Evidence for altered synthesis of type II collagen in patients with osteoarthritis

Journal of Clinical Investigation

Volumn 102, Issue 12, 1998, Pages 2115-2125

  Nelson, Fred ^f   Dahlberg, Leif ^g   Laverty, Sheila ^a,b   Reiner, Agnes ^a   Pidoux, Isabelle ^a   Ionescu, Mirela ^a   Fraser, Graeme L ^a   Brooks, Emerson ^c,h   Tanzer, Michael ^c   Rosenberg, Lawrence C ^d   Dieppe, Paul ^e,i   Poole, A Robin ^a  

^a MCGILL UNIVERSITY   (Canada)

^b UNIVERSITÉ DE MONTRÉAL   (Canada)

^c MONTREAL GENERAL HOSPITAL   (Canada)

^d MONTEFIORE MEDICAL CENTER   (United States)

^e UNIVERSITY OF BRISTOL   (United Kingdom)

^f Orthopaed Med Group of San Diego   (United States)

^g LUND UNIVERSITY HOSPITAL   (Sweden)

^h Prince Edward Island   (Canada)

ⁱ UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

Cartilage; Collagen; Immunoassay; Osteoarthritis; Synthesis

Indexed keywords

COLLAGEN TYPE 2;

ADULT; AGED; ARTICLE; COLLAGEN SYNTHESIS; EXTRACELLULAR MATRIX; HUMAN; IMMUNOASSAY; MAJOR CLINICAL STUDY; OSTEOARTHRITIS; PATHOPHYSIOLOGY; PRIORITY JOURNAL;

EID: 0032535446     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI4853     Document Type: Article

References (10)

1. Poole, A.R. 1993. Cartilage in health and disease. In Arthritis and Allied Conditions. A Textbook in Rheumatology, 12th ed. D. McCarthy and W. Koopman, editors. Lea and Febiger, Philadelphia. 279-333.
2. Mayne, R. 1989. Cartilage collagens. What is their function, and are they involved in articular disease. Arthritis Rheum. 32:241-246.
3. Hollander, A., T. Heathfield, C. Webber, Y. Iwata, R. Bourne, C. Rorabeck, and A.R. Poole. 1994. Increased damage to type II collagen in osteoarthritic articular cartilage detected by a new immunoassay. J. Clin. Invest. 93: 1722-1732.
4. Kempson, G.E., H. Muir, C. Pollard, and M. Tuke. 1973. The tensile properties of the cartilage of human femoral condyles related to the content of collagen and glycosaminoglycans. Biochim. Biophys. Acta. 297:456-472.
5. Mow, V.C., L.A. Setton, D.S. Ratcliffe, D.S. Howell, and J.A. Buckwalter. 1990. Structure-function relationships of articular cartilage and the effects of joint instability and trauma on cartilage function. In Cartilage Changes in Osteoarthritis. K.D. Brandt, editor. Indiana University School of Medicine, Ciba-Geigy. 22-42.
6. Prockop, D.J., K.I. Kivirikko, L. Tuderman, and N.A. Guzman. 1979. The biosynthesis of collagen and its disorders. N. Eng. J. Med. 301:13-23.
7. Peltonen, L., R. Halila, and L. Ryhänen. 1985. Enzymes converting procollagens to collagens. J. Cell. Biochem. 28:15-21.
8. Kujawa, M.J., M. Weitzhandler, A.R. Poole, L. Rosenberg, and A.I. Caplan. 1989. Association of the C-propeptide of type II collagen with mineralization of embryonic chick long bone and sternal development. Connect. Tissue Res. 23:179-199.
9. Poole, A.R., I. Pidoux, A. Reiner, H. Choi, and L.C. Rosenberg. 1984. Association of an extracellular protein (chondrocalcin) with the calcification of cartilage in enchondral bone formation. J. Cell Biol. 98:54-65.
10. Lee, E.R., and A.R. Poole. 1996. Ultrastructural localization of the C-propeptide released from type II procollagen in fetal bovine growth plate cartilage. J. Histochem. Cytochem. 44:433-443.