-
1
-
-
0029585928
-
Generation and characterization of an influenza virus neuraminidase variant with decreased sensitivity to the neuraminidase-specific inhibitor 4-guanidino-Neu5Ac2En
-
Blick, T. J., T. Tiong, A. Sahasrabudhe, J. N. Varghese, P. M. Colman, G. J. Hart, R. C. Bethell, and J. L. McKimm-Breschkin. 1995. Generation and characterization of an influenza virus neuraminidase variant with decreased sensitivity to the neuraminidase-specific inhibitor 4-guanidino-Neu5Ac2En. Virology 214:475-484.
-
(1995)
Virology
, vol.214
, pp. 475-484
-
-
Blick, T.J.1
Tiong, T.2
Sahasrabudhe, A.3
Varghese, J.N.4
Colman, P.M.5
Hart, G.J.6
Bethell, R.C.7
McKimm-Breschkin, J.L.8
-
2
-
-
0026508847
-
The 2.2 A resolution crystal structure of influenza B neuraminidase and its complex with sialic acid
-
Burmeister, W. P., R. W. Ruigrok, and S. Cusack. 1992. The 2.2 A resolution crystal structure of influenza B neuraminidase and its complex with sialic acid. EMBO J. 11:49-56.
-
(1992)
EMBO J.
, vol.11
, pp. 49-56
-
-
Burmeister, W.P.1
Ruigrok, R.W.2
Cusack, S.3
-
3
-
-
84958058579
-
Mucins and mucoids in relation to influenza virus action
-
Burnet, F. M. 1948. Mucins and mucoids in relation to influenza virus action. Aust. J. Exp. Biol. Med. Sci. 26:381-387.
-
(1948)
Aust. J. Exp. Biol. Med. Sci.
, vol.26
, pp. 381-387
-
-
Burnet, F.M.1
-
4
-
-
0031572287
-
A single sequence change destabilizes the influenza virus neuraminidase tetramer
-
Colacino, J. M., N. Y. Chirgadze, E. Garman, E. G. Murti, R. J. Loncharich, A. J. Baxter, K. A. Staschke, and W. G. Laver. 1997. A single sequence change destabilizes the influenza virus neuraminidase tetramer. Virology 236:66-75.
-
(1997)
Virology
, vol.236
, pp. 66-75
-
-
Colacino, J.M.1
Chirgadze, N.Y.2
Garman, E.3
Murti, E.G.4
Loncharich, R.J.5
Baxter, A.J.6
Staschke, K.A.7
Laver, W.G.8
-
5
-
-
0030875957
-
Selection of influenza A and B viruses for resistance to 4-guanidino-Neu5Ac2en in cell culture
-
Colacino, J. M., W. G. Laver, and G. M. Air. 1997. Selection of influenza A and B viruses for resistance to 4-guanidino-Neu5Ac2en in cell culture. J. Infect. Dis. 176(Suppl. 1):S66-S68.
-
(1997)
J. Infect. Dis.
, vol.176
, Issue.1 SUPPL.
-
-
Colacino, J.M.1
Laver, W.G.2
Air, G.M.3
-
6
-
-
0028113435
-
Influenza virus neuraminidase: Structure, antibodies, and inhibitors
-
Colman, P. M. 1994. Influenza virus neuraminidase: structure, antibodies, and inhibitors. Protein Sci. 3:1687-1696.
-
(1994)
Protein Sci.
, vol.3
, pp. 1687-1696
-
-
Colman, P.M.1
-
7
-
-
0345589943
-
-
Escarpe, P., and D. Mendel. Unpublished results
-
6a. Escarpe, P., and D. Mendel. Unpublished results.
-
-
-
-
8
-
-
0030028671
-
Characterization of mutants of influenza a virus selected with the neuraminidase inhibitor 4-guanidino-Neu5Ac2en
-
Gubareva, L. V., R. Bethell, G. J. Hart, K. G. Murti, C. R. Penn, and R. G. Webster. 1996. Characterization of mutants of influenza A virus selected with the neuraminidase inhibitor 4-guanidino-Neu5Ac2en. J. Virol. 70:1818-1827.
-
(1996)
J. Virol.
, vol.70
, pp. 1818-1827
-
-
Gubareva, L.V.1
Bethell, R.2
Hart, G.J.3
Murti, K.G.4
Penn, C.R.5
Webster, R.G.6
-
9
-
-
0031000886
-
Catalytic and framework mutations in the neuraminidase active site of influenza viruses that are resistant to 4-guanidino-Neu5Ac2en
-
Gubareva, L. V., M. J. Robinson, R. C. Bethell, and R. G. Webster. 1997. Catalytic and framework mutations in the neuraminidase active site of influenza viruses that are resistant to 4-guanidino-Neu5Ac2en. J. Virol. 71: 3385-3390.
-
(1997)
J. Virol.
, vol.71
, pp. 3385-3390
-
-
Gubareva, L.V.1
Robinson, M.J.2
Bethell, R.C.3
Webster, R.G.4
-
10
-
-
0018875646
-
Plaque inhibition assay for drug susceptibility testing of influenza viruses
-
Hayden, F., K. Cote, and R. G. Douglas, Jr. 1980. Plaque inhibition assay for drug susceptibility testing of influenza viruses. Antimicrob. Agents Chemother. 17:865-870.
-
(1980)
Antimicrob. Agents Chemother.
, vol.17
, pp. 865-870
-
-
Hayden, F.1
Cote, K.2
Douglas R.G., Jr.3
-
11
-
-
0002734071
-
Clinical and epidemiological importance of influenza a viruses resistant to amantadine and rimantadine
-
Hayden, F. G., and R. B. Couch. 1992. Clinical and epidemiological importance of influenza A viruses resistant to amantadine and rimantadine. Rev. Med. Virol. 2:89-96.
-
(1992)
Rev. Med. Virol.
, vol.2
, pp. 89-96
-
-
Hayden, F.G.1
Couch, R.B.2
-
12
-
-
0005998905
-
Efficacy and tolerability of oral GS 4104 for early treatment of experimental influenza in humans
-
abstr. LB-14. American Society for Microbiology, Washington, D.C.
-
Hayden, F. G., M. Lobo, J. J. Treanor, M. Miller, and R. G. Mills. 1997. Efficacy and tolerability of oral GS 4104 for early treatment of experimental influenza in humans, abstr. LB-14. In Abstracts of the 37th Interscience Conference on Antimicrobial Agents and Chemotherapy. American Society for Microbiology, Washington, D.C.
-
(1997)
Abstracts of the 37th Interscience Conference on Antimicrobial Agents and Chemotherapy
-
-
Hayden, F.G.1
Lobo, M.2
Treanor, J.J.3
Miller, M.4
Mills, R.G.5
-
13
-
-
9844220300
-
Efficacy and safety of the neuraminidase inhibitor zanamivir in the treatment of influenza virus infections
-
Hayden, F. G., A. D. M. E. Osterhaus, J. J. Treanor, D. M. Fleming, F. Y. Aoki, K. G. Nicholson, A. M. Bohnen, H. M. Hirst, O. Keene, and K. Wightman. 1997. Efficacy and safety of the neuraminidase inhibitor zanamivir in the treatment of influenza virus infections. N. Engl. J. Med. 337:874-880.
-
(1997)
N. Engl. J. Med.
, vol.337
, pp. 874-880
-
-
Hayden, F.G.1
Osterhaus, A.D.M.E.2
Treanor, J.J.3
Fleming, D.M.4
Aoki, F.Y.5
Nicholson, K.G.6
Bohnen, A.M.7
Hirst, H.M.8
Keene, O.9
Wightman, K.10
-
14
-
-
0028049979
-
Anti-influenza virus activity of the neuraminidase inhibitor 4-guanidino-Neu5Ac2en in cell culture and in human respiratory epithelium
-
Hayden, F. G., B. S. Rollins, and L. K. Madren. 1994. Anti-influenza virus activity of the neuraminidase inhibitor 4-guanidino-Neu5Ac2en in cell culture and in human respiratory epithelium. Antiviral Res. 25:123-131.
-
(1994)
Antiviral Res.
, vol.25
, pp. 123-131
-
-
Hayden, F.G.1
Rollins, B.S.2
Madren, L.K.3
-
15
-
-
0030032258
-
Safety and efficacy of the neuraminidase inhibitor GG167 in experimental human influenza
-
Hayden, F. G., J. J. Treanor, A. F. Betts, M. Lobo, J. D. Esinhart, and E. K. Hussey. 1996. Safety and efficacy of the neuraminidase inhibitor GG167 in experimental human influenza. JAMA 275:295-299.
-
(1996)
JAMA
, vol.275
, pp. 295-299
-
-
Hayden, F.G.1
Treanor, J.J.2
Betts, A.F.3
Lobo, M.4
Esinhart, J.D.5
Hussey, E.K.6
-
16
-
-
0028940702
-
Structures of aromatic inhibitors of influenza virus neuraminidase
-
Jedrzejas, M. J., S. Singh, W. J. Brouillette, W. G. Laver, G. M. Air, and M. Luo. 1995. Structures of aromatic inhibitors of influenza virus neuraminidase. Biochemistry 34:3144-3151.
-
(1995)
Biochemistry
, vol.34
, pp. 3144-3151
-
-
Jedrzejas, M.J.1
Singh, S.2
Brouillette, W.J.3
Laver, W.G.4
Air, G.M.5
Luo, M.6
-
17
-
-
0031048319
-
Influenza neuraminidase inhibitors possessing a novel hydrophobic interaction in the enzyme active site: Design, synthesis, and structural analysis of carbocyclic sialic acid analogues with potent anti-influenza activity
-
Kim, C. U., W. Lew, M. A. Williams, H. Liu, L. Zhang, S. Swaminathan, N. Bischofberger, M. S. Chen, D. B. Mendel, C. Y. Tai, W. G. Laver, and R. C. Stevens. 1997. Influenza neuraminidase inhibitors possessing a novel hydrophobic interaction in the enzyme active site: design, synthesis, and structural analysis of carbocyclic sialic acid analogues with potent anti-influenza activity. J. Am. Chem. Soc. 119:681-690.
-
(1997)
J. Am. Chem. Soc.
, vol.119
, pp. 681-690
-
-
Kim, C.U.1
Lew, W.2
Williams, M.A.3
Liu, H.4
Zhang, L.5
Swaminathan, S.6
Bischofberger, N.7
Chen, M.S.8
Mendel, D.B.9
Tai, C.Y.10
Laver, W.G.11
Stevens, R.C.12
-
18
-
-
15444353753
-
Structure-activity relationship studies of novel carbocyclic in influenza neuraminidase inhibitors
-
16a. Kim, C. U., W. Lew, M. A. Williams, H. Wu, L. Zhang, X. Chen, P. A. Escarpe, D. B. Mendel, W. G. Laver, and R. C. Stevens. 1998. Structure-activity relationship studies of novel carbocyclic in influenza neuraminidase inhibitors. J. Med. Chem. 41:2451-2460.
-
(1998)
J. Med. Chem.
, vol.41
, pp. 2451-2460
-
-
Kim, C.U.1
Lew, W.2
Williams, M.A.3
Wu, H.4
Zhang, L.5
Chen, X.6
Escarpe, P.A.7
Mendel, D.B.8
Laver, W.G.9
Stevens, R.C.10
-
19
-
-
0023803844
-
The molecular biology of influenza virus pathogenicity
-
Klenk, H.-D., and R. Rott. 1988. The molecular biology of influenza virus pathogenicity. Adv. Virus Res. 34:247-280.
-
(1988)
Adv. Virus Res.
, vol.34
, pp. 247-280
-
-
Klenk, H.-D.1
Rott, R.2
-
20
-
-
0007600773
-
Adaptation of egg-grown and transfectant viruses for growth in mammalian cells: Selection of hemagglutinin mutants with elevated pH of membrane fusion
-
Lin, Y. P., S. A. Wharton, J. Martin, J. J. Skehel, D. C. Wiley, and D. A. Steinhauer. 1997. Adaptation of egg-grown and transfectant viruses for growth in mammalian cells: selection of hemagglutinin mutants with elevated pH of membrane fusion. Virology 233:402-410.
-
(1997)
Virology
, vol.233
, pp. 402-410
-
-
Lin, Y.P.1
Wharton, S.A.2
Martin, J.3
Skehel, J.J.4
Wiley, D.C.5
Steinhauer, D.A.6
-
21
-
-
0028813628
-
Influenza type a virus neuraminidase does not play a role in viral entry, replication, assembly, or budding
-
Liu, C., M. C. Eichelberger, R. W. Compans, and G. M. Air. 1995. Influenza type A virus neuraminidase does not play a role in viral entry, replication, assembly, or budding. J. Virol. 69:1099-1106.
-
(1995)
J. Virol.
, vol.69
, pp. 1099-1106
-
-
Liu, C.1
Eichelberger, M.C.2
Compans, R.W.3
Air, G.M.4
-
22
-
-
0030053758
-
Generation and characterization of variants of NWS/G70C influenza virus after in vitro passage in 4-amino-Neu5Ac2en and 4-guanidino-Neu5Ac2en
-
McKimm-Breschkin, J. L., T. J. Blick, A. Sahasrabudhe, T. Tiong, D. Marshall, G. J. Hart, R. C. Bethell, and C. R. Penn. 1996. Generation and characterization of variants of NWS/G70C influenza virus after in vitro passage in 4-amino-Neu5Ac2en and 4-guanidino-Neu5Ac2en. Antimicrob. Agents Chemother. 40:40-46.
-
(1996)
Antimicrob. Agents Chemother.
, vol.40
, pp. 40-46
-
-
McKimm-Breschkin, J.L.1
Blick, T.J.2
Sahasrabudhe, A.3
Tiong, T.4
Marshall, D.5
Hart, G.J.6
Bethell, R.C.7
Penn, C.R.8
-
23
-
-
0030296267
-
Mutation in the influenza virus neuraminidase gene resulting in decreased sensitivity to the neuraminidase inhibitor 4-guanidino-Neu5Ac2en leads to instability of the enzyme
-
McKimm-Breschkin, J. L., M. McDonald, T. J. Blick, and P. M. Colman. 1996. Mutation in the influenza virus neuraminidase gene resulting in decreased sensitivity to the neuraminidase inhibitor 4-guanidino-Neu5Ac2en leads to instability of the enzyme. Virology 225:240-242.
-
(1996)
Virology
, vol.225
, pp. 240-242
-
-
McKimm-Breschkin, J.L.1
McDonald, M.2
Blick, T.J.3
Colman, P.M.4
-
24
-
-
0031911783
-
Mutations in a conserved residue in the influenza virus neuraminidase active site decreases sensitivity to Neu5Ac2en-derived inhibitors
-
McKimm-Breschkin, J. L., A. Sahasrabudhe, T. J. Blick, M. McDonald, P. M. Colman, G. J. Hart, R. C. Bethell, and J. N. Varghese. 1997. Mutations in a conserved residue in the influenza virus neuraminidase active site decreases sensitivity to Neu5Ac2en-derived inhibitors. J. Virol. 72:2456-2462.
-
(1997)
J. Virol.
, vol.72
, pp. 2456-2462
-
-
McKimm-Breschkin, J.L.1
Sahasrabudhe, A.2
Blick, T.J.3
McDonald, M.4
Colman, P.M.5
Hart, G.J.6
Bethell, R.C.7
Varghese, J.N.8
-
25
-
-
0031919227
-
Oral administration of a prodrug of the influenza neuraminidase inhibitor GS 4071 protects mice and ferrets against influenza infection
-
Mendel, D. B., C. Y. Tai, P. A. Escarpe, W.-X. Li, R. W. Sidwell, J. H. Huffman, C. Sweet, K. J. Jakeman, J. Merson, S. A. Lacy, W. Lew, M. A. Williams, L. Zhang, M. S. Chen, N. Bischofberger, and C. U. Kim. 1998. Oral administration of a prodrug of the influenza neuraminidase inhibitor GS 4071 protects mice and ferrets against influenza infection. Antimicrob. Agents Chemother. 42:640-646.
-
(1998)
Antimicrob. Agents Chemother.
, vol.42
, pp. 640-646
-
-
Mendel, D.B.1
Tai, C.Y.2
Escarpe, P.A.3
Li, W.-X.4
Sidwell, R.W.5
Huffman, J.H.6
Sweet, C.7
Jakeman, K.J.8
Merson, J.9
Lacy, S.A.10
Lew, W.11
Williams, M.A.12
Zhang, L.13
Chen, M.S.14
Bischofberger, N.15
Kim, C.U.16
-
26
-
-
0030787081
-
Pandemic influenza: Confronting a reemergent threat
-
Monto, A. S., I. A. Iacuzio, and J. R. LaMontague. 1997. Pandemic influenza: confronting a reemergent threat. J. Infect. Dis. 176(Suppl. 1):51-53.
-
(1997)
J. Infect. Dis.
, vol.176
, Issue.1 SUPPL.
, pp. 51-53
-
-
Monto, A.S.1
Iacuzio, I.A.2
Lamontague, J.R.3
-
27
-
-
0026721079
-
Implications of viral resistance to amantadine in control of influenza A
-
Monto, A. S., and N. H. Arden. 1992. Implications of viral resistance to amantadine in control of influenza A. Clin. Infect. Dis. 15:362-367.
-
(1992)
Clin. Infect. Dis.
, vol.15
, pp. 362-367
-
-
Monto, A.S.1
Arden, N.H.2
-
28
-
-
0009611933
-
Passage of influenza strains in the presence of aminoadamantane
-
Oxford, J. S., I. S. Logan, and C. W. Potter. 1970. Passage of influenza strains in the presence of aminoadamantane. Ann. N. Y. Acad. Sci. 173:300-313.
-
(1970)
Ann. N. Y. Acad. Sci.
, vol.173
, pp. 300-313
-
-
Oxford, J.S.1
Logan, I.S.2
Potter, C.W.3
-
29
-
-
0017151109
-
Inhibition of influenza virus replication in tissue culture by 2-deoxy-2,3-dehydro-N-trifluoroacetylneuraminic acid (FANA): Mechanism of action
-
Palese, P., and R. W. Compans. 1976. Inhibition of influenza virus replication in tissue culture by 2-deoxy-2,3-dehydro-N-trifluoroacetylneuraminic acid (FANA): mechanism of action. J. Gen. Virol. 33:159-163.
-
(1976)
J. Gen. Virol.
, vol.33
, pp. 159-163
-
-
Palese, P.1
Compans, R.W.2
-
30
-
-
0016272701
-
Characterization of temperature sensitive influenza virus mutants
-
Palese, P., K. Tobita, M. Ueda, and R. W. Compans. 1974. Characterization of temperature sensitive influenza virus mutants. Virology 61:397-410.
-
(1974)
Virology
, vol.61
, pp. 397-410
-
-
Palese, P.1
Tobita, K.2
Ueda, M.3
Compans, R.W.4
-
31
-
-
0000024891
-
Selection of influenza virus with reduced sensitivity in vitro to the neuraminidase inhibitor GG167 (4-guanidino-Neu5Ac2en): Changes in haemagglutinin may compensate for loss of neuraminidase activity
-
L. E. Brown, A. W. Hampson, and R. G. Webster (ed.), Elsevier, Amsterdam, The Netherlands
-
Penn, C. R., J. M. Barnett, R. C. Bethell, R. Fenton, K. L. Gearing, N. Healy, and A. J. Jowett. 1996. Selection of influenza virus with reduced sensitivity in vitro to the neuraminidase inhibitor GG167 (4-guanidino-Neu5Ac2en): changes in haemagglutinin may compensate for loss of neuraminidase activity, p. 735-740. In L. E. Brown, A. W. Hampson, and R. G. Webster (ed.), Options for the control of influenza III. Elsevier, Amsterdam, The Netherlands.
-
(1996)
Options for the Control of Influenza III
, pp. 735-740
-
-
Penn, C.R.1
Barnett, J.M.2
Bethell, R.C.3
Fenton, R.4
Gearing, K.L.5
Healy, N.6
Jowett, A.J.7
-
32
-
-
0018421350
-
Fluorometric assay of neuraminidase with a sodium (4-methylumbelliferyl-α-D-N-acetylneuraminate) substrate
-
Potier, M., L. Mameli, M. Bélisle, L. Dallaire, and S. B. Melançon. 1979. Fluorometric assay of neuraminidase with a sodium (4-methylumbelliferyl-α-D-N-acetylneuraminate) substrate. Anal. Biochem. 94:287-296.
-
(1979)
Anal. Biochem.
, vol.94
, pp. 287-296
-
-
Potier, M.1
Mameli, L.2
Bélisle, M.3
Dallaire, L.4
Melançon, S.B.5
-
33
-
-
0028827789
-
GG167 (4-guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid) is a potent inhibitor of influenza virus in ferrets
-
Ryan, D. M., J. Ticehurst, and M. H. Dempsey. 1995. GG167 (4-guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid) is a potent inhibitor of influenza virus in ferrets. Antimicrob. Agents Chemother. 39:2583-2584.
-
(1995)
Antimicrob. Agents Chemother.
, vol.39
, pp. 2583-2584
-
-
Ryan, D.M.1
Ticehurst, J.2
Dempsey, M.H.3
-
34
-
-
0027981472
-
Inhibition of influenza virus replication in mice by GG167 (4-guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid) is consistent with extracellular activity of viral neuraminidase (sialidase)
-
Ryan, D. M., J. Ticehurst, M. H. Dempsey, and C. R. Penn. 1994. Inhibition of influenza virus replication in mice by GG167 (4-guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic acid) is consistent with extracellular activity of viral neuraminidase (sialidase). Antimicrob. Agents Chemother. 38:2270-2275.
-
(1994)
Antimicrob. Agents Chemother.
, vol.38
, pp. 2270-2275
-
-
Ryan, D.M.1
Ticehurst, J.2
Dempsey, M.H.3
Penn, C.R.4
-
35
-
-
0008447689
-
Influenza virus variants resistant to GG167 with mutations in the haemagglutinin
-
L. E. Brown, A. W. Hampson, and R. G. Webster (ed.), Elsevier, Amsterdam, The Netherlands
-
Sahasrabudhe, A., T. Blick, and J. McKimm-Breschkin. 1996. Influenza virus variants resistant to GG167 with mutations in the haemagglutinin, p. 748-752. In L. E. Brown, A. W. Hampson, and R. G. Webster (ed.), Options for the control of influenza III. Elsevier, Amsterdam, The Netherlands.
-
(1996)
Options for the Control of Influenza III
, pp. 748-752
-
-
Sahasrabudhe, A.1
Blick, T.2
McKimm-Breschkin, J.3
-
36
-
-
0032007378
-
Inhibition of influenza a virus infections in mice by GS4104, an orally effective influenza virus neuraminidase inhibitor
-
Sidwell, R. W., J. H. Huffman, D. L. Barnard, K. W. Bailey, M.-H. Wong, A. Morrison, T. Syndergaard, and C. U. Kim. 1998. Inhibition of influenza A virus infections in mice by GS4104, an orally effective influenza virus neuraminidase inhibitor. Antiviral Res., 37:107-120.
-
(1998)
Antiviral Res.
, vol.37
, pp. 107-120
-
-
Sidwell, R.W.1
Huffman, J.H.2
Barnard, D.L.3
Bailey, K.W.4
Wong, M.-H.5
Morrison, A.6
Syndergaard, T.7
Kim, C.U.8
-
37
-
-
0022508596
-
Effect of selenazofurin on influenza A and B virus infections of mice
-
Sidwell, R. W., J. H. Huffman, E. W. Call, H. Alaghamandaan, P. D. Cook, and R. K. Robins. 1986. Effect of selenazofurin on influenza A and B virus infections of mice. Antiviral Res. 6:343-353.
-
(1986)
Antiviral Res.
, vol.6
, pp. 343-353
-
-
Sidwell, R.W.1
Huffman, J.H.2
Call, E.W.3
Alaghamandaan, H.4
Cook, P.D.5
Robins, R.K.6
-
38
-
-
0030591866
-
Novel inhibitors of influenza sialidases related to GG167. Structure-activity, crystallographic and molecular dynamic studies with 4H-pyran-2-carboxylic acid 6-carboxamides
-
Smith, P. W., S. L. Sollis, P. D. Howes, P. C. Cherry, K. N. Cobley, H. Taylor, A. R. Whittington, J. Scicinski, R. C. Bethell, N. Taylor, T. Skarzynski, A. Cleasby, O. Singh, A. Wonacott, J. Varghese, and P. Colman. 1996. Novel inhibitors of influenza sialidases related to GG167. Structure-activity, crystallographic and molecular dynamic studies with 4H-pyran-2-carboxylic acid 6-carboxamides. Bioorg. Med. Chem. Lett. 6:2931-2936.
-
(1996)
Bioorg. Med. Chem. Lett.
, vol.6
, pp. 2931-2936
-
-
Smith, P.W.1
Sollis, S.L.2
Howes, P.D.3
Cherry, P.C.4
Cobley, K.N.5
Taylor, H.6
Whittington, A.R.7
Scicinski, J.8
Bethell, R.C.9
Taylor, N.10
Skarzynski, T.11
Cleasby, A.12
Singh, O.13
Wonacott, A.14
Varghese, J.15
Colman, P.16
-
39
-
-
0030572487
-
Novel inhibitors of influenza sialidase related to GG167 synthesis of 4-amino and guanidino-4H-pyran-2-carboxylic acid-6-propylamides; selective inhibitors of influenza A virus sialidase
-
Sollis, S. L., P. W. Smith, P. D. Howes, P. C. Cherry, and R. C. Bethell. 1996. Novel inhibitors of influenza sialidase related to GG167 synthesis of 4-amino and guanidino-4H-pyran-2-carboxylic acid-6-propylamides; selective inhibitors of influenza A virus sialidase. Bioorg. Med. Chem. Lett. 6:1805-1808.
-
(1996)
Bioorg. Med. Chem. Lett.
, vol.6
, pp. 1805-1808
-
-
Sollis, S.L.1
Smith, P.W.2
Howes, P.D.3
Cherry, P.C.4
Bethell, R.C.5
-
40
-
-
0029560199
-
Molecular basis for the resistance of influenza viruses to 4-guanidino-Neu5Ac2En
-
Staschke, K. A., J. M. Colacino, A. J. Baxter, G. M. Air, A. Bansal, W. J. Hornback, J. E. Munroe, and W. G. Laver. 1995. Molecular basis for the resistance of influenza viruses to 4-guanidino-Neu5Ac2En. Virology 214: 642-646.
-
(1995)
Virology
, vol.214
, pp. 642-646
-
-
Staschke, K.A.1
Colacino, J.M.2
Baxter, A.J.3
Air, G.M.4
Bansal, A.5
Hornback, W.J.6
Munroe, J.E.7
Laver, W.G.8
-
41
-
-
14444284599
-
Characterization of an avian influenza a (H5N1) virus isolated from a child with a fatal respiratory illness
-
Subbarao, K., A. Klimov, J. Katz, H. Regnery, W. Lim, H. Hall, M. Perdue, D. Swayne, C. Bender, J. Huang, M. Hemphill, T. Rowe, M. Shaw, X. Xu, K. Fukuda, and N. Cox. 1998. Characterization of an avian influenza A (H5N1) virus isolated from a child with a fatal respiratory illness. Science 279:393-396.
-
(1998)
Science
, vol.279
, pp. 393-396
-
-
Subbarao, K.1
Klimov, A.2
Katz, J.3
Regnery, H.4
Lim, W.5
Hall, H.6
Perdue, M.7
Swayne, D.8
Bender, C.9
Huang, J.10
Hemphill, M.11
Rowe, T.12
Shaw, M.13
Xu, X.14
Fukuda, K.15
Cox, N.16
-
42
-
-
0027967179
-
Inhibition of the growth of influenza viruses in vitro by 4-guanidino-2,4-dideoxy-N-acetylneuraminic acid
-
Thomas, G. P., M. Forsyth, C. R. Penn, and J. W. McCauley. 1994. Inhibition of the growth of influenza viruses in vitro by 4-guanidino-2,4-dideoxy-N-acetylneuraminic acid. Antiviral Res. 24:351-356.
-
(1994)
Antiviral Res.
, vol.24
, pp. 351-356
-
-
Thomas, G.P.1
Forsyth, M.2
Penn, C.R.3
McCauley, J.W.4
-
43
-
-
0026665418
-
The structure of the complex between influenza virus neuraminidase and sialic acid, the viral receptor
-
Varghese, J. N., J. L. McKimm-Breschkin, J. B. Caldwell, A. A. Kortt, and P. M. Colman. 1992. The structure of the complex between influenza virus neuraminidase and sialic acid, the viral receptor. Proteins 14:327-332.
-
(1992)
Proteins
, vol.14
, pp. 327-332
-
-
Varghese, J.N.1
McKimm-Breschkin, J.L.2
Caldwell, J.B.3
Kortt, A.A.4
Colman, P.M.5
-
44
-
-
0028454967
-
The synthesis of 2,3-didehydro-2,4-dideoxy-4-guanidinyl-N-acetylneuraminic acid: A potent influenza virus sialidase inhibitor
-
von Itzstein, M., M. Wan Yang, and B. Jin. 1994. The synthesis of 2,3-didehydro-2,4-dideoxy-4-guanidinyl-N-acetylneuraminic acid: a potent influenza virus sialidase inhibitor. Carbohydr. Res. 259:301-305.
-
(1994)
Carbohydr. Res.
, vol.259
, pp. 301-305
-
-
Von Itzstein, M.1
Wan Yang, M.2
Jin, B.3
-
45
-
-
0027287506
-
Rational design of potent sialidase-based inhibitors of influenza virus replication
-
von Itzstein, M., W.-Y. Wu, G. B. Kok, M. S. Pegg, J. C. Cyason, B. Jin, T. V. Phan, M. L. Smythe, H. F. White, S. W. Oliver, P. M. Colman, J. N. Varghese, D. M. Ryan, J. M. Woods, R. C. Bethell, V. J. Hotham, J. M. Cameron, and C. R. Penn. 1993. Rational design of potent sialidase-based inhibitors of influenza virus replication. Nature 363:418-423.
-
(1993)
Nature
, vol.363
, pp. 418-423
-
-
Von Itzstein, M.1
Wu, W.-Y.2
Kok, G.B.3
Pegg, M.S.4
Cyason, J.C.5
Jin, B.6
Phan, T.V.7
Smythe, M.L.8
White, H.F.9
Oliver, S.W.10
Colman, P.M.11
Varghese, J.N.12
Ryan, D.M.13
Woods, J.M.14
Bethell, R.C.15
Hotham, V.J.16
Cameron, J.M.17
Penn, C.R.18
-
46
-
-
0030800108
-
Structure-activity relationship of carbocyclic influenza neuraminidase inhibitors
-
Williams, M. A., W. Lew, D. B. Mendel, C. Y. Tai, P. A. Escarpe, W. G. Laver, R. C. Stevens, and C. U. Kim. 1997. Structure-activity relationship of carbocyclic influenza neuraminidase inhibitors. Bioorg. Med. Chem. Lett. 7:1837-1842.
-
(1997)
Bioorg. Med. Chem. Lett.
, vol.7
, pp. 1837-1842
-
-
Williams, M.A.1
Lew, W.2
Mendel, D.B.3
Tai, C.Y.4
Escarpe, P.A.5
Laver, W.G.6
Stevens, R.C.7
Kim, C.U.8
-
47
-
-
0027162942
-
4-Guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneurammic acid is a highly effective inhibitor both of the sialidase (neuraminidase) and of growth of a wide ranee of influenza A and B viruses in vitro
-
Woods, J. M., R. C. Bethell, J. A. V. Coates, N. Healy, S. A. Hiscox, B. A. Pearson, D. M. Ryan, J. Ticehurst, J. Tilling, S. M. Walcott, and C. R. Penn. 1993. 4-Guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneurammic acid is a highly effective inhibitor both of the sialidase (neuraminidase) and of growth of a wide ranee of influenza A and B viruses in vitro. Antimicrob. Agents Chemother. 37:1473-1479.
-
(1993)
Antimicrob. Agents Chemother.
, vol.37
, pp. 1473-1479
-
-
Woods, J.M.1
Bethell, R.C.2
Coates, J.A.V.3
Healy, N.4
Hiscox, S.A.5
Pearson, B.A.6
Ryan, D.M.7
Ticehurst, J.8
Tilling, J.9
Walcott, S.M.10
Penn, C.R.11
|