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1
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14044257834
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Vacuolar ATPase regulates zymogen activation in pancreatic acini
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Waterford SD, Kolodecik TR, Thrower EC, Gorelick FS. Vacuolar ATPase regulates zymogen activation in pancreatic acini. J Biol Chem 2005; 280: 5430-5434. The results of this report demonstrate that intracellular digestive enzyme activation, a key pathologic process in acute pancreatitis, is mediated by vacuolar ATPase, which is necessary for creating acidified compartments in the acinar cell. These compartments are the site of digestive enzyme activation.
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(2005)
J Biol Chem
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Waterford, S.D.1
Kolodecik, T.R.2
Thrower, E.C.3
Gorelick, F.S.4
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2
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15744392747
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Transgenic expression of pancreatic secretory trypsin inhibitor-1 ameliorates secretagogue-induced pancreatitis in mice
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Nathan JD, Romac J, Peng RY, et al. Transgenic expression of pancreatic secretory trypsin inhibitor-1 ameliorates secretagogue-induced pancreatitis in mice. Gastroenterology 2005; 128:717-727.
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Gastroenterology
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Nathan, J.D.1
Romac, J.2
Peng, R.Y.3
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3
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Protection against acute pancreatitis by activation of protease-activated receptor-2
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Sharma A, Tao X, Gopal A, et al. Protection against acute pancreatitis by activation of protease-activated receptor-2. Am J Physiol Gastrointest Liver Physiol 2005; 288:G388-G395.
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Am J Physiol Gastrointest Liver Physiol
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Sharma, A.1
Tao, X.2
Gopal, A.3
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4
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Protease-activated receptor 2 exerts local protection and mediates some systemic complications in acute pancreatitis
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Namkung W, Han W, Luo X, et al. Protease-activated receptor 2 exerts local protection and mediates some systemic complications in acute pancreatitis. Gastroenterology 2004; 126:1844-1859. This report demonstrates that trypsin-mediated activation of PAR-2 has dual effects in the mechanism of pancreatitis. Thus, activated trypsin during pancreatitis mediates both local protective and systemic deleterious responses.
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(2004)
Gastroenterology
, vol.126
, pp. 1844-1859
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Namkung, W.1
Han, W.2
Luo, X.3
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5
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9244227654
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Membrane-bound ICAM-1 is upregulated by trypsin and contributes to leukocyte migration in acute pancreatitis
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Hartwig W, Werner J, Warshaw AL, et al. Membrane-bound ICAM-1 is upregulated by trypsin and contributes to leukocyte migration in acute pancreatitis. Am J Physiol Gastrointest Liver Physiol 2004; 287:G1194-G1199.
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Am J Physiol Gastrointest Liver Physiol
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Hartwig, W.1
Werner, J.2
Warshaw, A.L.3
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6
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2+-dependent cell death in rat pancreatic acinar cells
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2+-dependent cell death in rat pancreatic acinar cells. Gastroenterology 2002; 122:1941-1953.
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Gastroenterology
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Kim, J.Y.1
Kim, K.H.2
Lee, J.A.3
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7
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3042637611
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Effects of secretagogues and bile acids on mitochondrial membrane potential of pancreatic acinar cells: Comparison of different modes of evaluating DeltaPsim
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Voronina SG, Barrow SL, Gerasimenko OV, et al. Effects of secretagogues and bile acids on mitochondrial membrane potential of pancreatic acinar cells: comparison of different modes of evaluating DeltaPsim. J Biol Chem 2004; 279:27327-27338. This study shows that secretagogues and bile acids cause depolarization and ATP depletion in pancreatic acinar cells by their effects on intracellular calcium levels. The effects on the mitochondria lead to necrotic cell death.
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(2004)
J Biol Chem
, vol.279
, pp. 27327-27338
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Voronina, S.G.1
Barrow, S.L.2
Gerasimenko, O.V.3
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10
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0035179805
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Phosphatidylinositol 3-kinase-dependent activation of trypsinogen modulates the severity of acute pancreatitis
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Singh VP, Saluja AK, Bhagat L, et al. Phosphatidylinositol 3-kinase-dependent activation of trypsinogen modulates the severity of acute pancreatitis. J Clin Invest 2001; 108:1387-1395.
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J Clin Invest
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Singh, V.P.1
Saluja, A.K.2
Bhagat, L.3
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11
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0842321784
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Phosphatidylinositide 3-kinase gamma regulates key pathologic responses to cholecystokinin in pancreatic acinar cells
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Gukovsky I, Cheng JH, Nam KJ, et al. Phosphatidylinositide 3-kinase gamma regulates key pathologic responses to cholecystokinin in pancreatic acinar cells. Gastroenterology 2004; 126:554-566.
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(2004)
Gastroenterology
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Gukovsky, I.1
Cheng, J.H.2
Nam, K.J.3
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12
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4444260453
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PKC-delta and -epsilon regulate NF-kappaB activation induced by cholecystokinin and TNF-alpha in pancreatic acinar cells
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Satoh A, Gukovskaya AS, Nieto JM, et al. PKC-delta and -epsilon regulate NF-kappaB activation induced by cholecystokinin and TNF-alpha in pancreatic acinar cells. Am J Physiol Gastrointest Liver Physiol 2004; 287: G582-G591.
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Am J Physiol Gastrointest Liver Physiol
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Satoh, A.1
Gukovskaya, A.S.2
Nieto, J.M.3
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13
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11244275407
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Pancreatic ischemia associated with vasospasm in the early phase of human acute necrotizing pancreatitis
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Takeda K, Mikami Y, Fukuyama S, et al. Pancreatic ischemia associated with vasospasm in the early phase of human acute necrotizing pancreatitis. Pancreas 2005; 30:40-49. This study of over 100 patients shows that vasospastic lesions in the vascular bed of the pancreas lead to necrosis in severe necroting pancreatitis.
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(2005)
Pancreas
, vol.30
, pp. 40-49
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Takeda, K.1
Mikami, Y.2
Fukuyama, S.3
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14
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3042556344
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Endothelial nitric oxide synthase is protective in the initiation of caerulein-induced acute pancreatitis in mice
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DiMagno MJ, Williams JA, Hao Y, et al. Endothelial nitric oxide synthase is protective in the initiation of caerulein-induced acute pancreatitis in mice. Am J Physiol Gastrointest Liver Physiol 2004; 287:G80-G87. This study demonstrates that this specific isoform of nitric oxide synthase is a critical participant in regulation of blood flow in the pancreas during pancreatitis.
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(2004)
Am J Physiol Gastrointest Liver Physiol
, vol.287
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Dimagno, M.J.1
Williams, J.A.2
Hao, Y.3
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15
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Protective effect of central thyrotropin-releasing hormone analog on cerulein-induced acute pancreatitis in rats
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Yoneda M, Goto M, Nakamura K, et al. Protective effect of central thyrotropin-releasing hormone analog on cerulein-induced acute pancreatitis in rats. Regul Pept 2005; 125:119-124.
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Regul Pept
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Yoneda, M.1
Goto, M.2
Nakamura, K.3
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16
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Effect of central thyrotropin-releasing hormone on pancreatic blood flow in rats
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Goto M, Yoneda M, Nakamura K, et al. Effect of central thyrotropin-releasing hormone on pancreatic blood flow in rats. Regul Pept 2004; 121:57-63.
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Regul Pept
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Goto, M.1
Yoneda, M.2
Nakamura, K.3
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17
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19944429783
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VIP attenuation of the severity of experimental pancreatitis is due to VPAC1 receptor-mediated inhibition of cytokine production
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Kojima M, Ito T, Oono T, et al. VIP attenuation of the severity of experimental pancreatitis is due to VPAC1 receptor-mediated inhibition of cytokine production. Pancreas 2005; 30:62-70.
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(2005)
Pancreas
, vol.30
, pp. 62-70
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Kojima, M.1
Ito, T.2
Oono, T.3
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18
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0033624356
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Substance P is a determinant of lethality in diet-induced hemorrhagic pancreatitis in mice
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Maa J, Grady EF, Yoshimi SK, et al. Substance P is a determinant of lethality in diet-induced hemorrhagic pancreatitis in mice. Surgery 2000; 128:232-239.
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Surgery
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Maa, J.1
Grady, E.F.2
Yoshimi, S.K.3
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19
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20144363444
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Transient receptor potential vanilloid (TRPV-1) promotes neurogenic inflammation in the pancreas via activation of the neurokinin-1 receptor (NK-1R)
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Mutter MM, Wick EC, Day AL, et al. Transient receptor potential vanilloid (TRPV-1) promotes neurogenic inflammation in the pancreas via activation of the neurokinin-1 receptor (NK-1R). Pancreas 2005; 30:260-265.
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(2005)
Pancreas
, vol.30
, pp. 260-265
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Mutter, M.M.1
Wick, E.C.2
Day, A.L.3
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20
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0034128846
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Etiology and pathogenesis of acute pancreatitis: Current concepts
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Sakorafas GH, Tsiotou AG. Etiology and pathogenesis of acute pancreatitis: current concepts. J Clin Gastroenterol 2000; 30:343-356.
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Sakorafas, G.H.1
Tsiotou, A.G.2
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21
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21644434563
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Ethanol consumption potentiates viral pancreatitis and may inhibit pancreas regeneration: Preliminary findings
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Clemens DL, Jerrells TR. Ethanol consumption potentiates viral pancreatitis and may inhibit pancreas regeneration: preliminary findings. Alcohol 2004; 33:183-189. This pilot study provides information that an ethanol diet potentiates the severity of murine pancreatitis caused by human strain of coxackie virus.
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(2004)
Alcohol
, vol.33
, pp. 183-189
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Clemens, D.L.1
Jerrells, T.R.2
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22
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Histopathological features of diagnostic and clinical relevance in autoimmune pancreatitis: A study on 53 resection specimens and 9 biopsy specimens
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Zamboni G, Luttges J, Capelli P, et al. Histopathological features of diagnostic and clinical relevance in autoimmune pancreatitis: a study on 53 resection specimens and 9 biopsy specimens. Virchows Arch 2004; 445:552-563. This paper provides a detailed histopathologic description of cases of autoimmune pancreatitis.
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Virchows Arch
, vol.445
, pp. 552-563
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Zamboni, G.1
Luttges, J.2
Capelli, P.3
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23
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Autoimmune pancreatitis: Imaging features
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Sahani DV, Kalva SP, Farrell J, et al. Autoimmune pancreatitis: imaging features. Radiology 2004; 233:345-352.
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Sahani, D.V.1
Kalva, S.P.2
Farrell, J.3
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25
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Morphological changes after steroid therapy in autoimmune pancreatitis
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Kamisawa T, Egawa N, Nakajima H, et al. Morphological changes after steroid therapy in autoimmune pancreatitis. Scand J Gastroenterol 2004; 39:1154-1158. This study of 10 patients with autoimmune pancreatitis demonstrates rapid beneficial responses to corticosteroid therapy as measured by imaging studies.
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(2004)
Scand J Gastroenterol
, vol.39
, pp. 1154-1158
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Kamisawa, T.1
Egawa, N.2
Nakajima, H.3
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26
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Autoimmune pancreatitis: Increasing evidence for a clinical entity with various patterns
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Sahel J, Barthet M, Gasmi M. Autoimmune pancreatitis: increasing evidence for a clinical entity with various patterns. Eur J Gastroenterol Hepatol 2004; 16:1265-1268.
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Eur J Gastroenterol Hepatol
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Sahel, J.1
Barthet, M.2
Gasmi, M.3
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27
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IgG4 as a serological marker of autoimmune pancreatitis: The latest news
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Pezzilli R, Corinaldesi R. IgG4 as a serological marker of autoimmune pancreatitis: the latest news. JOP 2004; 5:531-533.
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(2004)
JOP
, vol.5
, pp. 531-533
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Pezzilli, R.1
Corinaldesi, R.2
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28
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An experimental model of autoimmune pancreatitis in the rat
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Davidson TS, Longnecker DS, Mickey WF. An experimental model of autoimmune pancreatitis in the rat. Am J Pathol 2005; 166:729-736.
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(2005)
Am J Pathol
, vol.166
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Davidson, T.S.1
Longnecker, D.S.2
Mickey, W.F.3
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29
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A randomized study of early nasogastric versus nasojejunal feeding in severe acute pancreatitis
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Eatock FC, Chong P, Menezes N, et al. A randomized study of early nasogastric versus nasojejunal feeding in severe acute pancreatitis. Am J Gastroenterol 2005; 100:432-439. This pilot study shows that intragastric administration of a low-fat elemental-like diet to patients with severe pancreatitis does not worsen outcome compared with intrajejunal administration of the diet.
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(2005)
Am J Gastroenterol
, vol.100
, pp. 432-439
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Eatock, F.C.1
Chong, P.2
Menezes, N.3
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30
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The effect of equicaloric medium-chain and long-chain triglycerides on pancreas enzyme secretion
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Symersky T, Vu MK, Frolich M, et al. The effect of equicaloric medium-chain and long-chain triglycerides on pancreas enzyme secretion. Clin Physiol Funct Imaging 2002; 22:307-311.
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Clin Physiol Funct Imaging
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Symersky, T.1
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Frolich, M.3
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Physiological effects of enteral and parenteral feeding on pancreaticobiliary secretion in humans
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O'Keefe SJ, Lee RB, Anderson FP, et al. Physiological effects of enteral and parenteral feeding on pancreaticobiliary secretion in humans. Am J Physiol Gastrointest Liver Physiol 2003; 284:G27-G36.
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O'Keefe, S.J.1
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Anderson, F.P.3
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