Cyclic amide derivatives as potential prodrugs. Synthesis and evaluation of N-hydroxymethylphthalimide esters of some non-steroidal anti-inflammatory carboxylic acid drugs

European Journal of Medicinal Chemistry

Volumn 33, Issue 2, 1998, Pages 123-131

  Omar, Farghaly A ^a  

^a Assiut University   (Egypt)

Author keywords

Chemical and enzymatic stability; Lipophilicity; N hydroxymethylphthalimide; NSAI prodrugs; Ulcerogenicity

Indexed keywords

ACETYLSALICYLIC ACID; ESTER; IBUPROFEN; INDOMETACIN; NAPROXEN; NONSTEROID ANTIINFLAMMATORY AGENT; PRODRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; CONTROLLED STUDY; DRUG METABOLISM; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TOXICITY; ELECTRON MICROSCOPE; GASTROINTESTINAL TOXICITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; IN VITRO STUDY; LIPOPHILICITY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; ORAL DRUG ADMINISTRATION; PARTITION COEFFICIENT; PLASMA; RABBIT; RAT; REACTION ANALYSIS; SHORT SURVEY; STOMACH JUICE; STOMACH MUCOSA; THIN LAYER CHROMATOGRAPHY;

EID: 0032007214     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0223-5234(98)80037-8     Document Type: Article

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