Osteoarthritis linkage scan: More loci for the geneticists to investigate

Annals of the Rheumatic Diseases

Volumn 65, Issue 10, 2006, Pages 1265-1266

  Loughlin, J ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CALMODULIN; INTERLEUKIN 1; INTERLEUKIN 4 RECEPTOR;

CHROMOSOME 11; CHROMOSOME 16; CHROMOSOME 3; CHROMOSOME 4; CHROMOSOME 8; CLINICAL FEATURE; DISEASE SEVERITY; DNA POLYMORPHISM; GENE LOCUS; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; HUMAN; LINKAGE ANALYSIS; OSTEOARTHRITIS; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REVIEW;

GENETIC PREDISPOSITION TO DISEASE; HUMANS; LINKAGE (GENETICS); OSTEOARTHRITIS; QUANTITATIVE TRAIT LOCI;

EID: 33750305723     PISSN: 00034967     EISSN: None     Source Type: Journal    
DOI: 10.1136/ard.2006.053967     Document Type: Review

References (28)

1. Greig C, Spreckley K, Aspinwall R, Gillaspy E, Grant M, Ollier W, et al. Linkage to nodal osteoarthritis: quantitative and qualitative analyses of data from a whole genome screen identifies trait dependent susceptibility loci. Ann Rheum Dis 2006;65:1131-8.
2. Chapman K, Mustafa Z, Irven CM, Carr AJ, Clipsham K, Smith A, et al. Osteoarthritis-susceptibility locus on chromosome 11q, detected by linkage. Am J Hum Genet 1999;65:167-74.
3. Loughlin J, Mustafa Z, Irven C, Smith A, Carr AJ, Sykes CK. Stratification analysis of an osteoarthritis genome screen - suggestive linkage to chromosomes 4, 6 and 16. Am J Hum Genet 1999;65:1795-8.
4. Leppävuori J, Kujala U, Kinnunen J, Kaprio J, Nissilä M, Heliövaara M, et al. Genome scan for predisposing loci for distal interphalangeal joint osteoarthritis: evidence for a locus on 2q. Am J Hum Genet 1999;65:1060-7.
5. Stefánsson SE, Jönsson H, Ingvarsson T, Manolescu I, Jónsson HH, Olafsdóttir G, et al. Genomewide scan for hand osteoarthritis: a novel mutation in Matrilin-3. Am J Hum Genet 2003;72:1448-59.
6. Demissie S, Cupples LA, Myers R, Aliabadi P, Levy D, Felson DT. Genome scan for quantity of hand osteoarthritis. Arthritis Rheum 2002;46:946-52.
7. Hunter DJ, Demissie S, Cupples LA, Aliabadi P, Felson DT. A genome scan for joint-specific hand OA susceptibility. Arthritis Rheum 2004;50:2489-96.
8. Mototani H, Mabuchi A, Saito S, Fujioka M, Iida A, Takatori Y, et al. A functional single nucleotide polymorphism in the core promoter region of CALM1 is associated with hip osteoarthritis in Japanese. Hum Mol Genet 2005;14:1009-17.
9. Spector TD, Reneland RH, Mah S, Valdes AM, Hart DJ, Kammerer S, et al. Association between a variation in LRCH1 and knee osteoarthritis. Arthritis Rheum 2006;54:524-32.
10. Loughlin J, Dowling B, Chapman K, Marcelline L, Mustafa Z, Southam L, et al. Functional variants within the secreted frizzled-related protein 3 gene are associated with hip osteoarthritis in females. Proc Natl Acad Sci USA 2004;101:9757-62.
11. Min JL, Meulenbelt I, Riyazi N, Kloppenburg M, Houwing-Duistermaat JJ, Seymour AB, et al. Association of the frizzled-related protein gene with symptomatic osteoarthritis at multiple sites. Arthritis Rheum 2005;52:1077-80.
12. Lories RJ, Boonen S, Peeters J, De Vlam K, Luyten FP. Evidence for a differential association of the Arg200Trp single-nucleotide polymorphism in FRZB with hip osteoarthritis and osteoporosis. Rheumatology 2006;45:113-14.
13. Lories RJ, Tylzanowski P, Reekmans K, Peeters J, Thomas TT, Luyten FP. sFRP3 knockout mice develop accelerated cartilage breakdown in experimental models of osteoarthritis. Arthritis Rheum. 2005;52: abstract 620, (Suppl).
14. Lane NE, Lian K, Nevitt MC, Zmuda JM, Lui L, Li J, et al. Frizzled-related protein variants are risk factors for hip osteoarthritis. Arthritis Rheum 2006;54:1246-54.
15. Loughlin J, Dowling B, Mustafa Z, Chapman K. Association of the interleukin-1 gene cluster on chromosome 2q13 with knee osteoarthritis. Arthritis Rheum 2002;46:1519-27.
16. Meulenbelt I, Seymour AB, Nieuwland M, Huizinga TWJ, van Duijn CM, Slagboom PE. Association of the interleukin-1 gene cluster with radiographic signs of osteoarthritis of the hip. Arthritis Rheum, 2004;50;1179-86.
17. Smith AJP, Keen U, Billingham MJ, Perry MJ, Elson CJ, Kirwan JR, et al. Extended haplotypes and linkage disequilibrium in the IL1R1-IL1A-IL1B-IL1RN gene cluster: association with knee osteoarthritis. Genes Immun 2004;5:451-60.
18. Smith AJP, Elson CJ, Perry MJ, Bidwell JL. Accuracy of haplotype association studies is enhanced by increasing number of polymorphic loci examined: comment on the article by Meulenbelt et al. Arthritis Rheum 2005;52:675.
19. Kizawa H, Kou I, Iida A, Sudo A, Miyamoto Y, Fukuda A, et al. An aspartic acid repeat polymorphism in asporin inhibits chondrogenesis and increases susceptibility to osteoarthritis. Nat Genet 2005;37:138-44.
20. Valdes AM, Van Oene M, Hart DJ, Surdulescu GL, Loughlin J, Doherty M, et al. Reproducible genetic associations between candidate genes and clinical knee osteoarthritis in men and women. Arthritis Rheum 2006;54:533-9.
21. Mustafa Z, Dowling B, Chapman K, Sinsheimer JS, Carr A, Loughlin J. Investigating the aspartic acid (D) repeat of asporin as a risk factor for osteoarthritis in a UK Caucasian population. Arthritis Rheum 2005;52:3502-6.
22. Kaliakatsos M, Tzetis M, Kanavakis E, Fytili P, Chouliaras G, Karachalios T, et al. Asporin and knee osteoarthritis in patients of Greek origin. Osteoarthritis Cartilage 2006;14:609-11.
23. Rodriguez-Lopez J, Pombo-Suarez M, Liz M, Gomez-Reino JJ, Gonzalez A. Lack of association of a variable number of aspartic acid residues in the asporin gene with osteoarthritis susceptibility: case-control studies in Spanish Caucasians. Arthritis Res Ther 2006;8:R55.
24. Loughlin J, Sinsheimer JS, Carr A, Chapman K. The CALM1 core promoter polymorphism associated with hip osteoarthritis in Japanese is not associated with hip osteoarthritis in a United Kingdom Caucasian population. Osteoarthritis Cartilage 2006;14:295-8.
25. Spector T, Ahmadi KR, Valdes AM. When is a replication not a replication? Or how to spot a good genetic association study. Arthritis Rheum 2006;54:1051-4.
26. Ingvarsson T, Stefánsson SE, Gulcher JR, Jónsson HH, Jónsson H, Frigge ML, et al. A large Icelandic family with early osteoarthritis of the hip associated with a susceptibility locus on chromosome 16p. Arthritis Rheum 2001;44:2548-55.
27. Forster T, Chapman K, Marcelline L, Mustafa Z, Southam L, Loughlin J. Finer linkage mapping of primary osteoarthritis susceptibility loci on chromosomes 4 and 16 in families with affected women. Arthritis Rheum 2004;50:98-102.
28. Forster T, Chapman K, Loughlin J. Common variants within the interleukin 4 receptor a gene (IL4R) are associated with susceptibility to osteoarthritis. Hum Genet 2004;114:391-5.