메뉴 건너뛰기




Volumn 18, Issue 8, 2006, Pages 644-651

Interconversion and tissue distribution of pentoxifylline and lisofylline in mice

Author keywords

Enantioselective disposition; Interconversion clearance, tissue to serum AUC ratio; Pharmacokinetic model

Indexed keywords

LISOFYLLINE; PENTOXIFYLLINE;

EID: 33750060076     PISSN: 08990042     EISSN: 1520636X     Source Type: Journal    
DOI: 10.1002/chir.20299     Document Type: Article
Times cited : (15)

References (24)
  • 2
    • 0036154530 scopus 로고    scopus 로고
    • Immunopharmacological potential of selective phosphodiesterase inhibition. I. Differential regulation of lipopolysaccharide-mediated proinflammatory cytokine (interleukin-6 and tumor necrosis factor-α) biosynthesis in alveolar epithelial cells
    • Haddad JJ, Land SC, Tarnow-Mordi WO, Zembala M, Kowalczyk D, Lauterbach R. Immunopharmacological potential of selective phosphodiesterase inhibition. I. Differential regulation of lipopolysaccharide-mediated proinflammatory cytokine (interleukin-6 and tumor necrosis factor-α) biosynthesis in alveolar epithelial cells. J Pharmacol Exp Ther 2002;300:559-566.
    • (2002) J Pharmacol Exp Ther , vol.300 , pp. 559-566
    • Haddad, J.J.1    Land, S.C.2    Tarnow-Mordi, W.O.3    Zembala, M.4    Kowalczyk, D.5    Lauterbach, R.6
  • 3
    • 0025059497 scopus 로고
    • Pentoxifylline inhibits lipopolysaccharide-induced serum tumor necrosis factor and mortality
    • Noel PS, Nelson R, Bokulic G, Bagby H, Lippton G, Lipscomb G, Summer W. Pentoxifylline inhibits lipopolysaccharide-induced serum tumor necrosis factor and mortality. Life Sci 1990;47:1023-1029.
    • (1990) Life Sci , vol.47 , pp. 1023-1029
    • Noel, P.S.1    Nelson, R.2    Bokulic, G.3    Bagby, H.4    Lippton, G.5    Lipscomb, G.6    Summer, W.7
  • 4
    • 9044224023 scopus 로고    scopus 로고
    • Effects of pentoxifylline on circulating cytokine concentrations and hemodynamics in patients with septic shock: Results from a double-blind, randomized, placebo-controlled study
    • Zeni F, Pain P, Vindimian M, Gay JP, Gery P, Bertrand M, Page Y, Page D, Vermesch R, Bertrand JC. Effects of pentoxifylline on circulating cytokine concentrations and hemodynamics in patients with septic shock: results from a double-blind, randomized, placebo-controlled study. Crit Care Med 1996;24:207-214.
    • (1996) Crit Care Med , vol.24 , pp. 207-214
    • Zeni, F.1    Pain, P.2    Vindimian, M.3    Gay, J.P.4    Gery, P.5    Bertrand, M.6    Page, Y.7    Page, D.8    Vermesch, R.9    Bertrand, J.C.10
  • 5
    • 0032916980 scopus 로고    scopus 로고
    • Effect of the immunomodulating agent, pentoxifylline, in the treatment of sepsis in prematurely delivered infants: A placebo-controlled, double-blind trial
    • Lauterbach R, Pawlik D, Kowalczyk D, Ksyciński W, Helwich E, Zembala M. Effect of the immunomodulating agent, pentoxifylline, in the treatment of sepsis in prematurely delivered infants: a placebo-controlled, double-blind trial. Crit Care Med 1999;27:807-814.
    • (1999) Crit Care Med , vol.27 , pp. 807-814
    • Lauterbach, R.1    Pawlik, D.2    Kowalczyk, D.3    Ksyciński, W.4    Helwich, E.5    Zembala, M.6
  • 6
    • 0029068531 scopus 로고
    • Hemorrheologic effects of metabolites of pentoxifylline (Trental)
    • Ambrus JL, Stadler S, Kulaylat M. Hemorrheologic effects of metabolites of pentoxifylline (Trental). J Med 1995;26:65-75.
    • (1995) J Med , vol.26 , pp. 65-75
    • Ambrus, J.L.1    Stadler, S.2    Kulaylat, M.3
  • 7
    • 0030046730 scopus 로고    scopus 로고
    • Substituted xanthines, pteridinediones, and related compounds as potential anti-inflammatory agents. Synthesis and biological evaluation of inhibitors of tumor necrosis factor α
    • Cottam HB, Shih H, Tehrani LR, Wasson DB, Carson DA. Substituted xanthines, pteridinediones, and related compounds as potential anti-inflammatory agents. Synthesis and biological evaluation of inhibitors of tumor necrosis factor α. J Med Chem 1996;39:2-9.
    • (1996) J Med Chem , vol.39 , pp. 2-9
    • Cottam, H.B.1    Shih, H.2    Tehrani, L.R.3    Wasson, D.B.4    Carson, D.A.5
  • 9
    • 9944249163 scopus 로고    scopus 로고
    • Lisofylline: A potential lead for the treatment of diabetes
    • Yang Z, Chen M, Nadler JL. Lisofylline: a potential lead for the treatment of diabetes. Biochem Pharm 2005;69:1-5.
    • (2005) Biochem Pharm , vol.69 , pp. 1-5
    • Yang, Z.1    Chen, M.2    Nadler, J.L.3
  • 10
    • 0038447123 scopus 로고    scopus 로고
    • Receptors, mediators, and mechanisms involved in bacterial sepsis and septic shock
    • Van Amersfoort ES, Van Berkel TJC, Kuiper J. Receptors, mediators, and mechanisms involved in bacterial sepsis and septic shock. Clin Microbiol Rev 2003;16:379-414.
    • (2003) Clin Microbiol Rev , vol.16 , pp. 379-414
    • Van Amersfoort, E.S.1    Van Berkel, T.J.C.2    Kuiper, J.3
  • 11
    • 0030476589 scopus 로고    scopus 로고
    • Metabolism of lisofylline and pentoxifylline in human liver microsomes and cytosol
    • Lillibridge JA, Kalhorn TF, Slattery JT. Metabolism of lisofylline and pentoxifylline in human liver microsomes and cytosol. Drug Metab Dis 1996;24:1174-1179.
    • (1996) Drug Metab Dis , vol.24 , pp. 1174-1179
    • Lillibridge, J.A.1    Kalhorn, T.F.2    Slattery, J.T.3
  • 12
    • 0003571287 scopus 로고    scopus 로고
    • Stockholm: Swedish Pharmaceutical Press
    • nd ed. Stockholm: Swedish Pharmaceutical Press; 1997. p 770.
    • (1997) nd Ed. , pp. 770
    • Gabrielsson, J.1    Weiner, D.2
  • 13
    • 0031662749 scopus 로고    scopus 로고
    • Pharmacokinetics of pentoxifylline and its metabolites in healthy mice and in mice infected with Candida albicans
    • Miller K, Louie A, Baltch AL, Smith RP, Davis PJ, Gordon MA. Pharmacokinetics of pentoxifylline and its metabolites in healthy mice and in mice infected with Candida albicans. Antimicrob Agents Chemother 1998;42:2405-2409.
    • (1998) Antimicrob Agents Chemother , vol.42 , pp. 2405-2409
    • Miller, K.1    Louie, A.2    Baltch, A.L.3    Smith, R.P.4    Davis, P.J.5    Gordon, M.A.6
  • 14
    • 0022578529 scopus 로고
    • Inhibition of pentoxifylline clearance by cimetidine
    • Luke DR, Rocci ML, Hoholick C. Inhibition of pentoxifylline clearance by cimetidine. J Pharm Sci 1986;75:155-157.
    • (1986) J Pharm Sci , vol.75 , pp. 155-157
    • Luke, D.R.1    Rocci, M.L.2    Hoholick, C.3
  • 15
    • 0015394134 scopus 로고
    • Zur pharmakokinetik von 3,7-dimethyl-1-(5-oxo-hexyl)-xanthin (BL 191) am menschen
    • Hinze HJ. Zur Pharmakokinetik von 3,7-Dimethyl-1-(5-oxo-hexyl)-xanthin (BL 191) am Menschen. Arzneim-Forsch 1972;22:1492-1495.
    • (1972) Arzneim-Forsch , vol.22 , pp. 1492-1495
    • Hinze, H.J.1
  • 19
    • 0036063383 scopus 로고    scopus 로고
    • Stereoselective metabolism of pentoxifylline in vitro and in vivo in humans
    • Nicklasson M, Björkman S, Roth B, Jönsson M, Hoglund P. Stereoselective metabolism of pentoxifylline in vitro and in vivo in humans. Chirality 2002;14:643-652.
    • (2002) Chirality , vol.14 , pp. 643-652
    • Nicklasson, M.1    Björkman, S.2    Roth, B.3    Jönsson, M.4    Hoglund, P.5
  • 21
    • 0017128325 scopus 로고
    • Bioavailability and pharmacokinetics of pentoxifylline from Trental 400' in man
    • Hinze HJ, Grigoleit HG, Rethy B. Bioavailability and pharmacokinetics of pentoxifylline from Trental 400' in man. Pharmatherapeutica 1976;1:160-171.
    • (1976) Pharmatherapeutica , vol.1 , pp. 160-171
    • Hinze, H.J.1    Grigoleit, H.G.2    Rethy, B.3
  • 22
    • 0025051922 scopus 로고
    • Localization of pulmonary carbonyl reductase in guinea pig and mouse: Enzyme histochemical and immunohistochemical studies
    • Matsura K, Hara A, Sawada H, Bunai Y, Ohya I. Localization of pulmonary carbonyl reductase in guinea pig and mouse: enzyme histochemical and immunohistochemical studies. J Histochem Cytochem 1990;38:217-223.
    • (1990) J Histochem Cytochem , vol.38 , pp. 217-223
    • Matsura, K.1    Hara, A.2    Sawada, H.3    Bunai, Y.4    Ohya, I.5
  • 24
    • 0030975513 scopus 로고    scopus 로고
    • Effect of lisofylline and pentoxifylline on the bacterial-stimulated production of TNF-α, IL-1β and IL-10 by human leucocytes
    • Van Furth AM, Verhard-Seijmonsbergen EM, Van Furth R, Langermans JAM. Effect of lisofylline and pentoxifylline on the bacterial-stimulated production of TNF-α, IL-1β and IL-10 by human leucocytes. Immunology 1997;91:193-196.
    • (1997) Immunology , vol.91 , pp. 193-196
    • Van Furth, A.M.1    Verhard-Seijmonsbergen, E.M.2    Van Furth, R.3    Langermans, J.A.M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.