Chronic intragastric administration of gamma-butyrolactone produces physical dependence in baboons

Psychopharmacology

Volumn 189, Issue 1, 2006, Pages 71-82

  Goodwin, Amy K ^a,e   Griffiths, Roland R ^a   Brown, P Rand ^a   Froestl, Wolfgang ^b   Jakobs, Cornelis ^c   Gibson, K Michael ^d   Weerts, Elise M ^a,e  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b AC IMMUNE SA   (Switzerland)

^c VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^d CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

^e JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

GABA B receptor antagonists; GHB; Operant behavior; Withdrawal

Indexed keywords

3 AMINOPROPYLBUTYLPHOSPHINIC ACID; 4 AMINOBUTYRIC ACID B RECEPTOR; 4 AMINOBUTYRIC ACID B RECEPTOR BLOCKING AGENT; 4 HYDROXYBUTYRIC ACID; BENZODIAZEPINE RECEPTOR BLOCKING AGENT; FLUMAZENIL; GAMMA BUTYROLACTONE;

ANIMAL EXPERIMENT; ARTICLE; BABOON; BEHAVIOR; BLOOD LEVEL; CATHETER; CONTROLLED STUDY; DOSE RESPONSE; DRUG DEPENDENCE; DRUG EFFECT; FOOD; INSTRUMENTAL CONDITIONING; ISOTOPE DILUTION ASSAY; MALE; METABOLISM; MOTOR PERFORMANCE; MUSCLE RELAXATION; NONHUMAN; PAPIO ANUBIS; PRIORITY JOURNAL; SEDATION; TASK PERFORMANCE; WITHDRAWAL SYNDROME;

4-BUTYROLACTONE; ANIMALS; BEHAVIOR, ANIMAL; CATHETERS, INDWELLING; CONDITIONING, OPERANT; DOSE-RESPONSE RELATIONSHIP, DRUG; FLUMAZENIL; FOOD; GABA ANTAGONISTS; GABA-A RECEPTOR ANTAGONISTS; GABA-B RECEPTOR ANTAGONISTS; MALE; MOTOR SKILLS; MUSCLE RELAXATION; ORGANOPHOSPHORUS COMPOUNDS; PAPIO ANUBIS; RECEPTORS, GABA-A; RECEPTORS, GABA-B; SLEEP; SODIUM OXYBATE; SUBSTANCE WITHDRAWAL SYNDROME; SUBSTANCE-RELATED DISORDERS; TIME FACTORS;

EID: 33750222590     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00213-006-0534-9     Document Type: Article

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