T cells stimulated by CD40L positive leukemic blasts-pulsed dendritic cells meet optimal functional requirements for adoptive T-cell therapy

Leukemia

Volumn 20, Issue 11, 2006, Pages 2015-2024

  D'Amico, G ^a   Bonamino, M ^b,d   Dander, E ^a   Marin, V ^a   Basso, G ^c   Balduzzi, A ^a   Biagi, E ^a   Biondi, A ^a  

^a UNIVERSITY OF MILANO BICOCCA   (Italy)

^b FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^c UNIVERSITY OF PADOVA   (Italy)

^d Instituto Nacional de Câncer   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA4 INTEGRIN; CD40 LIGAND; CHEMOKINE RECEPTOR CCR7; CHEMOKINE RECEPTOR CXCR4; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; MACROPHAGE INFLAMMATORY PROTEIN 3BETA; STROMAL CELL DERIVED FACTOR 1; TUMOR NECROSIS FACTOR ALPHA;

ACUTE LYMPHOBLASTIC LEUKEMIA; ADOPTIVE TRANSFER; ARTICLE; B LYMPHOCYTE; BLAST CELL; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL DIFFERENTIATION; CELL GROWTH; CELL LINEAGE; CELL MIGRATION; CELL STIMULATION; CHEMOTAXIS; CHILD; CLINICAL ARTICLE; COCULTURE; CYTOKINE RELEASE; CYTOLYSIS; CYTOTOXICITY; DENDRITIC CELL; EFFECTOR CELL; FLUORESCENCE ACTIVATED CELL SORTING; HUMAN; HUMAN CELL; IMMUNE RESPONSE; LEUKEMIA CELL; LYMPHOCYTE TRANSFER; LYMPHOID ORGAN; MIXED LYMPHOCYTE REACTION; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE; TH1 CELL;

EID: 33750285576     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/sj.leu.2404390     Document Type: Article

References (61)

1. Pui CH, Campana D, Evans WE. Childhood acute lymphoblastic leukaemia, current status and future perspective. Lancet Oncol 2001; 2: 597-607.
2. Ladenstein R, Peters C, Gadner H. The present role of bone marrow and stem cell transplantation in the therapy of children with acute leukemia. Proc Natl Acad Sci USA 1997; 824: 38-64.
3. Cardoso AA, Seamon MJ, Afonso HM, Ghia P, Boussiotis VA, Freeman GJ et al. Ex vivo generation of human anti-BCP leukemia-specific autologous cytolytic T cells. Blood 1997; 90: 549-561.
4. Stripecke R, Levine AM, Pullarkat V, Cardoso AA. Immunotherapy with acute leukemia cells modified into antigen-presenting cells: Ex vivo culture and gene transfer methods. Leukemia 2002; 16: 1974-1983.
5. Costello RT, Gastaut JA, Olive D. What is the real role of CD40 in cancer immunotherapy? Immunol Today 1999; 20: 488-493.
6. Haining WN, Cardoso AA, Keczkemethy HL, Fleming M, Neuberg D, DeAngelo DJ et al. Failure to define window of time for autologous tumor vaccination in patients with newly diagnosed or relapsed acute lymphoblastic leukemia. Exp Hematol 2005; 33: 286-294.
7. Rosenberg SA, Yang JC, Restifo NP. Cancer immunotherapy: Moving beyond current vaccines. Nat Med 2004; 10: 909-915.
8. Knutson KL, Disis ML. Tumor antigen-specific T helper cells in cancer immunity and immunotherapy. Cancer Immunol Immunother 2005; 54: 721-728.
9. Hung K, Hayashi R, Lafond-Walker A, Lowenstein C, Pardoll D, Levitsky H. The central role of CD4(+) T cells in the antitumor immune response. J Exp Med 1998; 188: 2357-2368.
10. Fruh K, Yang Y. Antigen presentation by MHC class I and its regulation by interferon gamma. Curr Opin Immunol 1999; 11: 76-78.
11. Dranoff G, Jaee E, Lazenby A, Golumbek P, Levitsky H, Brose K et al. Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity. Proc Natl Acad Sci USA 1993; 90: 3539-3543.
12. Schattner EJ, Mascarenhas J, Bishop J, Yoo DH, Chadburn A, Crow MK et al. CD4+ T-cell induction of fas-mediated apoptosis in Burkitt's lymphoma B cells. Blood 1996; 88: 1375-1382.
13. Thomas WD, Hersey P. TNF-related apoptosis-inducing ligand (TRAIL) induces apoptosis in fas ligand-resistant melanoma cells and mediates CD4 T cell killing of target cells. J Immunol 1998; 161: 2195-2200.
14. Echchakir H, Bagot M, Dorothee G, Martinvalet D, Le Gouvello S, Boumsell L. T cell lymphoma reactive CD4+ cytotoxic T lymphocyte clones display a Th1 cytokine profile and use a fas-independent pathway for specific tumor cell lysis. J Invest Dermatol 2000; 115: 74-80.
15. Cohen PA, Peng L, Plautz GE, Kim JA, Weng DE, Shu S. CD4+ T cells in adoptive immunotherapy and the indirect mechanism of tumor rejection. Crit Rev Immunol 2000; 20: 17-56.
16. Kalams SA, Walker BD. The critical need for CD4 help in maintaining effective cytotoxic T lymphocyte responses. J Exp Med 1998; 188: 2199-2204.
17. Ossendorp F, Toes RE, Offringa R, van der Burg SH, Melief CJ. Importance of CD4(+) T helper cell responses in tumor immunity. Immunol Lett 2000; 74: 75-79.
18. Gao FG, Khammanivong V, Liu WJ, Leggatt GR, Frazer IH, Fernando GJ. Antigen-specific CD4+ T-cell help is required to activate a memory CD8+ T cell to a fully functional tumor killer cell. Cancer Res 2002; 62: 6438-6441.
19. Grewal IS, Flavell RA. CD40 and CD154 in cell - mediated immunity. Ann Rev Immunol 1998; 16: 111-155.
20. Cella M, Sheidegge D, Palmer-Lehmann K, Lane P, Lanzavecchia A, Alber G. Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation. J Exp Med 1996; 184: 747-752.
21. Trinchieri G. Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat Rev Immunol 2003; 3: 133-146.
22. Mihara K, Imai C, Coustan-Smith E, Dome JS, Dominici M, Vanin E et al. Development and functional characterization of human bone marrow mesenchymal cells immortalized by enforced expression of telomerase. Br J Haematol 2003; 120: 846-849.
23. Bonamino M, Serafini M, D'Amico G, Gaipa G, Todisco E, Bernasconi S et al. Functional transfer of CD40L gene in human B-cell precursor ALL blasts by second generation SIN lentivectors. Gene Therapy 2000; 11: 85-93.
24. D'Amico G, Bonamino M, Marin V, Biondi A. Potential use of CD40 ligand for immunotherapy of childhood B-Cell precursor acute lymphoblastic leukaemia. Best Prac Res Clinic Haem 2004; 17: 465-477.
25. Zennou V, Petit C, Guetard D, Nerhbass U, Montagnier L, Charneau P. HIV-1 genome nuclear import is mediated by a central DNA flap. Cell 2000; 101: 173-185.
26. Zufferey R, Donello JE, Trono D, Hope TJ. Woodchuck hepatitis virus posttranscriptional regulatory element enhances expression of transgenes delivered by retroviral vectors. J Virol 1999; 73: 2886-2892.
27. D'Amico G, Vulcano M, Bugarin C, Bianchi G, Pirovano G, Bonamino M et al. CD40 activation of BCP-ALL cells generates IL-10-producing, IL-12-defective APCs that induce allogeneic T-cell anergy. Blood 2004; 104: 744-751.
28. Biagi E, Yvon E, Dotti G. Amrolia PJ, Takahashi S, Popat U et al. Bystander transfer of functional human CD40 ligand from gene-modified fibroblasts to B-chronic lymphocytic leukemia cells. Hum Gene Ther 2003; 14: 545-559.
29. Biagi E, Dotti G, Yvon E, Lee E, Pule M, Vigouroux S et al. Molecular transfer of CD40 and OX40 ligands to leukemic human B cells induces expansion of autologous tumor-reactive cytotoxic T lymphocytes. Blood 2005; 105: 2436-2442.
30. Watanabe S, Shimosato Y, Kameya T. Kuroki M, Kitahara T, Minato K et al. Leukemic distribution of a human acute lymphocytic leukemia cell line (ichikawa strain) in nude mice conditioned with whole body irradiation. Cancer Res 1978; 38: 3494-3498.
31. Crazzolara R, Kreczy A, Mann G, Heitger A, Eibl G, Fink FM et al. High expression of the chemokine receptor CXCR4 predicts extramedullary organ infiltration in childhood acute lymphoblastic leukemia. Br J Haematol 2001; 115: 545-553.
32. Lock RB, Liem N, Farnsworth ML, Milross CG, Xue C, Tajbakhsh M et al. The nonobese diabetic/sever combined immunodeficient (NOD/SCID) mouse model of childhood acute lymphoblastic leukemia reveals intrinsic differences in biological characteristics at diagnosis and relapse. Blood 2002; 99: 4100-4108.
33. Lanzavecchia A, Sallusto F. Understanding the generation and function of memory T cell subsets. Curr Opin Immunol 2005; 17: 326-332.
34. Rose DM, Han J, Ginsberg MH. Alpha4 integrins and the immune response. Immunol Rev 2002; 186: 118-124.
35. Frenette PS, Subbarao S, Mazo IB, von Adrian UH, Wagner DD. Endothelial selectins and vascular adhesion-molecule-1 promote hematopoietic progenitor homing to bone marrow. Proc Natl Acad Sci 1998; 95: 14423-14428.
36. Stamenkovic I. The L-selectin adhesion system. Curr Opin Hematol 1995; 2: 68-75.
37. Nagasawa TA. Chemokine, SDF-1/PBSF, and its receptor, CXC chemokine receptor 4, as mediators of hematopoiesis. Int J hematol 2000; 72: 408-411.
38. Lapidot T. Mechanism of human stem cell migration and repopulation of NOD/SCID and B2mnull NOD/SCID mice. The role of SDF-1/CXCR4 interactions. Ann NY Acad Sci 2001; 938: 83-95.
39. Ngo VN, Tang HL, Cyster JG. Epstein-Barr virus-induced molecule 1 ligand chemokine is expressed by dendritic cells in lymphoid tissues and strongly attracts naive T cells and activated B cells. J Exp Med 1998; 188: 181-185.
40. Kim CH, Pelus LM, White JR, Applebaum E, Johanson K, Broxmeyer HE. CK beta-11/macrophage inflammatory protein-3 beta/EBI1-ligand chemokine is an efficacious chemoattractant for T and B cells. J Immunol 1998; 160: 2224-2418.
41. Finn OJ. Cancer vaccines: Between the idea and the reality. Nat Rev Immunol 2003; 3: 630-641.
42. Van Der Bruggen P, Zhang P, Chaux V, Van Stroobant C, Panichelli C, Schultz J et al. Tumor-specific shared antigenic peptides recognized by human T cells. Immunol Rev 2002; 188: 51-64.
43. Mortarini R, Piris A, Maurichi A, Molla A, Bersani I, Bono A et al. Lack of terminally differentiated tumor-specific CD8+ T cells at tumor site in spite of antitumor immunity to self-antigens in human metastatic melanoma. Cancer Res 2003; 63: 2535-2545.
44. Marincola FM, Jaffee EM, Hicklin DJ, Ferrone S. Escape of human solid tumors from T-cell recognition: Molecular mechanisms and functional significance. Adv Immunol 2000; 74: 181-273.
45. Kuniyoshi JS, Kuniyoshi CJ, Lim AM, Wang FY, Bade ER, Lau R et al. Dendritic cell secretion of IL-15 is induced by recombinant huCD40LT and augments the stimulation of antigen-specific cytolytic T cells. Cell Immunol 1999; 193: 48-58.
46. Ribas A, Butterfield LH, Amarnani SN, Dissette VB, Kim D, Meng WS et al. CD40 cross-linking bypasses the absolute requirement for CD4 T cells during immunization with melanoma antigen gene-modified dendritic cells. Cancer Res 2001; 61: 8787-8793.
47. Montagna D, Maccario R, Locatelli F, Rosti V, Yang Y, Farness P et al. Ex vivo priming for long-term maintenance of antileukemia human cytotoxic T cells suggests a general procedure for adoptive immunotherapy. Blood 2001; 98: 3359-3366.
48. Kaech SM, Ahmed R. Memory CD8+ T cell differentiation: Initial antigen encounter triggers a developmental program in naive cells. Nat Immunol 2001; 5: 415-422.
49. Sallusto F, Lenig D, Forster R, Lipp M, Lanzavecchia A. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 1999; 401: 708-712.
50. Zinkernagel RM, Callahan GN, Althage G, Cooper S, Streilein JW, Klein J. The lymphoreticular system in triggering virus plus self-specific cytotoxic T cells: Evidence for T help. J Exp Med 1978; 147: 897-911.
51. Cassell D, Forman J. Linked recognition of helper and cytotoxic antigenic determinants for the generation of cytotoxic T lymphocytes. Ann NY Acad Sci 1988; 532: 51-60.
52. Langenkamp A, Messi M, Lanzavecchia A, Sallusto F. Kinetics of dendritic cell activation: Impact on priming of TH1, TH2 and nonpolarized T cells. Nat Immunol 2000; 1: 311-316.
53. Lanzavecchia A, Sallusto F. The instructive role of dendritic cells on T cell responses: Lineages, plasticity and kinetics. Curr Opin Immunol 2001; 3:291-298.
54. Fruh K, Yang Y. Antigen presentation by MHC class I and its regulation by interferon gamma. Curr Opin Immunol 1999; 1: 76-81.
55. Lertmemongkolchai G, Cai G, Hunter CA, Bancroft GJ. Bystander activation of CD8(+) T cells contributes to the rapid production of IFN-gamma in response to bacterial pathogens. J Immunol 2001; 166: 1097-1105.
56. Berg RE, Crossley E, Murray S, Forman J. Memory CD8+ T cells provide innate immune protection against Listeria monocytogenes in the absence of cognate antigen. J Exp Med 2003; 198: 1583-1593.
57. Berg RE, Cordes CJ, Forman J. Contribution of CD8+ T cells to innate immunity: IFN-gamma secretion induced by IL-12 and IL-18. Eur J Immunol 2002; 32: 2807-2816.
58. Di Rosa F, Pabst R. The bone marrow: A nest for migratory memory T cells. Trends Immunol 2005; 26: 360-366.
59. Seder RA, Ahmed R. Similarities and differences in CD4+ and CD8+ effector and memory T cell generation. Nat Immunol 2003; 4: 835-842.
60. Kaech SM, Wherry EJ, Ahmed R. Effector and memory T-cell differentiation: Implications for vaccine development. Nat Rev Immunol 2002; 2: 251-262.
61. Biagi E, Rousseau R, Yvon E, Schwartz M, Dotti G, Foster A et al. Responses to human CD40 ligand/human interleukin-2 autologous cell vaccine in patients with B-cell chronic lymphocytic leukemia. Clin Cancer Res 2005; 11: 6916-6923.