Bone mineral and collagen quality in iliac crest biopsies of patients given teriparatide: New results from the Fracture Prevention Trial

Journal of Clinical Endocrinology and Metabolism

Volumn 90, Issue 8, 2005, Pages 4644-4649

  Paschalis, Eleftherios P ^a,c   Glass, Emmett V ^b   Donley, David W ^b   Eriksen, Erik F ^b  

^a HOSPITAL FOR SPECIAL SURGERY   (United States)

^b ELI LILLY AND COMPANY   (United States)

^c LUDWIG BOLTZMANN INSTITUTE FOR LUNG VASCULAR RESEARCH   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID DERIVATIVE; COLLAGEN; DEHYDRODIHYDROXYSINONORLEUCINE; PARATHYROID HORMONE[1-34]; PLACEBO; PYRIDINOLINE; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; BONE BIOPSY; BONE MATRIX; BONE MINERAL; BONE MINERALIZATION; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSS LINKING; CRYSTAL STRUCTURE; DRUG EFFICACY; FEMALE; FRACTURE; HUMAN; HUMAN TISSUE; ILIAC CREST; INFRARED SPECTROSCOPY; OSSIFICATION; PHYSICAL CHEMISTRY; POSTMENOPAUSE OSTEOPOROSIS; PRIORITY JOURNAL; RANDOMIZATION; RANDOMIZED CONTROLLED TRIAL;

AGED; BIOPSY; BONE DENSITY; CALCIFICATION, PHYSIOLOGIC; COLLAGEN; CROSS-LINKING REAGENTS; FEMALE; FRACTURES, BONE; HUMANS; ILIUM; MIDDLE AGED; OSTEOPOROSIS, POSTMENOPAUSAL; TERIPARATIDE;

EID: 23844549871     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2004-2489     Document Type: Article

References (42)

1. Neer RM, Arnaud CD, Zanchetta JR, Prince R, Gaich GA, Reginster JY, Hodsman AB, Eriksen EF, Ish-Shalom S, Genant HK, Wang O, Mitlak BH 2001 Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis. N Engl J Med 344:1434-1441
2. Brommage R, Hotchkiss C, Lees C, Stancill M, Hock J, Jerome C 1999 Daily treatment with human recombinant parathyroid hormone-(1-34), LY333334, for 1 year increases bone mass in ovariectomized monkeys. J Clin Endocrinol Metab 84:3757-3763
3. Burr D, Hirano T, Turner C, Hotchkiss C, Brommage R, Hock J 2001 Intermittently administered hPTH (1-34) treatment increases intracortical bone turnover and porosity without reducing bone strength in the humerus of ovariectomized cynomolgus monkeys. J Bone Miner Res 16:157-165
4. Turner C, Burr D, Hock J, Brommage R, Sato M 2001 The effects of PTH (1-34) on bone structure and strength in ovariectomized monkeys. Adv Exp Med Biol 496:165-179
5. Paschalis EP, Burr DB, Mendelsohn R, Hock JM, Boskey AL 2003 Bone mineral and collagen quality in humeri of ovariectomized cynomolgus monkeys given rhPTH(1-34) for 18 months. J Bone Miner Res 18:769-775
6. Mendelsohn R, Paschalis EP, Boskey AL 1999 Infrared spectroscopy, microscopy, and microscopic imaging of mineralizing tissues. spectra-structure correlations from human iliac crest biopsies. J Biomed Optics 4:14-21
7. Paschalis EP, DiCarlo E, Betts F, Sherman P, Mendelsohn R, Boskey AL 1996 FTIR microspectroscopic analysis of human osteonal bone. Calcif Tissue Int 59:480-487
8. Paschalis EP, Verdelis K, Doty SB, Boskey AL, Mendelsohn R, Yamauchi M 2001 Spectroscopic characterization of collagen cross-links in bone. J Bone Miner Res 16:1821-1828
9. Snively C, Koenig J 1999 Characterizing the performance of a fast FT-IR imaging spectrometer. Appl Spectrosc 53:170-177
10. Paschalis EP, Boskey AL, Kassem M, Eriksen EF 2003 Effect of hormone replacement therapy on bone quality in early postmenopausal women. J Bone Miner Res 18:955-959
11. Melton LJI, Atkinson EJ, O'Fallon WM, Wahner HW, Riggs BL 1993 Long-term fracture prediction by bone mineral assessed at different skeletal sites. J Bone Miner Res 8:1227-1233
12. Melton LJI, Atkinson EJ, O'Connor MK, O'Fallon WM, Riggs BL 2000 De-terminants of bone loss from the femoral neck in women of different ages. J Bone Miner Res 15:24-31
13. Faulkner KG, Cummings SR, Black D, Palermo L, Gluer CC, Genant HK 1993 Simple measurement of femoral geometry predicts hip fracture: The study of osteoporotic fractures. J Bone Miner Res 8:1211-1217
14. Faulkner KG 2000 Bone matters: are density increases necessary to reduce fracture risk? J Bone Miner Res 15:183-187
15. Veenland JF, Link TM, Konermann W, Meier N, Grashuis JL, Gelsema ES 1997 Unraveling the role of structure and density in determining vertebral bone strength. Calcif Tissue Int 61:474-479
16. Marshall D, Johnell O, Wedel H 1996 Meta-analysis of how well measures of bone mineral density predict occurrence of osteoporotic fractures. BMJ 312: 1254-1259
17. McCreade RB, Goldstein AS 2000 Biomechanics of fracture: is bone mineral density sufficient to assess risk? J Bone Miner Res 15:2305-2308
18. Currey JD 1984 Effects of differences in mineralization on the mechanical properties of bone. Philos Trans R Soc London B Biol Sci 304:509-518
19. Turner C 2002 Biomechanics of bone: determinants of skeletal fragility and bone quality. Osteoporos Int 13:97-104
20. Fratzl P, Groschner M, Vogl G, Plenk Jr H, Eschberger J, Fratzl-Zelman N, Koller K, Klaushofer K 1992 Mineral crystals in calcified tissues: a comparative study by SAXS. J Bone Miner Res 7:329-334
21. Fratzl P, Roschger P, Eschberger J, Abendroth B, Klaushofer K 1994 Abnormal bone mineralization after fluoride treatment in osteoporosis: a small-angle x-ray-scattering study. J Bone Miner Res 9:1541-1549
22. Misof BM, Roschger P, Cosman F, Kurland ES, Tesch W, Messmer P, Dempster DW, Nieves J, Shane E, Fratzl P, Klaushofer K, Bilezikian J, Lindsay R 2003 Effects of intermittent parathyroid hormone administration on bone mineralization density in iliac crest biopsies from patients with osteoporosis: a paired study before and after treatment. J Clin Endocrinol Metab 88:1150-1156
23. Roschger P, Fratzl P, Eschberger J, Klaushofer K 1998 Validation of quantitative backscattered electron imaging for the measurement of mineral density distribution in human bone biopsies. Bone 23:319-326
24. Roschger P, Fratzl P, Klaushofer K, Rodan G 1997 Mineralization of cancellous bone after alendronate and sodium fluoride treatment: a quantitative backscattered electron imaging study on minipig ribs. Bone 20:393-397
25. Roschger P, Rinnerthaler S, Yates J, Rodan GA, Fratzl P, Klaushofer K 2001 Alendronate increases degree and uniformity of mineralization in cancellous bone and decreases the porosity in cortical bone of osteoporotic women. Bone 29:185-191
26. Paschalis EP, Betts F, DiCarlo E, Mendelsohn R, Boskey AL 1997 FTIR microspectroscopic analysis of human iliac crest biopsies from untreated osteoporotic bone. Calcif Tissue Int 61:487-492
27. Paschalis EP, Betts F, DiCarlo E, Mendelsohn R, Boskey AL 1997 FTIR microspectroscopic analysis of normal human cortical and trabecular bone. Calcif Tissue Int 61:480-486
28. Jager I, Fratzl P 2000 Mineralized collagen fibrils: a mechanical model with a staggered arrangement of mineral particles. Biophys J 79:1737-1746
29. Gao H, Ji B, Jager IL, Arzt E, Fratzl P 2003 Materials become insensitive to flaws at nanoscale: lessons from nature. Proc Natl Acad Sci USA 100:5597-5600
30. Bailey A, Sims T, Ebbesen E, Mansell J, Thomsen J, Mosekilde L 1999 Age-related changes in the biochemical properties of human cancellous bone collagen: relationship to bone strength. Calcif Tissue Int 65:203-210
31. Bailey AJ, Wotton SF, Sims TJ, Thompson PW 1992 Post-translational modifications in the collagen of human osteoporotic femoral head. Biochem Biophys Res Commun 185:801-805
32. Bailey AJ, Wotton SF, Sims TJ, Thompson PW 1993 Biochemical changes in the collagen of human osteoporotic bone matrix. Connect Tissue Res 29:119-132
33. Masse P, Rimnac C, Yamauchi M, Coburn P, Rucker B, Howell S, Boskey A 1996 Pyridoxine deficiency affects biomechanical properties of chick tibial bone. Bone 18:567-574
34. Oxlund H, Barckman M, Ortoft G, Andreassen TT 1995 Reduced concentrations of collagen cross-links are associated with reduced strength of bone. Bone 17:365S-371S
35. Prockop DJ, Constantinou CD, Dombrowski KE, Hojima Y, Kadler KE, Kuivaniemi H, Tromp G, Vogel BE 1989 Type I procollagen: the gene-protein system that harbors most of the mutations causing osteogenesis imperfecta and probably more common heritable disorders of connective tissue. Am J Med Genet 34:60-67
36. Prockop DJ, Kivirikko KI 1984 Heritable diseases of collagen. N Engl J Med 311:376-396
37. Prockop DJ, Kivirikko KI 1995 Collagens: molecular biology, diseases, and potentials for therapy. Annu Rev Biochem 64:403-434
38. Yamauchi M 1996 Collagen: the major matrix molecule in mineralized tissues. In: Anderson JJB, Garner SC, eds. Calcium and phosphorus in health and disease. New York: CRC Press; 127-141
39. Mann V, Hobson E, Li B, Stewart T, Grant S, Robins S, Aspden R, Ralston S 2001 A COL1A1 Sp1 binding site polymorphism predisposes to osteoporotic fracture by affecting bone density and quality. J Clin Invest 197:899-907
40. Zioupos P, Currey J, Hamer A 1999 The role of collagen in the declining mechanical properties of aging human cortical bone. J Biomed Mater Res 45:108-116
41. Otsubo K, Katz EP, Mechanic GL, Yamauchi M 1992 The COOH terminal locus of free aldehyde in bone collagen: the loss of cross-linking connectivity with mineralization. Biochemistry 31:396-402
42. Paschalis EP, Recker R, DiCarlo E, Doty SB, Atti E, Boskey AL 2003 Distribution of collagen cross-links in normal human trabecular bone. J Bone Miner Res 18:1942-1946