Methylene blue decreases ischemia-reperfusion (I/R)-induced spinal cord injury: An in vivo study in an I/R rabbit model

European Surgical Research

Volumn 38, Issue 5, 2006, Pages 482-488

  Bardakci, H ^a   Kaplan, S ^a   Karadeniz, U ^a   Ozer, C ^b   Bardakci, Y ^b   Ozogul, C ^b   Birincioglu, C L ^a   Cobanoglu, A ^a  

^a TURKIYE YUKSEK IHTISAS HOSPITAL   (Turkey)

^b GAZI UNIVERSITY   (Turkey)

Author keywords

Experimental rabbit model; Ischemia reperfusion injury; Methylene blue; Spinal cord injury

Indexed keywords

ANTIOXIDANT; GLUTATHIONE; HEPARIN; MALONALDEHYDE; METHYLENE BLUE; SODIUM CHLORIDE;

ABDOMINAL AORTA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTERY CLAMP; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; HISTOLOGY; IN VIVO STUDY; NERVE CELL LESION; NEUROLOGIC EXAMINATION; NONHUMAN; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; PROPHYLAXIS; RABBIT; RENAL ARTERY; REPERFUSION INJURY; SCORING SYSTEM; SPINAL CORD INJURY; SPINAL CORD ISCHEMIA; TISSUE LEVEL; TREATMENT OUTCOME;

ANIMALS; ANTIOXIDANTS; GLUTATHIONE; HINDLIMB; LIPID PEROXIDATION; MALONDIALDEHYDE; METHYLENE BLUE; NEUROLOGIC EXAMINATION; OXIDATIVE STRESS; RABBITS; REPERFUSION INJURY; SPINAL CORD; SPINAL CORD INJURIES;

EID: 33750221823     PISSN: 0014312X     EISSN: None     Source Type: Journal    
DOI: 10.1159/000096007     Document Type: Article

References (40)

1. Connors JP, Ferguson TB, Roper CL, Weldon CS: The use of the TDMAC-heparin shunt in replacement of the descending thoracic aorta. Ann Surg 1975;181:735-741.
2. Svensson LG, Crawford ES, Hess KR, Coselli JS, Safi HJ: Experience with 1,509 patients undergoing thoracoabdominal aortic operations. J Vasc Surg 1993;17:357-368.
3. Salzano RP, Ellison LH, Altonji PF, Richter J, Deckers PJ: Regional deep hypothermia of the spinal cord protects against ischemic injury during thoracic aortic cross-clamping. Ann Thorac Surg 1994;57:65-71.
4. Svensson LG, Von Ritter CM, Groeneveld HT, Rickards ES, Hunter SJ, Robinson MF, Hinder RA: Cross-clamping of the thoracic aorta: influence of aortic shunts, papaverine, calcium channel blocker, allopurinol, and superoxide dismutase on spinal cord blood flow and paraplegia in baboons. Ann Thorac Surg 1986;204:38-47.
5. Rahman A, Ustundag B, Burma O, et al: Neuroprotective effect of regional carnitine on spinal cord ischemia-reperfusion injury. Eur J Cardiothorac Surg 2001;20:65-70.
6. Wan IY, Angelini GD, Bryan AJ, Ryder I, Underwood MJ: Prevention of spinal cord ischaemia during descending thoracic and thoracoabdominal aortic surgery. Eur J Cardiothorac Surg 2001;19:203-213.
7. Grisotto PC, dos Sandos AC, Continho-Netto J, Cherri Ji Piccinato CE: Indicators of oxidative injury and alterations of the cell membrane in the skeletal muscle of rats submitted to ischemia and reperfusion. J Surg Res 2000;92:1-6.
8. Qayumi AK, Janusz MT, Zis KD, Lyster DM, Jamieson E, Poostizadeh A, Jeeley EJE, Sangari MN: Additive effect of allopurinol and deferoxamine in the prevention of spinal cord injury caused by aortic cross-clamping. J Thorac Cardiovasc Surg 1994;107:1203-1209.
9. Agee JM, Flanagan T, Blackbourne LH, Kron IL, Tribble CG: Reducing postischemic paraplegia using conjugated superoxide dismutase. Ann Thorac Surg 1991;51:911-915.
10. Salaris SC, Babbs CF, Voorhees WD 3rd: Methylene blue as an inhibitor of superoxide generation by xanthine oxidase. A potential new drug for the attenuation of ischemia/reperfusion injury. Biochem Pharmacol 1991;42:499-506.
11. Kelner MJ, Bagnell R, Hale B, Alexander NM: Methylene blue competes with paraquat for reduction by flavo-enzymes resulting in decreased superoxide production in the presence of heme proteins. Arch Biochem Biophys 1988;262:422-426.
12. Kelner MJ, Bagnell R, Hale B, Alexander NM: Potential of methylene blue to block oxygen radical generation in reperfusion injury. Basic Life Sci 1988;49:895-898.
13. Galili Y, Ben-Abraham R, Weinbroum A, Marmur S, Iaina A, Volman Y, Peer G, Szold O, Soffer D, Klausner J, Rabau M, Kluger Y: Methylene blue prevents pulmonary injury after intestinal ischemia-reperfusion. J Trauma 1998;45:222-226.
14. Koelzow H, Gedney JA, Baumann J, Snook NJ, et al: The effect of methylene blue on the hemodynamic changes during ischemia reperfusion injury in orthotopic liver transplantation. Anesth Analg 2002;94:824-829.
15. 4 usage on spinal cord ischemia-reperfusion injury: electron microscopic and functional evaluation. Eur Surg Res 2004;36:20-25.
16. Kaplan S, Bisleri G, Morgan JA, Cheema FH, Oz MC: Resveratrol, a natural red wine polyphenol, reduces ischemia-reperfusion induced spinal cord injury. Ann Thorac Surg 2005;80:2242-2249.
17. Nakao Y, Otani H, Yamamura T, Hattori R, Osako M, Imamura H: Insulin-like growth factor 1 prevents neuronal cell death and paraplegia in the rabbit model of spinal cord ischemia. J Thorac Cardiovasc Surg 2001;122:136-143.
18. Casini A, Ferroli M, Pompella A: Lipid peroxidation and cellular damage in extrahepatic tissue of bromobenzene intoxicated mice. Am J Pathol 1986;123:520-531.
19. Aykac AG, Uysal M, Yalcin AS, Kocak-Toker N, Sivas A, Oz H: The effect of chronic ethanol ingestion on hepatic lipid peroxide, glutathione, glutathione peroxidase and glutathione transferase in rats. Toxicology 1985;36:71-76.
20. Wada T, Yao H, Miyamoto T, et al: Prevention and detection of spinal cord injury during thoracic and thoracoabdominal aortic repairs. Ann Thorac Surg 2001;72:80-85.
21. Ueno T, Furukawa K, Katayama Y, et al: Spinal cord protection: development of a paraplegia-preventive solution. Ann Thorac Surg 1994;58:116-120.
22. Rawe SE, Lee WA, Perot PL: Spinal cord glucose utilization after experimental spinal cord injury. Neurosurgery 1981;9:40-47.
23. Sinha K, Chaudhary G, Gupta YK: Protective effect of resveratrol against oxidative stress in middle cerebral artery occlusion model of stroke in rats. Life Sci 2002;71:655-665.
24. Zhao X, Alexander JS, Zhang S, Zhu Y, Sieber NJ, Aw TY, Carden DL: Redox regulation of the endothelial barrier integrity. Am J Physiol 2001;281:L879-L886.
25. Kamencic H, Griebel RW, Lyon AW, Paterson PG, Juurlink BH: Promoting glutathione synthesis after spinal cord trauma decreases secondary damage and promotes retention of function. FASEB J 2001;15:243-250.
26. Weinbroum AA, Paret G, Szold O, et al: Selective attenuation of acute lung ventilatory injury by methylene blue after liver ischemia-reperfusion: a drug response study in an isolated perfused double organ model. Transplantation 2001;72:385-392.
27. Mayer B, Brunner F, Schmidt K: Novel actions of methylene blue. Eur Heart J 1993;14(suppl I):22-26.
28. Peter C, Hongwan D, Kupfer A, Lauterburg BH: Pharmacokinetics and organ distribution of intravenous and oral methylene blue. Eur J Clin Pharmacol 2000;56:247-250.
29. Peer G, Itzhakov E, Wollman Y, Chernihovsky T, Grosskopf I, Segev D, Silverberg D, Blum M, Schwartz D, Iaina A: Methylene blue, a nitric oxide inhibitor, prevents haemodialysis hypotension. Nephrol Dial Transplant 2001;16:1436-1441.
30. Haluzik M, Nedvidkova J, Skrha J: The influence of NO synthase inhibitor and free oxygen radicals scavenger - methylene blue - on streptozotocin-induced diabetes in rats. Physiol Res 1998;47:337-341.
31. Ozal E, Kuralay E, Yildirim V, Kilic S, Bolcal C, Kucukarslan N, Gunay C, Demirkilic U, Tatar H: Preoperative methylene blue administration in patients at high risk for vasoplegic syndrome during cardiac surgery. Ann Thorac Surg 2005;79:1615-1619.
32. Levin RL, Degrange MA, Bruno GF, et al: Methylene blue reduces mortality and morbidity in vasoplegic patients after cardiac surgery. Ann Thorac Surg 2004;77:496-499.
33. Grayling M, Deakin CD: Methylene blue during cardiopulmonary bypass to treat refractory hypotension in septic endocarditis. J Thorac Cardiovasc Surg 2003;125:426-427.
34. Whitwam JG, Taylor AR, White JM: Potential hazard of methylene blue. Anaesthesia 1979;34:181-182.
35. Kearney TE, Manoguerra AS, Dunford JV Jr: Chemically induced methemoglobinemia from aniline poisoning. West J Med 1984;140:282-286.
36. Kirov MY, Evgenov OV, Evgenov NV, et al: Infusion of methylene blue in human septic shock: a pilot, randomized, controlled study. Crit Care Med 2001;29:1860-1867.
37. Ghiassi S, Sun YS, Kim VB, et al: Methylene blue enhancement of resuscitation after refractory hemorrhagic shock. J Trauma 2004;57:515-521.
38. Schenk P, Madl C, Rezaie-Majd S, Lehr S, Muller C: Methylene blue improves the hepatopulmonary syndrome. Ann Intern Med 2000;133:701-706.
39. Weinbroum AA, Kluger Y, Shapira I, Rudick V: Methylene blue abolishes aortal tone impairment induced by liver ischemia-reperfusion in a dose response manner: an isolated-perfused double-organ rat model study. Shock 2001;15:226-230.
40. Ilhan H, Alatas O, Tokar B, Colak O, Pasaoglu O, Koku N: Effects of the anti-ICAM-1 monoclonal antibody, allopurinol, and methylene blue on intestinal reperfusion injury. J Pediatr Surg 2003;38:1591-1595.