Assessment of bone mineral and matrix using backscatter electron imaging and FTIR imaging

Current Osteoporosis Reports

Volumn 4, Issue 2, 2006, Pages 71-75

  Boskey, Adele L ^a  

^a HOSPITAL FOR SPECIAL SURGERY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBONIC ACID; COLLAGEN; PHOSPHATE;

BONE MATRIX; BONE MINERAL; BONE MINERALIZATION; BONE STRUCTURE; CLINICAL ASSESSMENT; CRYSTAL STRUCTURE; HISTOGRAM; HUMAN; INFRARED RADIATION; INFRARED SPECTROSCOPY; NONHUMAN; OSTEOMALACIA; OSTEOPOROSIS; RADIODIAGNOSIS; REVIEW;

BONE DENSITY; BONE MATRIX; ELECTRONS; HUMANS; MICROSCOPY, ELECTRON, SCANNING; MICROSCOPY, ENERGY-FILTERING TRANSMISSION ELECTRON; OSTEOPOROSIS; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; SPECTRUM ANALYSIS, RAMAN;

EID: 33750361717     PISSN: 15441873     EISSN: 15442241     Source Type: Journal    
DOI: 10.1007/s11914-006-0005-6     Document Type: Review

References (49)

1. Felsenberg D, Boonen S: The bone quality framework: determinants of bone strength and their interrelationships, and implications for osteoporosis management. Clin Ther 2005, 27:1-11.
2. Rubin CD: Emerging concepts in osteoporosis and bone strength. Curr Med Res Opin 2005, 21:1049-1056.
3. Gokhale J, Robey PG, Boskey AL: The biochemistry of bone. In Osteoporosis, edn 2, vol. 1. Edited by Marcus R, Feldman D, Kelsey J. San Diego: Academic Press; 2001:107-189.
4. Young MF: Bone matrix proteins: their function, regulation, and relationship to osteoporosis. Osteoporos Int 2003, 14(Suppl 3):S35-S42.
5. Butler WT, Brunn JC, Qin C, McKee MD: Extracellular matrix proteins and the dynamics of dentin formation. Connect Tissue Res 2002, 43:301-307.
6. McCreadie BR, Goulet RW, Feldkamp LA, Goldstein SA: Hierarchical structure of bone and micro-computed tomography. Adv Exp Med Biol 2001, 496:67-83.
7. Wise LM, Waldman SD, Kasra M, et al.: Effect of zoledronate on bone quality in the treatment of aseptic loosening of hip arthroplasty in the dog. Calcif Tissue Int 2005, 77:367-375. This study validates back-scattered electron (BSE) imaging measurements based on density fractionation studies. Dose-dependent changes in bone material properties are demonstrated in a canine model of prosthetic loosening.
8. Burr DB, Miller L, Grynpas M, et al.: Tissue mineralization is increased following 1-year treatment with high doses of bisphosphonates in dogs. Bone 2003, 33:960-969.
9. Tong W, Glimcher MJ, Katz JL, et al.: Size and shape of mineralites in young bovine bone measured by atomic force microscopy. Calcif Tissue Int 2003, 72:592-598.
10. Hassenkam T, Jorgensen HL, Pedersen MB, et al.: Atomic force microscopy on human trabecular bone from an old woman with osteoporoticfractures. Micron 2005, 36:681-687. This paper shows abnormal collagen fibrils in an osteoporotic patient, suggesting a link between collagen structure and fracture risk.
11. Rubin MA, Jasiuk I, Taylor J, et al.: TEM analysis of the nanostructure of normal and osteoporotic human trabecular bone. Bone 2003, 33:270-282.
12. Gomberg BR, Saha PK, Wehrli FW: Method for cortical bone structural analysis from magnetic resonance images. Acad Radiol 2005, 12:1320-1332.
13. Majumdar S, Newitt D, Mathur A, et al.: Magnetic resonance imaging of trabecular bone structure in the distal radius: relationship with x-ray tomographic microscopy and biomechanics. Osteoporos Int 1996, 6:376-385.
14. Boivin G, Vedi S, Purdie DW, et al.: Influence of estrogen therapy at conventional and high doses on the degree of mineralization of iliac bone tissue: a quantitative microradiographic analysis in postmenopausal women. Bone 2005, 36:562-567.
15. Boyde A, Jones SJ: Backscattered electron imaging of dental tissues. Anat Embryol (Berl) 1983, 168:211-226.
16. Roschger P, Fratzl P, Eschberger J, Klaushofer K: Validation of quantitative backscattered electron imaging for the measurement of mineral density distribution in human bone biopsies. Bone 1998, 23:319-326.
17. Geoffroy V, Kneissel M, Fournier B, et al.: High bone resorption in adult aging transgenic mice overexpressing Cbfa1/Runx2 in cells of the osteoblastic lineage. Mol Cell Biol 2002, 22:6222-6233.
18. Zérath E, Grynpas M, Holy X, et al.: Spaceflight affects bone formation in rhesus monkeys: a histological and cell culture study. Am J Physiol 2002, 93:1047-1056.
19. Boyde A, Compston JE, Reeve J, et al.: Effect of estrogen suppression on the mineralization density of iliac crest biopsies in young women as assessed by backscattered electron imaging. Bone 1998, 22:241-250.
20. Stewart TL, Roschger P, Misof BM, et al.: Association of COLIA1 Sp1 alleles with defective bone nodule formation in vitro and abnormal bone mineralization in vivo. Calcif Tissue Int 2005, 77:113-118.
21. Skedros JG, Holmes JL, Vajda EG, Bloebaum RD: Cement lines of secondary osteons in human bone are not mineral-deficient: new data in a historical perspective. Anat Rec A Discov Mol Cell Evol Biol 2005, 286:781-803. This study, demonstrating that cement lines are not hypomineralized but, in fact, may be hypermineralized, provides an excellent discussion of the limitations of BSE measurements.
22. Sahar ND, Hong SI, Kohn DH: Micro- and nano-structural analyses of damage in bone. Micron 2005, 36:617-629. This review considers the application of a variety of high-resolution techniques (laser scanning confocal microscopy, Raman spectroscopy, transmission electron microscopy, and SEM) for the analysis of crack propagation and fracture in bone.
23. Boskey A, Mendelsohn R: Infrared analysis of bone in health and disease. J Biomed Opt 2005, 10:031102-031106. This article reviews in detail the technique of infrared analysis and how it can be applied to bone.
24. Carden A, Morris MD: Application of vibrational spectroscopy to the study of mineralized tissues. J Biomed Opt 2000, 5:259-268.
25. Reginato AJ: Calcium pyrophosphate dihydrate gout and other crystal deposition diseases. Curr Opin Rheumatol 1991, 3:676-683.
26. Mendelsohn R, Hassankhani A, DiCarlo E, Boskey A: FT-IR microscopy of endochondral ossification at 20 mu spatial resolution. Calcif Tissue Int 1989, 44:20-24.
27. Kim H, Rey C, Glimcher MJ: X-ray diffraction, electron microscopy, and Fourier transform infrared spectroscopy of apatite crystals isolated from chicken and bovine calcined cartilage. Calcif Tissue Int 1996, 59:58-63.
28. Gadaleta SJ, Paschalis EP, Betts F, et al.: Fourier transform infrared spectroscopy of the solution-mediated conversion of amorphous calcium phosphate to hydroxyapatite: new correlations between x-ray diffraction and infrared data. Calcif Tissue Int 1996, 58:9-16.
29. Ou-Yang H, Paschalis EP, Boskey AL, Mendelsohn R: Two-dimensional vibrational correlation spectroscopy of in vitro hydroxyapatite maturation. Biopolymers 2000, 57:129-139.
30. Paschalis EP, Betts F, DiCarlo E, et al.: FTIR microspectroscopic analysis of normal human cortical and trabecular bone. Calcif Tissue Int 1997, 61:480-486.
31. Paschalis EP, Betts F, DiCarlo E, et al.: FTIR microspectroscopic analysis of human iliac crest biopsies from untreated osteoporotic bone. Calcif Tissue Int 1997, 61:487-492.
32. Boskey AL, DiCarlo E, Paschalis E, et al.: Comparison of mineral quality and quantity in iliac crest biopsies from high- and low-turnover osteoporosis: an FT-IR microspectroscopic investigation. Osteoporos Int 2005, 16:2031-2038.
33. Monier-Faugere MC, Geng Z, Paschalis EP, et al.: Intermittent and continuous administration of the bisphosphonate ibandronate in ovariohysterectomized beagle dogs: effects on bone morphometry and mineral properties. J Bone Miner Res 1999, 14:1768-1778.
34. Gadeleta SJ, Boskey AL, Paschalis E, et al.: A physical, chemical, and mechanical study of lumbar vertebrae from normal, ovariectomized, and nandrolone decanoate-treated cynomolgus monkeys (Macaca fascicularis). Bone 2000, 27:541-550. This was the first study to demonstrate a relationship between mechanical strength and infrared properties in the same model.
35. Huang RY, Miller LM, Carlson CS, Chance MR: In situ chemistry of osteoporosis revealed by synchrotron infrared microspectroscopy. Bone 2003, 33:514-521.
36. Bohic S, Rey C, Legrand A, et al.: Characterization of the trabecular rat bone mineral: effect of ovariectomy and bisphosphonate treatment. Bone 2000, 26:341-348.
37. Busa B, Miller LM, Rubin CT, et al.: Rapid establishment of chemical and mechanical properties during lamellar bone formation. Calcif Tissue Int 2005, 77:386-394. This recent study demonstrated the relationship between bone elastic modulus and infrared parameters. It also provides new insight into the rate of secondary mineralization in rat bone.
38. Marcott C, Reeder RC, Paschalis EP, et al.: Infrared microspectroscopic imaging of biomineralized tissues using a mercury-cadmium-telluride focal-plane array detector. Cell Mol Biol (Noisy-le-grand) 1998, 44:109-115.
39. Faibish D, Gomes A, Boivin G, et al.: Infrared imaging of calcified tissue in bone biopsies from adults with osteomalacia. Bone 2005, 36:6-12.
40. Paschalis EP, Recker R, DiCarlo E, et al.: Distribution of collagen cross-links in normal human trabecular bone. J Bone Miner Res 2003, 18:1942-1946.
41. Paschalis EP, Shane E, Lyritis G, et al.: Bone fragility and collagen cross-links. J Bone Miner Res 2004, 19:2000-2004.
42. Paschalis EP, Burr DB, Mendelsohn R, et al.: Bone mineral and collagen quality in humeri of ovariectomized cynomolgus monkeys given rhPTH(1-34) for 18 months. J Bone Miner Res 2003, 18:769-775.
43. 2-. J Bone Miner Res 2001, 16:893-900.
44. Blank RD, Baldini TH, Kaufman M, et al.: Spectroscopically determined collagen Pyr/deH-DHLNL cross-link ratio and crystallinity indices differ markedly in recombinant congenic mice with divergent calculated bone tissue strength. Connect Tissue Res 2003, 44:134-142.
45. Ouyang H, Sherman PJ, Paschalis EP, et al.: Fourier transform infrared microscopic imaging: effects of estrogen and estrogen deficiency on fracture healing in rat femurs. Appl Spectrosc 2004, 58:1-9.
46. Paschalis EP, Boskey AL, Kassem M, Eriksen EF: Effect of hormone replacement therapy on bone quality in early postmenopausal women. J Bone Miner Res 2003, 18:955-959.
47. Paschalis EP, Glass EV, Donley DW, Eriksen EF: Bone mineral and collagen quality in iliac crest biopsies of patients given teriparatide: new results from the fracture prevention trial. J Clin Endocrinol Metab 2005, 90:4644-4649.
48. Faibish D, Ott SM, Boskey AL: Mineral changes in osteoporosis: a review. Clin Orthop Relat Res 2006, 443:28-38.
49. Draper ER, Morris MD, Camacho NP, et al.: Novel assessment of bone using time-resolved transcutaneous Raman spectroscopy. J Bone Miner Res 2005, 20:1968-1972. This innovative study suggests the potential for using Raman imaging in situ.