Allergy and intestinal dysmotility - Evidence of genuine causal linkage?

Current Opinion in Gastroenterology

Volumn 22, Issue 6, 2006, Pages 664-668

  Murch, Simon ^a  

^a UNIVERSITY OF WARWICK   (United Kingdom)

Author keywords

Allergy; Eosinophils; Intestinal motility; Irritable bowel syndrome; Mast cells; T helper 2 cytokines

Indexed keywords

BETA7 INTEGRIN; GAMMA INTERFERON; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 5;

ALLERGY; AUTONOMIC NERVOUS SYSTEM; CENTRAL NERVOUS SYSTEM; CONSTIPATION; EOSINOPHIL; EOSINOPHIL COUNT; EOSINOPHILIA; EOSINOPHILIC ESOPHAGITIS; ESOPHAGITIS; FOOD ALLERGY; GASTROESOPHAGEAL REFLUX; HUMAN; INTESTINAL DYSMOTILITY; IRRITABLE COLON; LACTOBACILLUS PARACASEI; MAST CELL; MAST CELL DEGRANULATION; MUCOSA; MYENTERIC PLEXUS; NOCICEPTION; NONHUMAN; PATHOGENESIS; PHENOTYPE; PROTEIN EXPRESSION; REVIEW; SYMPTOM; TH2 CELL;

ANIMALS; ESOPHAGITIS; GASTROINTESTINAL MOTILITY; HUMANS; HYPERSENSITIVITY; IRRITABLE BOWEL SYNDROME; MAST CELLS; T-LYMPHOCYTES, HELPER-INDUCER;

EID: 33750338154     PISSN: 02671379     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.mog.0000245546.18279.7e     Document Type: Review

References (40)

1. Cummings JH, Antoine JM, Azpiroz F, et al. PASSCLAIM - gut health and immunity. Eur J Nutr 2004; 43 (Suppl 2):II/118-II/173.
2. Khan WI, Blennerhassett PA, Deng Y, et al. IL-12 gene transfer alters gut physiology and host immunity in nematode-infected mice. Am J Physiol Gastrointest Liver Physiol 2001; 281:G102-G110.
3. Akiho H, Deng Y, Blennerhassett P, et al. Mechanisms underlying the maintenance of muscle hypercontractility in a model of postinfective gut dysfunction. Gastroenterology 2005; 129:131-141.
4. Morimoto M, Morimoto M, Zhao A, et al. Functional importance of regional differences in localized gene expression of receptors for IL-13 in murine gut. J Immunol 2006; 176:491-495.
5. H2-dependent enteropathy followed by tissue repair in T-cell receptor transgenic mice. J Allergy Clin Immunol 2006; 117:1125-1132. A transgenic mouse model which is the first to replicate important clinical features of food-sensitive enteropathy.
6. Siddiqui AA, Miner PB Jr. The role of mast cells in common gastrointestinal diseases. Curr Allergy Asthma Rep 2004; 4:47-54.
7. Saavedra Y, Vergara P. Hypersensitivity to ovalbumin induces chronic intestinal dysmotility and increases the number of intestinal mast cells. Neurogastroenterol Motil 2005; 17:112-122. A study which underlines the importance of mast cell reactivity in antigen-induced dysmotility. Induced changes in motility persisted for a notably long time after antigen withdrawal.
8. Wood JD. Histamine, mast cells, and the enteric nervous system in the irritable bowel syndrome, enteritis, and food allergies. Gut 2006; 55:445-447.
9. Sander LE, Lorentz A, Sellge G, et al. Selective expression of histamine receptors H1R, H2R, and H4R, but not H3R, in the human intestinal tract. Gut 2006; 55:498-504.
10. Rothenberg ME, Hogan SP. The eosinophil. Annu Rev Immunol 2006; 24:147-174. An outstanding and comprehensive review of eosinophiil biology and its relevance to allergic disease.
11. Hogan SP, Mishra A, Brandt EB, et al. A pathological function for eotaxin and eosinophils in eosinophilic gastrointestinal inflammation. Nat Immunol 2001; 2:353-360.
12. Martin ST, Collins CG, Fitzgibbon J, et al. Gastric motor dysfunction: is eosinophilic mural gastritis a causative factor? Eur J Gastroenterol Hepatol 2005; 17:983-986.
13. Dixon H, Blanchard C, Deschoolmeester ML, et al. The role of Th2 cytokines, chemokines and parasite products in eosinophil recruitment to the gastrointestinal mucosa during helminth infection. Eur J Immunol 2006; 36:1753-1763.
14. Berstad A, Arslan G, Lind R, Florvaag E. Food hypersensitivity - immunologic (peripheral) or cognitive (central) sensitisation? Psychoneuroendocrinology 2005; 30:983-989.
15. Grundy D, Al-Chaer ED, Aziz Q, et al. Fundamentals of neurogastroenterology: basic science. Gastroenterology 2006; 130:1391-1411. An important and comprehensive consensus statement on the current state and future challenges of neurogastroenterology research.
16. Kreis ME, Muller M, Zittel TT, et al. Mediators of neuronal activation in the rat brainstem following intestinal anaphylaxis. Neurosci Lett 2000; 289:45-48.
17. Gao J, Wu X, Owyang C, Li Y. Enhanced responses of the anterior cingulate cortex neurones to colonic distension in viscerally hypersensitive rats. J Physiol 2006; 570:169-183. The first study to demonstrate that mucosal allergy may induce a chronic visceral afferent nociceptive input leading to altered limbic function. Neurones within the anterior cingulate cortex showed increased spontaneous activity and showed increased response to rectal distension with lowered threshold of activation.
18. Cabot PJ, Carter L, Gaiddon C, et al. Immune cell-derived β-endorphin. J Clin Invest 1997; 100:142-148.
19. + T-cell modulation of visceral nociception in mice. Gastroenterology 2006; 130:1721-1728. T cell function may be important in prevention of intestinal hyperalgesia. Production of β-endorphin by CD4 T cells affects neural response to colonic dilatation. Further study may elucidate whether this property is restricted to particular T cell subtypes and whether β-endorphin production is modulated in allergic diseases.
20. Husebye E, Hellstrom PM, Sundler F, et al. Influence of microbial species on small intestinal myoelectric activity and transit in germ-free rats. Am J Physiol Gastrointest Liver Physiol 2001; 280:G368-G380.
21. Barbara G, Stanghellini V, Brandi G, et al. Interactions between commensal bacteria and gut sensorimotor function in health and disease. Am J Gastroenterol 2005; 100:2560-2568.
22. Verdu EF, Bercik P, Verma-Gandhu M, et al. Specific probiotic therapy attenuates antibiotic induced visceral hypersensitivity in mice. Gut 2006; 55:182-190.
23. Velin AK, Ericson AC, Braaf Y, et al. Increased antigen and bacterial uptake in follicle associated epithelium induced by chronic psychological stress in rats. Gut 2004; 53:494-500.
24. Yang PC, Jury J, Soderholm JD, et al. Chronic psychological stress in rats induces intestinal sensitization to luminal antigens. Am J Pathol 2006; 168:104-114. A study of potential clinical relevance, suggesting that psychological stress may play a role in promoting food allergic sensitisation.
25. Coeffier M, Lorentz A, Manns MP, Bischoff SC. Epsilon germ-line and IL-4 transcripts are expressed in human intestinal mucosa and enhanced in patients with food allergy. Allergy 2005; 60:822-827. Compartmentalisation of food allergic responses. Mucosal IgE production is enhanced in food allergy, but without matched systemic IgE responses.
26. Arslan G, Gilja OH, Lind R, et al. Response to intestinal provocation monitored by transabdominal ultrasound in patients with food hypersensitivity. Scand J Gastroenterol 2005; 40:386-394. Is the DBPCFC really the gold standard? Similar intestinal secretory responses to antigen challenge seen by ultrasound in patients deemed to have positive or negative challenges.
27. Tornblom H, Abrahamsson H, Barbara G, et al., The Swedish Motility Group. Inflammation as a cause of functional bowel disorders. Scand J Gastroenterol 2005; 40:1140-1148.
28. + blood T lymphocytes in patients with irritable bowel syndrome. Clin Gastroenterol Hepatol 2005; 3:980-986.
29. Van der Veek PP, Van den Berg M, De Kroon YE, et al. Role of tumor necrosis factor-α and interleukin-10 gene polymorphisms in irritable bowel syndrome. Am J Gastroenterol 2005; 100:2510-2516.
30. Barbara G, Stanghellini V, De Giorgio R, et al. Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome. Gastroenterology 2004; 126:693-702.
31. Atkinson W, Sheldon TA, Shaath N, Whorwell PJ. Food elimination based on IgG antibodies in irritable bowel syndrome: a randomised controlled trial. Gut 2004; 53:1459-1464.
32. Zar S, Benson MJ, Kumar D. Food-specific serum IgG4 and IgE titers to common food antigens in irritable bowel syndrome. Am J Gastroenterol 2005; 100:1550-1557.
33. Heine RG. Gastroesophageal reflux disease, colic and constipation in infants with food allergy. Curr Opin Allergy Clin Immunol 2006; 6:220-225.
34. Nielsen RG, Fenger C, Bindslev-Jensen C, Husby S. Eosinophilia in the upper gastrointestinal tract is not a characteristic feature in cow's milk sensitive gastro-oesophageal reflux disease. Measurement by two methodologies. J Clin Pathol 2006; 59:89-94.
35. Furuta GT. Eosinophilic esophagitis: an emerging clinicopathologic entity. Curr Allergy Asthma Rep 2002; 2:67-72.
36. Noel RJ, Putnam PE, Rothenberg ME. Eosinophilic esophagitis. New Engl J Med 2004; 351:940-941.
37. Simon D, Marti H, Heer P, et al. Eosinophilic esophagitis is frequently associated with IgE-mediated allergic airway diseases. J Allergy Clin Immunol 2005; 115:1090-1092.
38. Spergel JM, Andrews T, Brown-Whitehorn TF, et al. Treatment of eosinophilic esophagitis with specific food elimination diet directed by a combination of skin prick and patch tests. Ann Allergy Asthma Immunol 2005; 95:336-343.
39. Carroccio A, Scalici C, Maresi E, et al. Chronic constipation and food intolerance: a model of proctitis causing constipation. Scand J Gastroenterol 2005; 40:33-42.
40. Carroccio A, Di Prima L, Iacono G, et al. Multiple food hypersensitivity as a cause of refractory chronic constipation in adults. Scand J Gastroenterol 2006; 41:498-504.