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Volumn 5, Issue 10, 2006, Pages 2549-2555

The effect of a novel transition state inhibitor of methylthioadenosine phosphorylase on pemetrexed activity

Author keywords

[No Author keywords available]

Indexed keywords

5' METHYLTHIOADENOSINE PHOSPHORYLASE; ENZYME INHIBITOR; NUCLEOSIDE; PEMETREXED; PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE; SMALL INTERFERING RNA; THYMIDINE;

EID: 33750453339     PISSN: 15357163     EISSN: None     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-06-0313     Document Type: Article
Times cited : (16)

References (28)
  • 1
    • 0041629528 scopus 로고    scopus 로고
    • Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma
    • Vogelzang NJ, Rusthoven JJ, Symanowski J, et al. Phase III study of pemetrexed in combination with cisplatin versus cisplatin alone in patients with malignant pleural mesothelioma. J Clin Oncol 2003;21:2636-44.
    • (2003) J Clin Oncol , vol.21 , pp. 2636-2644
    • Vogelzang, N.J.1    Rusthoven, J.J.2    Symanowski, J.3
  • 2
    • 2442661845 scopus 로고    scopus 로고
    • Randomized phase III trial of pemetrexed versus docetaxel in patients with non-small-cell lung cancer previously treated with chemotherapy
    • Hanna N, Shepherd FA, Fossella FV, et al. Randomized phase III trial of pemetrexed versus docetaxel in patients with non-small-cell lung cancer previously treated with chemotherapy. J Clin Oncol 2004;22:1589-97.
    • (2004) J Clin Oncol , vol.22 , pp. 1589-1597
    • Hanna, N.1    Shepherd, F.A.2    Fossella, F.V.3
  • 3
    • 0030891198 scopus 로고    scopus 로고
    • LY231514, a pyrrolo[2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes
    • Shih C, Chen VJ, Gossett LS, et al. LY231514, a pyrrolo[2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes. Cancer Res 1997;57:1116-23.
    • (1997) Cancer Res , vol.57 , pp. 1116-1123
    • Shih, C.1    Chen, V.J.2    Gossett, L.S.3
  • 4
    • 0038515139 scopus 로고    scopus 로고
    • Homozygous deletion of CDKN2A and codeletion of the methylthioadenosine phosphorylase gene in the majority of pleural mesotheliomas
    • Illei PB, Rusch VW, Zakowski MF, Ladanyi M. Homozygous deletion of CDKN2A and codeletion of the methylthioadenosine phosphorylase gene in the majority of pleural mesotheliomas. Clin Cancer Res 2003;9: 2108-13.
    • (2003) Clin Cancer Res , vol.9 , pp. 2108-2113
    • Illei, P.B.1    Rusch, V.W.2    Zakowski, M.F.3    Ladanyi, M.4
  • 5
    • 3042575322 scopus 로고    scopus 로고
    • Pemetrexed (ALIMTA), a novel multitargeted antineoplastic agent
    • Adjei AA. Pemetrexed (ALIMTA), a novel multitargeted antineoplastic agent. Clin Cancer Res 2004;10:4276-80S.
    • (2004) Clin Cancer Res , vol.10
    • Adjei, A.A.1
  • 6
    • 0033119728 scopus 로고    scopus 로고
    • Use of alanosine as a methylthioadenosine phosphorylase-selective therapy for T-cell acute lymphoblastic leukemia in vitro
    • Batova A, Diccianni MB, Omura-Minamisawa M, et al. Use of alanosine as a methylthioadenosine phosphorylase-selective therapy for T-cell acute lymphoblastic leukemia in vitro. Cancer Res 1999;59:1492-7.
    • (1999) Cancer Res , vol.59 , pp. 1492-1497
    • Batova, A.1    Diccianni, M.B.2    Omura-Minamisawa, M.3
  • 7
    • 0030023025 scopus 로고    scopus 로고
    • Gene deletion chemoselectivity: Codeletion of the genes for p16(INK4), methylthioadenosine phosphorylase, and the α- and β-interferons in human pancreatic cell carcinoma lines and its implications for chemotherapy
    • Chen ZH, Zhang H, Savarese TM. Gene deletion chemoselectivity: codeletion of the genes for p16(INK4), methylthioadenosine phosphorylase, and the α- and β-interferons in human pancreatic cell carcinoma lines and its implications for chemotherapy. Cancer Res 1996;56:1083-90.
    • (1996) Cancer Res , vol.56 , pp. 1083-1090
    • Chen, Z.H.1    Zhang, H.2    Savarese, T.M.3
  • 8
    • 0029774143 scopus 로고    scopus 로고
    • Methylthioadenosine phosphorylase cDNA transfection alters sensitivity to depletion of purine and methionine in A549 lung cancer cells
    • Hori H, Tran P, Carrera CJ, et al. Methylthioadenosine phosphorylase cDNA transfection alters sensitivity to depletion of purine and methionine in A549 lung cancer cells. Cancer Res 1996;56:5653-8.
    • (1996) Cancer Res , vol.56 , pp. 5653-5658
    • Hori, H.1    Tran, P.2    Carrera, C.J.3
  • 9
    • 0030864215 scopus 로고    scopus 로고
    • Expression of methylthioadenosine phosphorylase cDNA in p16-, MTAP-malignant cells: Restoration of methylthioadenosine phosphorylase-dependent salvage pathways and alterations of sensitivity to inhibitors of purine de novo synthesis
    • Chen ZH, Olopade OI, Savarese TM. Expression of methylthioadenosine phosphorylase cDNA in p16-, MTAP-malignant cells: restoration of methylthioadenosine phosphorylase-dependent salvage pathways and alterations of sensitivity to inhibitors of purine de novo synthesis. Mol Pharmacol 1997;52:903-11.
    • (1997) Mol Pharmacol , vol.52 , pp. 903-911
    • Chen, Z.H.1    Olopade, O.I.2    Savarese, T.M.3
  • 10
    • 0036100974 scopus 로고    scopus 로고
    • Methylthioadenosine phosphorylase as target for chemoselective treatment of T-cell acute lymphoblastic leukemic cells
    • Efferth T, Miyachi H, Drexler HG, Gebhart E. Methylthioadenosine phosphorylase as target for chemoselective treatment of T-cell acute lymphoblastic leukemic cells. Blood Cells Mol Dis 2002;28:47-56.
    • (2002) Blood Cells Mol Dis , vol.28 , pp. 47-56
    • Efferth, T.1    Miyachi, H.2    Drexler, H.G.3    Gebhart, E.4
  • 11
    • 30344474013 scopus 로고    scopus 로고
    • Homozygous deletions of methylthioadenosine phosphorylase in human biliary tract cancers
    • Karikari CA, Mullendore M, Eshleman JR, et al. Homozygous deletions of methylthioadenosine phosphorylase in human biliary tract cancers. Mol Cancer Ther 2005;4:1860-6.
    • (2005) Mol Cancer Ther , vol.4 , pp. 1860-1866
    • Karikari, C.A.1    Mullendore, M.2    Eshleman, J.R.3
  • 12
    • 0346096864 scopus 로고    scopus 로고
    • Picomolar transition state analogue inhibitors of human 5′-methylthioadenosine phosphorylase and X-ray structure with MT-immucillin-A
    • Singh V, Shi W, Evans GB, et al. Picomolar transition state analogue inhibitors of human 5′-methylthioadenosine phosphorylase and X-ray structure with MT-immucillin-A. Biochemistry 2004;43:9-18.
    • (2004) Biochemistry , vol.43 , pp. 9-18
    • Singh, V.1    Shi, W.2    Evans, G.B.3
  • 13
    • 0025341331 scopus 로고
    • New colorimetric cytotoxicity assay for anticancer-drug screening
    • Skehan P, Storeng R, Scudiero D, et al. New colorimetric cytotoxicity assay for anticancer-drug screening. J Natl Cancer Inst 1990;82:1107-12.
    • (1990) J Natl Cancer Inst , vol.82 , pp. 1107-1112
    • Skehan, P.1    Storeng, R.2    Scudiero, D.3
  • 14
    • 0042846001 scopus 로고    scopus 로고
    • Characterization of methylthioadenosin phosphorylase (MTAP) expression in malignant melanoma
    • Behrmann I, Wallner S, Komyod W, et al. Characterization of methylthioadenosin phosphorylase (MTAP) expression in malignant melanoma. Am J Pathol 2003;163:683-90.
    • (2003) Am J Pathol , vol.163 , pp. 683-690
    • Behrmann, I.1    Wallner, S.2    Komyod, W.3
  • 15
    • 0346103806 scopus 로고    scopus 로고
    • Altered gene expression of folate enzymes in adjacent mucosa is associated with outcome of colorectal cancer patients
    • Odin E, Wettergren Y, Nilsson S, et al. Altered gene expression of folate enzymes in adjacent mucosa is associated with outcome of colorectal cancer patients. Clin Cancer Res 2003;9:6012-9.
    • (2003) Clin Cancer Res , vol.9 , pp. 6012-6019
    • Odin, E.1    Wettergren, Y.2    Nilsson, S.3
  • 16
    • 0026494947 scopus 로고
    • A dideazatetrahydrofolate analogue lacking a chiral center at C-6, N-[4-2-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo(2, 3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid, is an inhibitor of thymidylate synthase
    • Taylor EC, Kuhnt D, Shih C, et al. A dideazatetrahydrofolate analogue lacking a chiral center at C-6, N-[4-2-(2-amino-3,4-dihydro-4-oxo-7H-pyrrolo(2, 3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid, is an inhibitor of thymidylate synthase. J Med Chem 1992;35:4450-4.
    • (1992) J Med Chem , vol.35 , pp. 4450-4454
    • Taylor, E.C.1    Kuhnt, D.2    Shih, C.3
  • 17
    • 12944312685 scopus 로고    scopus 로고
    • Loss of reduced folate carrier function and folate depletion result in enhanced pemetrexed inhibition of purine synthesis
    • Zhao R, Zhang S, Hanscom M, Chattopadhyay S, Goldman ID. Loss of reduced folate carrier function and folate depletion result in enhanced pemetrexed inhibition of purine synthesis. Clin Cancer Res 2005;11:1294-301.
    • (2005) Clin Cancer Res , vol.11 , pp. 1294-1301
    • Zhao, R.1    Zhang, S.2    Hanscom, M.3    Chattopadhyay, S.4    Goldman, I.D.5
  • 18
    • 33644975527 scopus 로고    scopus 로고
    • The inverse relationship between reduced folate carrier function and pemetrexed activity in a human colon cancer cell line
    • Chattopadhyay S, Zhao R, Krupenko SA, Krupenko N, Goldman ID. The inverse relationship between reduced folate carrier function and pemetrexed activity in a human colon cancer cell line. Mol Cancer Ther 2006;5:438-49.
    • (2006) Mol Cancer Ther , vol.5 , pp. 438-449
    • Chattopadhyay, S.1    Zhao, R.2    Krupenko, S.A.3    Krupenko, N.4    Goldman, I.D.5
  • 19
    • 0344980120 scopus 로고    scopus 로고
    • Clinical and pharmacokinetic phase I study of multitargeted antifolate (LY231514) in combination with cisplatin
    • Thodtmann R, Depenbrock H, Dumez H, et al. Clinical and pharmacokinetic phase I study of multitargeted antifolate (LY231514) in combination with cisplatin. J Clin Oncol 1999;17:3009-16.
    • (1999) J Clin Oncol , vol.17 , pp. 3009-3016
    • Thodtmann, R.1    Depenbrock, H.2    Dumez, H.3
  • 20
    • 0031858217 scopus 로고    scopus 로고
    • Preclinical cellular pharmacology of LY231514 (MTA): A comparison with methotrexate, LY309887 and raltitrexed for their effects on intracellular folate and nucleoside triphosphate pools in CCRF-CEM cells
    • Chen VJ, Bewley JR, Andis SL, et al. Preclinical cellular pharmacology of LY231514 (MTA): a comparison with methotrexate, LY309887 and raltitrexed for their effects on intracellular folate and nucleoside triphosphate pools in CCRF-CEM cells. Br J Cancer 1998;78 Suppl 3:27-34.
    • (1998) Br J Cancer , vol.78 , Issue.SUPPL. 3 , pp. 27-34
    • Chen, V.J.1    Bewley, J.R.2    Andis, S.L.3
  • 21
    • 0022970777 scopus 로고
    • The effect of methotrexate on intracellular folate pools in human MCF-7 breast cancer cells. Evidence for direct inhibition of purine synthesis
    • Allegra CJ, Fine RL, Drake JC, Chabner BA. The effect of methotrexate on intracellular folate pools in human MCF-7 breast cancer cells. Evidence for direct inhibition of purine synthesis. J Biol Chem 1986; 261:6478-85.
    • (1986) J Biol Chem , vol.261 , pp. 6478-6485
    • Allegra, C.J.1    Fine, R.L.2    Drake, J.C.3    Chabner, B.A.4
  • 22
    • 0029907953 scopus 로고    scopus 로고
    • Frequent deletion in the methylthioadenosine phosphorylase gene in T-cell acute lymphoblastic leukemia: Strategies for enzyme-targeted therapy
    • Balova A, Diccianni MB, Nobori T, et al. Frequent deletion in the methylthioadenosine phosphorylase gene in T-cell acute lymphoblastic leukemia: strategies for enzyme-targeted therapy. Blood 1996;88:3083-90.
    • (1996) Blood , vol.88 , pp. 3083-3090
    • Balova, A.1    Diccianni, M.B.2    Nobori, T.3
  • 23
    • 23044502038 scopus 로고    scopus 로고
    • Homozygous deletion of the MTAP gene in invasive adenocarcinoma of the pancreas and in periampullary cancer: A potential new target for therapy
    • Hustinx SR, Hruban RH, Leoni LM, et al. Homozygous deletion of the MTAP gene in invasive adenocarcinoma of the pancreas and in periampullary cancer: a potential new target for therapy. Cancer Biol Ther 2005;4:83-6.
    • (2005) Cancer Biol Ther , vol.4 , pp. 83-86
    • Hustinx, S.R.1    Hruban, R.H.2    Leoni, L.M.3
  • 24
    • 0036305950 scopus 로고    scopus 로고
    • Methylthioadenosine phosphorylase gene deletions are common in osteosarcoma
    • Garcia-Castellano JM, Villanueva A, Healey JH, et al. Methylthioadenosine phosphorylase gene deletions are common in osteosarcoma. Clin Cancer Res 2002;8:782-7.
    • (2002) Clin Cancer Res , vol.8 , pp. 782-787
    • Garcia-Castellano, J.M.1    Villanueva, A.2    Healey, J.H.3
  • 25
    • 3142759350 scopus 로고    scopus 로고
    • Genetic analysis of human glioblastomas using a genomic microarray system
    • Suzuki T, Maruno M, Wada K, et al. Genetic analysis of human glioblastomas using a genomic microarray system. Brain Tumor Pathol 2004;21:27-34.
    • (2004) Brain Tumor Pathol , vol.21 , pp. 27-34
    • Suzuki, T.1    Maruno, M.2    Wada, K.3
  • 26
    • 0032548031 scopus 로고    scopus 로고
    • Homozygous deletions of methylthioadenosine phosphorylase (MTAP) are more frequent than p16INK4A (CDKN2) homozygous deletions in primary non-small cell lung cancers (NSCLC)
    • Schmid M, Malicki D, Nobori T, et al. Homozygous deletions of methylthioadenosine phosphorylase (MTAP) are more frequent than p16INK4A (CDKN2) homozygous deletions in primary non-small cell lung cancers (NSCLC). Oncogene 1998;17:2669-75.
    • (1998) Oncogene , vol.17 , pp. 2669-2675
    • Schmid, M.1    Malicki, D.2    Nobori, T.3
  • 27
    • 20444411897 scopus 로고    scopus 로고
    • Implications of P16/CDKN2A deletion in pleural mesotheliomas
    • Ladanyi M. Implications of P16/CDKN2A deletion in pleural mesotheliomas. Lung Cancer 2005;49 Suppl 1:S95-8.
    • (2005) Lung Cancer , vol.49 , Issue.SUPPL. 1
    • Ladanyi, M.1
  • 28
    • 33646043791 scopus 로고    scopus 로고
    • Methylthioadenosine phosphorylase gene deletions are frequently detected by fluorescence in situ hybridization in conventional chondrosarcomas
    • Chow WA, Bedell V, Gaytan P, et al. Methylthioadenosine phosphorylase gene deletions are frequently detected by fluorescence in situ hybridization in conventional chondrosarcomas. Cancer Genet Cytogenet 2006;166:95-100.
    • (2006) Cancer Genet Cytogenet , vol.166 , pp. 95-100
    • Chow, W.A.1    Bedell, V.2    Gaytan, P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.