Design, synthesis, and biological evaluation of substituted 2,3-dihydro-1H-cyclopenta[b]quinolin-9-ylamine related compounds as fructose-1,6-bisphosphatase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 23, 2006, Pages 7846-7853

  Rosini, Michela ^a   Mancini, Francesca ^a   Tarozzi, Andrea ^a   Colizzi, Francesco ^a   Andrisano, Vincenza ^a   Bolognesi, Maria L ^a   Hrelia, Patrizia ^a   Melchiorre, Carlo ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

Allosteric inhibitors; Anilinoquinazolines; Cyclopenta b quinoline derivatives; Fructose 1,6 bisphosphatase inhibitors; Type 2 diabetes

Indexed keywords

ENZYME INHIBITOR; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; FRUCTOSE 1,6 BISPHOSPHATASE INHIBITOR; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DESIGN; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; SUBSTITUTION REACTION;

AMINES; DRUG DESIGN; ENZYME INHIBITORS; FRUCTOSE-BISPHOSPHATASE; HUMANS; QUINOLINES; RECEPTOR, EPIDERMAL GROWTH FACTOR; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33750078118     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.07.059     Document Type: Article

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