Dose dependency of the serum bio/immuno GH ratio in childen during pharmacological secretion tests

Journal of Endocrinological Investigation

Volumn 29, Issue 2, 2006, Pages 109-114

  Chaler, E A ^a   Travaglino, P ^b   Pagani, S ^b   Bozzola, E ^b   Marino, R ^a   Berensztein, E ^a   Maceiras, M ^a   Tauber, M ^c   Rivarola, M A ^a   Belgorosky, A ^a   Bozzola, Mauro ^b  

^a Hospital de Pediatria SAMIC Prof Dr Juan P Garrahan   (Argentina)

^b UNIVERSITY OF PAVIA   (Italy)

^c CHU PURPAN   (France)

Author keywords

GH bioactivity and immunoactivity; GH deficiency; Nb2 cell bioassay; Short children

Indexed keywords

ARGININE; GROWTH HORMONE; INSULIN; LEVODOPA;

ANIMAL CELL; ARTICLE; AUTOSOMAL DOMINANT INHERITANCE; BIOASSAY; BLOOD SAMPLING; CELL PROLIFERATION; CHILD; CONCENTRATION RESPONSE; CONTROLLED STUDY; FEMALE; FLUOROMETRY; GENE MUTATION; GENETIC ANALYSIS; GROWTH DISORDER; GROWTH HORMONE BLOOD LEVEL; GROWTH HORMONE DEFICIENCY; HORMONE RELEASE; HUMAN; IMMUNOASSAY; IMMUNOREACTIVITY; MAJOR CLINICAL STUDY; MALE; NONHUMAN; PROVOCATION TEST; RAT; SHORT STATURE;

EID: 33645568230     PISSN: 03914097     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03344082     Document Type: Article

References (22)

1. Growth hormone research society. Consensus guidelines for the diagnosis and treatment of growth hormone (GH) deficiency in childhood and adolescence: summary statement of the GH Research Society. J Clin Endocrinol Metab 2000, 85: 3990-3.
2. Chaler E, Belgorosky A, Maceiras M, Mendioroz M, Rivarola MA. Between-assay differences in serum GH measurements: importance in the diagnosis of GH deficiency in childhood. Clin Chem 2001, 47: 1735-8.
3. 2 cell bio-assay in children with growth disorders. J Endocrinol Invest 1998, 21: 765-70.
4. Baumann G. Growth hormone heterogeneity: genes, isohormones, variants, and binding proteins. Endocr Rev 1991, 12: 424-49.
5. Radetti G, Bozzola M, Pagani S, Street ME, Ghizzoni L. Growth hormone immunoactivity does not reflect bioactivity. Pediatr Res 2000, 48: 619-22.
6. Strasburger CJ, Dattani MT. New growth hormone assays: potential benefits. Acta Paediatr (Suppl) 1997, 423: 5-11.
7. Tanaka T, Shiu RPC, Gout PW, Beer CT, Noble RL, Friesen HG. A new sensitive and specific bio-assay for lactogenic hormones: measurement of prolactin and growth hormone in human serum. J Clin Endocrinol Metab 1980, 51: 1058-63.
8. Takahashi Y, Shirono S, Arisaka O, et al. Biologically inactive growth hormone caused by an aminoacid substitution. J Clin Invest 1997, 100: 1159-65.
9. Binder G, Benz MR, Elmlinger M, Pflaum C-D, Strasburger CJ, Ranke MB. Reduced human growth hormone (hGH) bioactivity without a defect of the GH-1 gene in three patients with rhGH responsive growth failure. Clin Endocrinol (Oxf) 1999, 5: 89-95.
10. Rivarola MA, Mendilaharzu H, Warman MD, et al. Endocrine disorders in 66 suprasellar and pineal tumors of prepubertal and pubertal patients. Horm Res 1992, 37: 1-6.
11. Marino R, Chaler E, Warman M, et al. The serum growth hormone (GH) response to provocative tests is dependent on type of assay in autosomal dominant isolated GH deficiency because of an ARG183HIS (R183H) GH-1 gene mutation. Clin Chem 2003, 49: 1002-5.
12. Albertsson-Wikland K, Jansson C, Rosberg S, Novamo A. Time-resolved immunofluorometric assay of human growth hormone. Clin Chem 1993, 39: 1620-5.
13. Radetti G, Bozzola M, Paganini C, et al. Growth hormone bioactivity and levels of growth hormone, growth hormone-binding protein, insulin-like growth factor I, and insulin-like growth factor-binding proteins in premature and full-term newborns during the first month of life. Arch Pediatr Adolesc Med 1997, 151: 170-5.
14. Chen EY, Liao YC, Amith DH, et al. The human growth hormone locus: nucleotide swequence, biology and evolution. Genomics 1989, 4: 479-97.
15. Sanger F, Nicklen S, Coulson AR. DNA sequencing with chain-terminating inhibitors. Biotechnology 1992, 24: 104-8.
16. Wada M, Uchida H, Ikeda M, et al. The 20-kilodalton (kDa) human growth hormone (hGH) differs from the 22-kDa hGH in the complex formation with cell surface hGH receptor and hGH-binding protein circulating in human plasma. Mol Endocrinol 1998, 12: 146-56.
17. Gent J, van Kerkhof P, Roza M, Bu G, Strous GJ. Ligand-independent growth hormone receptor dimerization occurs in the endoplasmic reticulum and is required for ubiquitin system-dependent endocytosis. Proc Natl Acad Sci U S A 2002, 99: 9858-63.
18. Fuh G, Cunningham BC, Fukunaga R, Nagata S, Goeddel DV, Wells JA. Rational design of potent antagonists to the human growth hormone receptor. Science 1992, 256: 1677-80.
19. Martha Jr PM, Goorman KM, Blizzard RM, Rogol AD, Veldhuis JD. Endogenous growth hormone secretion and clearance rates in normal boys as determined by deconvolution analysis: relationship to age, pubertal status, and body mass. J Clin Endocrinol Metab 1992, 74: 336-44.
20. Giustina A, Veldhuis JD. Pathophysiology of the neuroregulation of growth hormone secretion in experimental animals and the human. Endocr Rev 1998, 19: 717-97.
21. Kowarsky AA, Schneider J, Ben-Galim E, Weldon VV, Daughaday WH. Growth failure with normal serum RIA-GH and low somatomedin activity: somatomedin restoration and growth acceleration after exogenous GH. J Clin Endocrinol Metab 1978, 47: 461-4.
22. Takahashi Y, Kaji H, Okimura Y, Goji K, Abe H, Chihara K. Brief report: short stature caused by a mutant growth hormone. N Engl J Med 1996, 334: 432-6.