Switching feedback mechanisms realize the dual role of MCIP in the regulation of calcineurin activity

FEBS Letters

Volumn 580, Issue 25, 2006, Pages 5965-5973

  Shin, Sung Young ^a   Choo, Sang Mok ^a   Kim, Dongsan ^b   Baek, Song Joon ^b   Wolkenhauer, Olaf ^c   Cho, Kwang Hyun ^b  

^a University of Ulsan   (South Korea)

^b Seoul National University   (South Korea)

^c UNIVERSITY OF ROSTOCK   (Germany)

Author keywords

CaN NFAT signaling pathway; Cardiac hypertrophy; Computer simulations; Dual role; Dynamical analysis; Mathematical modeling; MCIP; Negative feedback; Switching mechanism

Indexed keywords

CALCINEURIN; MODULATORY CALCINEURIN INTERACTING PROTEIN; PROTEIN; TRANSCRIPTION FACTOR NFAT; UNCLASSIFIED DRUG;

ARTICLE; CELL NUCLEUS MEMBRANE; COMPUTER SIMULATION; DISSOCIATION; GENE OVEREXPRESSION; HEART VENTRICLE HYPERTROPHY; HYPOTHESIS; MATHEMATICAL MODEL; MOLECULAR DYNAMICS; NEGATIVE FEEDBACK; POSITIVE FEEDBACK; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN SYNTHESIS INHIBITION;

ANIMALS; CALCINEURIN; CARDIOMEGALY; COMPUTER SIMULATION; FEEDBACK; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MICE, KNOCKOUT; MODELS, CARDIOVASCULAR; MUSCLE PROTEINS; MYOCARDIUM; NFATC TRANSCRIPTION FACTORS; SIGNAL TRANSDUCTION; STRESS; STRESS, PHYSIOLOGICAL;

EID: 33750152697     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2006.09.064     Document Type: Article

References (23)

1. Vega R.B., Yang J., Rothermel B.A., Bassel-Duby R., and Williams R.S. Multiple domains of MCIP1 contribute to inhibition of calcineurin activity. J. Biol. Chem. 277 (2002) 30401-30407
2. Vega R.B., Rothermel B.A., Weinheimer C.J., Kovacs A., Naseem R.H., Bassel-Duby R., Williams R.S., and Olson E.N. Dual roles of modulatory calcineurin-interacting protein 1 in cardiac hypertrophy. Proc. Natl. Acad. Sci. USA 100 (2003) 669-674
3. Yang J., Rothermel B., Vega R.B., Frey N., McKinsey T.A., Olson E.N., Bassel-Duby R., and Williams R.S. Independent signals control expression of the calcineurin inhibitory proteins MCIP1 and MCIP2 in striated muscles. Circ. Res. 87 (2000) e61-e68
4. Rothermel B.A., Vega R.B., and Williams R.S. The role of modulatory calcineurin-interacting. Trends Cardiovasc. Med. 13 (2003) 15-21
5. Rothermel B., Vega R.B., Yang J., Wu H., Bassel-Duby R., and Williams R.S. A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling. J. Biol. Chem. 275 (2000) 8719-8725
6. Sanna B., Brandt E.B., Kaiser R.A., Pfluger P., Witt S.A., Kimball T.R., van Rooij E., De Windt L.J., Rothenberg M.E., Tschop M.H., Benoit S.C., and Molkentin J.D. Modulatory calcineurin-interacting proteins 1 and 2 function as calcineurin facilitators in vivo. Proc Natl. Acad. Sci. USA 103 (2006) 7327-7332
7. Rothermel B.A., McKinsey T.A., Vega R.B., Nicol R.L., Mammen P., Yang J., Antos C.L., Shelton J.M., Bassel-Duby R., Olson E.N., and Williams R.S. Myocyte-enriched calcineurin-interacting protein, MCIP1, inhibits cardiac hypertrophy in vivo. Proc. Natl. Acad. Sci. USA 98 (2001) 3328-3333
8. Abbasi S., Lee J.D., Su B., Chen X., Alcon J.L., Yang J., Kellems R.E., and Xia Y. Protein kinase-mediated regulation of calcineurin through the phosphorylation of modulatory calcineurin-interacting protein 1. J. Biol. Chem. 281 (2006) 7717-7726
9. Quintana A.R., Wang D., Forbes J.E., and Waxham M.N. Kinetics of calmodulin binding to calcineurin. Biochem. Biophys. Res. Commun. 334 (2005) 674-680
10. Wilkins B.J., and Molkentin J.D. Calcium-calcineurin signaling in the regulation of cardiac hypertrophy. Biochem. Biophys. Res. Commun. 322 (2004) 1178-1191
11. Wujcik D. EGFR as a target: rationale for therapy. Semin. Oncol. Nurs. 22 (2006) 5-9
12. Frey N., and Olson E.N. Cardiac hypertrophy: the good, the bad, and the ugly. Annu. Rev. Physiol. 65 (2003) 45-79
13. Arron J.R., Winslow M.M., Polleri A., Chang C.P., Wu H., Gao X., Neilson J.R., Chen L., Heit J.J., Kim S.K., Yamasaki N., Miyakawa T., Francke U., Graef I.A., and Crabtree G.R. NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21. Nature 441 (2006) 595-600
14. Hoffman A., Levchenko A., Scott M.L., and Baltimore D. The IκB-NF-κB signaling module: temporal control and selective gene activation. Science 298 (2002) 1241-1245
15. Bhalla U.S., and Iyengar R. Emergent properties of networks of biological signaling pathways. Science 203 (1999) 381-387
16. Antos C.L., McKinsey T.A., Frey N., Kutschke W., McAnally J., Shelton J.M., Richardson J.A., Hill J.A., and Olson E.N. Activated glycogen synthase-3β suppresses cardiac hypertrophy in vivo. Proc. Natl. Acad. Sci. USA 99 (2002) 907-912
17. Rusnak F., and Mertz P. Calcineurin: form and function. Physiol. Rev. 80 (2000) 1483-1521
18. Vega R.B., Bassel-Duby R., and Olson E.N. Control of Cardiac growth and function by calcineurin signaling. J. Biol. Chem. 278 (2003) 36981-36984
19. Fareh J., Touyz R.M., Thibault G., and Schiffrin E.L. Basal and angiotensin II-induced cytosolic free calcium in adult rat cardiomyocytes and fibroblasts after volume overload. Hypertension 26 (1995) 1149-1153
20. Kawaguchi1 H., Sano1 H., Okada1 H., Iizuka1 K., Okamoto1 H., Kudo1 T., Murakami1 T., and Kitabatake1 A. Increased calcium release from sarcoplasmic reticulum stimulated by inositol trisphosphate in spontaneously hypertensive rat heart cells. Mol. Cell. Biochem. 119 (1993) 51-57
21. Wilkins B.J., and Molkentin J.D. Calcineurin and cardiac hypertrophy: Where have we been? Where are we going?. J. Physiol. 541 (2002) 1-8
22. Bers D.M. Excitation-contraction coupling and cardiac contractile force (2003), Kluwer Academic Publisher, Dordrecht
23. Molkentin J.D., Lu J.R., Antos C.L., Markham B., Richardson J., Robbins J., Grant S.R., and Olson E.N. A calcineurin-dependent transcriptional pathway for cardiac hypertrophy. Cell 93 (1998) 215-228