Dexamethasone nano-aggregates composed of PEG-PLA-PEG triblock copolymers for anti-proliferation of smooth muscle cells

International Journal of Pharmaceutics

Volumn 326, Issue 1-2, 2006, Pages 169-173

  Park, Tae Gwan ^a   Yoo, Hyuk Sang ^b  

^a Korea Advanced Institute of Science and Technology (KAIST)   (South Korea)

^b Kangwon National University   (South Korea)

Author keywords

Anti proliferation; Dexamethasone; Nano aggregate; Smooth muscle cell

Indexed keywords

COPOLYMER; DEXAMETHASONE; MACROGOL; POLYLACTIC ACID;

ANIMAL CELL; ARTERY INTIMA PROLIFERATION; ARTICLE; CELL CYCLE ARREST; CELL PROLIFERATION; CONTROLLED STUDY; DISPERSION; DOSE RESPONSE; DRUG EFFECT; DRUG RELEASE; DRUG SYNTHESIS; FLOW CYTOMETRY; NANOTECHNOLOGY; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; RAT; SMOOTH MUSCLE FIBER;

ANIMALS; BALLOON DILATATION; CELL LINE; CELL PROLIFERATION; DEXAMETHASONE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG CARRIERS; LACTIC ACID; MYOCYTES, SMOOTH MUSCLE; NANOPARTICLES; NANOTECHNOLOGY; POLYESTERS; POLYETHYLENE GLYCOLS; POLYMERS; RATS; TECHNOLOGY, PHARMACEUTICAL; THYMIDINE;

EID: 33750458648     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2006.06.041     Document Type: Article

References (15)

1. Clagett G.P., Robinowitz M., Youkey J.R., Fisher Jr. D.F., Fry R.E., Myers S.I., Lee E.L., Collins Jr. G.J., and Virmani R. Morphogenesis and clinicopathologic characteristics of recurrent carotid disease. J. Vasc. Surg. 3 (1986) 10-23
2. Dixon E.R., Weinberg J.A., and Lew D.B. Effect of dexamethasone on bovine airway smooth muscle cell proliferation. J. Asthma 36 (1999) 519-525
3. Jeong B., Bae Y.H., and Kim S.W. In situ gelation of PEG-PLGA-PEG triblock copolymer aqueous solutions and degradation thereof. J. Biomed. Mater. Res. 50 (2000) 171-177
4. Jeong B., Bae Y.H., Lee D.S., and Kim S.W. Biodegradable block copolymers as injectable drug-delivery systems. Nature 388 (1997) 860-862
5. Kwon G.S., Naito M., Yokoyama M., Okano T., Sakurai Y., and Kataoka K. Physical entrapment of adriamycin in AB block copolymer micelles. Pharm. Res. 12 (1995) 192-195
6. Lee J., Cho E.C., and Cho K. Incorporation and release behavior of hydrophobic drug in functionalized poly(d,l-lactide)-block-poly(ethylene oxide) micelles. J. Control. Release 94 (2004) 323-335
7. Lincoff A.M., Furst J.G., Ellis S.G., Tuch R.J., and Topol E.J. Sustained local delivery of dexamethasone by a novel intravascular eluting stent to prevent restenosis in the porcine coronary injury model. J. Am. Coll. Cardiol. 29 (1997) 808-816
8. Radke P.W., Weber C., Kaiser A., Schober A., and Hoffmann R. Dexamethasone and restenosis after coronary stent implantation: new indication for an old drug?. Curr. Pharm. Des. 10 (2004) 349-355
9. Reil T.D., Sarkar R., Kashyap V.S., Sarkar M., and Gelabert H.A. Dexamethasone suppresses vascular smooth muscle cell proliferation. J. Surg. Res. 85 (1999) 109-114
10. Sheihet L., Dubin R.A., Devore D., and Kohn J. Hydrophobic drug delivery by self-assembling triblock copolymer-derived nanospheres. Biomacromolecules 6 (2005) 2726-2731
11. Suh H., Jeong B., Rathi R., and Kim S.W. Regulation of smooth muscle cell proliferation using paclitaxel-loaded poly(ethylene oxide)-poly(lactide/glycolide) nanospheres. J. Biomed. Mater. Res. 42 (1998) 331-338
12. Tang Y., Liu S.Y., Armes S.P., and Billingham N.C. Solubilization and controlled release of a hydrophobic drug using novel micelle-forming ABC triblock copolymers. Biomacromolecules 4 (2003) 1636-1645
13. Yokoyama M., Kwon G.S., Okano T., Sakurai Y., Seto T., and Kataoka K. Preparation of micelle-forming polymer-drug conjugates. Bioconjug. Chem. 3 (1992) 295-301
14. Yoo H.S., and Park T.G. Biodegradable polymeric micelles composed of doxorubicin conjugated PLGA-PEG block copolymer. J. Control. Release 70 (2001) 63-70
15. Yoon J.J., Kim J.H., and Park T.G. Dexamethasone-releasing biodegradable polymer scaffolds fabricated by a gas-foaming/salt-leaching method. Biomaterials 24 (2003) 2323-2329