Efficient asymmetric synthesis of novel gastrin receptor antagonist AG-041R via highly stereoselective alkylation of oxindole enolates

Journal of Organic Chemistry

Volumn 71, Issue 22, 2006, Pages 8559-8564

  Emura, Takashi ^a   Esaki, Toru ^a   Tachibana, Kazutaka ^a   Shimizu, Makoto ^b  

^a CHUGAI PHARMACEUTICAL CO LTD   (Japan)

^b MIE UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ACID; ALKYLATION; ESTERS; NITROGEN COMPOUNDS; STEREOCHEMISTRY; SYNTHESIS (CHEMICAL);

BROMOACETIC ACID ESTERS; OXINDOLE ENOLATES; STEREOSELECTIVE ALKYLATION; TETRASUBSTITUTED CHIRAL INTERMEDIATES;

AROMATIC COMPOUNDS;

2 [1 (2,2 DIETHOXYETHYL) 2 OXO 3 (3 4 TOLYLUREIDO) 2,3 DIHYDRO 1H INDOL 3 YL] N 4 TOLYLACETAMIDE; AG 041R; BROMOACETIC ACID; CHOLECYSTOKININ B RECEPTOR ANTAGONIST; GASTRIN ANTAGONIST; MENTHOL; OXINDOLE; UNCLASSIFIED DRUG;

ALKYLATION; ARTICLE; CHEMICAL ANALYSIS; CHEMICAL MODIFICATION; CHEMICAL REACTION; CHEMICAL STRUCTURE; DIASTEREOISOMER; DRUG SYNTHESIS; STEREOCHEMISTRY;

ALKYLATION; INDOLES; MOLECULAR STRUCTURE; RECEPTOR, CHOLECYSTOKININ B; STEREOISOMERISM;

EID: 33750492631     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo061541v     Document Type: Article

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