Recent advances in the molecular biology and physiology of nucleoside and nucleobase transporters

Drug Development Research

Volumn 52, Issue 1-2, 2001, Pages 431-437

  Pastor Anglada, Marçal ^a   Baldwin, Stephen A ^b  

^a UNIVERSITY OF BARCELONA   (Spain)

^b UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

Cancer; Drugs; Nucleoside; Parasitic protozoa; Transporters

Indexed keywords

NUCLEIC ACID BASE; NUCLEOSIDE;

ACTIVE TRANSPORT; ALPHA HELIX; CHIMERA; CONFERENCE PAPER; ELECTROPHYSIOLOGY; MOLECULAR BIOLOGY; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN TRANSPORT; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION; THERMODYNAMICS;

EID: 0035042673     PISSN: 02724391     EISSN: None     Source Type: Journal    
DOI: 10.1002/ddr.1144     Document Type: Conference Paper

References (8)

1. Baldwin SA, Mackey JR, Cass CE, Young JD. 1999. Nucleosicle transporters: molecular biology and implications for therapeutic development. Mol Med Today 5:216-224.
2. Craig JE, Zhang Y, Gallagher MR 1994. Cloning of the nupC gene of Escherichia coli encoding a nucleoside transport system, and identification of an adjacent insertion element, IS 186. Mol Microbiol 11:1159-1168.
3. Griffith DA, Jarvis SM. 1996. Nucleoside and nucleobase transport systems of mammalian cells. Biochim Biophys Acta 1286:153-181.
4. Griffiths M, Beaumont N, Yao SYM, Sundaram M, Bouman CE, Davies A, Kwong FYP, Coe I, Cass CE, Young JD, Baldwin SA. 1997. Cloning of a human nucleoside transporter implicated in the cellular uptake of adenosine and chemotherapeutic drugs. Nat Med 3:89-93.
5. Huang QQ, Yao SYM, Ritzel MWL, Paterson ARP, Cass CE, Young JD. 1994. Cloning and functional expression of a complementary DMA encoding a mammalian nueleoside transport protein. J Biol Chem 269:17757-17760.
6. +-nucleoside transporters in the human intestine. Am J Physiol (in press).
7. Pastor-Anglada M, Felipe A, Casado FJ. 1998. Transport and mode of action of nueleoside derivatives used in chemical and antiviral therapies. Trends Pharmacol Sci 19:424-130.
8. Wang J, Schaner ME, Thomassen S, Su SF, Piquette-Miller M, Giacomini KM. 1997. Functional and molecular characteristics of Na+-dependent nueleoside transporters. Pharni Res 14:1524-1532.