pardey-Maldonado, B, Benaim, M, Baez, S, Orozco, B, Lechin, AE. (2004c) Circulating neurotransmitter profiles during the different wake-sleep stages in normal subjects. Psychoneuroendocrinology 29: 669-685.
110. Lechin, F, van der Dijs, B, Lechin, AE. (2005) Circulating serotonin, catecholamines and CNS circuitry related to some cardiorespiratory and vascular disorders. J Appl Res 5: 605-621.
111. Lechin, F, van der Dijs, B. (2005) Blood pressure and autonomic system assessment throughout the sleep cycle in normal adults. Sleep 28: 645-646.
112. Lechin, F, van der Dijs, B, Hernandez-Adrian, G. (2006a) Dorsal Raphe DR vs Median Raphe MR serotonergic antagonism: Physiological, behavioral and pharmacological antagonisms. Clinical and therapeutical considerations. Prog Neuro Psychopharmacol Biol Psychiatry 30: 565-585.
113. Lechin, F, van der Dijs, B, Hernandez-Adrian, G, Orozco, B, Rodriguez, S, Baez, S. (2006b) Effects of sibutramine on circulating neurotransmitters in healthy subjects. Neurotoxicology 27: 184-191.
114. Levitt, P, Moore, RY. (1974) Origin and organization of brainstem catecholamines innervation in the rat. J Comp Neurol 186: 505-528.
115. Li, YW, Wesselingh, SL, Blessing, WW. (1992) Projections from rabbit caudal medulla to C1 and A5 sympathetic premotor neurons, demonstrated with phaseolus leucoagglutinin and herpes simplex virus. J Comp Neurol 317: 379-395.
116. Lindvall, O, Bjorklund, A. (1974) The organization of the ascending catecholamine neuron systems in the rat brain as revealed by the glyoxylic acid fluorescence method. Acta Physiol Scand Suppl 412: 1-48.
117. Liu, JP, Clarke, IJ, Funder, JW, Engler, D. (1991) Evidence that the central noradrenergic and adrenergic pathways activate the hypothalamic- pituitary-adrenal axis in the sheep. Endocrinology 129: 200-209.
118. Loewy, D, Marson, L, Parkinson, D, Perry, MA, Sawyer, WB. (1986) Descending noradrenergic pathways involved in the A5 depressor response. Brain Res 386: 313-324.
119. Loewy, AD, Franklin, MF, Haxhiu, MA. (1994) CNS monoamine cell groups projecting to pancreatic vagal motor neurons: a transneuronal labeling study using pseudorabies virus. Brain Res 638: 248-260.
120. Lorens, S A, Van de Kar, L D. (1987) Differential effects of serotonin (5-HT1A and 5-HT2) agonists and antagonists on renin and corticosterone secretion. Neuroendocrinology 45: 305-310.
121. Lovick, TA. (1993) Integrated activity of cardiovascular and pain regulatory systems: role in adaptive behavioural responses. Prog Neurobiol 40: 631-644.
122. Makino, S, Shibasaki, T, Yamauchi, N, Nishioka, T, Mimoto, T, Wakabayashi, I, Gold, PW, Hashimoto, K. (1999) Psychological stress increased corticotropin-releasing hormone mRNA and content in the central nucleus of the amygdala but not in the hypothalamic paraventricular nucleus in the rat. Brain Res 850: 136-143.
123. Malpas, SC. (1998) The rhythmicity of sympathetic nerve activity. Prog Neurobiol 56: 65-96.
124. 2 receptors: A mechanism limiting excessive sympathic-adrenal discharge in humans. J Clin Endocrinol Metab 66: 626-631.
125. Marwaha, J, Aghajanian, GK. (1982) Relative potencies of alpha-1 and alpha-2 antagonists in the locus coeruleus, dorsal raphe and dorsal lateral geniculate nuclei: an electrophysiological study. J Pharmacol Exp Ther 222: 287-293.
126. Matthews, KL, Chen, CP, Esiri, MM, Keene, J, Minger, SL, Francis, PT. (2002) Noradrenergic changes, aggressive behavior, and cognition in patients with dementia. Biol Psychiatry 51: 407-416.
127. Matthews, SC, Nelesen, RA, Dimsdale, JE. (2005) Depressive symptoms are associated with increased systemic vascular resistance to stress. Psychosom Med 67: 509-513.
128. McAuley, MA, Macrae, IM, Reid, JL. (1989) The cardiovascular actions of clonidine and neuropeptide-Y in the ventrolateral medulla of the rat. Br J Pharmacol 97: 1067-1074.
129. McCall, RB, Humphrey, SJ. (1982) Involvement of serotonin in the central regulation of blood pressure: evidence for a facilitating effect on sympathetic nerve activity. J Pharmacol Exp Ther 222: 94-102.
130. McCall, RB. (1984) Evidence for a serotonergically mediated sympathoexcitatory response to stimulation of medullary raphe nuclei. Brain Res 311: 31-39.
131. McDougall, SJ, Widdop, RE, Lawrence, AJ. (2005) Differential gene expression in WKY and SHR brain following acute and chronic air-puff stress. Brain Res Mol Brain Res 133: 329-336.
132. McQuade, R, Sharp, T. (1995) Release of cerebral 5-hydroxytryptamine evoked by electrical stimulation of the dorsal and median raphe nuclei: effect of a neurotoxic amphetamine. Neuroscience 68: 1079-1088.
133. McQuade, R, Sharp, T. (1997) Functional mapping of dorsal and median raphe 5-hydroxytryptamine pathways in forebrain of the rat using microdialysis. J Neurochem 69: 791-796.
134. Minson, JB, Llewellyn-Smith, IJ, Arnolda, LF, Pilowsky, PM, Oliver, JR, Chalmers, JP. (1994) Disinhibition of the rostral ventral medulla increases blood pressure and Fos expression in bulbospinal neurons. Brain Res 646: 44-52.
135. Miyawaki, T, Kawamura, H, Mitsubayashi, H, Usui, W, Yasugi, T. (1992) Altered basal firing pattern and postactivation inhibition of locus coeruleus neurons in spontaneously hypertensive rats. Neurosci Lett 137: 37-40.
136. Morilak, DA, Fornal, C, Jacobs, BL. (1986) Single unit activity of noradrenergic neurons in locus coeruleus and serotonergic neurons in the nucleus raphe dorsalis of freely moving cats in relation to the cardiac cycle. Brain Res 399: 262-270.
137. Mundey, MK, Fletcher, A, Marsden, CA. (1994) Effect of the putative 5-HT1A antagonists WAY100135 and SDZ 216-525 on 5-HT neuronal firing in the guinea-pig dorsal raphe nucleus Neuropharmacology 33(1): 61-66
138. Murase, S, Inui, K, Nosaka, S. (1994) Baroreceptor inhibition of the locus coeruleus noradrenergic neurons. Neuroscience 61: 635-643.
139. Murase, S, Takayama, M, Nosaka, S. (1993) Chemical stimulation of the nucleus locus coeruleus: cardiovascular responses and baroreflex modification. Neurosci Lett 153: 1-4.
140. Neil, JJ, Loewy, AD. (1982) Decreases in blood pressure in response to L-glutamate microinjections into the A5 catecholamine cell group. Brain Res 241: 271-278.
141. O'Donohue, TL, Crowley, WR, Jacobowitz, DM. (1979) Biochemical mapping of the noradrenergic ventral bundle projection sites: evidence for a noradrenergic - dopaminergic interaction. Brain Res 172: 87-100.
142. Ogawa, M. (1978) Interaction between noradrenergic and serotonergic mechanisms on the central regulation of blood pressure in the rat: a study using experimental central hypertension produced by chemical lesions of the locus coeruleus. Jpn Circ J 42: 581-597.
143. Ogawa, M, Fujita, Y, Ozaki, M. (1979) Experimental central hypertension produced by chemical degeneration of the locus coeruleus in the rat. Jpn Circ J 43: 89-98.
144. Oishi, R, Watanabe, S, Ohmori, K, Shibata, S, Ueki, S. (1979) Effect of stimulation of locus coeruleus on the evoked potential in the amygdala in rats. Jpn J Pharmacol 29: 105-111.
145. Owens, MJ, Knight, DL, Ritchie, JC, Nemeroff, CB. (1991a) The 5-hydroxytryptamine2 agonist, (+-)-1-(2,5-dimethoxy-4-bromophenyl)-2- aminopropane stimulates the hypothalamic-pituitary-adrenal (HPA) axis. I. Acute effects on HPA axis activity and corticotropin-releasing factor-containing neurons in the rat brain. J Pharmacol Exp Ther 256: 787-794.
146. 2 agonist, (+-)-1-(2,5-dimethoxy-4-bromophenyl)-2- aminopropane stimulates the hypothalamic-pituitary-adrenal (HPA) axis. II. Biochemical and physiological evidence for the development of tolerance after chronic administration. J Pharmacol Exp Ther 256: 795-800.
147. Park, SP. (2002) In vivo microdialysis measures of extracellular norepinephrine in the rat amygdala during sleep-wakefulness. J Korean Med Sci 17: 395-399.
148. Petrov, T, Krukoff, TL, Jhamandas, JH. (1993) Branching projections of catecholaminergic brainstem neurons to the paraventricular hypothalamic nucleus and the central nucleus of the amygdala in the rat. Brain Res 609: 81-92.
149. Pieribone, VA, Aston-Jones, G, Bohn, MC. (1988) Adrenergic and nonadrenergic neurons in the C1 and C3 areas project to locus coeruleus: a fluorescent double labeling study. Neurosci Lett 85: 297-303.
150. Pineyro, G, Blier, P. (1996) Regulation of 5-hydroxytryptamine release from rat midbrain raphe nuclei by 5-hydroxytryptamine1D receptors: effect of tetrodotoxin, G protein inactivation and long-term antidepressant administration. J Pharmacol Exp Ther 276: 697-707.
151. Pudovkina, OL, Cremers, TI, Westerink, BH. (2002) The interaction between the locus coeruleus and dorsal raphe nucleus studied with dual-probe microdialysis. Eur J Pharmacol 445: 7-42.
152. Pudovkina, OL, Kawahara, Y, de Vries, J, Westerink, BH. (2001) The release of noradrenaline in the locus coeruleus and prefrontal cortex studied with dual-probe microdialysis. Brain Res 906: 38-45.
153. Robertson, D, Johnson, GA, Robertson, RM, Nies, AS, Shand, DG, Oates, JA. (1979) Comparative assessment of stimuli that release neuronal and
154. Robinson, RL, Culberson, JL, Carmichael, SW. (1983) Influence of hypothalamic stimulation on the secretion of adrenal medullary catecholamines. J Auton Nerv Syst 8: 89-96.
155. Robinson, SE. (1982) Interaction of the median raphe nucleus and hypothalamic serotonin with cholinergic agents and pressor responses in the rat. J Pharmacol Exp Ther 223: 662-668.
156. Russell, V, de Villiers, A, Sagvolden, T, Lamm, M, Taljaard, J. (1995) Altered dopaminergic function in the prefrontal cortex, nucleus accumbens and caudate-putamen of an animal model of attention deficit hyperactivity disorder - the spontaneously hypertensive rat. Brain Res 676: 343-351.
157. Saavedra, JM, Grobecker, H, Zivin, J. (1976) Catecholamines in the raphe nuclei of the rat. Brain Res 114: 337-345.
158. Saha, S, Drinkhill, MJ, Moore, JP, Batten, TF. (2005) Central nucleus of amygdala projections to rostral ventrolateral medulla neurones activated by decreased blood pressure. Eur J Neurosci 21: 1921-1930.
159. Salome, N, Viltart, O, Leman, S, Sequeira, H. (2001) Activation of ventrolateral medullary neurons projecting to spinal autonomic areas after chemical stimulation of the central nucleus of amygdala: a neuroanatomical study in the rat. Brain Res 890: 287-295.
160. Sanchez, A, Toledo-Pinto, EA, Menezes, ML, Pereira, OCM. (2003) Changes in norepinephrine and epinephrine concentrations in adrenal gland of the rats submitted to acute immobilization stress. Pharmacol Res 48: 607-613.
161. Sawchenko, PE, Swanson, LW, Grzanna, R, Howe, PR, Bloom, SR, Polak, JM. (1985) Colocalization of neuropeptide Y immunoreactivity in brainstem catecholaminergic neurons that project to the paraventricular nucleus of the hypothalamus. J Comp Neurol 241: 138-153.
162. Schlenker, EH. (2005) Integration in the PVN: another piece of the puzzle. Am J Physiol Regul Integr Comp Physiol 289: R653-R655.
163. Schneider, C, Singewald, N, Philippu, A. (1995) Inhibition of catecholamine (noradrenaline, dopamine) release in the locus coeruleus and the hypothalamus by baroreceptor activation: identification of the involved baroreceptors. Naunyn Schmiedeberg's Arch Pharmacol 352: 291-296.
164. Schreiberg, GL, Dunaieva, LP. (1976) Catecholamines, system hypothalamus-hypophysis-adrenal cortex and stress. In: Catecholamines and stress. Usdin, E, Kvetnanky, R, Kopin, IJ, Eds., Pergamon Press: Oxford, pp. 157.
165. Senba, E, Matsunaga, K, Tohyama, M, Noguchi, K. (1993) Stress-induced c-fos expression in the rat brain: activation mechanism of sympathetic pathway. Brain Res Bull 31: 329-344.
166. Simonsick, EM, Wallace, RB, Blazer, DG, Berkman, LF. (1995) Depressive symptomatology and hypertension-associated morbidity and mortality in older adults. Psychosom Med 57: 427-435.
167. Singewald, N, Schneider, C, Philippu, A. (1993) Effects of blood pressure changes on the catecholamine release in the locus coeruleus of cats anaesthetized with pentobarbital or chloralose. Naunyn Schmiedeberg's Arch Pharmacol 348: 242-248.
168. Singewald, N, Zhou, GY, Schneider, C. (1995) Release of excitatory and inhibitory amino acids from the locus coeruleus of conscious rats by cardiovascular stimuli and various forms of acute stress. Brain Res 704: 42-50.
169. Sinha, JN, Sharma, DK, Gurtu, S, Pant, KK, Bhargava, KP. (1984) Nucleus locus coeruleus: evidence for alpha 1-adrenoceptor mediated hypotension in the cat. Naunyn Schmiedeberg's Arch Pharmacol 326: 193-197.
170. Smits, JF, van Essen, H, Struyker-Boudier, AJ. (1978) Serotonin-mediated cardiovascular responses to electrical stimulation of the raphe nuclei in the rat. Life Sci 23: 173-178.
171. Strack, AM, Sawyer, WB, Hughes, JH, Platt, KB, Loewy, AD. (1989) A general pattern of CNS innervation of the sympathetic outflow demonstrated by transneuronal pseudorabies viral infections. Brain Res 491: 156-162.
172. Sumners, C, Phillips, MI. (1983) Central injection of angiotensin II alters catecholamine activity in rat brain. Am J Physiol 244: R257-R263.
173. Sun, MK. (1995) Central neural organization and control of sympathetic nervous system in mammals. Prog Neurobiol 47: 157-233.
174. Suzuki, T, Higa, S, Sakoda, S, Hayashi, A, Yamamura, Y, Takaba, Y, Nakajima, A. (1981) Orthostatic hypotension in familial amyloid polyneuropathy: treatment with DL-threo-3,4-dihydroxyphenylserine. Neurology 31: 1323-1326.
175. Sved, AF, Felsten, G. (1987) Stimulation of the locus coeruleus decreases arterial pressure. Brain Res 414: 119-132.
176. Svensson, TH. (1987) Peripheral, autonomic regulation of locus coeruleus noradrenergic neurons in brain: putative implications for psychiatry and psychopharmacology. Psychopharmacology 92: 1-7.
177. Swenson, RM, Vogel, WH. (1983) Plasma Catecholamine and corticosterone as well as brain catecholamine changes during coping in rats exposed to stressful footshock. Pharmacol Biochem Behav 18: 689-693.
178. Szabo, ST, Blier, P. (2001) Functional and pharmacological characterization of the modulatory role of serotonin on the firing activity of locus coeruleus norepinephrine neurons. Brain Res 922: 9-20.
179. Tanaka, M, Matsumoto, Y, Murakami, T, Hisa, Y, Ibata, Y. (1996) The origins of catecholaminergic innervation in the rostral ventromedial medulla oblongata of the rat. Neurosci Lett 207: 53-56.
180. Tao, R, Auerbach, SB. (2003) Influence of inhibitory and excitatory inputs on serotonin efflux differs in the dorsal and median raphe nuclei. Brain Res 961: 109-120.
181. Trulson, ME, Frederickson, CJ. (1987) A comparison of the electrophysiological and pharmacological properties of serotonin-containing neurons in the nucleus raphe dorsalis, raphe medianus and raphe pallidus recorded from mouse brain slices in vitro: role of autoreceptors. Brain Res Bull 18: 179-190.
182. Tsukamoto, K, Sved, AF, Ito, S, Komatsu, K, Kanmatsuse, K. (2000) Enhanced serotonin-mediated responses in the nucleus tractus solitarius of spontaneously hypertensive rats. Brain Res 863: 1-8.
183. Van de Kar, LD, Lorens, SA, McWilliams, CR, Kunimoto, K, Urban, JH, Bethea, CL. (1984) Role of midbrain raphe in stress-induced renin and prolactin secretion. Brain Res 311: 333-341.
184. Van Gaalen, M, Kawahara, H, Kawahara, Y, Westerink, BH. (1997) The locus coeruleus noradrenergic system in the rat brain studied by dual-probe microdialysis. Brain Res 763: 56-62.
185. van Giersbergen, PL, Palkovits, M, De Jong, W. (1992) Involvement of neurotransmitters in the nucleus tractus solitarii in cardiovascular regulation. Physiol Rev 72: 789-824.
186. Verdecchia, P, Schillaci, G, Gatteschi, C, Zampi, I, Battistelli, M, Bartoccini, C, Porcellati, C. (1993) Blunted nocturnal fall in blood pressure in hypertensive women with future cardiovascular morbid events. Circulation 88: 986-992.
187. Vertes, RP, Fortin, WJ, Crane, AM. (1999) Projections of the median raphe nucleus in the rat. J Comp Neurol 407: 555-582.
188. Vitale, G, Arletti, R, Sandrini, M. (2005) Acute noise stress analgesia in relation to 5-HT2 and mu-opioid receptor changes in the frontal cortex of young mice. Life Sci 77: 2500-2513.
189. Ward, DG, Gunn, CG. (1976) Locus coeruleus complex: differential modulation of depressor mechanisms. Brain Res 107: 407-411.
190. Watanabe, T, Nakagawa, T, Yamamoto, R, Maeda, A, Minami, M, Satoh, M. (2003) Involvement of noradrenergic system within the central nucleus of the amygdala in naloxone-precipitated morphine withdrawal-induced conditioned place aversion in rats. Psychopharmacology 170: 80-88.
191. Weitemier, AZ, Ryabinin, AE. (2006) Urocortin 1 in the dorsal raphe regulates food and fluid consumption, but not ethanol preference in C57BL/6J mice. Neuroscience 137: 1439-1445.
192. Whitnall, MH. (1993) Regulation of the hypothalamic corticotropin- releasing hormone neurosecretory system. Prog Neurobiol 40: 573-629.
193. Willette, RN, Barcas, PP, Krieger, AJ, Sapru, HN. (1984) Endogenous GABAergic mechanisms in the medulla and the regulation of blood pressure. J Pharmacol Exp Ther 230: 34-39.
194. Williams, JA, Reiner, PB. (1993) Noradrenaline hyperpolarizes identified rat mesopontine cholinergic neurons in vitro. J Neurosci 13: 3878-3883.
195. Wirtz, PH, von Kanel, R, Frey, K, Ehlert, U, Fischer, JE. (2004) Glucocorticoid sensitivity of circulating monocytes in essential hypertension. Am J Hypertens 17(6), 489-494.
196. Yao, ST, Lawrence, AJ. (2005) A comparative autoradiographic study of the density of [3H]SR95531, [3H]MK-801 and [3H]cGMP binding in the locus coeruleus and central pontine grey of spontaneously hypertensive and Wistar-Kyoto rats. Naunyn Schmiedeberg's Arch Pharmacol 371: 434-439.
197. Young, JB, Rosa, RM, Landsberg, L. (1984) Dissociation of sympathetic nervous system and adrenal medullary responses. Am J Physiol 247: E35-E40.
198. Young, WS III, Uhl, GR, Kuhar, MJ. (1978) Iontophoresis of neurotensin in the area of the locus coeruleus. Brain Res 150: 431-435.
199. Yusof, AP, Coote, JH. (1988) Patterns of activity in sympathetic postganglionic nerves to skeletal muscle, skin and kidney during stimulation of the medullary raphe area of the rat. J Auton Nerv Syst 24: 71-79.
200. Zimmermann, H, Ganong, WF. (1980) Pharmacological evidence that stimulation of central serotonergic pathways increases renin secretion. Neuroendocrinology 30: 101-107.