Nuclear and mitochondrial localization of the putative RNA helicase DHX32

Experimental and Molecular Pathology

Volumn 81, Issue 3, 2006, Pages 245-248

  Alli, Zaman ^a   Ackerley, Cameron ^a   Chen, Yong ^a   Al Saud, Bandar ^a   Abdelhaleem, Mohamed ^a  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

DHX32; Electron microscopy; Mitochondria; Nucleus; RNA helicase

Indexed keywords

DHX32 PROTEIN; RNA HELICASE; UNCLASSIFIED DRUG;

ARTICLE; CELL LABELING; CELL NUCLEUS; CELL STRAIN HL 60; CELLULAR DISTRIBUTION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; ELECTRON MICROSCOPY; FEMALE; GENE; GENE EXPRESSION REGULATION; HELA CELL; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; MITOCHONDRION; MYELOID LEUKEMIA; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RNA METABOLISM; RNA SYNTHESIS; SEQUENCE HOMOLOGY;

CELL NUCLEUS; CYTOPLASM; DEAD-BOX RNA HELICASES; HELA CELLS; HL-60 CELLS; HUMANS; MICROSCOPY, IMMUNOELECTRON; MITOCHONDRIA; PROTEIN TRANSPORT; RNA;

EID: 33750494301     PISSN: 00144800     EISSN: 10960945     Source Type: Journal    
DOI: 10.1016/j.yexmp.2006.07.005     Document Type: Article

References (16)

1. Abdelhaleem M. The novel helicase homologue DDX32 is down-regulated in acute lymphoblastic leukemia. Leuk. Res. 26 (2002) 945-954
2. Abdelhaleem M. Do RNA helicases have a role in cancer?. Biochim. Biophys. Acta CR, Rev. Cancer 1704 (2004) 37-46
3. Abdelhaleem M. Over-expression of RNA helicases in cancer. Anticancer Res. 24 (2004) 3951-3954
4. Abdelhaleem M. RNA helicases: regulators of differentiation. Clin. Biochem. 38 (2005) 499-503
5. Abdelhaleem M., Maltais L., and Wain H. The human DDX and DHX gene families of putative RNA helicases. Genomics 81 (2003) 618-622
6. Alli Z., Ho M., and Abdelhaleem M. Expression of DHX32 in lymphoid tissues. Exp. Mol. Pathol. 79 (2005) 219-223
7. de la Cruz J., Kressler D., and Linder P. Unwinding RNA in Saccharomyces cerevisiae: DEAD-box proteins and related families. Trends Biochem. Sci. 24 (2003) 192-198
8. Dziembowski A., Piwowarski J., Hoser R., Minczuk M., Dmochowska A., Siep M., van der S.H., Grivell L., and Stepien P.P. The yeast mitochondrial degradosome. Its composition, interplay between RNA helicase and RNase activities and the role in mitochondrial RNA metabolism. J. Biol. Chem. 278 (2003) 1603-1611
9. Fernandez-Silva P., Enriquea J.A., and Montoya J. Replication and transcription of mammalian mitochondrial DNA. Exp. Physiol. 88 (2003) 41-56
10. Gagliardi D., Stepien P.P., Temperley R.J., Lightowlers R.N., and Chrzanowska-Lightowlers Z.M. Messenger RNA stability in mitochondria: different means to an end. Trends Genet. 20 (2004) 260-267
11. Iborra F.J., Kimura H., and Cook P.R. The functional organization of mitochondrial genomes in human cells. BMC Biol. 2 (2004) 9
12. Lee C.M., Sedman J., Neupert W., and Stuart R.A. The DNA helicase, Hmi1p, is transported into mitochondria by a C-terminal cleavable targeting signal. J. Biol. Chem. 274 (1999) 20937-20942
13. Niemer I., Schmelzer C., and Borner G.V. Overexpression of DEAD box protein pMSS116 promotes ATP-dependent splicing of a yeast group II intron in vitro. Nucleic Acids Res. 23 (1995) 2966-2972
14. Stojanovski D., Johnston A.J., Streimann I., Hoogenraad N.J., and Ryan M.T. Import of nuclear-encoded proteins into mitochondria. Exp. Physiol. 88 (2003) 57-64
15. Tanner N.K., and Linder P. DExD/H Box RNA helicases, from generic motors to specific dissociation functions. Mol. Cell 8 (2001) 251-262
16. Valgardsdottir R., Brede G., Eide L.G., Frengen E., and Prydz H. Cloning and characterization of MDDX28, a putative dead-box helicase with mitochondrial and nuclear localization. J. Biol. Chem. 276 (2001) 32056-32063