Inhibitory effect of RGDS peptide on experimental choroidal neovascularization in a rat model

Chinese Journal of Ophthalmology

Volumn 42, Issue 9, 2006, Pages 825-831

  He, Hua ^a   Zhang, Hong ^a   Wang, Zhi Tao ^a   Zhao, Chun Ming ^a   Xiang, Nan ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Choroidal neovascularization; Laser coagulation; Oligopeptides

Indexed keywords

ALPHA5 INTEGRIN; ARGINYLGLYCYLASPARTYLSERINE; BLOOD CLOTTING FACTOR 8 ANTIBODY; DEXTRAN; FLUORESCEIN ISOTHIOCYANATE; PHOSPHATE BUFFERED SALINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHOROID; CONTROLLED STUDY; DISEASE COURSE; DOSE RESPONSE; DRUG ACTIVITY; DRUG EFFECT; DRUG EFFICACY; EYE FUNDUS; FEASIBILITY STUDY; FLUORESCENCE ANGIOGRAPHY; HISTOLOGY; IMMUNOREACTIVITY; INDOCYANINE GREEN ANGIOGRAPHY; INHIBITION KINETICS; LASER COAGULATION; MOLECULAR WEIGHT; NONHUMAN; PIGMENT EPITHELIUM; RAT; SCLERA; SUBRETINAL NEOVASCULARIZATION; TRANSMISSION ELECTRON MICROSCOPY;

ANIMALS; CHOROIDAL NEOVASCULARIZATION; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; OLIGOPEPTIDES; RANDOM ALLOCATION; RATS; RATS, INBRED BN; VITREOUS BODY;

EID: 33750585070     PISSN: 04124081     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Brook PC, Clark DA, Cheresh DA. Requirement of vascular integrin alpha v beta 3 for angiogenesis. Science, 1994, 264:569-571.
2. Luna J, Tobe T, Mousa SA, et al. Antagonists of integrin alpha v beta 3 inhibit retinal neovascularization in a murine model. Lab Invest, 1996,75:563-573.
3. Friedlander M, Theesfeld CL, Sugita M, et al. Involvement of integrins alpha v beta 3 and alpha v beta 5 in ocuiar neovascular diseases. Proc Natl Acad Sci USA,1996,93:9764-9769.
4. Brooks PC, Montgomery AM, Rosenfeld M, et al. Integrin alpha v beta 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels. Cell, 1994,79:1157-1164.
5. Eliceiri BP, Cheresh DA. The role of alphav untegrins during angiogenesis: insights into potential mechanisms of action and clinical development. J Clin Invest, 1999,103:1227-1230.
6. Friedlander M, Brooks PC, Shaffer RW, et al. Definition of two angiogenic pathways by distinct alpha v integrins. Science, 1995, 270:1500-1502.
7. Stupack DG, Cheresh DA. Get a ligand, get a life: integrins, signaling and cell survival. J Cell Sci, 2002,115:3729-3738.
8. Kamizuru H, Kimura H, Yasukawa T, et al. Monoclonal antibody-mediated drug targeting to choroidal neovascularization in the rat. Invest Ophthalmol Vis Sci, 2001,42:2664-2672.
9. Clark RA, Tonnesen MG, Gailit J, et al. Transient functional expression of alphaVbeta 3 on vascular cells during wound repair. Am J Pathol, 1996,148:1407-1421.
10. Sepp NT, Li LJ, Lee KH, et al. Basic fibroblast growth factor increases expression of the alpha v beta 3 integrin complex on human microvascular endothelial cells. J Invest Dermatol, 1994,103:295-299.
11. Meerovitch K, Bergeron F, Leblond L, et al. A novel RGD antagonist that targets both alphavbeta3 and alpha5beta1 induces apoptosis of angiogenic endothelial cells on type I collagen. Vascul Pharmacol, 2003,40:77-89.
12. Kenyon BM, Browne F, D'Amato RJ. Effects of thalidomide and related metabolites in a mouse corneal model of neovascularization. Exp Eye Res, 1997,64:971-978.
13. Pasqualini R, Ruoslahti E. Organ targeting in vivo using phage display peptide libraries. Nature, 1996,380:364-366.
14. Rajotte D, Arap W, Hagedorn M, et al. Molecular heterogeneity of the vascular endothelium revealed by in vivo phage display. J Clin Invest, 1998,102:430-437.
15. Pierschbacher MD, Ruoslahti E. Variants of the cell recognition site of fibronectin that retain attachment-promoting activity. Proc Natl Acad Sci USA, 1984,81:5985-5988.
16. Suzuki S, Oldberg A, Hayman EG, et al. Complete amino acid sequence of human vitronectin deduced from cDNA. Similarity of cell attachment sites in vitronectin and fibronectin. EMBO J, 1985, 4: 2519-2524.
17. Brooks PC. Cell adhesion molecules in angiogenesis. Cancer Metastasis Rev, 1996,15:187-194.
18. Yasukawa T, Hoffmann S, Eichler W, et al. Inhibition of experimental choroidal neovascularization in rats by an alpha (v)-integrin antagonist. Curr Eye Res, 2004,28:359-366.
19. Buckley CD, Pilling D, Henriquez NV, et al. RGD peptides induce apoptosis by direct caspase-3 activation. Nature, 1999, 397:534-539.
20. Jones MK, Wang H, Peskar BM, et al. Inhibition of angiogenesis by nonsteroidal anti-inflammatory drugs: insight into mechanisms and implications for cancer growth and ulcer healing. Nat Med, 1999,5: 1418-1423.
21. Storgard CM, Stupack DG, Jonczyk A, et al. Decreased angiogenesis and arthritic disease in rabbits treated with an alphavbeta3 antagonist. J Clin Invest, 1999,103:47-54.
22. Edelman JL, Castro MR. Quantitative image analysis of laser-induced choroidal neovascularization in rat. Exp Eye Res, 2000,71:523-533.