Hypoxanthine effect on equilibrative and concentrative adenosine transport in human lymphocytes. Implications in the phatogenesis of Lesch-Nyhan syndrome

Nucleosides, Nucleotides and Nucleic Acids

Volumn 25, Issue 9-11, 2006, Pages 1065-1069

  Prior, C ^a   Torres, R J ^a   Puig, J G ^a  

^a HOSPITAL UNIVERSITARIO LA PAZ   (Spain)

Author keywords

Adenosine; CNT; ENT; HPRT; Hypoxanthine; Lesch Nyhan

Indexed keywords

ADENOSINE; HYPOXANTHINE; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE;

ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; ENZYME DEFICIENCY; HUMAN; LESCH NYHAN SYNDROME; LYMPHOCYTE; PATHOGENESIS; PERIPHERAL LYMPHOCYTE;

ADENOSINE; BIOLOGICAL TRANSPORT; CASE-CONTROL STUDIES; HUMANS; HYPOXANTHINE; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; LESCH-NYHAN SYNDROME; LYMPHOCYTES;

EID: 33750469043     PISSN: 15257770     EISSN: 15322335     Source Type: Journal    
DOI: 10.1080/15257770600890988     Document Type: Article

References (18)

1. Latini, S.; Pedata, F. Adenosine in the central nervous system: release mechanism and extracellular concentrations. J. Neurochem. 2001, 79, 463-484.
2. Katasuragi, T.; Ushijima, I.; Furukawa, T. The clonidine-induced self-injurious behaviour of mice involves purinergic mechanisms. Pharmacol. Biochem. Behav. 1984, 20, 943-946.
3. Seegmiller, J.E.; Rosenbloom, F.M.; Kelley, W.N. Enzyme defect associated with a sex-linked human neurological disorder and excessive purine synthesis. Science 1967, 155, 1682-1684.
4. Lesh, M.; Nyhan, W.L. A familial disorder of uric acid metabolism and central nervous system function. Am. J. Med. 1964, 36, 561-570.
5. Pelled, D.; Sperling, O.; Zoref-Shani, E. Abnormal purine and pyrimidine content in primary astroglia cultures from hypoxanthine-guanine phosphoribosyltransferase-deficient transgenic mice. J. Neurochem. 1999, 72, 1139-1145.
6. Pastor-Anglada, M.; Baldwin, S.A. Recent advances in the molecular biology and physiology of nucleoside and nucleobase transporters. Drug. Dev. Res. 2001, 52, 431-437.
7. Torres, R.J.; DeAntonio, I.; Prior, C.; Puig, J.G. Adenosine transport in pheripheral blood lymphocytes from Lesch-Nyhan patients. Biochem. J. 2004, 377, 733-739.
8. Baldwin, S.A.; Beal, P.R.; Yao, S.Y.M.; King, A.E.; Cass, C.E.; Young, J.D. The equilibrative nucleoside trasnporter family, SLC29. Pflugers Arch. Eur. J. Physiol. 2004, 447, 735-743.
9. Gray, J.H.; Owen, R.P.; Giacomini, K.M. The concentrative nucleoside trasnporter family, SLC28. Pflugers Arch. Eur. J. Physiol. 2004, 447, 728-734.
10. Soler, C.; Felipe, A.; Mata, J.F.; Casado, F.J.; Celada, A.; Pastor-Anglada, M. Regulation of nucleoside transport by lipopolysaccharide, phorbol esters, and tumor necrosis factor-alpha in human B-lymphocytes. J. Biol. Chem. 1998, 273, 26939-26945.
11. Boyum, A. Separation of leukocytes from blood and bone marrow. Scand J. Clin. Lab. Invest. 1968, 21, 77.
12. Watts, R.W.E.; Spellacy, E.; Gibbs, D.A.; Allsop, J.; McKeran, R.O.; Slavin, G.E. Clinical, post-mortem, biochemical and therapeutic observations on the Lesch-Nyhan syndrome with particular reference to the neurological manifestations. Q. J. Med. 1982, 201, 43-78.
13. Ernst, M.; Zametkin, A.J.; Matochik, J.A.; Pascualvaca, D.; Jons, P.H.; Hardy, C.; Hankerson, J.G.; Doudet, D.J.; Cohen, R.M. Presynaptic dopaminergic deficits in Lesch-Nyhan disease. N. Engl. J. Med. 1996, 334, 1568-172.
14. Wong, D.F.; Harris, J.C.; Naidu, S.; Yokoi, F.; Marenco, S.; Dannals, R.F.; Ravert, H.T.; Yaster, M.; Evans, A.; Rousset, O.; Bryan, R.N.; Gjedde, A.; Kuhar, M.J.; Breese, G.R. Dopamine transporters are markedly reduced in Lesch-Nyhan disease in vivo. Proc. Natl. Acad. Sci. USA 1996, 93, 5539-5543.
15. Jinnah, H.A.; Wojcik, B.E.; Hunt, M.; Narang, N.; Lee, K.Y.; Goldstein, M.; Wamsley, J.K.; Langlais, P.J.; Friedmann, T. Dopamine deficiency in a genetic mouse model of Lesch-Nyhan disease. J. Neurosci. 1994, 14, 1164-1175.
16. Park, T.S.; Gidday, J.M. Effect of dipyridamole on cerebral extracellular adenosine level in vivo. J. Cereb. Blood Flow. Metab. 1990, 10, 424-427.
17. Melani, A.; Corsi, C.; Gimenez-Llort, L.; Martinez, M.; Ogren, S.O.; Pedata, F.; Ferre, S. Effect of N-methyl-D-aspartate on motor activity and in vivo adenosine striatal outflow in the rat. Eur. J. Pharmacol. 1999, 385, 15-19.
18. Ferre, S.; Fredholm, B.B.; Morelli, M.; Popoli, P.; Fuxe, K. Adenosine-dopamine receptor-receptor interactions as an integrative mechanism in the basal ganglia. Trends Neurosci. 1997, 20, 482-487.