Import of nuclear-encoded proteins into mitochondria

Experimental Physiology

Volumn 88, Issue 1, 2003, Pages 57-64

  Stojanovski, Diana ^a   Johnston, Amelia J ^a   Streimann, Illo ^a   Hoogenrad, Nicholas J ^a   Ryan, Michael T ^a  

^a LA TROBE UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; CELL MEMBRANE PROTEIN; MITOCHONDRIAL PROTEIN; NUCLEAR PROTEIN;

ADAPTATION; ANIMAL CELL; BIOGENESIS; CELL COMPARTMENTALIZATION; CELL FUNCTION; CELL MEMBRANE; CONTROLLED STUDY; CYTOSOL; GENE TRANSLOCATION; GENETIC CODE; MITOCHONDRION; NONHUMAN; OUTER MEMBRANE; PROTEIN SYNTHESIS; PROTEIN TARGETING; PROTEIN TRANSPORT; REVIEW;

EID: 0037250848     PISSN: 09580670     EISSN: None     Source Type: Journal    
DOI: 10.1113/eph8802501     Document Type: Review

References (82)

1. Abdul KM, Terada K, Yano M, Ryan MT, Streimann I, Hoogenraad NJ & Mori M (2000). Functional analysis of human metaxin in mitochondrial protein import in cultured cells and its relationship with the Tom complex. Biochem Biophys Res Commun 276, 1028-1034.
2. Abe Y, Shodai T, Muto T, Mihara K, Torii H, Nishikawa S, Endo T & Kohda D (2000). Structural basis of presequence recognition by the mitochondrial protein import receptor Tom20. Cell 100, 551-560.
3. Ahting U, Thieffry M, Engelhardt H, Hegerl R, Neupert W & Nussberger S (2001). Tom40, the pore-forming component of the protein-conducting TOM channel in the outer membrane of mitochondria. J Cell Biol 153, 1151-1160.
4. Ahting U, Thun C, Hegerl R, Typke D, Nargang FE, Neupert W & Nussberger S (1999). The TOM core complex: the general protein import pore of the outer membrane of mitochondria. J Cell Biol 147,959-968.
5. Alconada A, Kubrich M, Moczko M, Honlinger A & Pfanner N (1995). The mitochondrial receptor complex: the small subunit Mom8b/Isp6 supports association of receptors with the general insertion pore and transfer of preproteins. Mol Cell Biol 15, 6196-6205.
6. Armstrong LC, Komiya T, Bergman BE, Mihara K & Bornstein P (1997). Metaxin is a component of a preprotein import complex in the outer membrane of the mammalian mitochondrion. J Biol Chem 272, 6510-6518.
7. Bauer MF, Rothbauer U, Muhlenbein N, Smith RJ, Gerbitz K, Neupert W, Brunner M & Hoffmann S (1999). The mitochondrial TIM22 preprotein translocase is highly conserved throughout the eukaryotic kingdom. FEBS Lett 464, 41-47.
8. Bauer MF, Sirrenberg C, Neupert W & Brunner M (1996). Role of Tim23 as voltage sensor and presequence receptor in protein import into mitochondria. Cell 87, 33-41.
9. Blom J, Dekker PJ & Meijer M (1995). Functional and physical interactions of components of the yeast mitochondrial innermembrane import machinery (MIM). Eur J Biochem 232, 309-314.
10. Bolliger L, Junne T, Schatz G & Lithgow T (1995). Acidic receptor domains on both sides of the outer membrane mediate translocation of precursor proteins into yeast mitochondria. EMBO J 14, 6318-6326.
11. Brix J, Dietmeier K & Pfanner N (1997). Differential recognition of preproteins by the purified cytosolic domains of the mitochondrial import receptors Tom20, Tom22, and Tom70. J Biol Chem 272, 20730-20735.
12. Brix J, Rudiger S, Bukau B, Schneider-Mergener J & Pfanner N (1999). Distribution of binding sequences for the mitochondrial import receptors Tom20, Tom22, and Tom70 in a presequence-carrying preprotein and a non-cleavable preprotein. J Biol Chem 274, 16522-16530.
13. Cheng MY, Hartl FU, Martin J, Pollock RA, Kalousek F, Neupert W, Hallberg EM, Hallberg RL & Horwich AL (1989). Mitochondrial heat-shock protein hsp60 is essential for assembly of proteins imported into yeast mitochondria. Nature 337, 620-625.
14. Court DA, Kleene R, Neupert W & Lill R (1996a). Role of the N- and C-termini of porin in import into the outer membrane of Neurospora mitochondria. FEBS Lett 390, 73-77.
15. Court DA, Nargang FE, Steiner H, Hodges RS, Neupert W & Lill R (1996b). Role of the intermembrane-space domain of the preprotein receptor Tom22 in protein import into mitochondria. Mol Cell Biol 16, 4035-4042.
16. Davis AJ, Sepuri NB, Holder J, Johnson AE & Jensen RE (2000). Two intermembrane space TIM complexes interact with different domains of Tim23p during its import into mitochondria. J Cell Biol 150, 1271-1282.
17. Dekker PJ, Keil P, Rassow J, Maarse AC, Pfanner N & Meijer M (1993). Identification of MIM23, a putative component of the protein import machinery of the mitochondrial inner membrane. FEBS Lett 330, 66-70.
18. Dekker PJ, Muller H, Rassow J & Pfanner N (1996). Characterization of the preprotein translocase of the outer mitochondrial membrane by blue native electrophoresis. Biol Chem 377, 535-538.
19. Dekker PJ, Ryan MT, Brix J, Muller H, Honlinger A & Pfanner N (1998). Preprotein translocase of the outer mitochondrial membrane: molecular dissection and assembly of the general import pore complex. Mol Cell Biol 18, 6515-6524.
20. Diekert K, Kispal G, Guiard B & Lill R (1999). An internal targeting signal directing proteins into the mitochondrial intermembrane space. Proc Natl Acad Sci U S A 96, 11752-11757.
21. Dietmeier K, Honlinger A, Bomer U, Dekker PJ, Eckerskorn C, Lottspeich F, Kubrich M, Pfanner N (1997). Tom5 functionally links mitochondrial preprotein receptors to the general import pore. Nature 388, 195-200.
22. Donzeau M, Kaldi K, Adam A, Paschen S, Wanner G, Guiard B, Bauer MF, Neupert W & Brunner M (2000). Tim23 links the inner and outer mitochondrial membranes. Cell 101, 401-412.
23. Eilers M & Schatz G (1986). Binding of a specific ligand inhibits import of a purified precursor protein into mitochondria. Nature 322, 228-232.
24. Emtage JL & Jensen RE (1993). MAS6 encodes an essential inner membrane component of the yeast mitochondrial protein import pathway. J Cell Biol 122, 1003-1012.
25. Frey TG & Mannella CA (2000). The internal structure of mitochondria. Trends Biochem Sci 25, 319-324.
26. Gakh O, Cavadini P & Isaya G (2002). Mitochondrial processing peptidases. Biochim Biophys Acta 1592, 63-77.
27. Goping IS, Millar DG & Shore GC (1995). Identification of the human mitochondrial protein import receptor, huMas20p. Complementation of delta mas20 in yeast. FEBS Lett 373, 45-50.
28. Hachiya N, Alam R, Sakasegawa Y, Sakaguchi M, Mihara K & Omura T (1993). A mitochondrial import factor purified from rat liver cytosol is an ATP-dependent conformational modulator for precursor proteins. EMBO J 12, 1579-1586.
29. Hachiya N, Mihara K, Suda K, Horst M, Schatz G & Lithgow T (1995). Reconstitution of the initial steps of mitochondrial protein import. Nature 376, 705-709.
30. Hanson B, Nuttal S & Hoogenraad N (1996). A receptor for the import of proteins into human mitochondria. Eur J Biochem 235, 750-753.
31. Hell K, Herrmann J, Pratje E, Neupert W & Stuart RA (1997). Oxalp mediates the export of the N- and C-termini of pCoxII from the mitochondrial matrix to the intermembrane space. FEBS Lett 418, 367-370.
32. Hell K, Neupert W & Stuart RA (2001). Oxalp acts as a general membrane insertion machinery for proteins encoded by mitochondrial DNA. EMBO J 20, 1281-1288.
33. Hill K, Model K, Ryan MT, Dietmeier K, Martin F, Wagner R & Pfanner N (1998). Tom40 forms the hydrophilic channel of the mitochondrial import pore for preproteins. Nature 395, 516-521.
34. Honlinger A, Bomer U, Alconada A, Eckerskorn C, Lottspeich F, Dietmeier K & Pfanner N (1996). Tom7 modulates the dynamics of the mitochondrial outer membrane translocase and plays a pathway-related role in protein import. EMBO J 15, 2125-2137.
35. Hoogenraad N & Ryan MT (2001). Translocation of proteins into mitochondria. IUBMB Life 51, 345-350.
36. Ishihara N & Mihara K (1998). Identification of the protein import components of the rat mitochondrial inner membrane, rTIM17, rTIM23, and rTIM44. J Biochem (Tokyo) 123, 722-732.
37. Johnston AJ, Hoogenraad J, Dougan DA, Truscott KN, Yano M, Mori M, Hoogenraad NJ & Ryan MT (2002). Insertion and assembly of human Tom7 into the preprotein translocase complex of the outer mitochondrial membrane. J Biol Chem 277, 42197-42204.
38. Kerscher O, Holder J, Srinivasan M, Leung RS & Jensen RE (1997). The Tim54p-Tim22p complex mediates insertion of proteins into the mitochondrial inner membrane. J Cell Biol 139, 1663-1675.
39. Koehler CM (2000). Protein translocation pathways of the mitochondrion. FEBS Lett 476, 27-31.
40. Koehler CM, Jarosch E, Tokatlidis K, Schmid K, Schweyen RJ & Schatz G (1998). Import of mitochondrial carriers mediated by essential proteins of the intermembrane space. Science 279, 369-373.
41. Koehler CM, Leuenberger D, Merchant S, Renold A, Junne T & Schatz G (1999). Human deafness dystonia syndrome is a mitochondrial disease. Proc Natl Acad Sci U S A 96, 2141-2146.
42. Koehler CM, Murphy MP, Bally NA, Leuenberger D, Oppliger W, Dolfini L, Junne T, Schatz G & Or E (2000). Tim18p, a new subunit of the TIM22 complex that mediates insertion of imported proteins into the yeast mitochondrial inner membrane. Mol Cell Biol 20, 1187-1193.
43. Komiya T & Mihara K (1996). Protein import into mammalian mitochondria. Characterization of the intermediates along the import pathway of the precursor into the matrix. J Biol Chem 271, 22105-22110.
44. Kovermann P, Truscott KN, Guiard B, Rehling P, Sepuri NB, Muller H, Jensen RE, Wagner R & Pfanner N (2002). Tim22, the essential core of the mitochondrial protein insertion complex, forms a voltage-activated and signal-gated channel. Mol Cell 9, 363-373.
45. Kronidou NG, Oppliger W, Bolliger L, Hannavy K, Glick BS, Schatz G & Horst M (1994). Dynamic interaction between Isp45 and mitochondrial hsp70 in the protein import system of the yeast mitochondrial inner membrane. Proc Natl Acad Sci U S A 91, 12818-12822.
46. Kunkele KP, Heins S, Dembowski M, Nargang FE, Benz R, Thieffry M, Walz J, Lill R, Nussberger S & Neupert W (1998). The preprotein translocation channel of the outer membrane of mitochondria. Cell 93, 1009-1019.
47. Leuenberger D, Bally NA, Schatz G & Koehler CM (1999). Different import pathways through the mitochondrial intermembrane space for inner membrane proteins. EMBO J 18, 4816-4822.
48. Lithgow T, Junne T, Suda K, Gratzer S & Schatz G (1994). The mitochondrial outer membrane protein Mas22p is essential for protein import and viability of yeast. Proc Natl Acad Sci U S A 91, 11973-11977.
49. Maarse AC, Blom J, Grivell LA & Meijer M (1992). MPI1, an essential gene encoding a mitochondrial membrane protein, is possibly involved in protein import into yeast mitochondria. EMBO J 11, 3619-3628.
50. Martin J, Mahlke K & Pfanner N (1991). Role of an energized inner membrane in mitochondrial protein import. Delta psi drives the movement of presequences. J Biol Chem 266, 18051-18057.
51. Model K, Meisinger C, Prinz T, Wiedemann N, Truscott KN, Pfanner N & Ryan MT (2001). Multistep assembly of the protein import channel of the mitochondrial outer membrane. Nat Struct Biol 8, 361-370.
52. Model K, Prinz T, Ruiz T, Radermacher M, Krimmer T, Kuhlbrandt W, Pfanner N & Meisinger C (2002). Protein translocase of the outer mitochondrial membrane: role of import receptors in the structural organization of the TOM complex. J Mol Biol 316, 657-666.
53. Murakami K & Mori M (1990). Purified presequence binding factor (PBF) forms an import-competent complex with a purified mitochondrial precursor protein. EMBO J 9, 3201-3208.
54. Neupert W (1997). Protein import into mitochondria. Annu Rev Biochem 66, 863-917.
55. Neupert W & Brunner M (2002). The protein import motor of mitochondria. Nat Rev Mol Cell Biol 3, 555-565.
56. Nuttall SD, Hanson BJ, Mori M & Hoogenraad NJ (1997). hTom34: a novel translocase for the import of proteins into human mitochondria. DNA Cell Biol 16, 1067-1074.
57. Ono H & Tuboi S (1988). The cytosolic factor required for import of precursors of mitochondrial proteins into mitochondria. J Biol Chem 263, 3188-3193.
58. Paschen SA, Rothbauer U, Kaldi K, Bauer MF, Neupert W & Brunner M (2000). The role of the TIM8-13 complex in the import of Tim23 into mitochondria. EMBO J 19, 6392-6400.
59. Pfanner N & Geissler A (2001). Versatility of the mitochondrial protein import machinery. Nat Rev Mol Cell Biol 2, 339-349.
60. Rapaport D & Neupert W (1999). Biogenesis of Tom40, core component of the TOM complex of mitochondria. J Cell Biol 146, 321-331.
61. Rospert S, Junne T, Glick BS & Schatz G (1993). Cloning and disruption of the gene encoding yeast mitochondrial chaperonin 10, the homolog of E. coli groES. FEBS Left 335, 358-360.
62. Ryan KR, Menold MM, Garrett S & Jensen RE (1994). SMS1, a high-copy suppressor of the yeast mas6 mutant, encodes an essential inner membrane protein required for mitochondrial protein import. Mol Biol Cell 5, 529-538.
63. Ryan MT, Muller H & Pfanner N (1999). Functional staging of ADP/ATP carrier translocation across the outer mitochondrial membrane. J Biol Chem 274, 20619-20627.
64. Ryan MT, Naylor DJ, Hoj PB, Clark MS & Hoogenraad NJ (1997). The role of molecular chaperones in mitochondrial protein import and folding. Int Rev Cytol 174, 127-193.
65. Ryan MT & Pfanner N (2001). Hsp70 proteins in protein translocation. Adv Protein Chem 59, 223-242.
66. Schlossmann J, Dietmeier K, Pfanner N & Neupert W (1994). Specific recognition of mitochondrial preproteins by the cytosolic domain of the import receptor MOM72. J Biol Chem 269, 11893-11901.
67. Seki N, Moczko M, Nagase T, Zufall N, Ehmann B, Dietmeier K, Schafer E, Nomura N & Pfanner N (1995). A human homolog of the mitochondrial protein import receptor Mom19 can assemble with the yeast mitochondrial receptor complex. FEBS Lett 375, 307-310.
68. Sheffield WP, Shore GC & Randall SK (1990). Mitochondrial precursor protein. Effects of 70-kilodalton heat shock protein on polypeptide folding, aggregation, and import competence. J Biol Chem 265, 11069-11076.
69. Sirrenberg C, Bauer MF, Guiard B, Neupert W & Brunner M (1996). Import of carrier proteins into the mitochondrial inner membrane mediated by Tim22. Nature 384, 582-585.
70. Sirrenberg C, Endres M, Folsch H, Stuart RA, Neupert W & Brunner M (1998). Carrier protein import into mitochondria mediated by the intermembrane proteins Tim10/Mrs11 and Tim12/Mrs5. Nature 391, 912-915.
71. Srere PA (1980). The infrastructure of the mitochondrial matrix. Trends Biochem Sci 5, 120-121.
72. Suzuki H, Maeda M & Mihara K (2002). Characterization of rat TOM70 as a receptor of the preprotein translocase of the mitochondrial outer membrane. J Cell Sci 115, 1895-1905.
73. Suzuki H, Okazawa Y, Komiya T, Saeki K, Mekada E, Kitada S, Ito A & Mihara K (2000). Characterization of rat TOM40, a central component of the preprotein translocase of the mitochondrial outer membrane. J Biol Chem 275, 37930-37936.
74. Terada K & Mori M (2000). Human DnaJ homologs dj2 and dj3, and bag-1 are positive cochaperones of hsc70. J Biol Chem 275, 24728-24734.
75. Terada K, Ohtsuka K, Imamoto N, Yoneda Y & Mori M (1995). Role of heat shock cognate 70 protein in import of ornithine transcarbamylase precursor into mammalian mitochondria. Mol Cell Biol 15, 3708-3713.
76. Terada K, Ueda I, Ohtsuka K, Oda T, Ichiyama A & Mori M (1996). The requirement of heat shock cognate 70 protein for mitochondrial import varies among precursor proteins and depends on precursor length. Mol Cell Biol 16, 6103-6109.
77. Truscott KN, Kovermann P, Geissler A, Merlin A, Meijer M, Driessen AJ, Rassow J, Pfanner N & Wagner R (2002). A presequence- and voltage-sensitive channel of the mitochondrial preprotein translocase formed by Tim23. Nat Struct Biol 8, 1074-1082.
78. Van Wilpe S, Ryan MT, Hill K, Maarse AC, Meisinger C, Brix J, Dekker PJ, Moczko M, Wagner R, Meijer M, Guiard B, Honlinger A & Pfanner N (1999). Tom22 is a multifunctional organizer of the mitochondrial preprotein translocase. Nature 401, 485-489.
79. Wattenberg B & Lithgow T (2001). Targeting of C-terminal (tail)anchored proteins: understanding how cytoplasmic activities are anchored to intracellular membranes. Traffic 2, 66-71.
80. Wiedemann N, Pfanner N & Ryan MT (2001). The three modules of ADP/ATP carrier cooperate in receptor recruitment and translocation into mitochondria. EMBO J 20, 951-960.
81. Yano M, Hoogenraad N, Terada K & Mori M (2000). Identification and functional analysis of human Tom22 for protein import into mitochondria. Mol Cell Biol 20, 7205-7213.
82. Zhao Q, Wang J, Levichkin IV, Stasinopoulos S, Ryan MT & Hoogenraad NJ (2002). A mitochondrial specific stress response in mammalian cells. EMBO J 21, 4411-4419.