Over-expression of RNA helicases in cancer

Anticancer Research

Volumn 24, Issue 6, 2004, Pages 3951-3953

  Abdelhaleem, Mohamed ^a,b  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b NONE   (Canada)

Author keywords

Cancer; Review; RNA helicases

Indexed keywords

RNA HELICASE;

CARCINOGENESIS; DDX GENE; DHX GENE; GENE; MULTIGENE FAMILY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; RNA METABOLISM; ANIMAL; BIOSYNTHESIS; ENZYMOLOGY; GENETICS; HUMAN; NEOPLASM; UPREGULATION;

ANIMALS; HUMANS; NEOPLASMS; RNA HELICASES; UP-REGULATION;

EID: 14944360753     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (36)

1. Balvay L, Libri D and Fiszman MY: Pre-mRNA secondary structure and the regulation of splicing. Bioessays 15: 165-169, 1993.
2. Van der Velden AW and Thomas AA: The role of the 5′ untranslated region of an mRNA in translation regulation during development. Int J Biochem Cell Biol 31: 87-106, 1999.
3. Tanner NK and Linder P: From RNA helicases to RNPases. Mol Cell 8: 251-262, 2001.
4. Linder P, Lasko PF, Ashburner M, Leroy P, Nielsen PJ, Nishi K, Schnier J and Slonimski PP: Birth of the D-E-A-D box. Nature 337: 121-122, 1989.
5. de la Cruz J, Kressler D and Linder P: Unwinding RNA in Saccharomyces cerevisiae: DEAD-box proteins and related families. Trends Biochem Sci 24: 192-198, 1999.
6. Abdelhaleem M, Maltais L and Wain H: The human DDX and DHX gene families of putative RNA helicases. Genomics 81: 618-622, 2003.
7. Abdelhaleem M: Do human RNA helicases have a role in cancer? BBA 1704: 37-46, 2004.
8. Godbout R and Squire J: Amplification of a DEAD box protein gene in retinoblastoma cell lines. Proc Natl Acad Sci USA 90: 7578-7582, 1993.
9. Squire JA, Thorner PS, Weitzman S, Maggi JD, Dirks P, Doyle J, Hale M and Godbout R: Co-amplification of MYCN and a DEAD box gene (DDX1) in primary neuroblastoma. Oncogene 10: 1417-1422, 1995.
10. Godbout R, Packer M and Bie W: Overexpression of a DEAD box protein (DDX1) in neuroblastoma and retinoblastoma cell lines. J Biol Chem 273: 21161- 21168, 1998.
11. Chen HC, Lin WC, Tsay YG, Lee SC and Chang CJ: An RNA helicase, DDX1, interacting with poly(A) RNA and heterogeneous nuclear ribonucleoprotein K.J Biol Chem 277: 40403-40409, 2002.
12. Bleoo S, Sun X, Hendzel MJ, Rowe M, Packer M and Godbout R: Association of human DEAD box protein DDX1 with a cleavage stimulation factor involved in 3′-end processing of pre-MRNA. Mol Biol Cell 12: 3046-3059, 2001.
13. Eberle J, Krasagakis K and Orfanos CE: Translation initiation factor eIF-4A1 mRNA is consistently overexpressed in human melanoma cells in vitro. Int J Cancer 71: 396-401, 1997.
14. Shuda M, Kondoh N, Tanaka K, Ryo A, Wakatsuki T, Hada A, Goseki N, Igari T, Hatsuse K, Aihara T, Horiuchi S, Shichita M, Yamamoto N and Yamamoto M: Enhanced expression of translation factor mRNAs in hepatocellular carcinoma. Anticancer Res 20: 2489-2494, 2000.
15. Wang WB, Boing S, Zhou XQ, Ji P, Dong Y, Yao Q and Muller-Tidow C: Identification of metastasis-associated genes in early stage non-small cell lung cancer by subtractive hybridization. Sheng Wu Hua Xue. Yu Sheng Wu Wu Li Xue.Bao. (Shanghai) 34: 273-278, 2002.
16. Gingras C, Raught B and Sonenberg N: eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation. Annu Rev Biochem 68: 913-963, 1999.
17. Svitkin YV, Pause A, Haghighat A, Pyronnet S, Witherell G, Belsham GJ and Sonenberg N: The requirement for eukaryotic initiation factor 4A (eIF4A) in translation is in direct proportion to the degree of mRNA 5′ secondary structure. RNA 7: 382-394, 2001.
18. Eberle J, Fecker LF, Bittner JU, Orfanos CE and Geilen CC: Decreased proliferation of human melanoma cell lines caused by antisense RNA against translation factor eIF-4A1. Br J Cancer 86: 1957-1962, 2002.
19. Causevic M, Hislop RG, Kernohan NM, Carey FA, Kay RA, Steele RJ and Fuller-Pace FV: Overexpression and poly-ubiquitylation of the DEAD-box RNA helicase p68 in colorectal tumours. Oncogene 20: 7734-7743, 2001.
20. Liu ZR: p68 RNA helicase is an essential human splicing factor that acts at the U1 snRNA-5′ splice site duplex. Mol Cell Biol 22: 5443-5450, 2002.
21. Guil S, Gattoni R, Carrascal M, Abian J, Stevenin J and Bach-Elias M: Roles of hnRNP A1, SR proteins, and p68 helicase in c-H-ras alternative splicing regulation. Mol Cell Biol 23: 2927-2941, 2003.
22. Akao Y, Marukawa O, Morikawa H, Nakao K, Kamei M, Hachiya T and Tsujimoto Y: The rck/p54 candidate proto-oncogene product is a 54-kilodalton D-E-A-D box protein differentially expressed in human and mouse tissues. Cancer Res 55: 3444-3449, 1995.
23. Nakagawa Y, Morikawa H, Hirata I, Shiozaki M, Matsumoto A, Maemura K, Nishikawa T, Niki M, Tanigawa N, Ikegami M, Katsu K and Akao Y: Overexpression of rck/p54, a DEAD box protein, in human colorectal tumours. Br J Cancer 80: 914-917,1999.
24. Hashimoto K, Nakagawa Y, Morikawa H, Niki M, Egashira Y, Hirata I, Katsu K and Akao Y: Co-overexpression of DEAD box protein rck/p54 and c-myc protein in human colorectal adenomas and the relevance of their expression in cultured cell lines. Carcinogenesis 22: 1965-1970, 2001.
25. Akao Y, Yoshida H, Matsumoto K, Matsui T, Hogetu K, Tanaka N and Usukura J: A tumour-associated DEAD-box protein, rck/p54 exhibits RNA unwinding activity toward c-myc RNAs in vitro. Genes Cells 8: 671-676, 2003.
26. Lee CG and Hurwitz J: Human RNA helicase A is homologous to the maleless protein of Drosophila. J Biol Chem 268: 16822-16830, 1993.
27. Zhang S, Maacke H and Grosse F: Molecular cloning of the gene encoding nuclear DNA helicase II. A bovine homologue of human RNA helicase A and Drosophila Mle protein. J Biol Chem 270: 16422-16427, 1995.
28. Wei X, Pacyna-Gengelbach M, Schluns K, An Q, Gao Y, Cheng S and Petersen I: Analysis of the RNA helicase A gene in human lung cancer. Oncol Rep 11: 253-258, 2004.
29. Zhong X and Safa AR: RNA helicase A in the MEF1 transcription factor complex up-regulates the MDR1 gene in multidrug-resistant cancer cells. J Biol Chem 279: 17134-17141, 2004.
30. Anderson SF, Schlegel BP, Nakajima T, Wolpin ES and Parvin JD: BRCA1 protein is linked to the RNA polymerase II holoenzyme complex via RNA helicase A. Nat Genet 19: 254-256, 1998.
31. Schlegel P, Starita LM and Parvin JD: Overexpression of a protein fragment of RNA helicase A causes inhibition of endogenous BRCA1 function and defects in ploidy and cytokinesis in mammary epithelial cells. Oncogene 22: 983-991, 2003.
32. Martelange V, De Smet C, De Plaen E, Lurquin C and Boon T: Identification on a human sarcoma of two new genes with tumor-specific expression. Cancer Res 60: 3848-3855, 2000.
33. Holzmann K, Gerner C, Poltl A, Schafer R, Obrist P, Ensinger C, Grimm R and Sauermann G: A human common nuclear matrix protein homologous to eukaryotic translation initiation factor 4A. Biochem Biophys Res Commun 267: 339-344, 2000.
34. Lee S, Baek M, Yang H, Bang YJ, Kim WH, Ha JH, Kim DK and Jeoung DI: Identification of genes differentially expressed between gastric cancers and normal gastric mucosa with cDNA microarrays. Cancer Lett 184: 197-206, 2002.
35. Cho B, Lim YD, Lee S, Park Y, Lee H, Kim WH, Yang H, Bang YJ and Jeoung DI: Identification and characterization of a novel cancer/testis antigen gene CAGE. Biochem Biophys Res Commun 292: 715-726, 2002.
36. Frick DN: Helicases as antiviral drug targets. Drug News Perspect 16: 355-362, 2003.