Cytochrome P450 active site plasticity: Attenuation of imidazole binding in cytochrome P450cam by an L244A mutation

Protein Engineering, Design and Selection

Volumn 19, Issue 11, 2006, Pages 491-496

  Verras, Andreas ^a   Alian, Akram ^a   Ortiz De Montellano, Paul R ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Active site conformation; Azole drug resistance; Cytochrome P450 inhibition; Imidazole binding to P450; Protein maleability

Indexed keywords

CRYSTAL STRUCTURE; NITROGEN COMPOUNDS; PROTEINS; SUBSTRATES;

ACTIVE SITE CONFORMATION; AZOLE DRUG RESISTANCE; CYTOCHROME P450 INHIBITION; IMIDAZOLE BINDING; PROTEIN MALEABILITY;

PIGMENTS;

1 METHYLIMIDAZOLE; ALANINE; CAMPHOR; CYTOCHROME P450; HEME; IMIDAZOLE; IMIDAZOLE DERIVATIVE; IRON; LEUCINE; LIGAND; MUTANT PROTEIN; VALINE;

ARTICLE; BINDING AFFINITY; CRYSTAL STRUCTURE; DRUG PROTEIN BINDING; ENZYME ACTIVE SITE; ENZYME SUBSTRATE; OXIDATION; PLASTICITY; PRIORITY JOURNAL; WILD TYPE;

AMINO ACID SUBSTITUTION; CAMPHOR 5-MONOOXYGENASE; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; HEME; IMIDAZOLES; IRON; LIGANDS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION; PROTEIN ENGINEERING; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY;

DRYOBALANOPS;

EID: 33750370837     PISSN: 17410126     EISSN: 17410134     Source Type: Journal    
DOI: 10.1093/protein/gzl035     Document Type: Article

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