Chemoreflex sympathoexcitation was not altered by the antagonism of glutamate receptors in the commissural nucleus tractus solitarii in the working heart-brainstem preparation of rats

Experimental Physiology

Volumn 91, Issue 3, 2006, Pages 551-559

  Braga, Valdir A ^a   Machado, Benedito H ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA METHYL 4 CARBOXYPHENYLGLYCINE; GLUTAMATE RECEPTOR; GLUTAMATE RECEPTOR ANTAGONIST; KYNURENIC ACID;

ADRENERGIC SYSTEM; ANIMAL EXPERIMENT; ARTICLE; BRADYCARDIA; BRAIN STEM; CHEMORECEPTOR REFLEX; CHOLINERGIC SYSTEM; CONTROLLED STUDY; ELECTROCARDIOGRAM; HEART; HEART RATE; MALE; MICROINJECTION; NEUROTRANSMISSION; NONHUMAN; PHRENIC NERVE; RAT; SOLITARY TRACT NUCLEUS;

EID: 33646093735     PISSN: 09580670     EISSN: 1469445X     Source Type: Journal    
DOI: 10.1113/expphysiol.2005.033100     Document Type: Article

References (20)

1. Antunes VR Braga VA & Machado BH 2005 Autonomic and respiratory responses to microinjection of ATP into the intermediate or caudal nucleus tractus solitarius in the working heart-brainstem preparation of the rat Clin Exp Pharmacol Physiol 32 467 472
2. Antunes VR & Machado BH 2003 Antagonism of glutamatergic metabotropic receptors in the NTS of awake rats does not affect the gain of the baroreflex Auton Neurosci 103 65 71
3. Braga VA Antunes VR & Machado BH 2005 Changes in the phrenic and sympathetic nerve activities in response to microinjection of l -glutamate into the caudal NTS in the working heart-brainstem preparation of the rat FASEB J 19 A596
4. Chitravanshi VC Kachroo A & Sapru HN 1994 A midline area in the nucleus commissuralis of NTS mediates the phrenic nerve responses to carotid chemoreceptor stimulation Brain Res 662 127 132
5. Chitravanshi VC & Sapru HN 1995 Chemoreceptor-sensitive neurons in commissural subnucleus of nucleus tractus solitarius of the rat Am J Physiol 268 851 858
6. Colombari E Menani JV & Talman WT 1996 Commissural NTS contributes to pressor responses to glutamate injected into medial NTS of awake rats Am J Physiol 270 R1220 R1225
7. Finley JCW & Katz DM 1992 The central organization of carotid body afferent projections to the brainstem of the rat Brain Res 572 108 116
8. Haibara AS Bonagamba LGH & Machado BH 1999 Sympathoexcitatory neurotransmission of the chemoreflex in the NTS of awake rats Am J Physiol 276 R69 R80
9. Haibara AS Colombari E Chianca DA Jr. Bonagamba LGH & Machado BH 1995 NMDA receptors in the NTS are involved in bradycardic but not in pressor response of chemoreflex Am J Physiol 269 H1421 H1427
10. Machado BH 2004 Chemoreflex and sympathoexcitation In Neural Mechanisms of Cardiovascular Regulation ed Dun NJ Machado BH & Pilowsky PM pp 31 58 Kluwer Academic Publishers Norwell MA USA
11. Machado BH & Bonagamba LGH 1992 Microinjection of l -glutamate into the nucleus tractus solitarii increases arterial pressure in conscious rats Brain Res 576 131 138
12. Machado BH & Bonagamba LGH 2005 Antagonism of glutamate receptors in the intermediate and caudal NTS of awake rats produced no changes in the hypertensive response to chemoreflex activation Auton Neurosci 117 25 32
13. Mizusawa A Ogawa H Kikuchi Y Hida W Kurosawa H Okabe S Takishima T & Shirato K 1994 In vivo release of glutamate in nucleus tractus solitarii of the rat during hypoxia J Physiol 478 55 65
14. Paton JF 1996 A working heart-brainstem preparation of the mouse J Neurosci Methods 65 63 68
15. Paton JFR De Paula PM Spyer KM Machado BH & Boscan P 2002 Sensory afferent selective role of P2 receptors in the nucleus tractus solitarii for mediating the cardiac component of the peripheral chemoreceptor reflex in rats J Physiol 543 995 1005
16. Paton JFR Li YW Schwaber JS & Kasparov S 1999 Reflex response and convergence of pharyngoesophageal and peripheral chemoreceptors in the nucleus of the solitary tract Neurosc 95 141 153
17. Sapru HN 1996 Carotid chemoreflex. Neural pathways and transmitters Adv Exp Med Biol 410 357 364
18. Sato MA Schoorlemmer GHM Menani JV Lopes OU & Colombari E 2003 Recovery of high blood pressure after chronic lesions of the commissural NTS in SHR Hypertension 42 713 718
19. Vardhan A Kachroo A & Sapru HN 1993 Excitatory amino acid receptors in commissural nucleus of the NTS mediate carotid chemoreceptor responses Am J Physiol 264 R41 R50
20. Zhang W & Mifflin SW 1993 Excitatory amino acid receptors within NTS mediate arterial chemoreceptor reflexes in rats Am J Physiol 265 H770 H773