Structure-activity relationship studies on a novel series of (S)-2β-substituted 3α-[bis(4-fluoro- or 4-chlorophenyl)methoxy] tropane analogues for in vivo investigation

Journal of Medicinal Chemistry

Volumn 49, Issue 21, 2006, Pages 6391-6399

  Zhou, Mu Fa ^a   Cao, Jianjing ^a   Kopajtic, Theresa ^a   Desai, Rajeev I ^a,b   Katz, Jonathan L ^a   Newman, Amy Hauck ^a  

^a NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

^b MCLEAN HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 BETA CARBOETHOXY 3ALPHA [BIS(4 CHLOROPHENYL)METHOXY]TROPANE; 2 BETA CARBOMETHOXY 3ALPHA [BIS(4 CHLOROPHENYL)METHOXY]TROPANE; 2 BETA ETHENYL 3ALPHA [BIS(4 FLUOROPHENYL)METHOXY]TROPANE; 3ALPHA [BIS(4 CHLOROPHENYL)METHOXY]TROPANE DERIVATIVE; 3ALPHA [BIS(4 FLUOROPHENYL)METHOXY]TROPANE DERIVATIVE; AHN 1055; AHN 2005; CARRIER PROTEIN; COCAINE; DOPAMINE; DOPAMINE TRANSPORTER; DOPAMINE UPTAKE INHIBITOR; JHW 007; MONOAMINE; MUSCARINIC M1 RECEPTOR; MUSCARINIC RECEPTOR; NORADRENALIN TRANSPORTER; PSYCHOSTIMULANT AGENT; SEROTONIN TRANSPORTER; TROPANE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHEMICAL MODIFICATION; CHEMICAL REACTION; COCAINE DEPENDENCE; DRUG ACTIVITY; DRUG DISCRIMINATION; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; LOCOMOTION; MALE; NONHUMAN; RAT; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION;

ANIMALS; BRAIN; CENTRAL NERVOUS SYSTEM STIMULANTS; COCAINE; DISCRIMINATION LEARNING; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; MALE; NOREPINEPHRINE PLASMA MEMBRANE TRANSPORT PROTEINS; PROTEIN BINDING; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, MUSCARINIC M1; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TROPANES;

EID: 33750140933     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm060762q     Document Type: Article

References (34)

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