메뉴 건너뛰기




Volumn 20, Issue 7, 2006, Pages 741-750

Management of colorectal cancer in older patients

Author keywords

[No Author keywords available]

Indexed keywords

BEVACIZUMAB; CAPECITABINE; CETUXIMAB; FLUOROPYRIMIDINE DERIVATIVE; FLUOROURACIL; FOLINIC ACID; IRINOTECAN; OXALIPLATIN; ANTINEOPLASTIC AGENT;

EID: 33750606711     PISSN: 08909091     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (1)

References (72)
  • 1
    • 34547136957 scopus 로고    scopus 로고
    • National Cancer Institute:, Available at, Accessed May 4
    • National Cancer Institute: SEER cancer statistics review, 1975-2001. Available at http://seer.cancer.gov/csr/1975_2001/results_merged/topic_med_age. pdf. Accessed May 4, 2006.
    • (2006) SEER cancer statistics review, 1975-2001
  • 2
    • 0033995153 scopus 로고    scopus 로고
    • What threshold for adjuvant therapy in older breast cancer patients?
    • Extermann M, Balducci L, Lyman GH: What threshold for adjuvant therapy in older breast cancer patients? J Clin Oncol 18:1709-1717, 2000.
    • (2000) J Clin Oncol , vol.18 , pp. 1709-1717
    • Extermann, M.1    Balducci, L.2    Lyman, G.H.3
  • 3
    • 22144473678 scopus 로고    scopus 로고
    • Management of advanced colorectal cancer in older patients
    • Lichtman SM: Management of advanced colorectal cancer in older patients. Oncology (Williston Park) 19:597-602, 2005.
    • (2005) Oncology (Williston Park) , vol.19 , pp. 597-602
    • Lichtman, S.M.1
  • 4
    • 0033849596 scopus 로고    scopus 로고
    • Measurement and impact of comorbidity in older cancer patients
    • Extermann M: Measurement and impact of comorbidity in older cancer patients. Crit Rev Oncol Hematol 35:181-200, 2000.
    • (2000) Crit Rev Oncol Hematol , vol.35 , pp. 181-200
    • Extermann, M.1
  • 5
    • 0029365836 scopus 로고
    • Physiological aspects of aging. Implications for the treatment of cancer
    • Lichtman SM: Physiological aspects of aging. Implications for the treatment of cancer. Drugs Aging 7:212-225, 1995.
    • (1995) Drugs Aging , vol.7 , pp. 212-225
    • Lichtman, S.M.1
  • 6
    • 16544371710 scopus 로고    scopus 로고
    • Enrollment of elderly patients in clinical trials for cancer drug registration: A 7-year experience by the US Food and Drug Administration
    • Talarico L, Chen G, Pazdur R: Enrollment of elderly patients in clinical trials for cancer drug registration: A 7-year experience by the US Food and Drug Administration. J Clin Oncol 22:4626-4631, 2004.
    • (2004) J Clin Oncol , vol.22 , pp. 4626-4631
    • Talarico, L.1    Chen, G.2    Pazdur, R.3
  • 7
    • 0033619959 scopus 로고    scopus 로고
    • Underrepresentation of patients 65 years of age or older in cancer-treatment trials
    • Hutchins LF, Unger JM, Crowley JJ, et al: Underrepresentation of patients 65 years of age or older in cancer-treatment trials. N Engl J Med 341:2061-2067, 1999.
    • (1999) N Engl J Med , vol.341 , pp. 2061-2067
    • Hutchins, L.F.1    Unger, J.M.2    Crowley, J.J.3
  • 8
    • 30744434127 scopus 로고    scopus 로고
    • Physiologic aspects of aging: Impact on cancer management and decision making, Part I
    • Sawhney R, Sehl M, Naeim A: Physiologic aspects of aging: Impact on cancer management and decision making, Part I. Cancer J 11:449-460, 2005.
    • (2005) Cancer J , vol.11 , pp. 449-460
    • Sawhney, R.1    Sehl, M.2    Naeim, A.3
  • 9
    • 9644283143 scopus 로고    scopus 로고
    • Changes in upper gastrointestinal physiology with age
    • Newton JL: Changes in upper gastrointestinal physiology with age. Mech Ageing Dev 125:867-870, 2004.
    • (2004) Mech Ageing Dev , vol.125 , pp. 867-870
    • Newton, J.L.1
  • 10
  • 11
    • 0016791510 scopus 로고
    • Age-related incidence of sclerotic glomeruli in human kidneys
    • Kaplan C, Pasternack B, Shah H, et al: Age-related incidence of sclerotic glomeruli in human kidneys. Am J Pathol 80:227-234, 1975.
    • (1975) Am J Pathol , vol.80 , pp. 227-234
    • Kaplan, C.1    Pasternack, B.2    Shah, H.3
  • 12
    • 0035175243 scopus 로고    scopus 로고
    • Effect of age on renal functional and orthostatic vascular response in healthy men
    • Adachi T, Kawamura M, Owada M, et al: Effect of age on renal functional and orthostatic vascular response in healthy men. Clin Exp Pharmacol Physiol 28:877-880, 2001.
    • (2001) Clin Exp Pharmacol Physiol , vol.28 , pp. 877-880
    • Adachi, T.1    Kawamura, M.2    Owada, M.3
  • 13
    • 0037429082 scopus 로고    scopus 로고
    • Serum creatinine is an inadequate screening test for renal failure in elderly patients
    • Swedko PJ, Clark HD, Paramsothy K, et al: Serum creatinine is an inadequate screening test for renal failure in elderly patients. Arch Intern Med 163:356-360, 2003.
    • (2003) Arch Intern Med , vol.163 , pp. 356-360
    • Swedko, P.J.1    Clark, H.D.2    Paramsothy, K.3
  • 14
    • 2942746552 scopus 로고    scopus 로고
    • Incidence of renal insufficiency in cancer patients and evaluation of information available on the use of anticancer drugs in renally impaired patients
    • Launay-Vacher V, Izzedine H, Rey JB, et al: Incidence of renal insufficiency in cancer patients and evaluation of information available on the use of anticancer drugs in renally impaired patients. Med Sci Monit 10:CR209-212, 2004.
    • (2004) Med Sci Monit , vol.10
    • Launay-Vacher, V.1    Izzedine, H.2    Rey, J.B.3
  • 15
    • 0028575867 scopus 로고
    • Establishment of creatinine clearance reference values for older women
    • Sokoll LJ, Russell RM, Sadowski JA, et al: Establishment of creatinine clearance reference values for older women. Clin Chem 40:2276-2281, 1994.
    • (1994) Clin Chem , vol.40 , pp. 2276-2281
    • Sokoll, L.J.1    Russell, R.M.2    Sadowski, J.A.3
  • 16
    • 0016916438 scopus 로고
    • Prediction of creatinine clearance from serum creatinine
    • Cockcroft DW, Gault MH: Prediction of creatinine clearance from serum creatinine. Nephron 16:31-41, 1976.
    • (1976) Nephron , vol.16 , pp. 31-41
    • Cockcroft, D.W.1    Gault, M.H.2
  • 17
    • 1342267612 scopus 로고    scopus 로고
    • Evaluation of the Cockroft-Gault, Jelliffe and Wright formulae in estimating renal function in elderly cancer patients
    • Marx GM, Blake GM, Galani E, et al: Evaluation of the Cockroft-Gault, Jelliffe and Wright formulae in estimating renal function in elderly cancer patients. Ann Oncol 15:291-295, 2004.
    • (2004) Ann Oncol , vol.15 , pp. 291-295
    • Marx, G.M.1    Blake, G.M.2    Galani, E.3
  • 18
    • 34250642821 scopus 로고    scopus 로고
    • A report from a SIOG Task Force on Renal Safety in the Elderly
    • Available at, Accessed May 4
    • Aapro M, Launay-Vacher V, Lichtman S, et al: A report from a SIOG Task Force on Renal Safety in the Elderly. International Society of Geriatric Oncology Newsletter. 1(1):1, 2005. Available at www.cancerworld.org/ cancerworldadmin/getStaticModFileaspx?id=893. Accessed May 4, 2006.
    • (2005) International Society of Geriatric Oncology Newsletter , vol.1 , Issue.1 , pp. 1
    • Aapro, M.1    Launay-Vacher, V.2    Lichtman, S.3
  • 19
    • 0028070572 scopus 로고
    • Representation of older patients in cancer treatment trials
    • Trimble EL, Carter CL, Cain D, et al: Representation of older patients in cancer treatment trials. Cancer 74:2208-2214, 1994.
    • (1994) Cancer , vol.74 , pp. 2208-2214
    • Trimble, E.L.1    Carter, C.L.2    Cain, D.3
  • 20
    • 0037811742 scopus 로고    scopus 로고
    • Barriers to clinical trial participation by older women with breast cancer
    • Kemeny MM, Peterson BL, Kornblith AB, et al: Barriers to clinical trial participation by older women with breast cancer. J Clin Oncol 21:2268-2275, 2003.
    • (2003) J Clin Oncol , vol.21 , pp. 2268-2275
    • Kemeny, M.M.1    Peterson, B.L.2    Kornblith, A.B.3
  • 21
    • 0037089630 scopus 로고    scopus 로고
    • How sociodemographics, presence of oncology specialists, and hospital cancer programs affect accrual to cancer treatment trials
    • Sateren WB, Trimble EL, Abrams J, et al: How sociodemographics, presence of oncology specialists, and hospital cancer programs affect accrual to cancer treatment trials. J Clin Oncol 20:2109-2117, 2002.
    • (2002) J Clin Oncol , vol.20 , pp. 2109-2117
    • Sateren, W.B.1    Trimble, E.L.2    Abrams, J.3
  • 22
    • 2542615200 scopus 로고    scopus 로고
    • Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer
    • Andre T, Boni C, Mounedji-Boudiaf L, et al: Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer. N Engl J Med 350:2343-2351, 2004.
    • (2004) N Engl J Med , vol.350 , pp. 2343-2351
    • Andre, T.1    Boni, C.2    Mounedji-Boudiaf, L.3
  • 23
    • 2542563257 scopus 로고    scopus 로고
    • Pooled analysis of fluorouracil-based adjuvant therapy for stage II and III colon cancer: Who benefits and by how much?
    • Gill S, Loprinzi CL, Sargent DJ, et al: Pooled analysis of fluorouracil-based adjuvant therapy for stage II and III colon cancer: Who benefits and by how much? J Clin Oncol 22:1797-1806, 2004.
    • (2004) J Clin Oncol , vol.22 , pp. 1797-1806
    • Gill, S.1    Loprinzi, C.L.2    Sargent, D.J.3
  • 24
    • 0024397951 scopus 로고
    • Surgical adjuvant therapy of large-bowel carcinoma: An evaluation of levamisole and the combination of levamisole and fluorouracil. The North Central Cancer Treatment Group and the Mayo Clinic
    • Laurie JA, Moertel CG, Fleming TR, et al: Surgical adjuvant therapy of large-bowel carcinoma: An evaluation of levamisole and the combination of levamisole and fluorouracil. The North Central Cancer Treatment Group and the Mayo Clinic. J Clin Oncol 7:1447-1456, 1989.
    • (1989) J Clin Oncol , vol.7 , pp. 1447-1456
    • Laurie, J.A.1    Moertel, C.G.2    Fleming, T.R.3
  • 25
    • 0025060806 scopus 로고
    • Levamisole and fluorouracil for adjuvant therapy of resected colon carcinoma
    • Moertel CG, Fleming TR, Macdonald JS, et al: Levamisole and fluorouracil for adjuvant therapy of resected colon carcinoma. N Engl J Med 322:352-358, 1990.
    • (1990) N Engl J Med , vol.322 , pp. 352-358
    • Moertel, C.G.1    Fleming, T.R.2    Macdonald, J.S.3
  • 26
    • 84944371744 scopus 로고    scopus 로고
    • NIH Consensus Conference: Adjuvant therapy for patients with colon and rectal cancer. JAMA 264:1444-1450, 1990.
    • NIH Consensus Conference: Adjuvant therapy for patients with colon and rectal cancer. JAMA 264:1444-1450, 1990.
  • 27
    • 0035815928 scopus 로고    scopus 로고
    • Age and adjuvant chemotherapy use after surgery for stage III colon cancer
    • Schrag D, Cramer LD, Bach PB, et al: Age and adjuvant chemotherapy use after surgery for stage III colon cancer. J Natl Cancer Inst 93:850-857, 2001.
    • (2001) J Natl Cancer Inst , vol.93 , pp. 850-857
    • Schrag, D.1    Cramer, L.D.2    Bach, P.B.3
  • 28
    • 0035448972 scopus 로고    scopus 로고
    • Who gets adjuvant treatment for stage II and III rectal cancer? Insight from Surveillance, Epidemiology, and End Results - Medicare
    • Schrag D, Gelfand SE, Bach PB, et al: Who gets adjuvant treatment for stage II and III rectal cancer? Insight from Surveillance, Epidemiology, and End Results - Medicare. J Clin Oncol 19:3712-3718, 2001.
    • (2001) J Clin Oncol , vol.19 , pp. 3712-3718
    • Schrag, D.1    Gelfand, S.E.2    Bach, P.B.3
  • 29
    • 0035715386 scopus 로고    scopus 로고
    • Variations in the use of adjuvant chemotherapy for node-positive colon cancer in the elderly: A population-based study
    • Sundararajan V, Grann VR, Jacobson JS, et al: Variations in the use of adjuvant chemotherapy for node-positive colon cancer in the elderly: A population-based study. Cancer J 7:213-218, 2001.
    • (2001) Cancer J , vol.7 , pp. 213-218
    • Sundararajan, V.1    Grann, V.R.2    Jacobson, J.S.3
  • 30
    • 0033950054 scopus 로고    scopus 로고
    • Stage III colon cancers: Why adjuvant chemotherapy is not offered to elderly patients
    • Mahoney T, Kuo YH, Topilow A, et al: Stage III colon cancers: Why adjuvant chemotherapy is not offered to elderly patients. Arch Surg 135:182-185, 2000.
    • (2000) Arch Surg , vol.135 , pp. 182-185
    • Mahoney, T.1    Kuo, Y.H.2    Topilow, A.3
  • 31
    • 0036498881 scopus 로고    scopus 로고
    • Age, sex, and racial differences in the use of standard adjuvant therapy for colorectal cancer
    • Potosky AL, Harlan LC, Kaplan RS, et al: Age, sex, and racial differences in the use of standard adjuvant therapy for colorectal cancer. J Clin Oncol 20:1192-1202, 2002.
    • (2002) J Clin Oncol , vol.20 , pp. 1192-1202
    • Potosky, A.L.1    Harlan, L.C.2    Kaplan, R.S.3
  • 32
    • 33644846283 scopus 로고    scopus 로고
    • Phase III study of fluorouracil, leucovorin, and levamisole in high-risk stage II and III colon cancer: Final report of Intergroup 0089
    • Haller DG, Catalano PJ, Macdonald JS, et al: Phase III study of fluorouracil, leucovorin, and levamisole in high-risk stage II and III colon cancer: Final report of Intergroup 0089. J Clin Oncol 23:8671-8678, 2005.
    • (2005) J Clin Oncol , vol.23 , pp. 8671-8678
    • Haller, D.G.1    Catalano, P.J.2    Macdonald, J.S.3
  • 33
    • 0035846320 scopus 로고    scopus 로고
    • A pooled analysis of adjuvant chemotherapy for resected colon cancer in elderly patients
    • Sargent DJ, Goldberg RM, Jacobson SD, et al: A pooled analysis of adjuvant chemotherapy for resected colon cancer in elderly patients. N Engl J Med 345:1091-1097, 2001.
    • (2001) N Engl J Med , vol.345 , pp. 1091-1097
    • Sargent, D.J.1    Goldberg, R.M.2    Jacobson, S.D.3
  • 34
    • 28844482345 scopus 로고    scopus 로고
    • Adjuvant chemotherapy for stage III colon cancer: Implications of race/ethnicity, age, and differentiation
    • Jessup JM, Stewart A, Greene FL, et al: Adjuvant chemotherapy for stage III colon cancer: Implications of race/ethnicity, age, and differentiation. JAMA 294:2703-2711, 2005.
    • (2005) JAMA , vol.294 , pp. 2703-2711
    • Jessup, J.M.1    Stewart, A.2    Greene, F.L.3
  • 35
    • 4644288273 scopus 로고    scopus 로고
    • Efficacy of 5-fluorouracil-based chemotherapy in elderly patients with metastatic colorectal cancer: A pooled analysis of clinical trials
    • Folprecht G, Cunningham D, Ross P, et al: Efficacy of 5-fluorouracil-based chemotherapy in elderly patients with metastatic colorectal cancer: A pooled analysis of clinical trials. Ann Oncol 15:1330-1338, 2004.
    • (2004) Ann Oncol , vol.15 , pp. 1330-1338
    • Folprecht, G.1    Cunningham, D.2    Ross, P.3
  • 36
    • 24144447004 scopus 로고    scopus 로고
    • Age and colorectal cancer with focus on the elderly: Trends in relative survival and initial treatment from a Danish population-based study
    • Iversen LH, Pedersen L, Riis A, et al: Age and colorectal cancer with focus on the elderly: Trends in relative survival and initial treatment from a Danish population-based study. Dis Colon Rectum 48:1755-1763, 2005.
    • (2005) Dis Colon Rectum , vol.48 , pp. 1755-1763
    • Iversen, L.H.1    Pedersen, L.2    Riis, A.3
  • 37
    • 0037322806 scopus 로고    scopus 로고
    • Severe toxicity related to the 5-fluorouracil/leucovorin combination (the Mayo Clinic regimen): A prospective study in colorectal cancer patients
    • Tsalic M, Bar-Sela G, Beny A, et al: Severe toxicity related to the 5-fluorouracil/leucovorin combination (the Mayo Clinic regimen): A prospective study in colorectal cancer patients. Am J Clin Oncol 26:103-106, 2003.
    • (2003) Am J Clin Oncol , vol.26 , pp. 103-106
    • Tsalic, M.1    Bar-Sela, G.2    Beny, A.3
  • 38
    • 2342419285 scopus 로고    scopus 로고
    • Weekly 5-fluorouracil and leucovorin: Achieving lower toxicity with higher dose-intensity in adjuvant chemotherapy after colorectal cancer resection
    • Patel K, Anthoney DA, Crellin AM, et al: Weekly 5-fluorouracil and leucovorin: Achieving lower toxicity with higher dose-intensity in adjuvant chemotherapy after colorectal cancer resection. Ann Oncol 15:568-573, 2004.
    • (2004) Ann Oncol , vol.15 , pp. 568-573
    • Patel, K.1    Anthoney, D.A.2    Crellin, A.M.3
  • 39
    • 9144238357 scopus 로고    scopus 로고
    • Oral capecitabine as an alternative to I.V. 5-fluorouracil-based adjuvant therapy for colon cancer: Safety results of a randomized, phase III trial
    • Scheithauer W, McKendrick J, Begbie S, et al: Oral capecitabine as an alternative to I.V. 5-fluorouracil-based adjuvant therapy for colon cancer: Safety results of a randomized, phase III trial. Ann Oncol 14:1735-1743, 2003.
    • (2003) Ann Oncol , vol.14 , pp. 1735-1743
    • Scheithauer, W.1    McKendrick, J.2    Begbie, S.3
  • 40
    • 21244497388 scopus 로고    scopus 로고
    • Capecitabine as adjuvant treatment for stage III colon cancer
    • Twelves C, Wong A, Nowacki MP, et al: Capecitabine as adjuvant treatment for stage III colon cancer. N Engl J Med 352:2696-2704, 2005.
    • (2005) N Engl J Med , vol.352 , pp. 2696-2704
    • Twelves, C.1    Wong, A.2    Nowacki, M.P.3
  • 41
    • 34250636392 scopus 로고    scopus 로고
    • Safety of capecitabine (X) compared to fluorouracil/leucovorin (5-FU/LV) for the adjuvant treatment of elderly colon cancer patients (pts) (abstract 3737)
    • 258s
    • Diaz-Rubio E, Burris H, Douillard JY et al: Safety of capecitabine (X) compared to fluorouracil/leucovorin (5-FU/LV) for the adjuvant treatment of elderly colon cancer patients (pts) (abstract 3737). J Clin Oncol 22(14S):258s, 2004.
    • (2004) J Clin Oncol 22(14S)
    • Diaz-Rubio, E.1    Burris, H.2    Douillard, J.Y.3
  • 42
    • 34250612328 scopus 로고    scopus 로고
    • A pooled analysis to assess safety and efficacy of the FOLFOX4 regimen (bimonthlyoxaliplatin plus fluorouracil/leucovorin) in elderly patients with colorectal cancer
    • Barcelona
    • Sargent D, Goldberg RM, Bleiberg H, et al: A pooled analysis to assess safety and efficacy of the FOLFOX4 regimen (bimonthlyoxaliplatin plus fluorouracil/leucovorin) in elderly patients with colorectal cancer. Proceedings of the World Congress of Gastrointestinal Cancer, Barcelona, page O-007, 2005.
    • (2005) Proceedings of the World Congress of Gastrointestinal Cancer
    • Sargent, D.1    Goldberg, R.M.2    Bleiberg, H.3
  • 43
    • 33644843853 scopus 로고    scopus 로고
    • OPTIMOX1: A randomized study of FOLFOX4 or FOLFOX7 with oxaliplatin in a stop-and-go gashion in advanced colorectal cancer - a GERCOR study
    • Toumigand C, Cervantes A, Figer A, et al: OPTIMOX1: A randomized study of FOLFOX4 or FOLFOX7 with oxaliplatin in a stop-and-go gashion in advanced colorectal cancer - a GERCOR study. J Clin Oncol 24:394-400, 2006.
    • (2006) J Clin Oncol , vol.24 , pp. 394-400
    • Toumigand, C.1    Cervantes, A.2    Figer, A.3
  • 44
    • 0032792959 scopus 로고    scopus 로고
    • Adjuvant or palliative chemotherapy for colorectal cancer in patients 70 years or older
    • Popescu RA, Norman A, Ross PJ, et al: Adjuvant or palliative chemotherapy for colorectal cancer in patients 70 years or older. J Clin Oncol 17:2412-2418, 1999.
    • (1999) J Clin Oncol , vol.17 , pp. 2412-2418
    • Popescu, R.A.1    Norman, A.2    Ross, P.J.3
  • 45
    • 1342290189 scopus 로고    scopus 로고
    • FOLFIRI followed by FOLFOX6 or the reverse sequence in advanced colorectal cancer: A randomized GERCOR study
    • Tournigand C, Andre T, Achille E, et al: FOLFIRI followed by FOLFOX6 or the reverse sequence in advanced colorectal cancer: A randomized GERCOR study. J Clin Oncol 22:229-237, 2004.
    • (2004) J Clin Oncol , vol.22 , pp. 229-237
    • Tournigand, C.1    Andre, T.2    Achille, E.3
  • 46
    • 0033558004 scopus 로고    scopus 로고
    • A multicenter, phase II trial of weekly irinotecan (CPT-11) in patients with previously treated colorectal carcinoma
    • Rothenberg ML, Cox JV, DeVore RF, et al: A multicenter, phase II trial of weekly irinotecan (CPT-11) in patients with previously treated colorectal carcinoma. Cancer 85:786-795, 1999.
    • (1999) Cancer , vol.85 , pp. 786-795
    • Rothenberg, M.L.1    Cox, J.V.2    DeVore, R.F.3
  • 47
    • 0034712536 scopus 로고    scopus 로고
    • Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: A multicentre randomised trial
    • Douillard JY, Cunningham D, Roth AD, et al: Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: A multicentre randomised trial. Lancet 355:1041-1047, 2000.
    • (2000) Lancet , vol.355 , pp. 1041-1047
    • Douillard, J.Y.1    Cunningham, D.2    Roth, A.D.3
  • 48
    • 29144469349 scopus 로고    scopus 로고
    • Combination of irinotecan (CPT-11) plus 5-fluorouracil and leucovorin (FOLFIRI regimen) as first line treatment for elderly patients with metastatic colorectal cancer: A phase II trial
    • Souglakos J, Pallis A, Kakolyris S, et al: Combination of irinotecan (CPT-11) plus 5-fluorouracil and leucovorin (FOLFIRI regimen) as first line treatment for elderly patients with metastatic colorectal cancer: A phase II trial. Oncology 69:384-390, 2005.
    • (2005) Oncology , vol.69 , pp. 384-390
    • Souglakos, J.1    Pallis, A.2    Kakolyris, S.3
  • 49
    • 20644437768 scopus 로고    scopus 로고
    • Irinotecan in combination with fluorouracil in a 48-hour continuous infusion as first-line chemotherapy for elderly patients with metastatic colorectal cancer: A Spanish Cooperative Group for the Treatment of Digestive Tumors study
    • Sastre J, Marcuello E, Masutti B, et al: Irinotecan in combination with fluorouracil in a 48-hour continuous infusion as first-line chemotherapy for elderly patients with metastatic colorectal cancer: A Spanish Cooperative Group for the Treatment of Digestive Tumors study. J Clin Oncol 23:3545-3551, 2005.
    • (2005) J Clin Oncol , vol.23 , pp. 3545-3551
    • Sastre, J.1    Marcuello, E.2    Masutti, B.3
  • 50
    • 0034727063 scopus 로고    scopus 로고
    • Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer. Irinotecan Study Group
    • Saltz LB, Cox JV, Blanke C, et al: Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer. Irinotecan Study Group. N Engl J Med 343:905-914, 2000.
    • (2000) N Engl J Med , vol.343 , pp. 905-914
    • Saltz, L.B.1    Cox, J.V.2    Blanke, C.3
  • 51
    • 9144256327 scopus 로고    scopus 로고
    • A phase I and pharmacokinetic study of irinotecan in patients with hepatic or renal dysfunction or with prior pelvic radiation: CALGB 9863
    • Venook AP, Enders Klein C, Fleming G, et al: A phase I and pharmacokinetic study of irinotecan in patients with hepatic or renal dysfunction or with prior pelvic radiation: CALGB 9863. Ann Oncol 14:1783-1790, 2003.
    • (2003) Ann Oncol , vol.14 , pp. 1783-1790
    • Venook, A.P.1    Enders Klein, C.2    Fleming, G.3
  • 52
    • 2942638081 scopus 로고    scopus 로고
    • XELOX (capecitabine plus oxaliplatin): Active first-line therapy for patients with metastatic colorectal cancer
    • Cassidy J, Tabernero J, Twelves C, et al: XELOX (capecitabine plus oxaliplatin): Active first-line therapy for patients with metastatic colorectal cancer. J Clin Oncol 22:2084-2091, 2004.
    • (2004) J Clin Oncol , vol.22 , pp. 2084-2091
    • Cassidy, J.1    Tabernero, J.2    Twelves, C.3
  • 53
    • 0033874892 scopus 로고    scopus 로고
    • Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer
    • de Gramont A, Figer A, Seymour M, et al: Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer. J Clin Oncol 18:2938-2947, 2000.
    • (2000) J Clin Oncol , vol.18 , pp. 2938-2947
    • de Gramont, A.1    Figer, A.2    Seymour, M.3
  • 54
    • 0032730143 scopus 로고    scopus 로고
    • Multicenter phase II study of bimonthly high-dose leucovorin, fluorouracil infusion, and oxaliplatin for metastatic colorectal cancer resistant to the same leucovorin and fluorouracil regimen
    • Andre T, Bensmaine MA, Louvet C, et al: Multicenter phase II study of bimonthly high-dose leucovorin, fluorouracil infusion, and oxaliplatin for metastatic colorectal cancer resistant to the same leucovorin and fluorouracil regimen. J Clin Oncol 17:3560-3568, 1999.
    • (1999) J Clin Oncol , vol.17 , pp. 3560-3568
    • Andre, T.1    Bensmaine, M.A.2    Louvet, C.3
  • 55
    • 25444442283 scopus 로고    scopus 로고
    • High activity and reduced neurotoxicity of bi-fractionated oxaliplatin plus 5-fluorouracil/leucovorin for elderly patients with advanced colorectal cancer
    • Mattioli R, Massacesi C, Recchia F, et al: High activity and reduced neurotoxicity of bi-fractionated oxaliplatin plus 5-fluorouracil/leucovorin for elderly patients with advanced colorectal cancer. Ann Oncol 16:1147-1151, 2005.
    • (2005) Ann Oncol , vol.16 , pp. 1147-1151
    • Mattioli, R.1    Massacesi, C.2    Recchia, F.3
  • 56
    • 22244477362 scopus 로고    scopus 로고
    • Capecitabine plus oxaliplatin for the first-line treatment of elderly patients with metastatic colorectal carcinoma: Final results of the Southern Italy Cooperative Oncology Group trial 0108
    • Comella P, Natale D, Farris A, et al: Capecitabine plus oxaliplatin for the first-line treatment of elderly patients with metastatic colorectal carcinoma: Final results of the Southern Italy Cooperative Oncology Group trial 0108. Cancer 104:282-289, 2005.
    • (2005) Cancer , vol.104 , pp. 282-289
    • Comella, P.1    Natale, D.2    Farris, A.3
  • 57
    • 33644839646 scopus 로고    scopus 로고
    • Capecitabine/oxaliplatin, a safe and active first-line regimen for older patients with metastatic colorectal cancer: Post hoc analysis of a large phase II study
    • Twelves CJ, Butts CA, Cassidy J, et al: Capecitabine/oxaliplatin, a safe and active first-line regimen for older patients with metastatic colorectal cancer: Post hoc analysis of a large phase II study. Clin Colorectal Cancer 5:101-107, 2005.
    • (2005) Clin Colorectal Cancer , vol.5 , pp. 101-107
    • Twelves, C.J.1    Butts, C.A.2    Cassidy, J.3
  • 58
    • 34250655829 scopus 로고    scopus 로고
    • Capecitabine and oxaliplatin: A phase II study with a new schedule of administration in elderly patients with advanced colorectal cancer (abstract 3681)
    • Comandone A, Pochettino P, Bergnolo P, et al: Capecitabine and oxaliplatin: A phase II study with a new schedule of administration in elderly patients with advanced colorectal cancer (abstract 3681). J Clin Oncol 23(16S), 2005.
    • (2005) J Clin Oncol 23(16S)
    • Comandone, A.1    Pochettino, P.2    Bergnolo, P.3
  • 59
    • 34250658135 scopus 로고    scopus 로고
    • XELOX (capecitabine and oxaliplatin) as 1st line treatment for elderly patients (pts) with advanced/metastatic colorectal cancer (MCRC) (abstract 3688)
    • Lopez-Gomez L, Escudero P, Yubero A, et al: XELOX (capecitabine and oxaliplatin) as 1st line treatment for elderly patients (pts) with advanced/metastatic colorectal cancer (MCRC) (abstract 3688). J Clin Oncol 22(14S), 2004.
    • (2004) J Clin Oncol 22(14S)
    • Lopez-Gomez, L.1    Escudero, P.2    Yubero, A.3
  • 60
    • 34250641611 scopus 로고    scopus 로고
    • Efficacy of reduced dose intensity FOLFOX-4 as first line palliative chemotherapy in elderly patients with advanced colorectal cancer (CRC) (abstract 3720)
    • Oh D-Y, Kim Y-J, Han S-W, et al: Efficacy of reduced dose intensity FOLFOX-4 as first line palliative chemotherapy in elderly patients with advanced colorectal cancer (CRC) (abstract 3720). J Clin Oncol 23(16S), 2005.
    • (2005) J Clin Oncol 23(16S)
    • Oh, D.-Y.1    Kim, Y.-J.2    Han, S.-W.3
  • 61
    • 21144452813 scopus 로고    scopus 로고
    • Capecitabine as first-line treatment for patients older than 70 years with metastatic colorectal cancer: An Oncopaz Cooperative Group study
    • Feliu J, Escudero P, Llosa F, et al: Capecitabine as first-line treatment for patients older than 70 years with metastatic colorectal cancer: An Oncopaz Cooperative Group study. J Clin Oncol 23:3104-3111, 2005.
    • (2005) J Clin Oncol , vol.23 , pp. 3104-3111
    • Feliu, J.1    Escudero, P.2    Llosa, F.3
  • 62
    • 2542561964 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
    • Hurwitz H, Fehrenbacher L, Novotny W, et al: Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 350:2335-2342, 2004.
    • (2004) N Engl J Med , vol.350 , pp. 2335-2342
    • Hurwitz, H.1    Fehrenbacher, L.2    Novotny, W.3
  • 63
    • 21244481589 scopus 로고    scopus 로고
    • High-dose bevacizumab improves survival when combined with FOLFOX4 in previously treated advanced colorectal cancer: Results from the Eastern Cooperative Oncology Group (ECOG) study E3200 (abstract 2)
    • 1s
    • Giantonio BJ, Catalano PJ, Meropol NJ, et al: High-dose bevacizumab improves survival when combined with FOLFOX4 in previously treated advanced colorectal cancer: Results from the Eastern Cooperative Oncology Group (ECOG) study E3200 (abstract 2). J Clin Oncol 23(16S):1s, 2005.
    • (2005) J Clin Oncol 23(16S)
    • Giantonio, B.J.1    Catalano, P.J.2    Meropol, N.J.3
  • 64
    • 22744445443 scopus 로고    scopus 로고
    • Safety and efficacy of bevacizumab (Bev) when added to oxaliplatin/fluoropyrimidine (O/F) regimens as first-line treatment of metastatic colorectal cancer (mCRC): Tree 1 & 2 studies (abstract 3515)
    • Hochster HS, Welles L, Hart L, et al: Safety and efficacy of bevacizumab (Bev) when added to oxaliplatin/fluoropyrimidine (O/F) regimens as first-line treatment of metastatic colorectal cancer (mCRC): Tree 1 & 2 studies (abstract 3515). J Clin Oncol 23(16S), 2005.
    • (2005) J Clin Oncol 23(16S)
    • Hochster, H.S.1    Welles, L.2    Hart, L.3
  • 65
    • 34250629343 scopus 로고    scopus 로고
    • Bevacizumab in combination with 5-FU/leucovorin improves survival in patients with metastatic colorectal cancer: A combined analysis (abstract 3616)
    • Mass RD, Fyfe G, Hambleton J, et al: Bevacizumab in combination with 5-FU/leucovorin improves survival in patients with metastatic colorectal cancer: A combined analysis (abstract 3616). J Clin Oncol 22(14S), 2004.
    • (2004) J Clin Oncol 22(14S)
    • Mass, R.D.1    Fyfe, G.2    Hambleton, J.3
  • 66
    • 20544478429 scopus 로고    scopus 로고
    • Addition of bevacizumab to bolus fluorouracil and leucovorin in first-line metastatic colorectal cancer: Results of a randomized phase II trial
    • Kabbinavar FF, Schulz J, McCleod M, et al: Addition of bevacizumab to bolus fluorouracil and leucovorin in first-line metastatic colorectal cancer: Results of a randomized phase II trial. J Clin Oncol 23:3697-3705, 2005.
    • (2005) J Clin Oncol , vol.23 , pp. 3697-3705
    • Kabbinavar, F.F.1    Schulz, J.2    McCleod, M.3
  • 67
    • 3242720345 scopus 로고    scopus 로고
    • Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer
    • Cunningham D, Humblet Y, Siena S, et al: Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. N Engl J Med 351:337-345, 2004.
    • (2004) N Engl J Med , vol.351 , pp. 337-345
    • Cunningham, D.1    Humblet, Y.2    Siena, S.3
  • 68
    • 2142641698 scopus 로고    scopus 로고
    • Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor
    • Saltz LB, Meropol NJ, Loehrer PJ Sr, et al: Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor. J Clin Oncol 22:1201-1208, 2004.
    • (2004) J Clin Oncol , vol.22 , pp. 1201-1208
    • Saltz, L.B.1    Meropol, N.J.2    Loehrer Sr, P.J.3
  • 69
    • 0037862765 scopus 로고    scopus 로고
    • Cetuximab (C225) alone or in combination with irinotecan (CPT-11) in patients with epidermal growth factor receptor (EGFR)-positive, irinotecan-refractory metastatic colorectal cancer (MCRC) (abstract 1012)
    • Cunningham D, Humblet Y, Siena S, et al: Cetuximab (C225) alone or in combination with irinotecan (CPT-11) in patients with epidermal growth factor receptor (EGFR)-positive, irinotecan-refractory metastatic colorectal cancer (MCRC) (abstract 1012). Proc Am Soc Clin Oncol 22:252, 2003.
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 252
    • Cunningham, D.1    Humblet, Y.2    Siena, S.3
  • 70
    • 34250639963 scopus 로고    scopus 로고
    • An international phase II study of cetuximab in combination with oxaliplatin/5-fluorouracil (5-FU)/folinic acid (FA) (FOLFOX-4) in the first-line treatment of patients with metastatic colorectal cancer (CRC) expressing epidermal growth factor receptor (EGFR). Preliminary results (abstract 248)
    • Tabernero JM, Van Cutsem E, Sastre J, et al: An international phase II study of cetuximab in combination with oxaliplatin/5-fluorouracil (5-FU)/folinic acid (FA) (FOLFOX-4) in the first-line treatment of patients with metastatic colorectal cancer (CRC) expressing epidermal growth factor receptor (EGFR). Preliminary results (abstract 248). J Clin Oncol 22(14S), 2004.
    • (2004) J Clin Oncol 22(14S)
    • Tabernero, J.M.1    Van Cutsem, E.2    Sastre, J.3
  • 71
    • 24044454968 scopus 로고    scopus 로고
    • Use of comprehensive geriatric assessment in older cancer patients: Recommendations from the Task Force on CGA of the International Society of Geriatric Oncology (SIOG)
    • Extermann M, Aapro M, Bernabei R, et al: Use of comprehensive geriatric assessment in older cancer patients: Recommendations from the Task Force on CGA of the International Society of Geriatric Oncology (SIOG). Crit Rev Oncol Hematol 55:241-252, 2005.
    • (2005) Crit Rev Oncol Hematol , vol.55 , pp. 241-252
    • Extermann, M.1    Aapro, M.2    Bernabei, R.3
  • 72
    • 27244441470 scopus 로고    scopus 로고
    • Developing a cancer-specific geriatric assessment: A feasibility study
    • Hurria A, Gupta S, Zauderer M, et al: Developing a cancer-specific geriatric assessment: A feasibility study. Cancer 104:1998-2005, 2005.
    • (2005) Cancer , vol.104 , pp. 1998-2005
    • Hurria, A.1    Gupta, S.2    Zauderer, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.