Structure-activity relationships for a novel series of thiazolyl phenyl ether derivatives exhibiting potent and selective acetyl-CoA carboxylase 2 inhibitory activity

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 23, 2006, Pages 6078-6081

  Clark, Richard F ^a   Zhang, Tianyuan ^a   Xin, Zhili ^a   Liu, Gang ^a   Wang, Ying ^a   Hansen, T Matthew ^a   Wang, Xiaojun ^a   Wang, Rongqi ^a   Zhang, Xiaolin ^a   Frevert, Ernst U ^a   Camp, Heidi S ^a   Beutel, Bruce A ^a   Sham, Hing L ^a   Gu, Yu Gui ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

Acetyl CoA carboxylase; Insulin resistance; Obesity; Type 2 diabetes

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; ACETYL COENZYME A CARBOXYLASE 2 INHIBITOR; DIPHENYL ETHER DERIVATIVE; ENZYME INHIBITOR; ISOENZYME; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL MODIFICATION; DRUG ACTIVITY; DRUG POTENCY; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; STRUCTURE ACTIVITY RELATION;

ACETYL-COA CARBOXYLASE; ENZYME INHIBITORS; MOLECULAR STRUCTURE; PHENYL ETHERS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33750515002     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.08.100     Document Type: Article

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