Cross-sectional study of complement C3 as a coronary risk factor among men and women

Clinical Science

Volumn 108, Issue 2, 2005, Pages 129-135

  Onat, Altan ^a,b   Uzunlar, Bülent ^c   Hergenç, Gülay ^d   Yazici, Mehmet ^e   Sari, Ibrahim ^c   Uyarel, Hüseyin ^c   Can, Günay ^b   Sansoy, Vedat ^a  

^a ISTANBUL UNIVERSITY   (Turkey)

^b ISTANBUL UNIVERSITY   (Turkey)

^c Yildiz Technical University ^*  (Turkey)

^d YILDIZ TECHNICAL UNIVERSITY   (Turkey)

^e ABANT IZZET BAYSAL UNIVERSITY   (Turkey)

Author keywords

C reactive protein; Complement C3; Coronary heart disease; Fibrinogen; Risk factor

Indexed keywords

ACUTE PHASE PROTEIN; C REACTIVE PROTEIN; CHOLESTEROL; COMPLEMENT COMPONENT C3; FIBRINOGEN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL;

ADULT; ARTICLE; ATHEROSCLEROSIS; BODY MASS; CARDIOVASCULAR RISK; CHOLESTEROL BLOOD LEVEL; COHORT ANALYSIS; CORONARY ARTERY THROMBOSIS; CORONARY RISK; FEMALE; HUMAN; INCOME; INSULIN BLOOD LEVEL; ISCHEMIC HEART DISEASE; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; OBESITY; PHYSICAL ACTIVITY; PRIORITY JOURNAL; SMOKING; SYSTOLIC BLOOD PRESSURE; TRIACYLGLYCEROL BLOOD LEVEL; WAIST CIRCUMFERENCE;

ADULT; AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; C-REACTIVE PROTEIN; CHOLESTEROL; COHORT STUDIES; COMPLEMENT C3; CORONARY DISEASE; CROSS-SECTIONAL STUDIES; FEMALE; FIBRINOGEN; HUMANS; INSULIN; MALE; METABOLIC SYNDROME X; MIDDLE AGED; OBESITY; ODDS RATIO; RISK FACTORS; SMOKING; TRIGLYCERIDES;

EID: 12944255793     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/CS20040198     Document Type: Article

References (29)

1. Zimmer, B., Hartung, H. P., Scharfenberger, G., Bitter-Suermann, P. and Hadding, U. (1982) Quantitative studies of the secretion of complement component C3 by resident, elicited and activated macrophages. Comparison with C2, C4 and lysosomal enzyme release. Eur. J. Immunol. 12, 426-430
2. Baumann, H. and Gauldie, J. (1994) The acute phase response. Immunol. Today 15, 74-80
3. Ernst, E. and Resch, K. L. (1993) Fibrinogen as a cardiovascular risk factor: a meta-analysis and review of the literature. Ann. Intern. Med. 118, 956-963
4. Ridker, P. M., Cushman, M., Stampfer, M. J., Tracy, R. P. and Hennekens, C. H. (1997) Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men. N. Engl. J. Med. 336, 973-979
5. Ridker, P. M., Hennekens, C. H., Buring, J. E. and Rifai, N. (2000) C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women. N. Engl. J. Med. 342, 836-843
6. Muscari, A., Bozzoli, C, Puddu, G. M. et al. (1995) Association of serum C3 levels with the risk of myocardial infarction. Am. J. Med. 98, 357-364
7. Muscari, A., Massarelli, G., Bastagli, L. et al. (2000) Relationship of serum C3 to fasting insulin, risk factors and previous ischemic events in middle aged men. Eur. Heart J. 21, 1081-1090
8. Onat, A., Sansoy, V., Yildirim, B., Keleç, I., Uysal, O. and Hergenç, G. (2001) C-reactive protein and coronary heart disease in Western Turkey. Am. J. Cardiol. 88, 601-607
9. Lagrand, W. K., Visser, C. A., Hermens, W. T. et al. (1999) C-reactive protein as a cardiovascular risk factor: more than an epiphenomenon? Circulation 100, 96-102
10. Germinario, R., Sniderman, A. D., Manuel, S., Lefebvre, S. P., Baldo, A. and Cianflone, K. (1993) Coordinate regulation of criacyglycerol synthesis and glucose transport by acylation-stimulating protein. Metab., Clin. Exp. 42, 574-580
11. Baldo, A., Sniderman, A., St-Luce, S. et al. (1993) The adipsin-acylation stimulating protein system and regulation of intracellular triglyceride synthesis. J. Clin. Invest. 92, 1543-1547
12. Muscari, A., Bastagli, L., Poggiopollini, G. et al. (2002) Different associations of C-reactive protein, fibrinogen and C3 with traditional risk factors in middle-aged men. Int. J. Cardiol. 83, 63-71
13. Onat, A. (2001) Risk factors and cardiovascular disease in Turkey. Atherosclerosis 156, 1-10
14. Onat, A., Avci, G. S., Şenocak, M., Örnek, E. and Gözükara, Y. (1992) Plasma lipids and their interrelation in Turkish adults. J. Epidemiol. Community Health 46, 470-476
15. Rose, G., Blackburn, H., Gillum, R. F. and Prineas, R. J. (1982) Cardiovascular Survey Methods, 2nd edition, pp. 124-127, WHO Geneva, Switzerland
16. National Cholesterol Education Expert Panel (2001) Executive summary of the third report of the National Cholesterol Education Program (NCEP) Expert Panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III). JAMA, J. Am. Med. Assoc. 285, 2486-2497
17. Friedewald, W. T., Levy, R. I. and Fredrickson, D. S. (1972) Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin. Chem. 18, 499-502
18. Clauss, A. (1957) Gerinnungsphysiologische Schnellmethode zur Bestimmung des Fibrinogens. Acta Haematol. 17, 237-246
19. Onat, A., Ceyhan, K., Başar, Ö., Erer, B., Toprak, S. and Sansoy, V. (2002) Metabolic syndrome: major impact on coronary risk in a population with low cholesterol levels: a prospective and cross-sectional evaluation. Atherosclerosis 165, 285-292
20. Gonzalez-Ortiz, M., Martinez-Abundis, E., Grover-Paez, F. and Pascoe-Gonzalez, S. (2002) Serum complement C3c concentration in non-obese young insulin-resistant Mexicans. Diabetes Nutr. Metab. 15, 256-259
21. Whicher, J., Rifai, N. and Biasucci, L. M. (2001) Markers of the acute phase response in cardiovascular disease: an update. Clin. Chem. Lab. Med. 39, 1054-1064
22. Muscari, A., Bastagli, L., Poggiopollini, G. et al. (2001) Short term effect of atorvastatin and vitamin E on serum levels of C3, a sensitive marker of the risk of myocardial infarction in men. Cardiovasc. Drugs Ther. 15, 453-458
23. Di Garbo, V., Bono, M., Di Raimondo, D., De Simone, R., Raneli, G. and Avellone, G. (2000) Non-lipid, dose-dependent effects of pravastatin treatment on hemostatic system and inflammatory response. Eur. J. Clin. Pharmacol. 56, 277-284
24. Muscari, A., Massarelli, G., Bastagli, L. et al. (1998) Relationship between serum C3 levels and traditional risk factors for myocardial infarction. Acta Cardiol. 53, 345-354
25. Bazzano, L. A., He, J., Muntner, P., Vupputuri, S. and Whelton, P. K. (2003) Relationship between cigarette smoking and novel risk factors for cardiovascular disease in the United States. Ann. Intern. Med. 138, 891-897
26. Yudkin, J. S. (2000) Relationship of serum C3 complement with insulin resistance and coronary heart disease: cause, consequence or common antecedent? Eur. Heart J. 21, 1036-1039
27. Danesh, J., Collins, R., Appleby, P. and Peto, R. (1998) Association of fibrinogen, C-reactive protein, albumin or leukocyte count with coronary heart disease. JAMA, J. Am. Med. Assoc. 279, 1477-1482
28. Ford, E. S. (2002) Does exercise reduce inflammation? Physical activity and C-reactive protein among U.S. adults. Epidemiology 13, 561-568
29. Jousilahti, P., Salomaa, V., Rasi, V., Vahtera, E. and Palosuo, T. (2003) Association of markers of systemic inflammation, C reactive protein, serum amyloid A, and fibrinogen, with socioeconomic status. J. Epidemiol. Community Health 57, 730-733