Elevation of a collagenase generated type II collagen neoepitope and proteoglycan epitopes in synovial fluid following induction of joint instability in the dog

Osteoarthritis and Cartilage

Volumn 10, Issue 8, 2002, Pages 662-669

  Chu, Q ^a   Lopez, M ^a   Hayashi, K ^a   Ionescu, M ^b   Billinghurst, R C ^b   Johnson, K A ^c   Poole, A R ^b   Markel, M D ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b MCGILL UNIVERSITY   (Canada)

^c OHIO STATE UNIVERSITY   (United States)

Author keywords

3B3( ); Canine; COL2 3 4 long; Cranial cruciate ligament; Knee; Monopolar radiofrequency energy; Osteoarthritis

Indexed keywords

AGGRECAN; BIOLOGICAL MARKER; COLLAGEN TYPE 2; COLLAGENASE; EPITOPE; PROTEOGLYCAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTERIOR CRUCIATE LIGAMENT RUPTURE; ARTICLE; COLLAGEN DEGRADATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DISEASE COURSE; DOG; EARLY DIAGNOSIS; JOINT INSTABILITY; KNEE ARTHROSCOPY; KNEE OSTEOARTHRITIS; MEDICAL RESEARCH; MONITORING; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; RADIOFREQUENCY; RHEUMATOLOGY; SULFATION; SYNOVIAL FLUID; TURNOVER TIME;

EID: 0036671512     PISSN: 10634584     EISSN: None     Source Type: Journal    
DOI: 10.1053/joca.2002.0812     Document Type: Article

References (34)

1. Markers of osteoarthritis: A review of the literature
2. Anabolic and catabolic markers of proteoglycan metabolism in osteoarthritis
3. Immunological markers of cartilage proteoglycan metabolism in animal and human osteoarthritis
4. Studies of the articular cartilage proteoglycan aggrecan in health and osteoarthritis
5. Changes in cartilage metabolism in arthritis are reflected by altered serum and synovial fluid levels of the cartilage proteoglycan aggrecan
6. Measurement of synovial fluid and serum concentrations of the 846 epitope of chondroitin sulfate and of carboxy propeptides of type II procollagen for diagnosis of osteochondral fragmentation in horses
7. Immunohistochemical detection and immunochemical analysis of type II collagen degradation in human normal, rheumatoid, and osteoarthritic articular cartilages and in explants of bovine articular cartilage cultured with interleukin 1
8. Changes in glycosaminoglycan epitope levels in knee joint fluid following injury
9. The quantitation of a native chondroitin sulfate epitope in synovial fluid lavages and articular cartilage from canine experimental osteoarthritis and disuse atrophy
10. Osteoarthritis in cynomolgus macaques. II. Detection of modulated proteoglycan epitopes in cartilage and synovial fluid
11. Immunology of cartilage
12. The mechanical properties of articular cartilage
13. Effects of proteoglycan extraction on the tensile behavior of articular cartilage
14. Cartilage in health and disease
15. Characterization of helical cleavages in type II collagen generated by matrixins
16. Enhanced cleavage of type II collagen by collagenase in osteoarthritic articular cartilage
17. Increased damage to type II collagen in osteoarthritic articular cartilage detected by a new immunoassay
18. Glycosaminoglycan sulfate in human osteoarthritis
19. Age-related changes protein-related epitopes of human articular-cartilage proteoglycans
20. Changes in joint cartilage aggrecan after knee injury and in osteoarthritis
21. The early molecular natural history of experimental osteoarthritis. I. Progressive discoordinate expression of aggrecan and type II procollagen messenger RNA in the articular cartilage of adult animals
22. Immunohistochemical analysis of 3-B-3(-) and 7-D-4 epitope expression in canine osteoarthritis
23. Synovial fluid interleukin 6, tumor necrosis factor, and nitric oxide values in dogs with osteoarthritis secondary to cranial cruciate ligament rupture
24. Changes in articular cartilage after meniscectomy
25. Longitudinal characterization of synovial fluid biomarkers in the canine meniscectomy model of osteoarthritis
26. A comparison of joint mechanics between anterior cruciate intact and deficient stifles: A new canine model of anterior cruciate ligament disruption
27. Synovial fluid chondroitin sulphate epitopes 3B3 and 7D4, and glycosaminoglycan in human knee osteoarthritis after exercise
28. Protein iodination using Iodo-Gen
29. An introduction to the pathophysiology of osteoarthritis
30. The synthesis of type II procollagen is markedly increased in osteoarthritic cartilage in vivo
31. Quantitation of keratan sulfate in blood as marker of cartilage metabolism
32. Concentrations of chondroitin sulfate epitope 3B3 and 7D4 in synovial fluid after intra-articular and extra capsular reconstruction of the cranial cruciate ligament in dogs
33. Degradative enzymes in osteoarthritis
34. Collagenase-1 and collagenase-3 synthesis in normal and early experimental osteoarthritic canine cartilage: An immunohistochemical study