Zinc supplementation and growth

Current Opinion in Clinical Nutrition and Metabolic Care

Volumn 9, Issue 6, 2006, Pages 757-762

  Ruz, Manuel ^a  

^a UNIVERSITY OF CHILE   (Chile)

Author keywords

Children; Growth; Infants; Supplementation; Zinc

Indexed keywords

IRON; ZINC;

ANTHROPOMETRY; BODY HEIGHT; BODY WEIGHT; CHILD; CHILD GROWTH; HUMAN; IRON THERAPY; MATERNAL NUTRITION; REVIEW; SUPPLEMENTATION; ZINC SUPPLEMENTATION;

ADOLESCENT; ADULT; BODY HEIGHT; BODY WEIGHT; CHILD; CHILD, PRESCHOOL; DIETARY SUPPLEMENTS; FEMALE; FETAL GROWTH RETARDATION; GROWTH; HUMANS; INFANT; INFANT, NEWBORN; MALE; NUTRITION PHYSIOLOGY; NUTRITIONAL STATUS; PREGNANCY; TRACE ELEMENTS; ZINC;

EID: 33750372696     PISSN: 13631950     EISSN: 15353885     Source Type: Journal    
DOI: 10.1097/01.mco.0000247479.87402.5b     Document Type: Review

References (36)

1. UNICEF/UNU/WHO/MI. Preventing iron deficiency in women and children: background and consensus on key technical issues and resources for advocacy, planning, and implementing national programs. International Nutrition Foundation and Micronutrient Initiative, Boston, Ottawa 1999.
2. Castillo-Duran C, Ruz M. Epidemiology of micronutrient deficiencies in developing and developed countries, specifically zinc, copper, selenium and iodine. In: Pettifor JM, Zlotkin S, editors. Micronutrient deficiencies during the weaning period and the first years of life Nestle Nutrition Workshop Series Pediatric Program, 54. Basel: Nestec Ltd., Vevey/S. Karger AG; 2004. pp. 37-52.
3. Ruz M. Zinc properties and determination. In: Trugo L, Finglas P, Caballero B, editors. Encyclopedia of food sciences and nutrition. London: Academic Press; 2003. pp. 6267-6272.
4. Fischer Walker C, Black RE. Zinc and the risk for infectious disease. Annu Rev Nutr 2004; 24:255-275.
5. Underwood LE, Thissen JP, Lemozy S, et al. Hormonal and nutritional regulation of IGF-I and its binding proteins. Horm Res 1994; 42:145-151.
6. McNall AD. The impaired growth induced by zinc deficiency in rats is associated with decreased expression of the hepatic IGF-I and GH receptor genes. J Nutr 1995; 125:874-879.
7. Ninh NX, Thissen JP, Maiter D, et al. Reduced liver insulin-like growth factor 1 gene expression in young zinc-deprived rats is associated with a decrease in liver growth hormone (GH) receptors and serum GH binding proteins. J Endocrinol 1995; 144:449-456.
8. Imamoglu S, Bereket A, Turan S, et al. Effect of zinc supplementation on growth hormone secretion, IGF-I, IGFBP-3, somatomedin generation, alkaline phosphatase, osteocalcin and growth in prepubertal children with idiopathic short stature. J Pediatr Endocrinol Metab 2005; 18:69-74.
9. Brown KH, Peerson JM, Rivera J, Allen LH. Effect of supplemental zinc on the growth and serum zinc concentrations of prepubertal children: a meta-analysis of randomized controlled trials. Am J Clin Nutr 2002; 75:1062-1071.
10. Rivera JA, Hotz C, Gonzalez-Cossio T, et al. The effect of micronutrient deficiencies on child growth: a review of results from community-based supplementation trials. J Nutr 2003; 133:4010S-4020S.
11. FAO/WHO/UNU. Human vitamin and mineral requirements. Rome. WHO and Food and Agriculture Organization of the United Nations 2002.
12. Richard SA, Zavaleta N, Caulfield LE, et al. Zinc and iron supplementation and malaria, diarrhea, and respiratory infections in children in the Peruvian Amazon. Am J Trop Med Hyg 2006; 75:126-132. This article studied a large number of individuals with height-for-age z-scores less than -2 in the Amazon; no growth effects as a result of zinc were observed.
13. Heinig MJ, Brown KH, Lonnerdal B, Dewey KG. Zinc supplementation does not affect growth, morbidity, or motor development of U.S. term breastfed infants at 4 to 10 mo of age. Am J Clin Nutr (in press) 84:594-560.
14. Wasantwisut E, Winichagoon P, Chitchumroonchokchai C, et al. Iron and zinc supplementation improved iron and zinc status, but not physical growth, of apparently healthy, breast-fed infants in rural communities of Northeast Thailand. J Nutr (in press) 136:2405-2411.
15. Berger J, Ninh NX, Khan NC, et al. Efficacy of combined iron and zinc supplementation on micronutrient status and growth in Vietnamese infants. Eur J Clin Nutr 2006; 60:443-454. A study conducted in 915 breast-fed infants that evaluated the biochemical and anthropometric consequences of iron-zinc interactions. It provides a detailed description of related parameters.
16. Giovannini M, Sala D, Usuelli M, et al. Double-blind, placebo-controlled trial comparing effects of supplementation with two different combinations of micronutrients delivered as sprinkles on growth, anemia, and iron deficiency in Cambodian infants. J Pediatr Gastroenterol Nutr 2006; 42:306-312.
17. Brooks WA, Santosham M, Naheed A, et al. Effect of weekly zinc supplements on incidence of pneumonia and diarrhoea in children younger than 2 years in an urban, low-income population in Bangladesh: randomised controlled trial. Lancet 2005; 366:999-1004. During the review period most of the studies lasted for 6-7 months; this study, however, provided zinc supplements for 12 months to 1665 Bangladeshi children.
18. Gardner JM, Powell CA, Baker-Henningham H, et al. Zinc supplementation and psychosocial stimulation: effects on the development of undernourished Jamaican children. Am J Clin Nutr 2005; 82:399-405. This study evaluates a nutritional factor (zinc) and a non-nutritional factor (psychosocial stimulation) as determinants of growth and development.
19. Penny ME, Marin RM, Duran A, et al. Randomized controlled trial of the effect of daily supplementation with zinc or multiple micronutrients on the morbidity, growth, and micronutrient status of young Peruvian children. Am J Clin Nutr 2004; 79:457-465.
20. Black MM, Sazawal S, Black RE, et al. Cognitive and motor development among small-for-gestational-age infants: impact of zinc supplementation, birth weight, and caregiving practices. Pediatrics 2004; 113:1297-1305.
21. Lind T, Lonnerdal B, Stenlund H, et al. A community-based randomized controlled trial of iron and zinc supplementation in Indonesian infants: effects on growth and development. Am J Clin Nutr 2004; 80:729-736.
22. Black MM, Baqui AH, Zaman K, et al. Iron and zinc supplementation promote motor development and exploratory behavior among Bangladeshi infants. Am J Clin Nutr 2004; 80:903-910.
23. Untoro J, Karyadi E, Wibowo L, et al. Multiple micronutrient supplements improve micronutrient status and anemia but not growth and morbidity of Indonesian infants: a randomized, double-blind, placebo-controlled trial. J Nutr 2005; 135:639S-645S.
24. Lopez de Romana G, Cusirramos S, Lopez de Romana D, et al. Efficacy of multiple micronutrient supplementation for improving anemia, micronutrient status, growth, and morbidity of Peruvian infants. J Nutr 2005; 135:646S-652S.
25. Smuts CM, Dhansay MA, Faber M, et al. Efficacy of multiple micronutrient supplementation for improving anemia, micronutrient status, and growth in South African infants. J Nutr 2005; 135:653S-659S.
26. Hop le T, Berger J. Multiple micronutrient supplementation improves anemia, micronutrient nutrient status, and growth of Vietnamese infants: double-blind, randomized, placebo-controlled trial. J Nutr 2005; 135:660S-665S.
27. Smuts CM, Lombard CJ, Benade AJ, et al., International Research on Infant Supplementation (IRIS) Study Group. Efficacy of a foodlet-based multiple micronutrient supplement for preventing growth faltering, anemia, and micronutrient deficiency of infants: the four country IRIS trial pooled data analysis. J Nutr 2005; 135:631S-638S. An outstanding effort by the members of the IRIS study group. This article summarizes the main aspects of the common protocol applied in the four countries (Indonesia, Peru, South Africa and Vietnam). It also provides a clear summary of the pooled results.
28. Solomons NW, Jacob RA. Studies on the bioavailability of zinc in humans: effects of heme and nonheme iron on the absorption of zinc. Am J Clin Nutr 1981; 34:475-482.
29. Olivares M, Pizarro F, Ruz M. Inhibition of iron absorption by zinc (abstract). Ped Res 2005; 57:924.
30. Fischer Walker C, Kordas K, Stoltzfus RJ, Black RE. Interactive effects of iron and zinc on biochemical and functional outcomes in supplementation trials. Am J Clin Nutr 2005; 82:5-12. An excellent review of iron and zinc interactions in supplementation trials.
31. Hafeez A, Mehmood G, Mazhar F. Oral zinc supplementation in pregnant women and its effect on birth weight: a randomised controlled trial. Arch Dis Child Fetal Neonatal Ed 2005; 90:F170-F171. This study conducted in Pakistan is the only published experience on maternal zinc supplementation and infant growth during 2005.
32. Hininger I, Favier M, Arnaud J, et al. Effects of a combined micronutrient supplementation on maternal biological status and newborn anthropometrics measurements: a randomised double-blind, placebo-controlled trial in apparently healthy pregnant women. Eur J Clin Nutr 2004; 58:52-59.
33. Merialdi M, Caulfield LE, Zavaleta N, et al. Randomized controlled trial of prenatal zinc supplementation and fetal bone growth. Am J Clin Nutr 2004; 79:826-830.
34. Castillo Duran C, Weisstaub G. Zinc supplementation and growth of the fetus and low birth weight infant. J Nutr 2003; 133:1494S-1497S.
35. Osendarp SJM, West CE, Black RE. The need for maternal zinc supplementation in developing countries: an unresolved issue. J Nutr 2003; 133:817S-827S.
36. Shah D, Sachdev HP. Zinc deficiency in pregnancy and fetal outcome. Nutr Rev 2006; 64:15-30. An excellent and updated review on this subject.