RANTES stimulates Ca 2+ mobilization and inositol trisphosphate (IP 3) formation in cells transfected with G protein-coupled receptor 75

British Journal of Pharmacology

Volumn 149, Issue 5, 2006, Pages 490-497

  Ignatov, A ^a,d   Robert, J ^b   Gregory Evans, C ^c   Schaller, H C ^a  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^b INSTITUT COCHIN   (France)

^c IMPERIAL COLLEGE LONDON   (United Kingdom)

^d UNIVERSITY HOSPITAL MAGDEBURG   (Germany)

Author keywords

Chemokine; GPCR; GPR75; HT22 cells; RANTES

Indexed keywords

1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 1H PYRROLE 2,5 DIONE; AMYLOID BETA PROTEIN; CALCIUM; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR 75; INOSITOL TRISPHOSPHATE; LUCIFERASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN KINASE B; RANTES; UNCLASSIFIED DRUG; WORTMANNIN; 1 (6 ((3 METHOXYESTRA 1,3,5(10) TRIEN 17 YL)AMINO)HEXYL) 1H PYRROLE 2,5 DIONE; 1-(6-((3-METHOXYESTRA-1,3,5(10)-TRIEN-17-YL)AMINO)HEXYL)-1H-PYRROLE-2,5-DIONE; 2 PYRROLIDONE DERIVATIVE; ANDROSTANE DERIVATIVE; ESTRANE DERIVATIVE; GPR75 PROTEIN, HUMAN; INOSINE TRIPHOSPHATE; MITOGEN ACTIVATED PROTEIN KINASE;

ARTICLE; BIOLUMINESCENCE; CELL SURVIVAL; CONTROLLED STUDY; DRUG EFFECT; DRUG INHIBITION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; INTRACELLULAR MEMBRANE; NEUROTOXICITY; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REPORTER GENE; ANIMAL; BIOSYNTHESIS; CELL LINE; CHO CELL; CRICETULUS; DOSE RESPONSE; FEMALE; GENE EXPRESSION PROFILING; GENETICS; HAMSTER; LUMINESCENCE; MALE; METABOLISM; METHODOLOGY; MOUSE; PHOSPHORYLATION;

AMYLOID BETA-PROTEIN; ANDROSTADIENES; ANIMALS; CALCIUM; CELL LINE; CELL SURVIVAL; CHO CELLS; CRICETINAE; CRICETULUS; DOSE-RESPONSE RELATIONSHIP, DRUG; ESTRENES; FEMALE; GENE EXPRESSION PROFILING; HUMANS; INOSINE TRIPHOSPHATE; LUCIFERASES; LUMINESCENT MEASUREMENTS; MALE; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; PYRROLIDINONES; RANTES; RECEPTORS, G-PROTEIN-COUPLED; TRANSFECTION;

EID: 33750444223     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/sj.bjp.0706909     Document Type: Article

References (18)

1. Bajetto A, Bonavia R, Barbero S, Florio T, Schettini G (2001). Chemokines and their receptors in the central nervous system. Front Neuroendocrinl 22: 147-184.
2. Cartier L, Hartley O, Dubois-Dauphin M, Krause KH (2005). Chemokine receptors in the central nervous system: role in brain inflammation and neurodegenerative diseases. Brain Res Brain Res Rev 48: 16-42.
3. Crane IJ, Kuppner MC, McKillop-Smith S, Knott RM, Forrester JV (1998). Cytokine regulation of RANTES production by human retinal pigment epithelial cells. Cell Immunol 184: 37-44.
4. Cummings JL, Vinters HV, Cole GM, Khachaturian ZS (1998). Alzheimer's disease: etiologies, pathophysiology, cognitive reserve, and treatment opportunities. Neurology 51: S2-S17 (Discussion S65-S17).
5. Hirata A, Masuda S, Tamura T, Kai K, Ojima K, Fukase A et al. (2003). Expression profiling of cytokines and related genes in regenerating skeletal muscle after cardiotoxin injection: a role for osteopontin. Am J Pathol 163: 203-215.
6. Howard AD, McAllister G, Feighner SD, Liu Q, Nargund RP, van der Ploeg LH et al. (2001). Orphan G protein-coupled receptors and natural ligand discovery. Trends Pharmacol Sci 22: 132-140.
7. Ignatov A, Lintzel J, Hermans-Borgmeyer I, Kreienkamp HJ, Joost P, Thomsen S et al. (2003). Role of the G protein-coupled receptor GPR12 as high-affinity receptor for sphingosylphosphorylcholine and its expression and function in brain development. J Neurosci 23: 907-914.
8. Jiang C, Chen G, Zeng X, Ouyang K, Hu Y (2003). Generation of a bioactive neuropeptide in a cell-free system. Anal Biochem 316: 34-40.
9. Li Y, Gonzales I, Meinkoth JL, Fieeld J, Kazanietz MG, Li Y et al. (2003). Lysophosphatidic acid promotes survival and differentiation of rat Schwann cells. J Biol Chem 278: 9585-9591.
10. Maceyka M, Payne SG, Milstein S, Spiegel S (2002). Sphingosine kinase, sphingosine-1-phosphate, and apoptosis. Biochim Biophys Acta 1585: 193-201.
11. Marinissen MJ, Gutkind JS (2001). G-protein-coupled receptors and signaling networks: emerging paradigms. Trends Pharmacol Sci 22: 368-376.
12. Mennicken F, Maki R, De Souza EB, Quirion R (1999). Chemokines and chemokine receptors in the CNS: a possible role in neuroinflammation and patterning. Trends Pharmacol Sci 20: 73-78.
13. Robert J, Auzan C, Ventura MA, Clauser E (2005). Mechanisms of cell-surface rerouting of an ER-retained mutant of the vasopressin V1b/V3 receptor by a pharmacological chaperone. J Biol Chem 280: 42198-42206.
14. Sauer CG, White K, Stohr H, Grimm T, Hutchinson A, Bernstein PS et al. (2001). Evaluation of the G protein coupled receptor-75 (GPR75) in age related macular degeneration. Br J Ophthalmol 85: 969-975.
15. Schall TJ, Jongstra J, Dyer BJ, Jorgensen J, Clayberger C, Davis MM et al. (1988). A human T cell-specific molecule is a member of a new gene family. J Immunol 141: 1018-1025.
16. Tarttelin EE, Kirshner LS, Bellingham J, Baffi J, Taymans SE, Gregory-Evans K et al. (1999). Cloning and characterization of a novel orphan G-protein-coupled receptor localized to human chromosome 2p16. Biochem Biophys Res Commun 260: 174-180.
17. Varadarajan S, Kanaski J, Aksenova M, Lauderback C, Butterfield DA (2001). Different mechanisms of oxidative stress and neurotoxicity for Alzheimer's A beta (1-42) and A beta (25-35). J Am Chem Soc 123: 5625-5631.
18. Wallece GR, Curnow S, Wloka K, Salmon M, Murray PI (2004). The role of chemokines and their receptors in ocular disease. Prog Retin Eye Res 23: 435-448.