Osteoarthritis-susceptibility locus on chromosome 11q, detected by linkage

American Journal of Human Genetics

Volumn 65, Issue 1, 1999, Pages 167-174

  Chapman, Kay ^a   Mustafa, Zehra ^a   Irven, Catherine ^a   Carr, Andrew J ^b   Clipsham, Kim ^b   Smith, Anne ^a   Chitnavis, Jai ^b   Sinsheimer, Janet S ^d   Bloomfield, Victoria A ^b   McCartney, Mary ^c   Cox, Olive ^b   Cardon, Lon R ^a   Sykes, Bryan ^a   Loughlin, John ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b NUFFIELD ORTHOPAEDIC CENTRE   (United Kingdom)

^c MUSGRAVE PARK HOSPITAL   (United Kingdom)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CHROMOSOME 11; CHROMOSOME 11Q; CHROMOSOME MAP; CHROMOSOME MARKER; FEMALE; GENE LOCUS; GENETIC LINKAGE; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; OSTEOARTHRITIS; PRIORITY JOURNAL; SIBLING;

EID: 0033358527     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: 10.1086/302465     Document Type: Article

References (31)

1. Aerssens J, Dequeker J, Peeters J, Breemans S, Boonen S (1998) Lack of association between osteoarthritis of the hip and gene polymorphisms of VDR, COL1A1 and COL2A1 in postmenopausal women. Arthritis Rheum 41:1946-1950
2. Chitnavis J, Sinsheimer JS, Clipsham K, Loughlin J, Sykes B, Burge PD, Carr AJ (1997) Genetic influences in end-stage osteoarthritis: sibling risks of hip and knee replacement for idiopathic osteoarthritis. J Bone Joint Surg Br 79-B:660-664
3. Cooper C, McAlindon T, Snow S, Vines K, Young P, Kirwan J, Dieppe P (1994) Mechanical and constitutional risk factors for symptomatic knee osteoarthritis: differences between medial tibio-femoral and patello-femoral disease. J Rheumatol 21:307-313
4. Creamer P, Hochberg MC (1997) Osteoarthritis. Lancet 350: 503-508
5. Deloukas P, Schuler GD, Gyapay G, Beasley EM, Soderlund C, Rodriguez-Tome P, Hui L, et al (1998) A physical map of 30,000 human genes. Science 282:744-746
6. Dequeker J, Mokassa L, Aerssens J, Boonen S (1997) Bone density and local growth factors in generalized osteoarthritis. Microsc Res Tech 37:358-371
7. Felson DT, Couropmitree NN, Chaisson CE, Hannan MT, Zhang Y, McAlindon TE, LaValley M, et al (1998) Evidence for a Mendelian gene in a segregation analysis of generalized radiographic osteoarthritis. Arthritis Rheum 41:1064-1071
8. Gong Y, Vikkula M, Boon L, Liu J, Beighton P, Ramesar R, Peltonen L, et al (1996) Osteoporosis-pseudoglioma syndrome, a disorder affecting skeletal strength and vision, is assigned to chromosome region 11q12-13. Am J Hum Genet 59:146-151
9. Goring HHH, Ott J (1997) Relationship estimation in affected sib pair analysis of late-onset diseases. Eur J Hum Genet 5: 69-77
10. Hager J, Dina C, Francke S, Dubois S, Houari M, Vatin V, Vaillant E, et al (1998) A genome-wide scan for human obesity genes reveals a major susceptibility locus on chromosome 10. Nat Genet 20:304-308
11. Heaney C, Shalev H, Elbedour K, Carmi R, Staack JB, Sheffield VC, Beier DR (1998) Human autosomal recessive osteopetrosis maps to 11q13, a position predicted by comparative mapping of the murine osteosclerosis (oc) mutation. Hum Mol Genet 7:1407-1410
12. Hirsch R, Lethbridge-Cejku M, Hanson R, Scott WW, Reichle R, Plato CC, Tobin JD, et al (1998) Familial aggregation of osteoarthritis. Arthritis Rheum 41:1227-1232
13. Holmans P, Craddock N (1997) Efficient strategies for genome scanning using maximum-likelihood affected-sib-pair analysis. Am J Hum Genet 60:657-666
14. Horton WA (1996) Evolution of the bone dysplasia family. Am J Med Genet 63:4-6
15. Johnson ML, Gong G, Kimberling W, Recker SM, Kimmel DB, Recker RR (1997) Linkage of a gene causing high bone mass to human chromosome 11 (11q12-13). Am J Hum Genet 60:1326-1332
16. Kaprio J, Kujala UM, Peltonen L, Koskenvuo M (1996) Genetic liability to osteoarthritis may be greater in women than men. BMJ 313:232
17. Kidd KK, Ott J (1984) Power and sample-size in linkage studies. Cytogenet Cell Genet 37:510-511
18. Koller DL, Rodriguez LA, Christian JC, Slemenda CW, Econs MJ, Hui SL, Morin P, et al (1998) Linkage of a QTL contributing to normal variation in bone mineral density to chromosome 11q12-13. J Bone Miner Res 13:1903-1908
19. Lane NE, Nevitt MC (1994) Osteoarthritis and bone mass. J Rheumatol 21:1393-1395
20. Lindberg H (1986) Prevalence of primary coxarthrosis in siblings of patients with primary coxarthrosis. Clin Orthop 203:273-275
21. Loughlin J, Irven C, Fergusson C, Sykes B (1994) Sibling pair analysis shows no linkage of generalized osteoarthritis to the loci encoding type II collagen, cartilage link protein or cartilage matrix protein. Br J Rheumatol 33:1103-1106
22. Mansell JP, Bailey AJ (1998) Abnormal cancellous bone collagen metabolism in osteoarthritis. J Clin Invest 101: 1596-1603
23. Matrisian LM (1992) The matrix-degrading metalloproteinases. Bioessays 14:455-463
24. O'Connell JR, Weeks DE (1998) PedCheck: a program for identification of genotype incompatibilities in linkage analysis. Am J Hum Genet 63:259-266
25. Pendas AM, Santamaria I, Alvarez MV, Pritchard M, Lopez-Otin C (1996) Fine physical mapping of the human matrix metalloproteinase genes clustered on chromosome 11q22.3. Genomics 37:264-265
26. Reed PW, Davies JL, Copeman JB, Bennett ST, Palmer SM, Pritchard LE, Gough SCL, et al (1994) Chromosome-specific microsatellite sets for fluorescence-based, semi-automated genome mapping. Nat Genet 7:390-395
27. Risch N (1990) Linkage strategies for genetically complex traits. I. multilocus models. Am J Hum Genet 46:222-228
28. Spector TD, Cicuttini F, Baker J, Loughlin J, Hart D (1996) Genetic influences on osteoarthritis in women: a twin study. BMJ 312:940-943
29. Uitterlinden AG, Burger H, Huang Q, Odding E, van Duijn CM, Hofman A, Birkenhager JC, et al (1997) Vitamin D receptor genotype is associated with radiographic osteoarthritis at the knee. J Clin Invest 100:259-263
30. Vikkula M, Palotie A, Ritvaniemi P, Ott J, Ala-Kokko L, Sievers U, Aho K, et al (1993) Early-onset osteoarthritis linked to the type II procollagen gene. Arthritis Rheum 36:401-409
31. Wright GD, Hughes AE, Regan M, Doherty M (1996) Association of two loci on chromosome 2q with nodal osteoarthritis. Ann Rheum Dis 55:317-319