Application of biomarkers in the clinical development of new drugs for chondroprotection in destructive joint diseases: A review

Biomarkers

Volumn 11, Issue 6, 2006, Pages 485-506

  Sumer, E U ^a   Schaller, S ^b   Sondergaard, B C ^a   Tanko L B ^c   Qvist, P ^a  

^a NORDIC BIOSCIENCE A S   (Denmark)

^b Pharmos Bioscience   (Denmark)

^c CENTER FOR CLINICAL AND BASIC RESEARCH   (Denmark)

Author keywords

Arthritis; Biomarkers; Clinical trials; Drugs; Experimental methods; Extracellular matrix

Indexed keywords

ADALIMUMAB; AGGRECAN; BIOLOGICAL MARKER; CARBOXY TERMINAL TELOPEPTIDE; CARTILAGE OLIGOMERIC MATRIX PROTEIN; CHONDROITIN SULFATE; COLLAGEN DERIVATIVE; COLLAGEN TYPE 1; COLLAGEN TYPE 2; COLLAGEN TYPE 2 CARBOXY TERMINAL TELOPEPTIDE; ETANERCEPT; GLUCOSAMINE SULFATE; GLUCOSYLGALACTOSYLPYRIDINOLINE; GLYCOPROTEIN GP 39; GLYCOSAMINOGLYCAN; HYALURONIC ACID; IBUPROFEN; INFLIXIMAB; KERATAN SULFATE; MATRIX METALLOPROTEINASE; OLIGOSACCHARIDE; PLACEBO; PROCOLLAGEN; PROCOLLAGEN TYPE 2 AMINOPEPTIDE; PROCOLLAGEN TYPE IIPC; RISEDRONIC ACID; SOYBEAN PROTEIN; TANOMASTAT; TISSUE INHIBITOR OF METALLOPROTEINASE 3; TUMOR NECROSIS FACTOR ALPHA ANTIBODY; UNCLASSIFIED DRUG;

BONE METABOLISM; BONE TURNOVER; CARTILAGE CELL; CELL CULTURE; CHONDROPROTECTION; CLINICAL TRIAL; COLLAGEN DEGRADATION; DISEASE ACTIVITY; DISEASE COURSE; HIGH RISK PATIENT; HUMAN; INTERMETHOD COMPARISON; JOINT DESTRUCTION; NITRATION; NONHUMAN; OSTEOARTHRITIS; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PREDICTION; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTEIN URINE LEVEL; REVIEW; RHEUMATOID ARTHRITIS; RISK ASSESSMENT; RISK FACTOR; SYNOVIUM; TANDEM REPEAT; TISSUE SPECIFICITY;

ARTHRITIS, RHEUMATOID; BIOLOGICAL MARKERS; CARTILAGE; DRUG DESIGN; HUMANS; JOINT DISEASES; OSTEOARTHRITIS; PROTECTIVE AGENTS;

EID: 33750326229     PISSN: 1354750X     EISSN: 13665804     Source Type: Journal    
DOI: 10.1080/13547500600886115     Document Type: Review

References (139)

1. Aakesson, K.(1999) Osteoarthritis and degenerative spine pathologies. In Dynamics of bone and cartilage metabolism. (pp. 637-648). Orlando FL: Academic Press.
2. Amirahmadi, SF and Pho, MH and Gray, RE and Crombie, DE and Whittingham, SF and Zuasti, BB and Van Damme, MP and Rowley, MJ. (2004) An arthritogenic monoclonal antibody to type II collagen CII-C1 impairs cartilage formation by cultured chondrocytes Immunology and Cell Biology, 82(4), pp. 427-434.
3. Andersson M, Petersson IF, Karlsson K, Jonsson NE, Månsson B, Heinegård D, SaxneT.2006. Diurnal variation in serum levels of cartilage oligomeric matrix protein (comp) in individuals with knee osteoarthritis or rheumatoid arthritis. Annals of Rheumatology Disease [Epub ahead of print].
4. Aoyama, T and Liang, B and Okamoto, T and Matsusaki, T and Nishijo, K and Ishibe, T and Yasura, K and Nagayama, S and Nakayama, T and Nakamura, T and Toguchida, J. (2005) PGE2 signal through EP2 promotes the growth of articular chondrocytes Journal of Bone Mineral Research, 20, pp. 377-389.
5. Archer, CW and Francis-West, P. (2003) The chondrocyte International Journal of Biochemistry and Cell Biology, 35(4), pp. 401-404.
6. Arjmandi, BH and Khalil, DA and Lucas, EA and Smith, BJ and Sinichy, N and Hodges, SB and Juma, S and Munson, ME and Payton, ME and Tivis, RD and Svanborg, A. (2004) Soy protein may alleviate osteoarthritis symptoms Phytomedicine, 11(7-8), pp. 567-575.
7. Barry, F and Boynton, RE and Liu, B and Murphy, JM. (2001) Chondrogenic differentiation of mesemchymal stem cells from bone marrow: differentiation-dependent gene expression of matrix components Experimental Cell Research, 268, pp. 189-200.
8. Billinghurst, RC and Dahlberg, L and Ionescu, M and Reiner, A and Bourne, R and Rorabeck, C and Mitchell, P and Hambor, J and Diekmann, O and Tschesche, H and Chen, J and Van Wart, H and Poole, AR. (1997) Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilage Journal of Clinical Investigation, 99(7), pp. 1534-1545.
9. Billinghurst, RC and Wu, W and Ionescu, M and Reiner, A and Dahlberg, L and Chen, J and Van Wart, H and Poole, AR. (2000) Comparison of the degradation of type II collagen and proteoglycan in nasal and articular cartilages induced by interleukin-1 and the selective inhibition of type II collagen cleavage by collagenase Arthritis and Rheumatism, 43(3), pp. 664-672.
10. Boers, M and Verhoeven, AC and Markusse, HM and Van De Laar, MA and Westhovens, R and Van Denderen, JC and Van Zeben, D and Dijkmans, BA and Peeters, AJ and Jacobs, P and Van Den Brink, HR and Schouten, HJ and Van der Heijde, DM and Boonen, A and Van der Linden, S. (1997) Randomised comparison of combined step-down prednisolone, methotrexate and sulphasalazine with sulphasalazine alone in early rheumatoid arthritis Lancet, 350(9074), pp. 309-318.
11. Brennan, FM and Browne, KA and Green, PA and Jaspar, JM and Maini, RN and Feldmann, M. (1997) Reduction of serum matrix metalloproteinase 1 and matrix metalloproteinase 3 in rheumatoid arthritis patients following anti-tumour necrosis factor-alpha (cA2) therapy British Journal of Rheumatology, 36(6), pp. 643-650.
12. Burger, EH and Boonekamp, PM and Nijweide, PJ. (1986) Osteoblast and osteoclast precursors in primary cultures of calvarial bone cells The Anatomical record, 214, pp. 32-40.
13. Cawston, TE. (1996) Metalloproteinase inhibitors and the prevention of connective tissue breakdown Pharmacology and Therapy, 70, pp. 163-182.
14. Cawston, TE and Curry, VA and Summers, CA and Clark, IM and Riley, GP and Life, PF and Spaull, JR and Goldring, MB and Koshy, PJ and Rowan, AD and Shingleton, WD. (1998) The role of oncostatin M in animal and human connective tissue collagen turnover and its localization within the rheumatoid joint Arthritis and Rheumatism, 41, pp. 1760-1771.
15. Cerejo, R and Dunlop, DD and Cahue, S and Channin, D and Song, J and Sharma, L. (2002) The influence of alignment on risk of knee osteoarthritis progression according to baseline stage of disease Arthritis and Rheumatism, 46(10), pp. 2632-2636.
16. Christenson, RH. (1997) Biochemical markers of bone metabolism: An overview Clinical Biochemistry, 30(8), pp. 573-593.
17. Christgau, S and Bitsch-Jensen, O and Hanover, BN and Gamwell, HE and Qvist, P and Alexandersen, P and Bang, HD. (2000) Serum CrossLaps for monitoring the response in individuals undergoing antiresorptive therapy Bone, 26, pp. 505-511.
18. Christgau, S and Cloos, PA. C. (2004) Cartilage degradation products as markers for evaluation of patients with rheumatic disease Clinical and Applied Immunology, 4(4), pp. 277-294.
19. Christgau, S and Garnero, P and Fledelius, C and Moniz, C and Ensig, M and Gineyts, E and Rosenquist, C and Qvist, P. (2001) Collagen type II C-telopeptide fragments as an index of cartilage degradation Bone, 29(3), pp. 209-215.
20. Christgau, S and Henrotin, Y and Tanko, LB and Rovati, LC and Collette, J and Bruyere, O and Deroisy, R and Reginster, JY. (2004) Osteoarthritic patients with high cartilage turnover show increased responsiveness to the cartilage protecting effects of glucosamine sulphate Clinical Experiments in Rheumatology, 22(1), pp. 36-42.
21. Chu, Q and Lopez, M and Hayashi, K and Ionescu, M and Billinghurst, RC and Johnson, KA and Poole, AR and Markel, MD. (2002) Elevation of a collagenase generated type II collagen neoepitope and proteoglycan epitopes in synovial fluid following induction of joint instability in the dog Osteoarthritis and Cartilage, 10(8), pp. 662-669.
22. Conrozier, T and Carlier, MC and Mathieu, P and Colson, F and Debard, AL and Richard, S and Favret, H and Bienvenu, J and Vignon, E. (2000) Serum levels of YKL-40 and C reactive protein in patients with hip osteoarthritis and healthy subjects: A cross sectional study Annals of Rheumatology Disease, 59(10), pp. 828-831.
23. Crnkic, M and Månsson, B and Larsson, L and Geborek, P and Heinegard, D and Saxne, T. (2003) Serum cartilage oligomeric matrix protein (COMP) decreases in rheumatoid arthritis patients treated with infliximab or etanercept Arthritis Research and Therapy, 5(4), pp. 181-185.
24. Dahlberg, L and Billinghurst, RC and Manner, P and Nelson, F and Webb, G and Ionescu, M and Reiner, A and Tanzer, M and Zukor, D and Chen, J and Van Wart, HE and Poole, AR. (2000) Selective enhancement of collagenase-mediated cleavage of resident type II collagen in cultured osteoarthritic cartilage and arrest with a synthetic inhibitor that spares collagenase 1 (matrix metalloproteinase 1) Arthritis and Rheumatism, 43, pp. 673-682.
25. De Ceuninck, F and Pastoureau, P and Agnellet, S and Bonnet, J and Vanhoutte, PM. (2001) Development of an enzyme-linked immunoassay for the quantification of YKL-40 (cartilage gp-39) in guinea pig serum using hen egg yolk antibodies Journal of Immunology Methods, 252(1-2), pp. 153-161.
26. Dean, DD and Martel-Pelletier, J and Pelletier, JP and Howell, DS and Woessner, JF. J. (1989) Evidence for metalloproteinase and metalloproteinase inhibitor imbalance in human osteoarthritic cartilage Journal of Clinical Investigation, 84, pp. 678-685.
27. Deberg, M and Labasse, A and Christgau, S and Cloos, P and Henriksen, DB and Chapelle, JP and Zegels, B and Reginster, JY and Henrotin, Y. (2005) New serum biochemical markers (Coll 2-1 and Coll 2-1 NO2) for studying oxidative-related type II collagen network degradation in patients with osteoarthritis and rheumatoid arthritis Osteoarthritis and Cartilage, 13, pp. 258-265.
28. DeGroot, J and Bank, RA and Tchetverikov, I and Verzijl, N and Tekoppele, JM. (2002) Molecular markers for osteoarthritis: The road ahead Current Opinion in Rheumatology, 14(5), pp. 585-589.
29. DelmasPD, GarneroP.1996. Biochemical markers of bone turnover. In:MArcusR, FeldmanD, KelseyJ(eds) Osteoporosis. San DiegoCA: Academic Press. p. 1075-1085.
30. Dequeker, J and Mohan, S and Finkelman, RD and Aerssens, J and Baylink, DJ. (1993) Generalized osteoarthritis associated with increased insulin-like growth factor types I and II and transforming growth factor beta in cortical bone from the iliac crest. Possible mechanism of increased bone density and protection against osteoporosis Arthritis and Rheumatism, 36(12), pp. 1702-1708.
31. Di Cesare, PE and Fang, C and Leslie, MP and Della Valle, CJ and Gold, JM and Tulli, H and Perris, R and Carlson, CS. (1999) Localization and expression of cartilage oligomeric matrix protein by human rheumatoid and osteoarthritic synovium and cartilage Journal of Orthopedic Research, 17(3), pp. 437-445.
32. Di Cesare, PE and Fang, C and Leslie, MP and Tulli, H and Perris, R and Carlson, CS. (2000) Expression of cartilage oligomeric matrix protein (COMP) by embryonic and adult osteoblasts Journal of Orthopedic Research, 18(5), pp. 713-720.
33. Dodge, GR and Hawkins, D and Boesler, E and Sakai, L and Jimenez, SA. (1998) Production of cartilage oligomeric matrix protein (COMP) by cultured human dermal and synovial fibroblasts Osteoarthritis and Cartilage, 6(6), pp. 435-440.
34. Downs, JT and Lane, CL and Nestor, NB and McLellan, TJ and Kelly, MA and Karam, GA and Mezes, PS and Pelletier, JP and Otterness, IG. (2001) Analysis of collagenase-cleavage of type II collagen using a neoepitope ELISA Journal of Immunology Methods, 247(1-2), pp. 25-34.
35. Elliott, AL and Kraus, VB and Luta, G and Stabler, T and Renner, JB and Woodard, J and Dragomir, AD and Helmick, CG and Hochberg, MC and Jordan, JM. (2005) Serum hyasluronan levels and radiographic knee and hip osteoarthritis in African Americans and Caucasians in the Johnston County Osteoarthritis Project Arthritis and Rheumatism, 52(1), pp. 105-111.
36. El-Maadawy SS, Wahl CL, Pidoux I, Ionescu M, Hellio Le Graverand-Gastineau M P, Poole AR. 2003. Induction of osteoarthritis by expression of an active human MMP-13 transgene in cartilage. Paper presented at the ACR/ARHP Annual Scientific Meeting, San Antonio, TX, USA. [abstract]
37. Eyre, DR. (1991) The collagens of articular cartilage Seminars in Arthritis and Rheumatism, 21(3), pp. 2-11.
38. Fawthrop, F and Yaqub, R and Belcher, C and Bayliss, M and Ledingham, J and Doherty, M. (1997) Chondroitin and keratan sulphate epitopes, glycosaminoglycans, and hyaluronan in progressive versus non-progressive osteoarthritis Annals in Rheumatism Disease, 56(2), pp. 119-122.
39. Fell, HB and Barratt, ME. (1973) The role of soft connective tissue in the breakdown of pig articular cartilage cultivated in the presence of complement-sufficient antiserum to pig erythrocytes. I. Histological changes International Archives in Allergy and Applied Immunology, 44, pp. 441-468.
40. Felson, DT and Anderson, JJ and Boers, M and Bombardier, C and Furst, D and Goldsmith, C and Katz, LM and Lightfoot, R, Jr and Paulus, H and Strand, V and Tugwell, P and Weinblatt, M and Williams, J and Wolfe, F and Kieszak, S. (1995) Preliminary definition of improvement in rheumatoid arthritis Arthritis and Rheumatism, 38, pp. 727-735.
41. Felson, DT and Neogi, T. (2004) Osteoarthritis: Is it a disease of cartilage or of bone? Arthritis and Rheumatism, 50, pp. 341-344.
42. Fex, E and Eberhardt, K and Saxne, T. (1993) Tissue-derived macromolecules and markers of inflammation in serum in early rheumatoid arthritis: Relationship to development of joint destruction in hands and feet British Journal of Rheumatology, 36(11), pp. 1161-1165.
43. Flugge, LA and Miller-Deist, LA and Petillo, PA. (1999) Towards a molecular understanding of arthritis Chemistry and Biology, 6, pp. 157-166.
44. Fosang, AJ and Last, K and Maciewicz, RA. (1996) Aggrecan is degraded by matrix metalloproteinases in human arthritis Journal of Clinical Investigation, 98(10), pp. 2292-2299.
45. Fosang, AJ and Stanton, H and Little, CB and Atley, LM. (2003) Neoepitopes as biomarkers of cartilage catabolism Inflammation Research, 52, pp. 277-282.
46. Funderburgh, JL and Caterson, B and Conrad, GW. (1987) Distribution of proteoglycans antigenically related to corneal keratan sulphate proteoglycan Journal of Biology and Chemistry, 262(24), pp. 11634-11640.
47. Garnero P, Bingham C, Aronstein W, Cohen S, Conaghan P, Cline G, Beary J, Meyer J.2004. Treatment with risedronate reduced urinary CTX-II, a specific biochemical marker of cartilage type II collagen degradation in a 24 month study of knee OA. ACR Abstract Book 656.
48. Garnero, P and Christgau, S and Delmas, PD. (2001) The biphosphonate zoledronate decreases type II collagen breakdown in patients with Paget's disease of bone Bone, 28(5), pp. 461-464.
49. Garnero, P and Delmas, PD. (1996) New developments in biochemical markers for osteoporosis Calciferous Tissue International, 59(Suppl. 1), pp. 2-9.
50. Garnero, P and Delmas, PD. (2003) Biomarkers in osteoarthritis Current Opinion in Rheumatology, 15, pp. 641-646.
51. Garnero, P and Gineyts, E and Christgau, S and Finck, B and Delmas, PD. (2002) Association of baseline levels of urinary glucosyl-galactosyl-pyridinoline and type II collagen C-telopeptide with progression of joint destruction in patients with early rheumatoid arthritis Arthritis and Rheumatism, 46(1), pp. 21-30.
52. Garnero P, Landewe R, Boers M, Verhoeven A, Van der Linden, Linden S, Christgau S, Van der Heijde D, Boonen A, Geusens P. 2002. Association of baseline levels of markers of bone and cartilage degradation with long-term progression of joint damage in patients with early rheumatoid arthritis: The COBRA study. Arthritis and Rheumatism 46(11): 2847-2856.
53. Garnero, P and Landewe, R and Van der Heijde, D and Gotlieb, L and Kupper, H and Geusens, P. (2004) Adalimumab monotherapy decreases urinary CTX-II, a specific molecular marker of cartilage type II collagen degradation in patients with active rheumatoid arthritis American College of Rheumatology Conference, 50, pp. 5567.
54. Garnero, P and Piperno, M and Gineyts, E and Christgau, S and Delmas, PD and Vignon, E. (2001) Cross sectional evaluation of biochemical markers of bone, cartilage, and synovial tissue metabolism in patients with knee osteoarthritis: Relations with disease activity and joint damage Annals of Rheumatology Disease, 60(6), pp. 619-626.
55. Garnero, P and Rousseau, JC and Delmas, PD. (2000) Molecular basis and clinical use of biochemical markers of bone, cartilage and synovium in joint diseases Arthritis and Rheumatism, 43(5), pp. 953-968.
56. Garnero, P and Sornay-Rendu, E and Arlot, M and Christiansen, C and Delmas, PD. (2004) Association between spine disc degeneration and type II collagen degradation in postmenopausal women: The OFELY study Arthritis and Rheumatism, 50(10), pp. 3137-3144.
57. Gineyts, E and Garnero, P and Delmas, PD. (2001) Urinary excretion of glucosyl-galactosyl pyridinoline: A specific biochemical marker of synovium degradation Rheumatology, 40, pp. 315-323.
58. Gineyts, E and Mo, JA and Ko, A and Henriksen, DB and Curtis, SP and Gertz, BJ and Garnero, P and Delmas, PD. (2004) Effects of ibuprofen on molecular markers of cartilage and synovium turnover in patients with knee osteoarthritis Annals of Rheumatology Disease, 63(7), pp. 857-861.
59. Goldring, SR and Goldring, MB.(1999) Rheumatoid arthritis and other inflammatory joint pathologies. In Dynamics of bone and cartilage metabolism. (pp. 623-636). Orlando FL: Academic Press.
60. Hakala, BE and White, C and Recklies, AD. (1993) Human cartilage gp-39 a major secretory product of articular chondrocytes and synovial cells is a mammalian member of a chitinase protein family Journal of Biology and Chemistry, 293, pp. 781-788.
61. Hascall, VC and Morales, TI and Hascall, GK and Handley, CJ and McQuillan, DJ. (1983) Biosynthesis and turnover of proteoglycans in organ culture of bovine articular cartilage Journal of Rheumatology (Suppl., 11, pp. 45-52.
62. Hauselmann, HJ and Hedbom, E.(1999) In-vitro models of cartilage metabolism. In Dynamics of bone and cartilage metabolism. (pp. 325-338). Orlando FL: Academic Press.
63. Hayami, T and Pickarski, M and Wesolowski, GA and McLane, J and Bone, A and Destefano, J and Rodan, GA and Le Duong, T. (2004) The role of subchondral bone remodeling in osteoarthritis Arthritis and Rheumatism, 50(4), pp. 1193-1206.
64. Henrissat, B and Bairoch, A. (1993) New families in the classification of glycosyl hydrolases based on amino acid sequence similarities Biochemistry Journal, 293, pp. 781-788.
65. Henrotin, YE and Deby-Dupont, GP and Deby, C and De Bruyn, M and Lamy, M and Franchimont, P. (1993) Production of active oxygen species by isolated human chondrocytes British Journal of Rheumatology, 32, pp. 562-567.
66. Ishiguro, N and Ito, T and Obata, K and Fujimoto, N and Iwata, H. (1996) Determination of stromelysin-1, 72 and 92 kDa type IV collegenase, tissue inhibitor of metalloproteinase-1 (TIMP-1) and TIMP-2 in synovial fluid and serum from patients with rheumatoid arthritis Journal of Rheumatology, 23, pp. 1599-1604.
67. Ishikawa, T and Nishigaki, F and Christgau, S and Noto, T and Mo, J and From, N and Minoura, K and Hirayama, Y and Ohkubo, Y and Mutoh, S. (2004) Cartilage destruction in collagen induced arthritis assessed with a new biochemical marker for collagen type II C-telopeptide fragments Journal of Rheumatology, 31, pp. 1174-1179.
68. Johansen, JS and Cintin, C and Jorgensen, M and Kamby, C and Price, PA. (1995) Serum YKL-40: A new potential marker of prognosis and location of metastases of patients with recurrent breast cancer European Journal of Cancer, 31(9), pp. 1437-1442.
69. Johansen, JS and Jensen, HS and Price, PA. (1993) A new biochemical marker for joint injury. Analysis of YKL-40 in serum and synovial fluid British Journal of Rheumatology, 32(11), pp. 949-955.
70. Johnstone, B and Hering, TM and Caplan, AI and Goldberg, VM and Yoo, JU. (1998) In vitro chondrogenesis of bone marrow-derived mesenchymal progenitor cells Experimental Cell Research, 238, pp. 265-272.
71. Jordan, JM and Luta, G and Stabler, T and Renner, JB and Dragomir, AD and Vilim, V and Hochberg, MC and Helmick, CG and Kraus, VG. (2003) Ethnic and sex differences in serum levels of cartilage oligomeric matrix protein: The Johnston County Osteoarthritis Project Arthritis and Rheumatism, 48, pp. 675-681.
72. Jordan KM, Syddall HE, Garnero P, Gineyts E, Dennison E, Aihie Sayer A, Delmas PD, Cooper C, Arden NK. 2005. urinary CTX-II and glucosyl-galactosyl-pyridinoline are associated with the presence and severity of radiographic knee osteoarthritis in men. Annals of Rheumatism Disease [Epub ahead of print].
73. Jung, M and Christgau, S and Lukoschek, M and Henriksen, D and Richter, W. (2004) Increased urinary concentration of collagen type II C-telopeptide fragments in patients with osteoarthritis Pathobiology, 71(2), pp. 70-76.
74. Karsdal, MA and Larsen, L and Engsig, MT and Lou, H and Ferreras, M and Lochter, A and Delaisse, JM and Foged, NT. (2002) Matrix metalloproteinase-dependent activation of latent transforming growth factor-beta controls the conversion of osteoblasts into osteocytes by blocking osteoblast apoptosis Journal of Biology and Chemistry, 277, pp. 44061-44067.
75. Keyszer, G and Lambirini, I and Nagel, R and Keysser, C and Keysser, M and Gromnica-Ihle, E. (1999) Circulating levels of matrix metalloproteinases MMP-3 and MMP-1, tissue inhibitor of metalloproteinases 1 (TIMP-1) and MMP-1/TIMP-1 complex in rheumatic disease: Correlation with clinical activity in rheumatoid arthritis versus other surrogate markers Journal of Rheumatology, 26, pp. 251-258.
76. Kiani, C and Chen, L and Wu, YJ and Yee, AJ and Yang, BB. (2002) Structure and function of aggrecan Cell Research, 12(1), pp. 19-32.
77. Kirkpatrick, RB and Emery, JG and Connor, JR and Dodds, R and Lysko, PG and Rosenberg, M. (1997) Induction and expression of human cartilage glycoprotein 39 in rheumatoid inflammatory and peripheral blood monocyte-derived macrophages Experimental Cell Research, 237(1), pp. 46-54.
78. Knudson, CB and Knudson, W. (2001) Cartilage proteoglycans Cell and Developmental Biology, 12, pp. 69-79.
79. Kojima, T and Mwale, F and Yasuda, T and Girard, C and Poole, AR and Laverty, S. (2001) Early degradation of type IX and type II collagen with the onset of experimental inflammatory arthritis Arthritis and Rheumatism, 44(1), pp. 120-127.
80. Kongtawelert, P and Ghosh, P. (1990) A new sandwich-ELISA method for the determination of keratan sulphate peptides in biological fluids employing a monoclonal antibody and labelled avidin biotin technique Clinica et Chimica Acta, 195(1-2), pp. 17-26.
81. Konttinen, YT and Ainola, M and Valleala, H and Ma, J and Ida, H and Mandelin, J and Kinne, RW and Santavirta, S and Sorsa, T and Lopez-Otin, C and Takagi, M. (1999) Analysis of 16 different matrix metalloproteinases (MMP-1 to MMP-20) in the synovial membrane: Different profiles in trauma and rheumatoid arthritis Annals of Rheumatology Disease, 58(11), pp. 691-697.
82. Koshy, PJ and Henderson, N and Logan, C and Life, PF and Cawston, TE and Rowan, AD. (2002) Interleukin 17 induces cartilage collagen breakdown: novel synergistic effects in combination with proinflammatory cytokines Annals of Rheumatology Disease, 61, pp. 704-713.
83. Landewe, RB and Boers, M and Verhoeven, AC and Westhovens, R and Van De Laar, MA and Markusse, HM and Van Denderen, JC and Weststedt, ML and Peeters, AJ and Dijkmans, BA and Jacobs, P and Boonen, A and Van der Heijde, DM and Van der Linden, S. (2002) COBRA combination therapy in patients with early rheumatoid arthritis: Long-term structural benefits of a brief intervention Arthritis and Rheumatism, 46(2), pp. 347-356.
84. Landewe, R and Geusens, P and Boers, M and Van der Heijde, D and Lems, W and Te Koppelle, J and Van der Linden, S and Garnero, P. (2004) Markers for type II collagen breakdown predict the effect of disease-modifying treatment on long-term radiographic progression in patients with rheumatoid arthritis Arthritis and Rheumatism, 50(5), pp. 1390-1399.
85. Lee, DA and Reisler, T and Bader, DL. (2003) Expansion of chondrocytes for tissue engineering in alginate beads enhances chondrocytic phenotype compared with conventional monolayer techniques Acta Orthopedica Scandinavica, 74, pp. 6-15.
86. Leff, RL and Elias, I and Ionescu, M and Reiner, A and Poole, AR. (2003) Molecular changes in human osteoarthritic cartilage after 3 weeks of oral administration of BAY 12-9566, a matrix metalloproteinase inhibitor Journal of Rheumatology, 30(3), pp. 544-549.
87. Lemons, ML and Sandy, JD and Anderson, DK and Howland, DR. (2001) Intact aggrecan and fragments generated by both aggrecanse and metalloproteinase-like activities are present in the developing and adult rat spinal cord and their relative abundance is altered by injury Journal of Neurosciences, 21(13), pp. 4772-4781.
88. Lesko, LL and Atkinson, AJ., Jr. (2001) Use of biomarkers and surrogate endpoints in drug development and regulatory decision making: Criteria, validation, strategies Annual Review in Pharmacology and Toxicology, 41, pp. 347-366.
89. Loeser, RF and Carlson, CS and Del Carlo, M and Cole, A. (2002) Detection of nitrotyrosine in aging and osteoarthritic cartilage: correlation of oxidative damage with the presence of interleukin-1 beta and with chondrocyte resistance to insulin-like growth factor 1 Arthritis and Rheumatism, 46, pp. 2349-2357.
90. Lohmander, LS and Hoerrner, LA and Lark, MW. (1993) Metalloproteinases tissue inhibitor and proteoglycan fragments in knee synovial fluid in human osteoarthritis Arthritis and Rheumatism, 36, pp. 181-189.
91. Lohmander, LS and Yoshihara, Y and Roos and Kobayashi, T and Yamada, H and Shinmei, M. (1996) Procollagen II C-propeptide in joint fluid: changes in concentration with age, time after knee injury, and osteoarthritis Journal of Rheumatology, 23(10), pp. 1765-1769.
92. Lunstrum, GP and Keene, DR and Weksler, NB and Cho, YJ and Cornwall, M and Horton, WA. (1999) Chondrocyte differentiation in a rat mesenchymal cell line Journal of Histochemistry and Cytochemistry, 47, pp. 1-6.
93. Majeed, M and McQueen, F and Yeoman, S and McLean, L. (2004) Relationship between serum hyaluronic acid level and disease activity in early rheumatoid arthritis Annals of Rheumatology Disease, 63(9), pp. 1166-1168.
94. Manicourt, DH and Poilvache, P and Nzeuesseu, A and Van Egeren, A and Devogelaer, JP and Lenz, ME. (1999) Serum levels of hyaluronan, antigenic keratan sulfate, matrix metalloproteinase 3, and tissue inhibitor of metalloproteinases 1 change predictability in rheumatoid arthritis patients who have begun activity after a night of bed rest Arthritis and Rheumatism, 42, pp. 1861-1869.
95. Manning, WK and Bonner, WM., Jr. (1967) Isolation and culture of chondrocytes from human adult articular cartilage Arthritis and Rheumatism, 10, pp. 235-239.
96. Månsson, B and Carey, D and Alini, M and Ionescu, M and Rosenberg, LC and Poole, AR and Heinegård, D and Saxne, T. (1995) Cartilage and bone metabolism in rheumatoid arthritis Journal of Clinical Investigation, 95, pp. 1071-1077.
97. Martin, JA and Buckwalter, JA. (2002) Aging, articular cartilage chondrocyte senescence and osteoarthritis Biogerontology, 3, pp. 257-264.
98. Mehmet, H and Scudder, P and Tang, PW and Hounsell, EF and Caterson, B and Feizi, T. (1986) The antigenic determinants recognized by three monoclonal antibodies to keratan sulphate involve sulphated hepta- or larger oligosaccharides of the poly(N-acetyllactosamine) series European Journal of Biochemistry, 157(2), pp. 385-391.
99. Meulenbelt, I and Kloppenburg, M and Kroon, HM and Houwing-Duistermaat, JJ and Garnero, P and Hellio Le Graverand, MP and DeGroot, J and Slagboom, PE. (2006) Urinary CTX-II levels are associated with radiographic subtypes of osteoarthritis in hip, knee, hand and facet joints in subject with familial osteoarthritis at multiple sites: The GARP study Annals of Rheumatology Disease, 65, pp. 360-365.
100. Moller, HJ and Larsen, FS and Ingemann-Hansen, T and Poulsen, JH. (1994) ELISA for the core protein of the cartilage large aggregating proteoglycan, aggrecan: Comparison with the concentrations of immunogenic keratan sulphate in synovial fluid, serum and urine Clinica et Chimica Acta, 225(1), pp. 43-55.
101. Mouritzen, U and Christgau, S and Lehmann, HJ and Tanko, LB and Christiansen, C. (2003) Cartilage turnover assessed with a newly developed assay measuring collagen type II degradation products: influence of age, sex, menopause, hormone replacement therapy, and body mass index Annals of Rheumatology Disease, 62, pp. 332-336.
102. Muller, G and Michel, A and Altenburg, E. (1998) COMP (cartilage oligomeric matrix protein) is synthesized in ligament, tendon, meniscus, and articular cartilage Connective Tissue Research, 39(4), pp. 233-244.
103. Nelson, F and Dahlberg, L and Laverty, S and Reiner, A and Pidoux, I and Ionescu, M and Fraser, GL and Brooks, E and Tanzer, M and Rosenberg, LC and Dieppe, P and Poole, RA. (1998) Evidence for altered synthesis of type II collagen in patients with osteoarthritis Journal of Clinical Investigation, 102(12), pp. 2115-2125.
104. Oestergaard S, Chouinard L, Doyle N, Smith SS, Tanko LB, Qvist P. 2006. Early elevation in circulating levels of C-telopeptides of type II collagen predicts structural damage in articular cartilage in rodent model of collagen induced arthritis (CIA). Arthritis and Rheumatism (submitted).
105. Oldberg, A and Antonsson, P and Lindblom, K and Heinegard, D. (1992) COMP (cartilage oligomeric matrix protein) is structurally related to the thrombospondins Journal of Biology and Chemistry, 267(31), pp. 22346-22350.
106. Ory, PA. (2003) Interpreting radiographic data in rheumatoid arthritis Annals of Rheumatology Disease, 62(7), pp. 597-604.
107. Paik, DC and Dillon, J and Galicia, E and Tilson, MD. (2001) The nitrite/ collagen reaction: Non-enzymatic nitration as a model system for age related damage Connective Tissue Research, 42, pp. 111-122.
108. Pavelka, K and Forejtova, S and Olejarova, M and Gatterova, J and Senolt, L and Spacek, P and Braun, M and Hulejova, M and Stovickova, J and Pavelkova, A. (2004) Hyaluronic acid levels may have predictive value for the progression of knee osteoarthritis Osteoarthritis and Cartilage, 12(4), pp. 277-283.
109. Perrimon, N and Bernfield, M. (2000) Cellular functions of proteoglycans - an overview Cell and Developmental Biology, 12, pp. 65-67.
110. Poole, AR and Dieppe, PA. (1994) Biological markers in rheumatoid arthritis Seminars in Arthritis and Rheumatism, 23(6), pp. 17-31.
111. Poole, AR and Ionescu, M and Swan, A and Dieppe, PA. (1994) Changes in cartilage metabolism in arthritis are reflected by altered serum and synovial fluid levels of the cartilage proteoglycan aggrecan. Implications for pathogenesis Journal of Clinical Investigation, 94(1), pp. 25-33.
112. Posthumus, MD and Limburg, PC and Westra, J and Van Leeuwen, MA and Van Rijswijk, MH. (2003) Serum matrix metalloproteinase 3 levels in comparison to C-reactive protein in periods with and without progression of radiological damage in patients with early rheumatoid arthritis Clinical and Experimental Rheumatology, 21(4), pp. 465-472.
113. Qvist, P and Christgau, S and Pedersen, BJ and Schlemmer, A. (2002) Circadian variation in the serum concentration of C-terminal telopeptide of type I collagen (Serum CTX): Effects of gender, age, menopausal status, posture, daylight, serum cortisol, and fasting Bone, 31, pp. 57-61.
114. Recklies, AD and Baillargeon, L and White, C. (1998) Regulation of cartilage oligomeric matrix protein synthesis in human synovial cells and articular chondrocytes Arthritis and Rheumatism, 41(6), pp. 997-1006.
115. Reijman, M and Hazes, JM and Bierma-Zeinstra, SM and Koes, BW and Christgau, S and Christiansen, C and Uitterlinden, AG and Pols, HA. (2004) A new marker for osteoarthritis: Cross-sectional and longitudinal approach Arthritis and Rheumatism, 50(8), pp. 2471-2478.
116. Rizkalla, G and Reiner, A and Bogoch, E and Poole, AR. (1992) Studies of the articular cartilage proteoglycan aggrecan in health and osteoarthritis. Evidence for molecular heterogeneity and extensive molecular changes in disease Journal of Clinical Investigation, 90(6), pp. 2268-2277.
117. Rolan, P. (1997) The contribution of clinical pharmacology surrogates and models to drug development - a critical appraisal British Journal of Clinical Pharmacology, 44, pp. 219-225.
118. Rosenberg, K and Olsson, H and Morgelin, M and Heinegard, D. (1998) Cartilage oligomeric matrix protein shows high affinity zinc-dependent interaction with triple helical collagen Journal of Biology and Chemistry, 273(32), pp. 20397-20403.
119. Rousseau, JC and Zhu, Y and Miossec, P and Vignon, E and Sandell, LJ and Garnero, P and Delmas, PD. (2004) Serum levels of type IIA procollagen amino terminal propeptide (PIIANP) are decreased in patients with knee osteoarthritis and rheumatoid arthritis Osteoarthritis and Cartilage, 12(6), pp. 440-447.
120. Roy-Beaudry, M and Martel-Pelletier, J and Pelletier, JP and M'Barek, KN and Christgau, S and Shipkolye, F and Moldovan, F. (2003) Endothelin 1 promotes osteoarthritic cartilage degradation via matrix metalloproteinase 1 and matrix metalloprotease 13 induction Arthritis and Rheumatism, 48, pp. 2855-2864.
121. Saklatvala, J. (1986) Tumour necrosis factor alpha stimulates resorption and inhibits synthesis of proteoglycan in cartilage Nature, 322, pp. 547-549.
122. Schorle, CM and Finger, F and Zien, A and Block, JA and Gebhard, PM and Aigher, T. (2005) Phenotypic characterization of chondrosarcoma-derived cell lines Cancer Letters, 226(2), pp. 143-154.
123. Scott, DL and Houssien, DA. (1996) Clinical and laboratory assessments in rheumatoid arthritis and osteoarthritis British Journal of Rheumatology, 35(3), pp. 6-9.
124. Seibel, MJ. (2005) Biochemical markers of bone turnover: Part I: biochemistry and variability Clinical Biochemistry Reviews, 26(4), pp. 97-122.
125. Sharif, M and Kirwan, JR and Elson, CJ and Granell, R and Clarke, S. (2004) Suggestion of nonlinear or phasic progression of knee osteoarthritis based on measurements of serum cartilage oligomeric matrix protein levels over five years Arthritis and Rheumatism, 50(8), pp. 2479-2488.
126. Sharif, M and Saxne, T and Shepstone, L and Kirwan, JR and Elaon, CJ and Heinegaard, D and Dieppe, PA. (1995) Relationship between serum cartilage oligomeric matrix protein levels and disease progression in osteoarthritis of the knee joint British Journal of Rheumatology, 34(4), pp. 306-310.
127. Shingleton, WD. (2003) In vitro model of human articular cartilage degradation Methods in Molecular Biology, 225, pp. 99-106.
128. Skoumal, M and Kolarz, G and Klingler, A. (2003) Serum levels of cartilage oligomeric matrix protein. A predicting factor and a valuable parameter for disease management in rheumatoid arthritis Scandinavian Journal of Rheumatology, 32, pp. 156-161.
129. Song, X and Zeng, L and Jin, W and Thompson, J and Mizel, DE and Lei, K and Billinghurst, RC and Poole, AR and Wahl, SM. (1999) Secretory leukocyte protease inhibitor suppresses the inflammation and joint damage of bacterial cell wall-induced arthritis Journal of Experimental Medicine, 190, pp. 535-542.
130. Sugiyama, S and Itokazu, M and Shimizu, K. (2003) Procollagen II C propeptide level in the synovial fluid as a predictor of radiographic progression in early knee osteoarthritis Annals of Rheumatology Disease, 62, pp. 27-32.
131. Takigawan, M and Okawa, T and Pan, H and Aoki, C and Takahashi, K and
132. Van der Vliet, A and Eiserich, JP and O'Neill, CA and Halliwell, B. (1995) Tyrosine modification by reactive nitrogen species: A closer look Archives of Biochemistry and Biophysics, 319(2), pp. 341-349.
133. Verstappen, SM. M and Poole, AR and Ionescu, M and King, LE and Abrahamowicz, M and Hofman, DM and Bijlsma, JW. J and Lafeber, F. (2006) Radiographic joint damage in rheumatoid arthritis is associated with differences in cartilage turnover and can be predicted by serum biomarkers: An evaluation from 1 to 4 years after diagnosis Arthritis Research and Therapy, 8(1), pp. R31.
134. Vilim, V and Olejerova, M and Machachek, S and Gatterova, J and Kraus, VB and Pavelka, K. (2002) Serum levels of cartilage oligomeric matrix protein (COMP) correlate with radiographic progression of knee osteoarthritis Osteoarthritis and Cartilage, 10(9), pp. 707-713.
135. Volck, B and Price, PA and Johansen, JS and Sorensen, O and Benfeld, TL and Nielsen, HJ and Calafat, J and Borregaard, N. (1998) YKL-40, a mammalian member of the chitinase family, is a matrix protein of specific granules in human neutrophils Proceedings of the Association of American Physicians, 110(4), pp. 351-360.
136. Walakovits, LA and Moore, VL and Bhardwaj, N and Gallick, GS and Lark, MW. (1991) Detection of high levels of stromelysin and collagenase in synovial fluid from patients with rheumatoid arthritis and post-traumatic knee injury Arthritis and Rheumatism, 35, pp. 35-42.
137. Wislowska, M and Jablonska, B. (2005) Serum cartilage oligomeric matrix protein (COMP) in rheumatoid arthritis and knee osteoarthritis Clinical Rheumatology, 24(3), pp. 278-284.
138. Wollheim, F. (2000) Markers of disease in rheumatoid arthritis Current Opinion in Rheumatology;, 12(3), pp. 200-204.
139. Yoo, JU and Barthel, TS and Nishimura, K and Solchaga, L and Caplan, AI and Goldberg, VM and Johnstone, B. (1998) The chondrogenic potential of human bone-marrow-derived mesenchymal progenitor cells Journal of Bone and Joint Surgery A, 80, pp. 1745-1757.