Development of long-acting dopamine transporter ligands as potential cocaine-abuse therapeutic agents: Chiral hydroxyl-containing derivatives of 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine and 1-[2-(diphenylmethoxy) ethyl]-4-(3-phenylpropyl)piperazine

Journal of Medicinal Chemistry

Volumn 45, Issue 6, 2002, Pages 1321-1329

  Hsin, Ling Wei ^a,b   Dersch, Christina M ^c   Baumann, Michael H ^c   Stafford, David ^d   Glowa, John R ^d   Rothman, Richard B ^c   Jacobson, Arthur E ^a   Rice, Kenner C ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^c NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

^d NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 [2 (BENZHYDRYLOXY)ETHYL] 4 (3 PHENYLPROPYL)PIPERAZINE; 1 [2 (DIPHENYLMETHOXY)ETHYL] 4 (3 PHENYLPROPYL)PIPERAZINE DERIVATIVE; 1 [2 [BIS(4 FLUOROPHENYL)METHOXY]ETHYL] 4 (3 PHENYLPROPYL)PIPERAZINE DERIVATIVE; 1 [4 [2 (DIPHENYLMETHOXY)ETHYL]PIPERAZINYL] 3 PHENYLPROPAN 2 OL; 1 [4 [2 [BIS(4 FLUOROPHENYL)METHOXY]ETHYL]PIPERAZINYL] 3 PHENYLPROPAN 2 OL; DOPAMINE TRANSPORTER; PIPERAZINE DERIVATIVE; UNCLASSIFIED DRUG; VANOXERINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; COCAINE DEPENDENCE; DOPAMINERGIC TRANSMISSION; DRUG POTENCY; DRUG SYNTHESIS; DRUG USE; MALE; NONHUMAN; RAT; RHESUS MONKEY;

ANIMALS; BEHAVIOR, ANIMAL; BENZHYDRYL COMPOUNDS; COCAINE-RELATED DISORDERS; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; DOPAMINE UPTAKE INHIBITORS; HUMANS; LIGANDS; MACACA MULATTA; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MICRODIALYSIS; NERVE TISSUE PROTEINS; PIPERAZINES; PROPANOLS; RATS; RATS, SPRAGUE-DAWLEY; STEREOISOMERISM;

EID: 0037075822     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010430f     Document Type: Article

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