Synthesis and evaluation of a new series of substituted acyl(thio)urea and thiadiazolo [2,3-a] pyrimidine derivatives as potent inhibitors of influenza virus neuraminidase

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 24, 2006, Pages 8574-8581

  Sun, Chuanwen ^a,b   Zhang, Xiaodong ^b   Huang, Hai ^a   Zhou, Pei ^a  

^a FUDAN UNIVERSITY   (China)

^b SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

Acyl(thio)ureas derivatives; Antiviral activity; Influenza virus; Neuraminidase inhibitor; Pyrimidine derivatives

Indexed keywords

5,7 DIETHOXY 2 (6 CHLORO 3 PYRIDINECARBONYLIMINO) 2H 1,2,4 THIADIAZOLO[2,3 A]PYRIMIDINE; ANTIVIRUS AGENT; N' (4,6 DIETHOXYPYRIMIDIN 2 YL) N [5 (2 CHLOROPHENYL) 2 FUROYL]THIOUREA; PYRIMIDINE DERIVATIVE; SIALIDASE INHIBITOR; THIOUREA DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ARTICLE; CELL CULTURE; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; DRUG TARGETING; ENZYME INHIBITION; IN VITRO STUDY; INFLUENZA VIRUS; NONHUMAN;

ANIMALS; ANTIVIRAL AGENTS; CELL LINE; DOGS; ENZYME INHIBITORS; HUMANS; INFLUENZA, HUMAN; INHIBITORY CONCENTRATION 50; KIDNEY; MODELS, CHEMICAL; MOLECULAR STRUCTURE; NEURAMINIDASE; ORTHOMYXOVIRIDAE; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; THIOUREA;

ORTHOMYXOVIRIDAE;

EID: 33750532297     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.08.034     Document Type: Article

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