메뉴 건너뛰기




Volumn 20, Issue 10, 2006, Pages 1829-1839

The Mll-Een knockin fusion gene enhances proliferation of myeloid progenitors derived from mouse embryonic stem cells and causes myeloid leukaemia in chimeric mice

Author keywords

[No Author keywords available]

Indexed keywords

CD11B ANTIGEN; EXTRA ELEVEN NINETEEN PROTEIN; HOX PROTEIN; HYBRID PROTEIN; MIXED LINEAGE LEUKEMIA PROTEIN; PEPTIDES AND PROTEINS; UNCLASSIFIED DRUG;

EID: 33750076358     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/sj.leu.2404342     Document Type: Article
Times cited : (15)

References (52)
  • 1
  • 2
    • 0026936328 scopus 로고
    • A trithorax-like gene is interrupted by chromosome 11q23 translocations in acute leukaemias
    • Djabali M, Selleri L, Parry P, Bower M, Young BD, Evans GA. A trithorax-like gene is interrupted by chromosome 11q23 translocations in acute leukaemias. Nat Genet 1992; 2: 113-118.
    • (1992) Nat Genet , vol.2 , pp. 113-118
    • Djabali, M.1    Selleri, L.2    Parry, P.3    Bower, M.4    Young, B.D.5    Evans, G.A.6
  • 3
    • 0028869112 scopus 로고
    • Altered Hox expression and segmental identity in Mll-mutant mice
    • Yu BD, Hess JL, Horning SE, Brown GA, Korsmeyer SJ. Altered Hox expression and segmental identity in Mll-mutant mice. Nature 1995; 378: 505-508.
    • (1995) Nature , vol.378 , pp. 505-508
    • Yu, B.D.1    Hess, J.L.2    Horning, S.E.3    Brown, G.A.4    Korsmeyer, S.J.5
  • 4
    • 0030954681 scopus 로고    scopus 로고
    • Defects in yolk sac hematopoiesis in Mll-null embryos
    • Hess JL, Yu BD, Li B, Hanson R, Korsmeyer SJ. Defects in yolk sac hematopoiesis in Mll-null embryos. Blood 1997; 90: 1799-1806.
    • (1997) Blood , vol.90 , pp. 1799-1806
    • Hess, J.L.1    Yu, B.D.2    Li, B.3    Hanson, R.4    Korsmeyer, S.J.5
  • 5
    • 0030658039 scopus 로고    scopus 로고
    • Oncogenic transcription factors in the human acute leukemias
    • Look AT. Oncogenic transcription factors in the human acute leukemias. Science 1997; 278: 1059-1064.
    • (1997) Science , vol.278 , pp. 1059-1064
    • Look, A.T.1
  • 6
    • 0027132061 scopus 로고
    • Rearrangements of the MLL gene in therapy-related acute myeloid leukemia in patients previously treated with agents targeting DNA-topoisomerase II
    • Super HJ, McCabe NR, Thirman MJ, Larson RA, Le Beau MM, Pedersen-Bjergaard J et al. Rearrangements of the MLL gene in therapy-related acute myeloid leukemia in patients previously treated with agents targeting DNA-topoisomerase II. Blood 1993; 82: 3705-3711.
    • (1993) Blood , vol.82 , pp. 3705-3711
    • Super, H.J.1    McCabe, N.R.2    Thirman, M.J.3    Larson, R.A.4    Le Beau, M.M.5    Pedersen-Bjergaard, J.6
  • 7
    • 0029113177 scopus 로고
    • Molecular analysis of 13 cases of MLL/11q23 secondary acute leukemia and identification of topoisomerase II consensus-binding sequences near the chromosomal breakpoint of a secondary leukemia with the t(4;11)
    • Domer PH, Head DR, Renganathan N, Raimondi SC, Yang E, Atlas M. Molecular analysis of 13 cases of MLL/11q23 secondary acute leukemia and identification of topoisomerase II consensus-binding sequences near the chromosomal breakpoint of a secondary leukemia with the t(4;11). Leukemia 1995; 9: 1305-1312.
    • (1995) Leukemia , vol.9 , pp. 1305-1312
    • Domer, P.H.1    Head, D.R.2    Renganathan, N.3    Raimondi, S.C.4    Yang, E.5    Atlas, M.6
  • 8
    • 0030041634 scopus 로고    scopus 로고
    • Distribution of 11q23 breakpoints within the MLL breakpoint cluster region in de novo acute leukemia and in treatment-related acute myeloid leukemia: Correlation with scaffold attachment regions and topoisomerase II consensus binding sites
    • Broeker PL, Super HG, Thirman MJ, Pomykala H, Yonebayashi Y, Tanabe S et al. Distribution of 11q23 breakpoints within the MLL breakpoint cluster region in de novo acute leukemia and in treatment-related acute myeloid leukemia: Correlation with scaffold attachment regions and topoisomerase II consensus binding sites. Blood 1996; 87: 1912-1922.
    • (1996) Blood , vol.87 , pp. 1912-1922
    • Broeker, P.L.1    Super, H.G.2    Thirman, M.J.3    Pomykala, H.4    Yonebayashi, Y.5    Tanabe, S.6
  • 9
    • 0027172909 scopus 로고
    • Molecular rearrangements on chromosome 11q23 predominate in infant acute lymphoblastic leukemia and are associated with specific biologic variables and poor outcome
    • Chen CS, Sorensen PH, Domer PH, Reaman GH, Korsmeyer SJ, Heerema NA et al. Molecular rearrangements on chromosome 11q23 predominate in infant acute lymphoblastic leukemia and are associated with specific biologic variables and poor outcome. Blood 1993; 81: 2386-2393.
    • (1993) Blood , vol.81 , pp. 2386-2393
    • Chen, C.S.1    Sorensen, P.H.2    Domer, P.H.3    Reaman, G.H.4    Korsmeyer, S.J.5    Heerema, N.A.6
  • 10
  • 11
    • 0035839952 scopus 로고    scopus 로고
    • Molecular mechanisms of leukemogenesis mediated by MLL fusion proteins
    • Ayton PM, Cleary ML. Molecular mechanisms of leukemogenesis mediated by MLL fusion proteins. Oncogene 2001; 20: 5695-5707.
    • (2001) Oncogene , vol.20 , pp. 5695-5707
    • Ayton, P.M.1    Cleary, M.L.2
  • 12
    • 17044413548 scopus 로고    scopus 로고
    • The versatile mixed lineage leukaemia gene MLL and its many associations in leukaemogenesis
    • Daser A, Rabbitts TH. The versatile mixed lineage leukaemia gene MLL and its many associations in leukaemogenesis. Semin Cancer Biol 2005; 15: 175-188.
    • (2005) Semin Cancer Biol , vol.15 , pp. 175-188
    • Daser, A.1    Rabbitts, T.H.2
  • 13
    • 0030791974 scopus 로고    scopus 로고
    • Immortalization and leukemic transformation of a myelomonocytic precursor by retrovirally transduced HRX-ENL
    • Lavau C, Szilvassy SJ, Slany R, Cleary ML. Immortalization and leukemic transformation of a myelomonocytic precursor by retrovirally transduced HRX-ENL. EMBO J 1997; 16: 4226-4237.
    • (1997) EMBO J , vol.16 , pp. 4226-4237
    • Lavau, C.1    Szilvassy, S.J.2    Slany, R.3    Cleary, M.L.4
  • 14
    • 0034282527 scopus 로고    scopus 로고
    • Chromatin-related properties of CBP fused to MLL generate a myelodysplastic-like syndrome that evolves into myeloid leukemia
    • Lavau C, Du C, Thirman M, Zeleznik-Le N. Chromatin-related properties of CBP fused to MLL generate a myelodysplastic-like syndrome that evolves into myeloid leukemia. EMBO J 2000; 19: 4655-4664.
    • (2000) EMBO J , vol.19 , pp. 4655-4664
    • Lavau, C.1    Du, C.2    Thirman, M.3    Zeleznik-Le, N.4
  • 15
    • 0034718552 scopus 로고    scopus 로고
    • Retrovirus-mediated gene transfer of MLL-ELL transforms primary myeloid progenitors and causes acute myeloid leukemias in mice
    • Lavau C, Luo RT, Du C, Thirman MJ. Retrovirus-mediated gene transfer of MLL-ELL transforms primary myeloid progenitors and causes acute myeloid leukemias in mice. Proc Natl Acad Sci USA 2000; 97: 10984-10989.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 10984-10989
    • Lavau, C.1    Luo, R.T.2    Du, C.3    Thirman, M.J.4
  • 16
    • 0034548830 scopus 로고    scopus 로고
    • A carboxy-terminal domain of ELL is required and sufficient for immortalization of myeloid progenitors by MLL-ELL
    • DiMartino JF, Miller T, Ayton PM, Landewe T, Hess JL, Cleary ML et al. A carboxy-terminal domain of ELL is required and sufficient for immortalization of myeloid progenitors by MLL-ELL. Blood 2000; 96: 3887-3893.
    • (2000) Blood , vol.96 , pp. 3887-3893
    • DiMartino, J.F.1    Miller, T.2    Ayton, P.M.3    Landewe, T.4    Hess, J.L.5    Cleary, M.L.6
  • 17
    • 0037093081 scopus 로고    scopus 로고
    • The AF10 leucine zipper is required for leukemic transformation of myeloid progenitors by MLL-AF10
    • DiMartino JF, Ayton PM, Chen EH, Naftzger CC, Young BD, Cleary ML. The AF10 leucine zipper is required for leukemic transformation of myeloid progenitors by MLL-AF10. Blood 2002; 99: 3780-3785.
    • (2002) Blood , vol.99 , pp. 3780-3785
    • DiMartino, J.F.1    Ayton, P.M.2    Chen, E.H.3    Naftzger, C.C.4    Young, B.D.5    Cleary, M.L.6
  • 18
    • 0036723650 scopus 로고    scopus 로고
    • MLL-AFX requires the transcriptional effector domains of AFX to transform myeloid progenitors and transdominantly interfere with forkhead protein function
    • So CW, Cleary ML. MLL-AFX requires the transcriptional effector domains of AFX to transform myeloid progenitors and transdominantly interfere with forkhead protein function. Mol Cell Biol 2002; 22: 6542-6552.
    • (2002) Mol Cell Biol , vol.22 , pp. 6542-6552
    • So, C.W.1    Cleary, M.L.2
  • 19
    • 0037438589 scopus 로고    scopus 로고
    • Common mechanism for oncogenic activation of MLL by forkhead family proteins
    • So CW, Cleary ML. Common mechanism for oncogenic activation of MLL by forkhead family proteins. Blood 2003; 101: 633-639.
    • (2003) Blood , vol.101 , pp. 633-639
    • So, C.W.1    Cleary, M.L.2
  • 20
    • 0042885909 scopus 로고    scopus 로고
    • Dimerization contributes to oncogenic activation of MLL chimeras in acute leukemias
    • So CW, Lin M, Ayton PM, Chen EH, Cleary ML. Dimerization contributes to oncogenic activation of MLL chimeras in acute leukemias. Cancer Cell 2003; 4: 99-110.
    • (2003) Cancer Cell , vol.4 , pp. 99-110
    • So, C.W.1    Lin, M.2    Ayton, P.M.3    Chen, E.H.4    Cleary, M.L.5
  • 21
    • 0042872887 scopus 로고    scopus 로고
    • MLL-GAS7 transforms multipotent hematopoietic progenitors and induces mixed lineage leukemias in mice
    • So CW, Karsunky H, Passegue E, Cozzio A, Weissman IL, Cleary ML. MLL-GAS7 transforms multipotent hematopoietic progenitors and induces mixed lineage leukemias in mice. Cancer Cell 2003; 3: 161-171.
    • (2003) Cancer Cell , vol.3 , pp. 161-171
    • So, C.W.1    Karsunky, H.2    Passegue, E.3    Cozzio, A.4    Weissman, I.L.5    Cleary, M.L.6
  • 22
    • 16844380787 scopus 로고    scopus 로고
    • Dimerization of MLL fusion proteins and FLT3 activation syngergize to induce multiple-lineage leukemogenesis
    • Ono R, Nakajima H, Ozaki K, Kumagai H, Kawashima T, Taki T et al. Dimerization of MLL fusion proteins and FLT3 activation syngergize to induce multiple-lineage leukemogenesis. J Clin Invest 2005; 115: 919-929.
    • (2005) J Clin Invest , vol.115 , pp. 919-929
    • Ono, R.1    Nakajima, H.2    Ozaki, K.3    Kumagai, H.4    Kawashima, T.5    Taki, T.6
  • 23
    • 15844394270 scopus 로고    scopus 로고
    • An Mll-AF9 fusion gene made by homologous recombination causes acute leukemia in chimeric mice: A method to create fusion oncogenes
    • Corral J, Lavenir I, Impey H, Warren AJ, Forster A, Larson TA et al. An Mll-AF9 fusion gene made by homologous recombination causes acute leukemia in chimeric mice: A method to create fusion oncogenes. Cell 1996; 85: 853-861.
    • (1996) Cell , vol.85 , pp. 853-861
    • Corral, J.1    Lavenir, I.2    Impey, H.3    Warren, A.J.4    Forster, A.5    Larson, T.A.6
  • 24
    • 0034252206 scopus 로고    scopus 로고
    • Interchromosomal recombination of Mll and Af9 genes mediated by cre-loxP in mouse development
    • Collins EC, Pannell R, Simpson EM, Forster A, Rabbitts TH. Interchromosomal recombination of Mll and Af9 genes mediated by cre-loxP in mouse development. EMBO Rep 2000; 1: 127-132.
    • (2000) EMBO Rep , vol.1 , pp. 127-132
    • Collins, E.C.1    Pannell, R.2    Simpson, E.M.3    Forster, A.4    Rabbitts, T.H.5
  • 25
    • 0345582392 scopus 로고    scopus 로고
    • Engineering de novo reciprocal chromosomal translocations associated with Mll to replicate primary events of human cancer
    • Forster A, Pannell R, Drynan LF, McCormack M, Collins EC, Daser A et al. Engineering de novo reciprocal chromosomal translocations associated with Mll to replicate primary events of human cancer. Cancer Cell 2003; 3: 449-458.
    • (2003) Cancer Cell , vol.3 , pp. 449-458
    • Forster, A.1    Pannell., R.2    Drynan, L.F.3    McCormack, M.4    Collins, E.C.5    Daser, A.6
  • 26
    • 13444311619 scopus 로고    scopus 로고
    • Conditional MLL-CBP targets GMP and models therapyrelated myeloproliferative disease
    • Wang J, Iwasaki H, Krivtsov A, Febbo PG, Thorner AR, Ernst P et al. Conditional MLL-CBP targets GMP and models therapyrelated myeloproliferative disease. EMBO J 2005; 24: 368-381.
    • (2005) EMBO J , vol.24 , pp. 368-381
    • Wang, J.1    Iwasaki, H.2    Krivtsov, A.3    Febbo, P.G.4    Thorner, A.R.5    Ernst, P.6
  • 27
    • 33745941911 scopus 로고    scopus 로고
    • A murine Mll-AF4 knockin model results in lymphoid and myeloid deregulation and hematological malignancy
    • Chen W, Li Q, Hudson WA, Kumur A, Kirchhof N, Kersey JH. A murine Mll-AF4 knockin model results in lymphoid and myeloid deregulation and hematological malignancy. Blood 2006; 108: 669-677.
    • (2006) Blood , vol.108 , pp. 669-677
    • Chen, W.1    Li, Q.2    Hudson, W.A.3    Kumur, A.4    Kirchhof, N.5    Kersey, J.H.6
  • 28
    • 33745103352 scopus 로고    scopus 로고
    • A conditional model of MLL-AF4 B-cell tumourigenesis using invertor technology
    • Metzler M, Forster A, Pannell R, Arends MJ, Daser A, Lobato MN et al. A conditional model of MLL-AF4 B-cell tumourigenesis using invertor technology. Oncogene 2006; 25: 3093-3103.
    • (2006) Oncogene , vol.25 , pp. 3093-3103
    • Metzler, M.1    Forster, A.2    Pannell, R.3    Arends, M.J.4    Daser, A.5    Lobato, M.N.6
  • 30
    • 9444283773 scopus 로고    scopus 로고
    • Gene expression profiling of pediatric acute myelogenous leukemia
    • Ross ME, Mahfouz R, Onciu M, Liu HC, Zhou X, Song G et al. Gene expression profiling of pediatric acute myelogenous leukemia. Blood 2004; 104: 3679-3687.
    • (2004) Blood , vol.104 , pp. 3679-3687
    • Ross, M.E.1    Mahfouz, R.2    Onciu, M.3    Liu, H.C.4    Zhou, X.5    Song, G.6
  • 31
    • 20844444316 scopus 로고    scopus 로고
    • New insights into MLL gene rearranged acute leukemias using gene expression profiling: Shared pathways, lineage commitment, and partner genes
    • Kohlmann A, Schoch C, Dugas M, Schnittger S, Hiddemann W, Kern W et al. New insights into MLL gene rearranged acute leukemias using gene expression profiling: Shared pathways, lineage commitment, and partner genes. Leukemia 2005; 19: 953-964.
    • (2005) Leukemia , vol.19 , pp. 953-964
    • Kohlmann, A.1    Schoch, C.2    Dugas, M.3    Schnittger, S.4    Hiddemann, W.5    Kern, W.6
  • 32
    • 0041370095 scopus 로고    scopus 로고
    • Transformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa7 and Hoxa9
    • Ayton PM, Cleary ML. Transformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa7 and Hoxa9. Genes Dev 2003; 17: 2298-2307.
    • (2003) Genes Dev , vol.17 , pp. 2298-2307
    • Ayton, P.M.1    Cleary, M.L.2
  • 33
    • 1442356858 scopus 로고    scopus 로고
    • Hoxa9 influences the phenotype but not the incidence of Mll-AF9 fusion gene leukemia
    • Kumar AR, Hudson WA, Chen W, Nishiuchi R, Yao Q, Kersey JH. Hoxa9 influences the phenotype but not the incidence of Mll-AF9 fusion gene leukemia. Blood 2004; 103: 1823-1828.
    • (2004) Blood , vol.103 , pp. 1823-1828
    • Kumar, A.R.1    Hudson, W.A.2    Chen, W.3    Nishiuchi, R.4    Yao, Q.5    Kersey, J.H.6
  • 35
    • 1842579481 scopus 로고    scopus 로고
    • Leukemic transformation of hematopoietic progenitors by MLL-GAS7 in the absence of Hoxa7 or Hoxa9
    • So CW, Karsunky H, Wong P, Weissman IL, Cleary ML. Leukemic transformation of hematopoietic progenitors by MLL-GAS7 in the absence of Hoxa7 or Hoxa9. Blood 2004; 103: 3192-3199.
    • (2004) Blood , vol.103 , pp. 3192-3199
    • So, C.W.1    Karsunky, H.2    Wong, P.3    Weissman, I.L.4    Cleary, M.L.5
  • 36
    • 0038620318 scopus 로고    scopus 로고
    • Prenatal and postnatal myeloid cells demonstrate stepwise progression in the pathogenesis of MLL fusion gene leukemia
    • Johnson JJ, Chen W, Hudson W, Yao Q, Taylor M, Rabbitts TH et al. Prenatal and postnatal myeloid cells demonstrate stepwise progression in the pathogenesis of MLL fusion gene leukemia. Blood 2003; 101: 3229-3235.
    • (2003) Blood , vol.101 , pp. 3229-3235
    • Johnson, J.J.1    Chen, W.2    Hudson, W.3    Yao, Q.4    Taylor, M.5    Rabbitts, T.H.6
  • 37
    • 0000778884 scopus 로고    scopus 로고
    • EEN encodes for a member of a new family of proteins containing an Src homology 3 domain and is the third gene located on chromosome 19p13 that fuses to MLL in human leukemia
    • So CW, Caldas C, Liu MM, Chen SJ, Huang QH, Gu LJ et al. EEN encodes for a member of a new family of proteins containing an Src homology 3 domain and is the third gene located on chromosome 19p13 that fuses to MLL in human leukemia. Proc Natl Acad Sci USA 1997; 94: 2563-2568.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 2563-2568
    • So, C.W.1    Caldas, C.2    Liu, M.M.3    Chen, S.J.4    Huang, Q.H.5    Gu, L.J.6
  • 38
    • 0033539120 scopus 로고    scopus 로고
    • Endophilin I mediates synaptic vesicle formation by transfer of arachidonate to lysophosphatidic acid
    • Schmidt A, Wolde M, Thiele C, Fest W, Kratzin H, Podtelejnikov AV et al. Endophilin I mediates synaptic vesicle formation by transfer of arachidonate to lysophosphatidic acid. Nature 1999; 401: 133-141.
    • (1999) Nature , vol.401 , pp. 133-141
    • Schmidt, A.1    Wolde, M.2    Thiele, C.3    Fest, W.4    Kratzin, H.5    Podtelejnikov, A.V.6
  • 39
    • 0033147449 scopus 로고    scopus 로고
    • SH3-domain-containing proteins function at distinct steps in clathrin-coated vesicle formation
    • Simpson F, Hussain NK, Qualmann B, Kelly RB, Kay BK, McPherson PS et al. SH3-domain-containing proteins function at distinct steps in clathrin-coated vesicle formation. Nat Cell Biol 1999; 1: 119-124.
    • (1999) Nat Cell Biol , vol.1 , pp. 119-124
    • Simpson, F.1    Hussain, N.K.2    Qualmann, B.3    Kelly, R.B.4    Kay, B.K.5    McPherson, P.S.6
  • 40
    • 0033199465 scopus 로고    scopus 로고
    • Endophilin/SH3p4 is required for the transition from early to late stages in clathrin-mediated synaptic vesicle endocytosis
    • Ringstad N, Gad H, Low P, Di Paolo G, Brodin L, Shupliakov O et al. Endophilin/SH3p4 is required for the transition from early to late stages in clathrin-mediated synaptic vesicle endocytosis. Neuron 1999; 24: 143-154.
    • (1999) Neuron , vol.24 , pp. 143-154
    • Ringstad, N.1    Gad, H.2    Low, P.3    Di Paolo, G.4    Brodin, L.5    Shupliakov, O.6
  • 41
    • 0034119048 scopus 로고    scopus 로고
    • The interaction between EEN and Abi-1, two MLL fusion partners, and synaptojanin and dynamin: Implications for leukaemogenesis
    • So CW, So CK, Cheung N, Chew SL, Sham MH, Chan LC. The interaction between EEN and Abi-1, two MLL fusion partners, and synaptojanin and dynamin: Implications for leukaemogenesis. Leukemia 2000; 14: 594-601.
    • (2000) Leukemia , vol.14 , pp. 594-601
    • So, C.W.1    So, C.K.2    Cheung, N.3    Chew, S.L.4    Sham, M.H.5    Chan, L.C.6
  • 42
    • 6344248913 scopus 로고    scopus 로고
    • Subcellular localization of EEN/endophilin A2, a fusion partner gene in leukaemia
    • Cheung N, So CW, Yam JW, So CK, Poon RY, Jin DY et al. Subcellular localization of EEN/endophilin A2, a fusion partner gene in leukaemia. Biochem J 2004; 383: 27-35.
    • (2004) Biochem J , vol.383 , pp. 27-35
    • Cheung, N.1    So, C.W.2    Yam, J.W.3    So, C.K.4    Poon, R.Y.5    Jin, D.Y.6
  • 43
    • 0842307321 scopus 로고    scopus 로고
    • Identification and characterization of EBP, a novel EEN binding protein that inhibits Ras signaling and is recruited into the nucleus by the MLL-EEN fusion protein
    • Yam JW, Jin DY, So CW, Chan LC. Identification and characterization of EBP, a novel EEN binding protein that inhibits Ras signaling and is recruited into the nucleus by the MLL-EEN fusion protein. Blood 2004; 103: 1445-1453.
    • (2004) Blood , vol.103 , pp. 1445-1453
    • Yam, J.W.1    Jin, D.Y.2    So, C.W.3    Chan, L.C.4
  • 44
    • 2442720107 scopus 로고    scopus 로고
    • Functional contribution of EEN to leukemogenic transformation by MLL-EEN fusion protein
    • Liu H, Chen B, Xiong H, Huang QH, Zhang QH, Wnag ZG et al. Functional contribution of EEN to leukemogenic transformation by MLL-EEN fusion protein. Oncogene 2004; 23: 3385-3394.
    • (2004) Oncogene , vol.23 , pp. 3385-3394
    • Liu, H.1    Chen, B.2    Xiong, H.3    Huang, Q.H.4    Zhang, Q.H.5    Wnag, Z.G.6
  • 46
    • 0031664853 scopus 로고    scopus 로고
    • A new logic for DNA engineering using recombination in Escherichia coli
    • Zhang Y, Buchholz F, Muyrers JP, Stewart AF. A new logic for DNA engineering using recombination in Escherichia coli. Nat Genet 1998; 20: 123-128.
    • (1998) Nat Genet , vol.20 , pp. 123-128
    • Zhang, Y.1    Buchholz, F.2    Muyrers, J.P.3    Stewart, A.F.4
  • 47
    • 0034161495 scopus 로고    scopus 로고
    • Tumorigenesis in mice with a fusion of the leukaemia oncogene Mll and the bacterial lacZ gene
    • Dobson CL, Warren AJ, Pannell R, Forster A, Rabbitts TH. Tumorigenesis in mice with a fusion of the leukaemia oncogene Mll and the bacterial lacZ gene. EMBO J 2000; 19: 843-851.
    • (2000) EMBO J , vol.19 , pp. 843-851
    • Dobson, C.L.1    Warren, A.J.2    Pannell, R.3    Forster, A.4    Rabbitts, T.H.5
  • 48
    • 19344361972 scopus 로고    scopus 로고
    • Generation of hematopoietic repopulating cells from human embryonic stem cells independent of ectopic HOXB4 expression
    • Wang L, Menendez P, Shojaei F, Li L, Mazurier F, Dick JE et al. Generation of hematopoietic repopulating cells from human embryonic stem cells independent of ectopic HOXB4 expression. J Exp Med 2005; 201: 1603-1614.
    • (2005) J Exp Med , vol.201 , pp. 1603-1614
    • Wang, L.1    Menendez, P.2    Shojaei, F.3    Li, L.4    Mazurier, F.5    Dick, J.E.6
  • 49
    • 0029091845 scopus 로고
    • Overexpression of HOXB4 in hematopoietic cells causes the selective expansion of more primitive populations in vitro and in vivo
    • Sauvageau G, Thorsteinsdottir U, Eaves CJ, Lawrence HJ, Largman C, Lansdorp PM et al. Overexpression of HOXB4 in hematopoietic cells causes the selective expansion of more primitive populations in vitro and in vivo. Genes Dev 1995; 9: 1753-1765.
    • (1995) Genes Dev , vol.9 , pp. 1753-1765
    • Sauvageau, G.1    Thorsteinsdottir, U.2    Eaves, C.J.3    Lawrence, H.J.4    Largman, C.5    Lansdorp, P.M.6
  • 50
    • 0037023528 scopus 로고    scopus 로고
    • HOXB4-induced expansion of adult hematopoietic stem cells ex vivo
    • Antonchuk J, Sauvageau G, Humphries RK. HOXB4-induced expansion of adult hematopoietic stem cells ex vivo. Cell 2002; 109: 39-45.
    • (2002) Cell , vol.109 , pp. 39-45
    • Antonchuk, J.1    Sauvageau, G.2    Humphries, R.K.3
  • 52
    • 3543041878 scopus 로고    scopus 로고
    • Defective downregulation of receptor tyrosine kinases in cancer
    • Bache KG, Slagsvold T, Stenmark H. Defective downregulation of receptor tyrosine kinases in cancer. EMBO J 2004; 23: 2707-2712.
    • (2004) EMBO J , vol.23 , pp. 2707-2712
    • Bache, K.G.1    Slagsvold, T.2    Stenmark, H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.