Substituted xanthines, pteridinediones, and related compounds as potential antiinflammatory agents. Synthesis and biological evaluation of inhibitors of tumor necrosis factor α

Journal of Medicinal Chemistry

Volumn 39, Issue 1, 1996, Pages 2-9

  Cottam, Howard B ^a   Shih, Hsiencheng ^a   Tehrani, Lida R ^a   Wasson, D Bruce ^a   Carson, Dennis A ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFLAMMATORY AGENT; BACTERIUM LIPOPOLYSACCHARIDE; CYCLIC AMP PHOSPHODIESTERASE; PENTOXIFYLLINE; TUMOR NECROSIS FACTOR ALPHA;

ALKYLATION; ANIMAL CELL; ARTICLE; CELL DAMAGE; CHRONIC INFLAMMATION; FEMALE; HUMAN; HUMAN CELL; LEUKOPENIA; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE;

3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; 4-(3-BUTOXY-4-METHOXYBENZYL)-2-IMIDAZOLIDINONE; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; LEUKOPENIA; LIPOPOLYSACCHARIDES; MICE; MICE, INBRED STRAINS; MOLECULAR STRUCTURE; MONOCYTES; NEUTROPHILS; PENTOXIFYLLINE; PHOSPHODIESTERASE INHIBITORS; PHOSPHORIC DIESTER HYDROLASES; PTERIDINES; TUMOR NECROSIS FACTOR-ALPHA; XANTHINES;

EID: 0030046730     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm940845j     Document Type: Article

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