Sustained local delivery of dexamethasone by a novel intravascular eluting stent to prevent restenosis in the porcine coronary injury model

Journal of the American College of Cardiology

Volumn 29, Issue 4, 1997, Pages 808-816

  Lincoff, A Michael ^a   Furst, Joseph G ^a   Ellis, Stephen G ^a   Tuch, Ronald J ^b   Topol, Eric J ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

^b MEDTRONIC INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEXAMETHASONE; POLYLACTIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERY INTIMA PROLIFERATION; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY OBSTRUCTION; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG SAFETY; FEMALE; HISTOLOGY; INTRACARDIAC DRUG ADMINISTRATION; NONHUMAN; PRIORITY JOURNAL; RESTENOSIS; STENT; SWINE;

ANIMALS; BIOCOMPATIBLE MATERIALS; CONSTRICTION, PATHOLOGIC; CORONARY DISEASE; CORONARY VESSELS; DEXAMETHASONE; DISEASE MODELS, ANIMAL; DRUG DELIVERY SYSTEMS; FEASIBILITY STUDIES; GLUCOCORTICOIDS; HYPERPLASIA; LACTIC ACID; MOLECULAR WEIGHT; POLYMERS; RECURRENCE; STENTS; SWINE; TUNICA INTIMA;

EID: 0030935847     PISSN: 07351097     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0735-1097(96)00584-0     Document Type: Article

References (39)

1. Lincoff AM, Topol EJ, Ellis SG. Local drug delivery for the prevention of restenosis. fact, fancy, and future. Circulation. 90:1994;2070-2084.
2. Azrin MA, Mitchel JF, Bow LM, et al. Effect of local delivery of heparin on platelet deposition during in-vivo balloon angioplasty using hydrogel-coated balloons [abstract]. Circulation. 88:(Suppl I):1993;I-310.
3. Mitchel JF, Fram DB, Palme DF, et al. Enhanced intracoronary thrombolysis with urokinase using a novel, local drug delivery system in vitro, in vivo, and clinical studies . Circulation. 91:1995;785-793.
4. Fernandez-Ortiz A, Meyer BJ, Mailhac A, et al. Intravascular local delivery: an iontophoretic approach [abstract]. Circulation. 88:(Suppl I):1993;I-308.
5. Langer R. New methods of drug delivery. Science. 249:1990;1527-1533.
6. MacDonald RG, Panush RS, Pepine CJ. Rationale for use of glucocorticoids in modification of restenosis after percutaneous transluminal coronary angioplasty. Am J Cardiol. 60:1987;56B-60B.
7. Berk BC, Gordon JB, Alexander RW. Pharmacologic roles of heparin and glucocorticoids to prevent restenosis after coronary angioplasty. J Am Coll Cardiol. 17:1991;111B-117B.
8. Villa AE, Guzman LA, Chen W, Golomb G, Levy RJ, Topol EJ. Local delivery of dexamethasone for prevention of neointimal proliferation in a rat model of balloon angioplasty. J Clin Invest. 93:1994;1243-1249.
9. Pepine CJ, Hirshfeld JW, Macdonald RG, et al. A controlled trial of corticosteroids to prevent restenosis after coronary angioplasty. Circulation. 81:1990;1753-1761.
10. Stone GW, Rutherford BD, McConahay DR, et al. A randomized trial of corticosteroids for the prevention of restenosis in 102 patients undergoing repeat coronary angioplasty. Cathet Cardiovasc Diagn. 18:1989;227-231.
11. Schwartz RS, Murphy JG, Edwards WD, Camrud AR, Vlietstra RE, Holmes DR. Restenosis after balloon angioplasty a practical proliferative model in porcine coronary arteries . Circulation. 82:1990;2190-2200.
12. Schwartz RS, Huber KC, Murphy JG, et al. Restenosis and the proportional neointimal response to coronary artery injury results in a porcine model . J Am Coll Cardiol. 19:1992;267-274.
13. Schwartz RS, Koval TM, Edwards WD, et al. Effect of external beam irradiation on neointimal hyperplasia after experimental coronary artery injury. J Am Coll Cardiol. 19:1992;1106-1113.
14. Azrin MA, Mitchel JF, Fram DB, et al. Decreased platelet deposition and smooth muscle cell proliferation after intramural heparin delivery with hydrogel-coated balloons. Circulation. 90:1994;433-441.
15. Fernandez-Ortiz A, Meyer BJ, Mailhac A, et al. A new approach for local intravascular drug delivery iontophoretic balloon . Circulation. 89:1994;1518-1522.
16. Edelman ER, Karnovsky MJ. Contrasting effects of the intermittent and continuous administration of heparin in experimental restenosis. Circulation. 89:1994;770-776.
17. Simons M, Edelman ER, DeKeyser JL, Langer R, Rosenberg RD. Antisense c-myb oligonucleotides inhibit intimal arterial smooth muscle cell accumulation in vivo. Nature. 359:1992;67-70.
18. Murphy JG, Schwartz RS, Edwards WD, Camrud AR, Vlietstra RE, Holmes DR. Percutaneous polymeric stents in porcine coronary arteries initial experience with polyethylene terephtalate stents . Circulation. 86:1992;1596-1604.
19. Zidar JP, Lincoff AM, Stack RS. Biodegradable stents. Topol EJ. Textbook of Interventional Cardiology. 2nd ed. 1994;787-802 WB Saunders, Philadelphia.
20. Holmes DR, Camrud AR, Jorgenson MA, Edwards WD, Schwartz RS. Polymeric stenting in the porcine coronary artery model differential outcome of exogenous fibrin sleeves versus polyurethane-coated stents . J Am Coll Cardiol. 24:1994;525-531.
21. Cox DA, Anderson PG, Roubin GS, Chou C-Y, Agrawal S, Cavender JB. Effect of local delivery of heparin and methotrexate on neointimal proliferation in stented porcine coronary arteries. Coronary Artery Dis. 3:1992;237-248.
22. Lambert TL, Dev V, Rechavia E, Forrester JS, Litvack F, Eigler NL. Localized arterial wall drug delivery from a polymer-coated removable metallic stent kinetics, distribution, and bioactivity of forskolin . Circulation. 90:1994;1003-1011.
23. Chawla AS, Chang TMS. In-vivo degradation of poly(lactic acid) of different molecular weights. Biomater Med Devices Artif Organs. 13:1985;153-162.
24. Guthrie SK, Heidt M, Pande A, Grunhaus L, Haskett RF, Hariharan M. A longitudinal evaluation of dexamethasone pharmacokinetics in depressed patients and normal controls. J Clin Psychopharmacol. 12:1992;191-196.
25. 3 catheter [abstract]. J Am Coll Cardiol. 23 Suppl:1994;186A.
26. Wilensky RL, March KL, Gradus-Pizlo I, et al. Regional and arterial localization of radioactive microparticles after local delivery by unsupported or supported porous balloon catheters. Am Heart J. 129:1995;852-859.
27. Camenzind E, Reijs A, Bakker W, van Geijlswijk I, van der Giessen W, Krenning E. A radio-isotopic technique to evaluate efficacy of local drug delivery following coronary angioplasty in human [abstract]. Circulation. 92:(Suppl I):1995;I-785.
28. van der Giessen WJ, Lincoff AM, Schwartz RS, et al. Marked inflammatory sequelae to implantation of biodegradable and nonbiodegradable polymers in porcine coronary arteries. Circulation. 94:1996;1690-1697.
29. Schakenraad JM, Oosterbaan P, Neiuwenhuis P. Biodegradable hollow fibers for the controlled release of drugs. Biomaterials. 9:1988;116-120.
30. Schakenraad JM, Hardonk MJ, Feijen J, Molenaar I, Nieuwenhuis P. Enzyme activity toward poly(L-lactic acid) implants. J Biomed Mater Res. 24:1990;529-545.
31. Bos RRM, Boering G, Rozema FR, Leenslag JW. Resorbable poly(l-lactide) plates and screws for the fixation of zygomatic fractures. J Oral Maxillofac Surg. 45:1987;751-753.
32. Suganuma J, Alexander H. Biological response of intramedullary bone to poly-l-lactic acid. J Appl Biomat. 4:1993;13-27.
33. Verheyen CCPM, de Wijn JR, van Blitterswijk CA, de Groot K. Examination of efferent lymph nodes after 2 years of transcortical implantation of poly(l-lactide) containing plugs a case report . J Biomed Mater Res. 27:1993;1115-1118.
34. Valente AJ, Rozek MM, Sprague EA, Schwartz CJ. Mechanisms in intimal monocyte-macrophage recruitment: a special role of monocyte chemotactic protein-1. Circulation. 86 Suppl III:1992;III-20-5.
35. Forrester JS, Fishbein M, Helfant R, Fagin J. A paradigm for restenosis based on cell biology clues for the development of new preventive therapies . J Am Coll Cardiol. 17:1991;758-769.
36. Parente L, Fitzgerald MF, Flower RJ, DeNucci G. The effect of glucocorticoids on lyso-PAF formation in vitro and in vivo. Agents Actions. 17:1985;312-313.
37. Krane SM, Amento EP. Glucorticoids and collagen disease. Adv Exp Med Biol. 171:1984;61-71.
38. Guzman LA, Labhasetwar V, Song C, Jang Y, Lincoff AM, Levy R. Single intraluminal infusion of biodegradable polymeric nanoparticles matrixed with dexamethasone decreases neointimal formation after vascular injury [abstract]. Circulation. 92 Suppl I:1995;I-293.
39. Muller DWM, Golomb G, Gordon D, Levy RJ. Site-specific dexamethasone delivery for the prevention of neointimal thickening after vascular stent implantation. Coronary Artery Dis. 5:1994;435-442.