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Volumn 26, Issue 4, 2006, Pages 309-317

New nucleic acid diagnostic tests in viral hepatitis

Author keywords

Antiviral therapy; Genotypes; Hepatitis B; Hepatitis C; Mutations; Viral genome; Viral load

Indexed keywords

ALANINE AMINOTRANSFERASE; ALPHA INTERFERON; ANTIVIRUS AGENT; DNA POLYMERASE; HEPATITIS B(E) ANTIGEN; NUCLEOSIDE ANALOG; NUCLEOSIDE DERIVATIVE; NUCLEOTIDE DERIVATIVE; PEGINTERFERON; PEGINTERFERON ALPHA2A; PEGINTERFERON ALPHA2B; RIBAVIRIN; VIRUS DNA; VIRUS RNA;

EID: 33750344132     PISSN: 02728087     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2006-951602     Document Type: Review
Times cited : (19)

References (51)
  • 2
    • 7244262077 scopus 로고    scopus 로고
    • Management of antiviral resistance in patients with chronic hepatitis B
    • Locarnini S, Hatzakis A, Heathcote J, et al. Management of antiviral resistance in patients with chronic hepatitis B. Antivir Ther 2004;9:679-693
    • (2004) Antivir Ther , vol.9 , pp. 679-693
    • Locarnini, S.1    Hatzakis, A.2    Heathcote, J.3
  • 3
    • 1842504404 scopus 로고    scopus 로고
    • Real time TaqMan PCR detection and quantitation of HBV genotypes A-G with the use of an internal quantitation standard
    • Weiss J, Wu H, Farrenkopf B, et al. Real time TaqMan PCR detection and quantitation of HBV genotypes A-G with the use of an internal quantitation standard. J Clin Virol 2004;30:86-93
    • (2004) J Clin Virol , vol.30 , pp. 86-93
    • Weiss, J.1    Wu, H.2    Farrenkopf, B.3
  • 4
    • 33645914428 scopus 로고    scopus 로고
    • Evaluation of the COBAS AmpliPrep-total nucleic acid isolation-COBAS TaqMan hepatitis B virus (HBV) quantitative test and comparison to the VERSANT HBV DNA 3.0 assay
    • Ronsin C, Pillet A, Bali C, Denoyel GA. Evaluation of the COBAS AmpliPrep-total nucleic acid isolation-COBAS TaqMan hepatitis B virus (HBV) quantitative test and comparison to the VERSANT HBV DNA 3.0 assay. J Clin Microbiol 2006;44:1390-1399
    • (2006) J Clin Microbiol , vol.44 , pp. 1390-1399
    • Ronsin, C.1    Pillet, A.2    Bali, C.3    Denoyel, G.A.4
  • 5
    • 23244453590 scopus 로고    scopus 로고
    • A 1-year trial of telbivudine, lamivudine, and the combination in patients with hepatitis B e antigen-positive chronic hepatitis B
    • Lai CL, Leung N, Teo EK, et al. A 1-year trial of telbivudine, lamivudine, and the combination in patients with hepatitis B e antigen-positive chronic hepatitis B. Gastroenterology 2005;129:528-536
    • (2005) Gastroenterology , vol.129 , pp. 528-536
    • Lai, C.L.1    Leung, N.2    Teo, E.K.3
  • 6
    • 20044392288 scopus 로고    scopus 로고
    • Occult hepatitis B virus infection in a North American community-based population
    • Minuk GY, Sun DF, Uhanova J, et al. Occult hepatitis B virus infection in a North American community-based population. J Hepatol 2005;42:480-485
    • (2005) J Hepatol , vol.42 , pp. 480-485
    • Minuk, G.Y.1    Sun, D.F.2    Uhanova, J.3
  • 7
    • 0021180942 scopus 로고
    • Hepatitis B virus DNA in nuclear and cytoplasmic fractions of infected human liver
    • Miller RH, Robinson WS. Hepatitis B virus DNA in nuclear and cytoplasmic fractions of infected human liver. Virology 1984;137:390-399
    • (1984) Virology , vol.137 , pp. 390-399
    • Miller, R.H.1    Robinson, W.S.2
  • 8
    • 0021934431 scopus 로고
    • Changes ot hepatitis B virus DNA in liver and serum caused by recombinant leukocyte interferon treatment: Analysis of intrahepatic replicative hepatitis B virus DNA
    • Yokosuka O, Omata M, Imazeki F, Okuda K, Summers J. Changes ot hepatitis B virus DNA in liver and serum caused by recombinant leukocyte interferon treatment: analysis of intrahepatic replicative hepatitis B virus DNA. Hepatology 1985;5:728-734
    • (1985) Hepatology , vol.5 , pp. 728-734
    • Yokosuka, O.1    Omata, M.2    Imazeki, F.3    Okuda, K.4    Summers, J.5
  • 9
    • 0028102990 scopus 로고
    • Evidence that hepatocyte turnover is required for rapid clearance of duck hepatitis B virus during antiviral therapy of chronically infected ducks
    • Fourel I, Cullen JM, Saputelli J, et al. Evidence that hepatocyte turnover is required for rapid clearance of duck hepatitis B virus during antiviral therapy of chronically infected ducks. J Virol 1994;68:8321-8330
    • (1994) J Virol , vol.68 , pp. 8321-8330
    • Fourel, I.1    Cullen, J.M.2    Saputelli, J.3
  • 10
    • 0032565689 scopus 로고    scopus 로고
    • Lamivudine therapy of WHV-infected woodchucks
    • Mason WS, Cullen J, Moraleda G, et al. Lamivudine therapy of WHV-infected woodchucks. Virology 1998;245:18-32
    • (1998) Virology , vol.245 , pp. 18-32
    • Mason, W.S.1    Cullen, J.2    Moraleda, G.3
  • 11
    • 0034234540 scopus 로고    scopus 로고
    • Increased hepatocyte turnover and inhibition of woodchuck hepatitis B virus replication by adefovir in vitro do not lead to reduction of the closed circular DNA
    • Dandri M, Burda MR, Will H, Petersen J. Increased hepatocyte turnover and inhibition of woodchuck hepatitis B virus replication by adefovir in vitro do not lead to reduction of the closed circular DNA. Hepatology 2000;32:139-146
    • (2000) Hepatology , vol.32 , pp. 139-146
    • Dandri, M.1    Burda, M.R.2    Will, H.3    Petersen, J.4
  • 12
    • 0027272784 scopus 로고
    • Analysis of the earliest steps of hepadnavirus replication: Genome repair after infectious entry into hepatocytes does not depend on viral polymerase activity
    • Kock J, Schlicht HG. Analysis of the earliest steps of hepadnavirus replication: genome repair after infectious entry into hepatocytes does not depend on viral polymerase activity. J Virol 1993;67:4867-4874
    • (1993) J Virol , vol.67 , pp. 4867-4874
    • Kock, J.1    Schlicht, H.G.2
  • 13
    • 0033751024 scopus 로고    scopus 로고
    • A quantitative competitive PCR assay for the covalently closed circular form of the duck hepatitis B virus
    • Addison WR, Wong WW, Fischer KP, Tyrrell DL. A quantitative competitive PCR assay for the covalently closed circular form of the duck hepatitis B virus. Antiviral Res 2000;48:27-37
    • (2000) Antiviral Res , vol.48 , pp. 27-37
    • Addison, W.R.1    Wong, W.W.2    Fischer, K.P.3    Tyrrell, D.L.4
  • 14
    • 0036343697 scopus 로고    scopus 로고
    • A new and sensitive method for the quantification of HBV cccDNA by real-time PCR
    • He ML, Wu J, Chen Y, Lin MC, Lau GK, Kung HF. A new and sensitive method for the quantification of HBV cccDNA by real-time PCR. Biochem Biophys Res Commun 2002;295:1102-1107
    • (2002) Biochem Biophys Res Commun , vol.295 , pp. 1102-1107
    • He, M.L.1    Wu, J.2    Chen, Y.3    Lin, M.C.4    Lau, G.K.5    Kung, H.F.6
  • 15
    • 0029968181 scopus 로고    scopus 로고
    • Hepatitis B virus nucleic acids associated with human peripheral blood mononuclear cells do not originate from replicating virus
    • Kock J, Theilmann L, Galle P, Schlicht H. Hepatitis B virus nucleic acids associated with human peripheral blood mononuclear cells do not originate from replicating virus. Hepatology 1996;23:405-413
    • (1996) Hepatology , vol.23 , pp. 405-413
    • Kock, J.1    Theilmann, L.2    Galle, P.3    Schlicht, H.4
  • 16
    • 0031778788 scopus 로고    scopus 로고
    • Molecular basis for persistent hepatitis B virus infection in the liver after clearance of serum hepatitis B surface antigen
    • Mason AL, Xu L, Guo L, Kuhns M, Perillo RP. Molecular basis for persistent hepatitis B virus infection in the liver after clearance of serum hepatitis B surface antigen. Hepatology 1998;27:1736-1742
    • (1998) Hepatology , vol.27 , pp. 1736-1742
    • Mason, A.L.1    Xu, L.2    Guo, L.3    Kuhns, M.4    Perillo, R.P.5
  • 17
    • 2942532722 scopus 로고    scopus 로고
    • Persistence of cccDNA during the natural history of chronic hepatitis B and decline during adefovir dipivoxil therapy
    • Werle-Lapostolle B, Bowden S, Locarnini S, et al. Persistence of cccDNA during the natural history of chronic hepatitis B and decline during adefovir dipivoxil therapy. Gastroenterology 2004;126:1750-1758
    • (2004) Gastroenterology , vol.126 , pp. 1750-1758
    • Werle-Lapostolle, B.1    Bowden, S.2    Locarnini, S.3
  • 18
    • 4644296081 scopus 로고    scopus 로고
    • Quantitation of covalently closed circular hepatitis B virus DNA in chronic hepatitis B patients
    • Wong DK, Yuen MF, Yuan H, et al. Quantitation of covalently closed circular hepatitis B virus DNA in chronic hepatitis B patients. Hepatology 2004;40:727-737
    • (2004) Hepatology , vol.40 , pp. 727-737
    • Wong, D.K.1    Yuen, M.F.2    Yuan, H.3
  • 19
    • 20444505037 scopus 로고    scopus 로고
    • Intrahepatic hepatitis B virus covalently closed circular DNA can be a predictor of sustained response to therapy
    • Sung JJ, Wong ML, Bowden S, et al. Intrahepatic hepatitis B virus covalently closed circular DNA can be a predictor of sustained response to therapy. Gastroenterology 2005;128:1890-1897
    • (2005) Gastroenterology , vol.128 , pp. 1890-1897
    • Sung, J.J.1    Wong, M.L.2    Bowden, S.3
  • 20
    • 33748929265 scopus 로고    scopus 로고
    • Peginterferon alpha-2b plus adefovir induce strong cccDNA decline and HBsAg reduction in patients with chronic hepatitis B
    • Wursthorn K, Lutgehetmann M, Dandri M, et al. Peginterferon alpha-2b plus adefovir induce strong cccDNA decline and HBsAg reduction in patients with chronic hepatitis B. Hepatology 2006;44:675-684
    • (2006) Hepatology , vol.44 , pp. 675-684
    • Wursthorn, K.1    Lutgehetmann, M.2    Dandri, M.3
  • 21
    • 19944428132 scopus 로고    scopus 로고
    • Pegylated interferon alfa-2b alone or in combination with lamivudine for HBeAg-positive chronic hepatitis B: A randomised trial
    • Janssen HL, van Zonneveld M, Senturk H, et al. Pegylated interferon alfa-2b alone or in combination with lamivudine for HBeAg-positive chronic hepatitis B: a randomised trial. Lancet 2005;365:123-129
    • (2005) Lancet , vol.365 , pp. 123-129
    • Janssen, H.L.1    Van Zonneveld, M.2    Senturk, H.3
  • 22
    • 33646084161 scopus 로고    scopus 로고
    • Variant of hepatitis B virus with primary resistance to adefovir
    • Schildgen O, Sirma H, Funk A, et al. Variant of hepatitis B virus with primary resistance to adefovir. N Engl J Med 2006;354:1807-1812
    • (2006) N Engl J Med , vol.354 , pp. 1807-1812
    • Schildgen, O.1    Sirma, H.2    Funk, A.3
  • 23
    • 0036792186 scopus 로고    scopus 로고
    • Monitoring drug resistance in chronic hepatitis B virus (HBV)-infected patients during lamivudine therapy: Evaluation of performance of INNO-LiPA HBV DR assay
    • Lok AS, Zoulim F, Locarnini S, et al. Monitoring drug resistance in chronic hepatitis B virus (HBV)-infected patients during lamivudine therapy: evaluation of performance of INNO-LiPA HBV DR assay. J Clin Microbiol 2002;40:3729-3734
    • (2002) J Clin Microbiol , vol.40 , pp. 3729-3734
    • Lok, A.S.1    Zoulim, F.2    Locarnini, S.3
  • 24
    • 0033844989 scopus 로고    scopus 로고
    • Rapid detection of genotypes and mutations in the pre-core promoter and the pre-core region of hepatitis B virus genome: Correlation with viral persistence and disease severity
    • Grandjacques C, Pradat P, Stuyver L, et al. Rapid detection of genotypes and mutations in the pre-core promoter and the pre-core region of hepatitis B virus genome: correlation with viral persistence and disease severity. J Hepatol 2000;33:430-439
    • (2000) J Hepatol , vol.33 , pp. 430-439
    • Grandjacques, C.1    Pradat, P.2    Stuyver, L.3
  • 25
    • 0033761078 scopus 로고    scopus 로고
    • Early detection of viral resistance by determination of hepatitis B virus polymerase mutations in patients treated by lamivudine for chronic hepatitis B
    • Nafa S, Ahmed S, Tavan D, et al. Early detection of viral resistance by determination of hepatitis B virus polymerase mutations in patients treated by lamivudine for chronic hepatitis B. Hepatology 2000;32:1078-1088
    • (2000) Hepatology , vol.32 , pp. 1078-1088
    • Nafa, S.1    Ahmed, S.2    Tavan, D.3
  • 26
    • 0033900351 scopus 로고    scopus 로고
    • Comparative evaluation of three human immunodeficiency virus genotyping systems: The HIV-GenotypR method, the HIV PRT GeneChip assay, and the HIV-1 RT line probe assay
    • Wilson JW, Bean P, Robins T, Graziano F, Persing DH. Comparative evaluation of three human immunodeficiency virus genotyping systems: the HIV-GenotypR method, the HIV PRT GeneChip assay, and the HIV-1 RT line probe assay. J Clin Microbiol 2000;38:3022-3028
    • (2000) J Clin Microbiol , vol.38 , pp. 3022-3028
    • Wilson, J.W.1    Bean, P.2    Robins, T.3    Graziano, F.4    Persing, D.H.5
  • 27
    • 33747153395 scopus 로고    scopus 로고
    • European multicenter evaluation of a high density DNA probe arrays for the detection of hepatitis B resistance mutations and identification of genotype
    • Tran N, Berne R, Chann R, et al. European multicenter evaluation of a high density DNA probe arrays for the detection of hepatitis B resistance mutations and identification of genotype. J Clin Microbiol 2006;44:2792-2800
    • (2006) J Clin Microbiol , vol.44 , pp. 2792-2800
    • Tran, N.1    Berne, R.2    Chann, R.3
  • 28
    • 2442697465 scopus 로고    scopus 로고
    • Real-time quantification of hepatitis B virus core-promoter and precore mutants during hepatitis E antigen seroconversion
    • Pang A, Yuen MF, Yuan HJ, Lai CL, Kwong YL. Real-time quantification of hepatitis B virus core-promoter and precore mutants during hepatitis E antigen seroconversion. J Hepatol 2004;40:1008-1017
    • (2004) J Hepatol , vol.40 , pp. 1008-1017
    • Pang, A.1    Yuen, M.F.2    Yuan, H.J.3    Lai, C.L.4    Kwong, Y.L.5
  • 29
    • 0036725230 scopus 로고    scopus 로고
    • Rapid detection of hepatitis B virus mutations using real-time PCR and melting curve analysis
    • Zhang M, Gong Y, Osiowy C, Minuk GY. Rapid detection of hepatitis B virus mutations using real-time PCR and melting curve analysis. Hepatology 2002;36:723-728
    • (2002) Hepatology , vol.36 , pp. 723-728
    • Zhang, M.1    Gong, Y.2    Osiowy, C.3    Minuk, G.Y.4
  • 30
    • 0035056344 scopus 로고    scopus 로고
    • Monitoring the emergence of hepatitis B virus polymerase gene variants during lamivudine therapy using the LightCycler
    • Whalley SA, Brown D, Teo CG, Dusheiko GM, Saunders NA. Monitoring the emergence of hepatitis B virus polymerase gene variants during lamivudine therapy using the LightCycler. J Clin Microbiol 2001;39:1456-1459
    • (2001) J Clin Microbiol , vol.39 , pp. 1456-1459
    • Whalley, S.A.1    Brown, D.2    Teo, C.G.3    Dusheiko, G.M.4    Saunders, N.A.5
  • 31
    • 0032897955 scopus 로고    scopus 로고
    • Transient selection of a hepatitis B virus polymerase gene mutant associated with a decreased replication capacity and famciclovir resistance
    • Pichoud C, Seignères B, Wang Z, Trepo C, Zoulim F. Transient selection of a hepatitis B virus polymerase gene mutant associated with a decreased replication capacity and famciclovir resistance. Hepatology 1999;29:230-237
    • (1999) Hepatology , vol.29 , pp. 230-237
    • Pichoud, C.1    Seignères, B.2    Wang, Z.3    Trepo, C.4    Zoulim, F.5
  • 32
    • 0031938029 scopus 로고    scopus 로고
    • Hepatitis B virus mutants associated with 3TC and famciclovir administration are replication defective
    • Melegari M, Scaglioni PP, Wands JR. Hepatitis B virus mutants associated with 3TC and famciclovir administration are replication defective. Hepatology 1998;27:628-633
    • (1998) Hepatology , vol.27 , pp. 628-633
    • Melegari, M.1    Scaglioni, P.P.2    Wands, J.R.3
  • 33
    • 0031780935 scopus 로고    scopus 로고
    • Identification and characterization of mutations in hepatitis B virus resistant to lamivudine
    • Allen MI, Deslauriers M, Andrews CW, et al. Identification and characterization of mutations in hepatitis B virus resistant to lamivudine. Hepatology 1998;27:1670-1677
    • (1998) Hepatology , vol.27 , pp. 1670-1677
    • Allen, M.I.1    Deslauriers, M.2    Andrews, C.W.3
  • 34
    • 33646360574 scopus 로고    scopus 로고
    • In vitro models for studying hepatitis B virus drug resistance
    • Zoulim F. In vitro models for studying hepatitis B virus drug resistance. Semin Liver Dis 2006;26:171-180
    • (2006) Semin Liver Dis , vol.26 , pp. 171-180
    • Zoulim, F.1
  • 35
    • 0344304757 scopus 로고    scopus 로고
    • In vitro antiviral susceptibility of full-length clinical hepatitis B virus isolates cloned with a novel expression vector
    • Yang H, Westland C, Xiong S, Delaney WE. In vitro antiviral susceptibility of full-length clinical hepatitis B virus isolates cloned with a novel expression vector. Antiviral Res 2004;61:27-36
    • (2004) Antiviral Res , vol.61 , pp. 27-36
    • Yang, H.1    Westland, C.2    Xiong, S.3    Delaney, W.E.4
  • 36
    • 4644323573 scopus 로고    scopus 로고
    • A new strategy for studying in vitro the drug susceptibility of clinical isolates of human hepatitis B virus
    • Durantel D, Carrouee-Durantel S, Werle-Lapostolle B, et al. A new strategy for studying in vitro the drug susceptibility of clinical isolates of human hepatitis B virus. Hepatology 2004;40:855-864
    • (2004) Hepatology , vol.40 , pp. 855-864
    • Durantel, D.1    Carrouee-Durantel, S.2    Werle-Lapostolle, B.3
  • 37
    • 32144433702 scopus 로고    scopus 로고
    • Resistance of human hepatitis B virus to reverse transcriptase inhibitors: From genotypic to phenotypic testing
    • Durantel D, Brunelle MN, Gros E, et al. Resistance of human hepatitis B virus to reverse transcriptase inhibitors: from genotypic to phenotypic testing. J Clin Virol 2005;34(suppl 1):S34-S43
    • (2005) J Clin Virol , vol.34 , Issue.SUPPL. 1
    • Durantel, D.1    Brunelle, M.N.2    Gros, E.3
  • 38
    • 33747119322 scopus 로고    scopus 로고
    • Antiviral therapy of chronic hepatitis B
    • Apr 25 (Epub ahead of print)
    • Zoulim F. Antiviral therapy of chronic hepatitis B. Antiviral Res 2006; Apr 25 (Epub ahead of print)
    • (2006) Antiviral Res
    • Zoulim, F.1
  • 39
    • 1242337438 scopus 로고    scopus 로고
    • Evolution of hepatitis B viral load and viral genome sequence during adefovir dipivoxil therapy
    • Werle B, Cinquin K, Marcellin P, et al. Evolution of hepatitis B viral load and viral genome sequence during adefovir dipivoxil therapy. J Viral Hepat 2004;11:74-83
    • (2004) J Viral Hepat , vol.11 , pp. 74-83
    • Werle, B.1    Cinquin, K.2    Marcellin, P.3
  • 40
    • 33645083291 scopus 로고    scopus 로고
    • Telbivudine versus lamivudine for chronic hepatitis B: First year results from the international phase III globe trial
    • Lai C, Gane E, Liaw Y-F, et al. Telbivudine versus lamivudine for chronic hepatitis B: first year results from the international phase III globe trial. Hepatology 2005;42(suppl 1):748A
    • (2005) Hepatology , vol.42 , Issue.SUPPL. 1
    • Lai, C.1    Gane, E.2    Liaw, Y.-F.3
  • 41
    • 27744537221 scopus 로고    scopus 로고
    • Long-term adefovir dipivoxil treatment induces regression of liver fibrosis in patients with HBeAg-negative chronic hepatitis B: Results after 5 years of therapy
    • Hadziyannis S, Tassopoulos N, Chang T, et al. Long-term adefovir dipivoxil treatment induces regression of liver fibrosis in patients with HBeAg-negative chronic hepatitis B: results after 5 years of therapy. Hepatology 2005;42 (suppl 1):745A
    • (2005) Hepatology , vol.42 , Issue.SUPPL. 1
    • Hadziyannis, S.1    Tassopoulos, N.2    Chang, T.3
  • 42
    • 13844250599 scopus 로고    scopus 로고
    • New insight on hepatitis B virus persistence from the study of intrahepatic viral cccDNA
    • Zoulim F. New insight on hepatitis B virus persistence from the study of intrahepatic viral cccDNA. J Hepatol 2005;42:302-308
    • (2005) J Hepatol , vol.42 , pp. 302-308
    • Zoulim, F.1
  • 43
    • 33746216127 scopus 로고    scopus 로고
    • Real-time PCR assays for hepatitis C virus (HCV) RNA quantitation are adequate for clinical management of patients with chronic HCV infection
    • Halfon P, Bourliere M, Penaranda G, Khiri H, Ouzan D. Real-time PCR assays for hepatitis C virus (HCV) RNA quantitation are adequate for clinical management of patients with chronic HCV infection. J Clin Microbiol 2006;44:2507-2511
    • (2006) J Clin Microbiol , vol.44 , pp. 2507-2511
    • Halfon, P.1    Bourliere, M.2    Penaranda, G.3    Khiri, H.4    Ouzan, D.5
  • 44
    • 22044444011 scopus 로고    scopus 로고
    • Use of virologic assays in the diagnosis and management of hepatitis C virus infection
    • Chevaliez S, Pawlotsky JM. Use of virologic assays in the diagnosis and management of hepatitis C virus infection. Clin Liver Dis 2005;9:371-382 v.
    • (2005) Clin Liver Dis , vol.9
    • Chevaliez, S.1    Pawlotsky, J.M.2
  • 45
    • 0041589440 scopus 로고    scopus 로고
    • Successful HCV genotyping of previously failed and low viral load specimens using an HCV RNA qualitative assay based on transcription-mediated amplification in conjunction with the line probe assay
    • Comanor L, Elkin C, Leung K, et al. Successful HCV genotyping of previously failed and low viral load specimens using an HCV RNA qualitative assay based on transcription-mediated amplification in conjunction with the line probe assay. J Clin Virol 2003;28:14-26
    • (2003) J Clin Virol , vol.28 , pp. 14-26
    • Comanor, L.1    Elkin, C.2    Leung, K.3
  • 46
    • 33644520948 scopus 로고    scopus 로고
    • Therapy of hepatitis C: From empiricism to eradication
    • Pawlotsky JM. Therapy of hepatitis C: from empiricism to eradication. Hepatology 2006;43(suppl 1):S207-S220
    • (2006) Hepatology , vol.43 , Issue.SUPPL. 1
    • Pawlotsky, J.M.1
  • 47
    • 30344436353 scopus 로고    scopus 로고
    • The face of future hepatitis C antiviral drug development: Recent biological and virologic advances and their translation to drug development and clinical practice
    • McHutchison JG, Bartenschlager R, Patel K, Pawlotsky JM. The face of future hepatitis C antiviral drug development: recent biological and virologic advances and their translation to drug development and clinical practice. J Hepatol 2006;44:411-421
    • (2006) J Hepatol , vol.44 , pp. 411-421
    • McHutchison, J.G.1    Bartenschlager, R.2    Patel, K.3    Pawlotsky, J.M.4
  • 48
    • 33646369669 scopus 로고    scopus 로고
    • Mutations conferring resistance to SCH6, a novel hepatitis C virus NS3/4A protease inhibitor: Reduced RNA replication fitness and partial rescue by second-site mutations
    • Yi M, Tong X, Skelton A, et al. Mutations conferring resistance to SCH6, a novel hepatitis C virus NS3/4A protease inhibitor: reduced RNA replication fitness and partial rescue by second-site mutations. J Biol Chem 2006;281:8205-8215
    • (2006) J Biol Chem , vol.281 , pp. 8205-8215
    • Yi, M.1    Tong, X.2    Skelton, A.3
  • 49
    • 33644636312 scopus 로고    scopus 로고
    • Preclinical profile of VX-950, a potent, selective, and orally bioavailable inhibitor of hepatitis C virus NS3-4A serine protease
    • Perni RB, Almquist SJ, Byrn RA, et al. Preclinical profile of VX-950, a potent, selective, and orally bioavailable inhibitor of hepatitis C virus NS3-4A serine protease. Antimicrob Agents Chemother 2006;50:899-909
    • (2006) Antimicrob Agents Chemother , vol.50 , pp. 899-909
    • Perni, R.B.1    Almquist, S.J.2    Byrn, R.A.3
  • 50
    • 33744930847 scopus 로고    scopus 로고
    • Selection and characterization of replicon variants dually resistant to thumb- and palm-binding nonnucleoside polymerase inhibitors of the hepatitis C virus
    • Le Pogam S, Kang H, Harris SF, et al. Selection and characterization of replicon variants dually resistant to thumb- and palm-binding nonnucleoside polymerase inhibitors of the hepatitis C virus. J Virol 2006;80:6146-6154
    • (2006) J Virol , vol.80 , pp. 6146-6154
    • Le Pogam, S.1    Kang, H.2    Harris, S.F.3
  • 51
    • 23444455496 scopus 로고    scopus 로고
    • Population genotyping of hepatitis C virus by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry analysis of short DNA fragments
    • Kim YJ, Kim SO, Chung HJ, et al. Population genotyping of hepatitis C virus by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry analysis of short DNA fragments. Clin Chem 2005;51:1123-1131
    • (2005) Clin Chem , vol.51 , pp. 1123-1131
    • Kim, Y.J.1    Kim, S.O.2    Chung, H.J.3


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