Studies on 5-lipoxygenase inhibitors. I. Synthesis and 5-lipoxygenase- inhibitory activity of novel hydroxamic acid derivatives

Chemical and Pharmaceutical Bulletin

Volumn 46, Issue 6, 1998, Pages 966-972

  Yatabe, Takumi ^a   Kawai, Yoshio ^a   Oku, Teruo ^a   Tanaka, Hirokazu ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

5 Lipoxygenase inhibitor; Air pouch model; D galactosamine induced hepatitis; FR122788; N (3,4 dihydro 5 phenoxy) 2 naphthyl methyl N hydroxy N' ethylurea; Neutrophil migration

Indexed keywords

ALANINE AMINOTRANSFERASE; AMINOTRANSFERASE; ARACHIDONATE 5 LIPOXYGENASE; ASPARTATE AMINOTRANSFERASE; HYDROXAMIC ACID DERIVATIVE; HYDROXYLAMINE; N [[(3,4 DIHYDRO 5 PHENOXY) 2 NAPHTHYL]METHYL] N HYDROXY N' ETHYLUREA; UNCLASSIFIED DRUG;

ARACHIDONIC ACID METABOLISM; ARTICLE; CATALYSIS; CELL MIGRATION; DRUG POTENCY; ENZYME ACTIVITY; ENZYME INHIBITION; NONHUMAN; RAT; SYNTHESIS;

EID: 0031903983     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.46.966     Document Type: Article

References (3)

1. Sirois P., Adv. Lipid Res., 21, 79 - 101 (1985).
2. Cashman J. R., Pharm. Res., 1985, 253 - 261.
3. Kiehl H., Missouri K., "The Chemistry and Biology of Hydroxamic Acids," Karger, Basle, 1982.