Inhibition of Fructose-1,6-bisphosphatase by a New Class of Allosteric Effectors

Journal of Biological Chemistry

Volumn 278, Issue 51, 2003, Pages 51176-51183

  Choe, Jun Young ^a   Nelson, Scott W ^a   Arienti, Kristen L ^b,c   Axe, Frank U ^b,c   Collins, Tassie L ^b,d   Jones, Todd K ^b,c   Kimmich, Rachel D A ^b,e   Newman, Michael J ^b,f   Norvell, Karl ^b   Ripka, William C ^b,g   Romano, Suzanne J ^b   Short, Kevin M ^b,c   Slee, Deborah H ^b   Fromm, Herbert J ^a   Honzatko, Richard B ^a  

^a IOWA STATE UNIVERSITY   (United States)

^b Ontogen Corporation   (United States)

^c JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

^d AMGEN INC   (United States)

^e Dihedron Corp   (United States)

^f Ferring Pharmaceuticals AS   (Denmark)

^g Cheminomics Group   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; CRYSTAL STRUCTURE; ENZYME INHIBITION; FRUCTOSE; HYDROGEN BONDS;

LIGANDS;

ENZYMES;

FRUCTOSE BISPHOSPHATASE; TETRAPEPTIDE;

ALLOSTERISM; ANIMAL CELL; ARTICLE; CATALYSIS; COMPETITIVE INHIBITION; CRYSTAL STRUCTURE; EFFECTOR CELL; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME SUBUNIT; GLUCONEOGENESIS; HYDROGEN BOND; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN QUATERNARY STRUCTURE; RESIDUE ANALYSIS;

ADENOSINE MONOPHOSPHATE; ALLOSTERIC REGULATION; ALLOSTERIC SITE; AMINO ACID SEQUENCE; CRYSTALLOGRAPHY, X-RAY; DRUG SYNERGISM; ESCHERICHIA COLI; FRUCTOSE-BISPHOSPHATASE; FRUCTOSEDIPHOSPHATES; KINETICS; MAGNESIUM; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; OLIGOPEPTIDES;

ANIMALIA; STAPHYLOCOCCUS PHAGE 187;

EID: 9144256705     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M308396200     Document Type: Article

References (41)

1. Benkovic, S. T., and de Maine, M. M. (1982) Adv. Enzymol. Relat. Areas Mol. Biol. 53, 45-82
2. Tejwani, G. A. (1983) Adv. Enzymol. Relat. Areas Mol. Biol. 54, 121-194
3. Van Schaftingen, E. (1987) Adv. Enzymol. Relat. Areas Mol. Biol. 59, 45-82
4. Pilkis, S. J., El-Maghrabi, M. R., and Claus, T. H. (1988) Annu. Rev. Biochem. 57, 755-783
5. Okar, D. A., and Lange, A. J. (1999) Biofactors 10, 1-14
6. Pilkis, S. J., El-Maghrabi, R. M., McGrane, M. M., Pilkis, J., and Claus, T. H. (1981) J. Biol. Chem. 256, 3619-3622
7. Nimmo, H. G., and Tipton, K. F. (1975) Eur. J. Biochem. 58, 567-574
8. Liu, F., and Fromm, H. J. (1988) J. Biol. Chem. 263, 9122-9128
9. Scheffler, J. E., and Fromm, H. J. (1986) Biochemistry 25, 6659-6665
10. Choe, J.-Y., Poland, B. W., Fromm, H. J., and Honzatko, R. B. (1998) Biochemistry 33, 11441-11450
11. Stone, S. R., and Fromm, H. J. (1980) Biochemistry 19, 620-625
12. Ke, H., Zhang, Y., Liang, J.-Y., and Lipscomb, W. N. (1991) Proc. Natl. Acad. Sci. U. S. A. 88, 2989-2993
13. Liu, F., and Fromm, H. J. (1988) J. Biol. Chem. 19, 9122-9128
14. Zhang, Y., Liang, J.-Y., Huang, S., and Lipscomb, W. M. (1994) J. Mol. Biol. 244, 609-624
15. Nelson, S. W., Kurbanov, F., Honzatko, R. B., and Fromm, H. J. (2001) J. Biol. Chem. 276, 6119-6124
16. Xue, Y., Huang, S., Liang, J.-Y., Zhang, Y., and Lipscomb, W. N. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 12482-12486
17. Choe, J.-Y., Fromm, H. J., and Honzatko, R. B. (2000) Biochemistry 39, 8565-8574
18. Choe, J.-Y., Nelson, S. W., Fromm, H. J., and Honzatko, R. B. (2003) J. Biol. Chem. 278, 16008-16014
19. Choe, J.-Y., Iancu, C. V., Fromm, H. J., and Honzatko, R. B. (2003) J. Biol. Chem. 278, 16015-16020
20. Nelson, S. W., Choe, J.-Y., Iancu, C. V., Honzatko, R. B., and Fromm, H. J. (2000) Biochemistry 39, 11100-11106
21. Wen, J., Nelson, S. W., Honzatko, R. B., Fromm, H. J., and Petrich, J. W. (2001) Photochem. Photobiol. 74, 679-685
22. Ke, H. M., Thorpe, C. M., Seaton, B., Lipscomb, W. N., and Marcus, F. (1990) J. Mol. Biol. 212, 513-539
23. Lu, G., Stec, B., Giroux, E. L., and Kantrowitz, E. R. (1996) Protein Sci. 5, 2333-2342
24. Wright, S. W., Carlo, A. A., Carty, M. D., Danley, D. E., Hageman, D. L., Karam, G. A., Levy, C. B., Mansour, M. N., Mathiowetz, A. M., McClure, L. D., Nestor, N. B., McPherson, R. K., Pandit, J., Pustilnik, L. R., Schulte, G. K., Soeller, W. C., Treadway, J. L., Wang, I.-K., and Bauer, P. H. (2002) J. Med. Chem. 45, 3865-3877
25. Laemmli, U. K. (1970) Nature 227, 680-685
26. Bradford, M. M. (1976) Anal. Biochem. 72, 248-252
27. Kuzmic, P. (1996) Anal. Biochem. 237, 260-273
28. Howard, A. J., Nielsen, C., and Xuong, N. H. (1985) Methods Enzymol. 114, 452-472
29. McRee, D. E. (1992) J. Mol. Graphics 10, 44-46
30. Brünger, A. T., Adams, P. D., Clore, G. M., DeLano, W. L., Gros, P., Grosse-Kunstleve, R. W., Jiang, J.-S., Kuszewski, J., Nilges, M., Pannu, M. S., Read, R. J., Rice, L. M., Simonson, T., and Warren, G. L. (1998) Acta Crystallogr. Sect. D Biol. Crystallogr. 54, 905-921
31. Engh, R. A., and Huber, R. (1991) Acta Crystallogr. Sect. A 47, 392-400
32. Laskowski, R. A., Mac Arthur, M. W., Moss, D. S., and Thornton, J. M. (1993) J. Appl. Crystallogr. 26, 283-291
33. Shyur, L.-F., Poland, B. W., Honzatko, R. B., and Fromm, H. J. (1997) J. Biol. Chem. 272, 26295-26299
34. McGrane, M. M., El-Maghrabi, M. R., and Pilkis, S. J. (1983) J. Biol. Chem. 258, 10445-10454
35. Lawson, J. W. R., Guynn, R. W., Cornell, N., and Veech, R. L. (1976) in Glucoaeogenesis: Its Regulation in Mammalian Species (Hanson, R. W., and Mehlman, Y. A., eds) pp. 481-512, John Wiley & Sons, Inc., New York
36. Lu, G., Giroux, E. L., and Kantrowitz, E. R. (1997) J. Biol. Chem. 297, 5076-5081
37. MacGregor, J. S., Singh, V. N., Davoust, S., Melloni, E., Pontremoli, S., and Horecker, B. L. (1980) Proc. Natl. Acad. Sci. U. S. A. 77, 3889-3892
38. Pontremoli, S., Melloni, E., and Horecker, B. L. (1983) Biochem. Soc. Trans. 11, 241-244
39. Rakus, D., and Dzugaj, A. (2000) Biochem. Biophys. Res. Commun. 275, 611-616
40. Moorhead, G. B. G., Hodgson, R. J., and Plaxton, W. C. (1994) Arch. Biochem. Biophys. 312, 326-335
41. Kraulis, J. (1991) J. Appl. Crystallogr. 24, 946-950