Effects of Omega-3 Fatty Acids on Heart Rate in Cardiac Transplant Recipients††Disclaimer: Saint Luke's Hospital holds a minority interest in OmegaMetrix, LLC, Kansas City, Missouri, a company offering blood omega-3 fatty acid testing.

American Journal of Cardiology

Volumn 98, Issue 10, 2006, Pages 1393-1395

  Harris, William S ^a,b   Gonzales, Michael ^a   Laney, Nathan ^a   Sastre, Antonio ^c   Borkon, A Michael ^a,b  

^a UNIVERSITY OF MISSOURI KANSAS CITY SCHOOL OF MEDICINE   (United States)

^b SAINT LUKE S MID AMERICA HEART INSTITUTE   (United States)

^c MIDWEST RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AZATHIOPRINE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM CHANNEL BLOCKING AGENT; CYCLOSPORIN; DOCOSAHEXAENOIC ACID; FISH OIL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; ICOSAPENTAENOIC ACID; OMEGA 3 FATTY ACID; PREDNISONE;

ADULT; ARTICLE; CARDIOVASCULAR DISEASE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; ELECTROCARDIOGRAPHY; FEMALE; FOLLOW UP; GRAFT RECIPIENT; GRAFT VERSUS HOST REACTION; HEART DENERVATION; HEART MUSCLE; HEART RATE; HEART TRANSPLANTATION; HUMAN; HYPOTHESIS; IMMUNOSUPPRESSIVE TREATMENT; MALE; ORTHOTOPIC TRANSPLANTATION; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; QRS COMPLEX; QT INTERVAL; RANDOMIZED CONTROLLED TRIAL; RISK REDUCTION; SUDDEN DEATH; SUPPLEMENTATION; VAGUS NERVE STIMULATION;

DOCOSAHEXAENOIC ACIDS; EICOSAPENTAENOIC ACID; ELECTROCARDIOGRAPHY; FEMALE; HEART RATE; HEART TRANSPLANTATION; HUMANS; MALE; MIDDLE AGED; PROSPECTIVE STUDIES;

EID: 33750521789     PISSN: 00029149     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.amjcard.2006.06.033     Document Type: Article

References (19)

1. Marchioli R., Barzi F., Bomba E., Chieffo C., Di Gregorio D., Di Mascio R., Franzosi M.G., Geraci E., Levantesi G., Maggioni A.P., et al., GISSI-Prevenzione Investigators. Early protection against sudden death by n-3 polyunsaturated fatty acids after myocardial infarction: time-course analysis of the results of the Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico (GISSI)-Prevenzione. Circulation 105 (2002) 1897-1903
2. Burr M.L., Fehily A.M., Gilbert J.F., Rogers S., Holliday R.M., Sweetnam P.M., Elwood P.C., and Deadman N.M. Effects of changes in fat, fish, and fibre intakes on death and myocardial reinfarction: Diet and Reinfarction Trial (DART). Lancet 2 (1989) 757-761
3. McLennan P.L., Abeywardena M.Y., and Charnock J.S. Reversal of the arrhythmogenic effects of long-term saturated fatty acid intake by dietary n-3 and n-6 polyunsaturated fatty acids. Am J Clin Nutr 51 (1990) 53-58
4. Billman G.E., Kang J.X., and Leaf A. Prevention of sudden cardiac death by dietary pure n-3 polyunsaturated fatty acids in dogs. Circulation 99 (1999) 2452-2457
5. Hock C.E., Beck L.D., Bodine R.C., and Reibel D.K. Influence of dietary n-3 fatty acids on myocardial ischemia and reperfusion. Am J Physiol 259 (1990) H1518-H1526
6. Schrepf R., Limmert T., Claus W.P., Theisen K., and Sellmayer A. Immediate effects of n-3 fatty acid infusion on the induction of sustained ventricular tachycardia. Lancet 363 (2004) 1441-1442
7. Sellmayer A., Witzgall H., Lorenz R., and Weber P.C. Effects of dietary fish oil on ventricular premature complexes. Am J Cardiol 76 (1995) 974-977
8. O'Keefe Jr. J.H., Abuissa H., Sastre A., Steinhaus D.M., and Harris W.S. Effects of omega-3 fatty acids on resting heart rate, heart rate recovery after exercise, and heart rate variability in men with healed myocardial infarctions and depressed ejection fractions. Am J Cardiol 97 (2006) 1127-1130
9. Mozaffarian D., Geelen A., Brouwer I.A., Geleijnse J.M., Zock P.L., and Katan M.B. Effect of fish oil on heart rate in humans: a meta-analysis of randomized controlled trials. Circulation 112 (2005) 1945-1952
10. Dallongeville J., Yarnell J., Ducimetiere P., Arveiler D., Ferrieres J., Montaye M., Luc G., Evans A., Bingham A., Hass B., et al. Fish consumption is associated with lower heart rates. Circulation 108 (2003) 820-825
11. Leaf A., Kang J.X., Xiao Y.F., and Billman G.E. Clinical prevention of sudden cardiac death by n-3 polyunsaturated fatty acids and mechanism of prevention of arrhythmias by n-3 fish oils. Circulation 107 (2003) 2646-2652
12. Pepe S., and McLennan P.L. Cardiac membrane fatty acid composition modulates myocardial oxygen consumption and postischemic recovery of contractile function. Circulation 105 (2002) 2303-2308
13. Christensen J.H., Christensen M.S., Dyerberg J., and Schmidt E.B. Heart rate variability and fatty acid content of blood cell membranes: a dose response study with n-3 fatty acids. Am J Clin Nutr 70 (1999) 331-337
14. Beckers F., Ramaekers D., Speijer G., Ector H., Vanhaecke J., Verheyden B., Van Cleemput J., Droogne W., Van de Werf F., and Aubert A.E. Different evolutions in heart rate variability after heart transplantation: 10-year follow-up. Transplantation 78 (2004) 1523-1531
15. Raczak G., La Rovere M.T., Mortara A., Assandri J., Prpa A., Pinna G.D., Maestri R., D'Armini A.M., Vigano M., and Cobelli F. Arterial baroreflex modulation of heart rate in patients early after heart transplantation: lack of parasympathetic reinnervation. J Heart Lung Transplant 18 (1999) 399-406
16. Harris W.S., Sands S.A., Windsor S.L., Ali H.A., Stevens T.L., Magalski A., Porter C.B., and Borkon A.M. Omega-3 fatty acids in cardiac biopsies from heart transplant patients: correlation with erythrocytes and response to supplementation. Circulation 110 (2004) 1645-1649
17. Uberfuhr P., Ziegler S., Schwaiblmair M., Reichart B., and Schwaiger M. Incomplete sympathic reinnervation of the orthotopically transplanted human heart: observation up to 13 years after heart transplantation. Eur J Cardiothorac Surg 17 (2000) 161-168
18. Geelen A., Brouwer I.A., Zock P.L., Kors J.A., Swenne C.A., Katan M.B., and Schouten E.G. N-3 fatty acids do not affect electrocardiographic characteristics of healthy men and women. J Nutr 132 (2002) 3051-3054
19. Zipes D.P. Management of cardiac arrhythmias: pharmacological, electrical, and surgical techniques. In: Braunwald E. (Ed). Heart Disease: A Textbook of Cardiovascular Medicine (1997), W.B. Saunders, Philadelphia, PA 593-639