Antibacterial activity of linear peptides spanning the carboxy-terminal β-sheet domain of arthropod defensins

Peptides

Volumn 27, Issue 11, 2006, Pages 2614-2623

  Varkey, Jobin ^a   Singh, Shashi ^a   Nagaraj, Ramakrishnan ^a  

^a CENTRE FOR CELLULAR AND MOLECULAR BIOLOGY   (India)

Author keywords

Arthropod defensins; Atomic force microscopy; Carboxy terminal analogs; Fluorescence microscopy; Salt sensitivity

Indexed keywords

ANTIINFECTIVE AGENT; DEFENSIN; DISULFIDE; INSECT PROTEIN;

AMINO ACID SEQUENCE; ANTIBACTERIAL ACTIVITY; ARTHROPOD; ARTICLE; ATOMIC FORCE MICROSCOPY; BACTERIAL MEMBRANE; BETA SHEET; CARBOXY TERMINAL SEQUENCE; DRUG POTENCY; ESCHERICHIA COLI; FLUORESCENCE MICROSCOPY; GRAM NEGATIVE BACTERIUM; MEMBRANE PERMEABILITY; NONHUMAN; NUCLEOTIDE SEQUENCE; OUTER MEMBRANE; PRIORITY JOURNAL; PROTEIN DOMAIN;

AMINO ACID SEQUENCE; ANIMALS; ANTI-BACTERIAL AGENTS; ARTHROPODS; BACTERIA; DEFENSINS; MOLECULAR SEQUENCE DATA; PEPTIDES; PROTEIN STRUCTURE, SECONDARY; SEQUENCE ALIGNMENT;

ARTHROPODA; ESCHERICHIA COLI; INSECTA; MAMMALIA; NEGIBACTERIA;

EID: 33750049357     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.peptides.2006.06.010     Document Type: Article

References (57)

1. Ahn H.S., Cho W., Kang S.H., Ko S.S., Park M.S., Cho H., et al. Design and synthesis of novel antimicrobial peptides on the basis of alpha helical domain of Tenecin 1, an insect defensin protein, and structure-activity relationship study. Peptides 27 (2006) 640-648
2. Atherton E., and Sheppard R.C. Solid phase synthesis: a practical approach (1989), IRL Press, Oxford
3. Blanco F.J., Jimenez M.A., Pineda A., Rico M., Santoro J., and Nieto J.L. NMR solution structure of the isolated N-terminal fragment of protein-G B1 domain. Evidence of trifluoroethanol induced native-like beta-hairpin formation. Biochemistry 33 (1994) 6004-6014
4. Blanco F.J., and Serrano L. Folding of protein G B1 domain studied by the conformational characterization of fragments comprising its secondary structure elements. Eur J Biochem 230 (1995) 634-649
5. Blondelle S.E., and Houghten R.A. Hemolytic and antimicrobial activities of the twenty four individual omission analogues of melittin. Biochemistry 30 (1991) 4671-4678
6. Bonmatin J.M., Bonnat J.L., Gallet X., Vovelle F., Ptak M., Reichhart J.M., et al. Two-dimensional 1H NMR study of recombinant insect defensin A in water: resonance assignments, secondary structure and global folding. J Biomol NMR 2 (1992) 235-256
7. Bulet P., Hetru C., Dimarcq J.L., and Hoffmann D. Antimicrobial peptides in insects; structure and function. Dev Comp Immunol 23 (1999) 329-344
8. Bulet P., Stocklin R., and Menin L. Antimicrobial peptides: from invertebrates to vertebrates. Immunol Rev 198 (2004) 169-184
9. Campopiano D.J., Clarke D.J., Polfer N.C., Barran P.E., Langley R.J., Govan J.R., et al. Structure-activity relationships in defensin dimers: a novel link between beta-defensin tertiary structure and antimicrobial activity. J Biol Chem 279 (2004) 48671-48679
10. Cociancich S., Ghazi A., Hetru C., Hoffmann J.A., and Letellier L. Insect defensin, an inducible antibacterial peptide, forms voltage-dependent channels in Micrococcus luteus. J Biol Chem 268 (1993) 19239-19245
11. Cociancich S., Goyffon M., Bontems F., Bulet P., Bouet F., Menez A., et al. Purification and characterization of a scorpion defensin, a 4 kDa antibacterial peptide presenting structural similarities with insect defensins and scorpion toxins. Biochem Biophys Res Commun 194 (1993) 17-22
12. Cociancich S., Dupont A., Hegy G., Lanot R., Holder F., Hetru C., et al. Novel inducible antibacterial peptides from a hemipteran insect, the sap-sucking bug Pyrrhocoris apterus. Biochem J 300 (1994) 567-575
13. Cornet B., Bonmatin J.M., Hetru C., Hoffmann J.A., Ptak M., and Vovelle F. Refined three-dimensional solution structure of insect defensin A. Structure 3 (1995) 435-448
14. Dimarcq J.L., Bulet P., Hetru C., and Hoffmann J. Cysteine-rich antimicrobial peptides in invertebrates. Biopolymers 47 (1998) 465-477
15. Engstrom Y. Induction and regulation of antimicrobial peptides in Drosophila. Dev Comp Immunol 23 (1999) 345-358
16. Fazio M.A., Oliveira Jr. V.X., Bulet P., Miranda M.T., Daffre S., and Miranda A. Structure-activity relationship studies of gomesin: importance of the disulfide bridges for conformation, bioactivities, and serum stability. Biopolymers 84 (2006) 205-218
17. Fehlbaum P., Bulet P., Chernysh S., Briand J.P., Roussel J.P., Letellier L., et al. Structure-activity analysis of thanatin, a 21-residue inducible insect defense peptide with sequence homology to frog skin antimicrobial peptides. Proc Natl Acad Sci USA 93 (1996) 1221-1225
18. Fishov I., and Woldringh C.L. Visualization of membrane domains in Escherichia coli. Mol Microbiol 32 (1999) 1166-1172
19. Froy O., and Gurevitz M. Arthropod and mollusk defensins-evolution by exon-shuffling. Trends Genet 19 (2003) 684-687
20. Hanzawa H., Shimada I., Kuzuhara T., Komano H., Kohda D., Inagaki F., et al. 1H nuclear magnetic resonance study of the solution conformation of an antibacterial protein, sapecin. FEBS Lett 269 (1990) 413-420
21. Harwig S.S., Waring A., Yang H.J., Cho Y., Tan L., and Lehrer R.I. Intramolecular disulfide bonds enhance the antimicrobial and lytic activities of protegrins at physiological sodium chloride concentrations. Eur J Biochem 240 (1996) 352-357
22. Hoffmann J.A. Innate immunity of insects. Curr Opin Immunol 7 (1995) 4-10
23. Hoover D.M., Rajashankar K.R., Blumenthal R., Puri A., Oppenheim J.J., Chertov O., et al. The structure of human beta-defensin-2 shows evidence of higher order oligomerization. J Biol Chem 275 (2000) 32911-32918
24. Hoover D.M., Chertov O., and Lubkowski J. The structure of human beta-defensin-1: new insights into structural properties of beta-defensins. J Biol Chem 276 (2001) 39021-39026
25. Hoover D.M., Wu Z., Tucker K., Lu W., and Lubkowski J. Antimicrobial characterization of human beta-defensin 3 derivatives. Antimicrob Agents Chemother 47 (2003) 2804-2809
26. Kimbrell D.A., and Beutler B. The evolution and genetics of innate immunity. Nat Rev Genet 2 (2001) 256-267
27. King D.S., Fields C.G., and Fields G.B. A cleavage method which minimizes side reactions following Fmoc solid phase peptide synthesis. Int J Pept Protein Res 36 (1990) 255-266
28. Kluver E., Schulz-Maronde S., Scheid S., Meyer B., Forssmann W.G., and Adermann K. Structure-activity relation of human beta-defensin 3: influence of disulfide bonds and cysteine substitution on antimicrobial activity and cytotoxicity. Biochemistry 44 (2005) 9804-9816
29. Krishnakumari V., Sharadadevi A., Singh S., and Nagaraj R. Single disulfide and linear analogues corresponding to the carboxy-terminal segment of bovine beta-defensin-2: effects of introducing the beta-hairpin nucleating sequence d-pro-gly on antibacterial activity and biophysical properties. Biochemistry 42 (2003) 9307-9315
30. Laederach A., Andreotti A.H., and Fulton D.B. Solution and micelle-bound structures of tachyplesin I and its active aromatic linear derivatives. Biochemistry 41 (2002) 12359-12368
31. Lai J.R., Huck B.R., Weisblum B., and Gellman S.H. Design of non-cysteine-containing antimicrobial beta-hairpins: structure-activity relationship studies with linear protegrin-1 analogues. Biochemistry 41 (2002) 12835-12842
32. Lambert J., Keppi E., Dimarcq J.L., Wicker C., Reichhart J.M., Dunbar B., et al. Insect immunity: isolation from immune blood of the dipteran Phormia terranovae of two insect antibacterial peptides with sequence homology to rabbit lung macrophage bactericidal peptides. Proc Natl Acad Sci USA 86 (1989) 262-266
33. Lee K.H., Hong S.Y., Oh J.E., Kwon M., Yoon J.H., Lee J., et al. Identification and characterization of the antimicrobial peptide corresponding to C-terminal beta-sheet domain of tenecin 1, an antibacterial protein of larvae of Tenebrio molitor. Biochem J 334 (1998) 99-105
34. Lehane M.J., Wu D., and Lehane S.M. Midgut-specific immune molecules are produced by the blood-sucking insect Stomoxys calcitrans. Proc Natl Acad Sci USA 94 (1997) 11502-11507
35. Maemoto A., Qu X., Rosengren K.J., Tanabe H., Henschen-Edman A., Craik D.J., et al. Functional analysis of the alpha-defensin disulfide array in mouse cryptdin-4. J Biol Chem 279 (2004) 44188-44196
36. Maget-Dana R., and Ptak M. Penetration of the insect defensin A into phospholipid monolayers and formation of defensin A-lipid complexes. Biophys J 73 (1997) 2527-2533
37. Mandal M., and Nagaraj R. Antibacterial activities and conformations of synthetic alpha-defensin HNP-1 and analogs with one, two and three disulfide bridges. J Pept Res 59 (2002) 95-104
38. Mandal M., Jagannadham M.V., and Nagaraj R. Antibacterial activities and conformations of bovine beta-defensin BNBD-12 and analogs: structural and disulfide bridge requirements for activity. Peptides 23 (2002) 413-418
39. Mandard N., Bulet P., Caille A., Daffre S., and Vovelle F. The solution structure of gomesin, an antimicrobial cysteine-rich peptide from the spider. Eur J Biochem 269 (2002) 1190-1198
40. Mani R., Waring A.J., Lehrer R.I., and Hong M. Membrane-disruptive abilities of beta-hairpin antimicrobial peptides correlate with conformation and activity: a 31P and 1H NMR study. Biochim Biophys Acta 1716 (2005) 11-18
41. Mygind P.H., Fischer R.L., Schnorr K.M., Hansen M.T., Sonksen C.P., Ludvigsen S., et al. Plectasin is a peptide antibiotic with therapeutic potential from a saprophytic fungus. Nature 437 (2005) 975-980
42. Nakajima Y., van der Goes van Naters-Yasui A., Taylor D., and Yamakawa M. Antibacterial peptide defensin is involved in midgut immunity of the soft tick, Ornithodoros moubata. Insect Mol Biol 11 (2002) 611-618
43. Nakajima Y., Ishibashi J., Yukuhiro F., Asaoka A., Taylor D., and Yamakawa M. Antibacterial activity and mechanism of action of tick defensin against Gram-positive bacteria. Biochim Biophys Acta 1624 (2003) 125-130
44. Oren Z., and Shai Y. Selective lysis of bacteria but not mammalian cells by diastereomers of melittin: structure-function study. Biochemistry 36 (1997) 1826-1835
45. Otvos Jr. L. Antibacterial peptides isolated from insects. J Pept Sci 6 (2000) 497-511
46. Rao A.G. Conformation and antimicrobial activity of linear derivatives of tachyplesin lacking disulfide bonds. Arch Biochem Biophys 361 (1999) 127-134
47. Romestand B., Molina F., Richard V., Roch P., and Granier C. Key role of the loop connecting the two beta strands of mussel defensin in its antimicrobial activity. Eur J Biochem 270 (2003) 2805-2813
48. Saido-Sakanaka H., Ishibashi J., Sagisaka A., Momotani E., and Yamakawa M. Synthesis and characterization of bactericidal oligopeptides designed on the basis of an insect antibacterial peptide. Biochem J 338 (1999) 29-33
49. Salzet M. Vertebrate innate immunity resembles a mosaic of invertebrate immune responses. Trends Immunol 22 (2001) 285-288
50. Schibli D.J., Hunter H.N., Aseyev V., Starner T.D., Wiencek J.M., McCray Jr. P.B., et al. The solution structures of the human beta-defensins lead to a better understanding of the potent bactericidal activity of HBD3 against Staphylococcus aureus. J Biol Chem 277 (2002) 8279-8289
51. Shaw N. Lipid composition as a guide to the classification of bacteria. Adv Appl Microbiol 17 (1974) 63-108
52. Taguchi S., Kuwasako K., Suenaga A., Okada M., and Momose H. Functional mapping against Escherichia coli for the broad-spectrum antimicrobial peptide, thanatin, based on an in vivo monitoring assay system. J Biochem (Tokyo) 128 (2000) 745-754
53. Thennarasu S., and Nagaraj R. Synthetic peptides corresponding to the beta-hairpin loop of rabbit defensin NP-2 show antimicrobial activity. Biochem Biophys Res Commun 254 (1999) 281-283
54. Viguera A.R., Jimenez M.A., Rico M., and Serrano L. Conformational analysis of peptides corresponding to beta-hairpins and a beta-sheet that represent the entire sequence of the alpha-spectrin SH3 domain. J Mol Biol 255 (1996) 507-521
55. Wade D., Andreu D., Mitchell S.A., Silveira A.M., Boman A., Boman H.G., et al. Antibacterial peptides designed as analogs or hybrids of cecropins and melittin. Int J Pept Protein Res 40 (1992) 429-436
56. Wu Z., Hoover D.M., Yang D., Boulegue C., Santamaria F., Oppenheim J.J., et al. Engineering disulfide bridges to dissect antimicrobial and chemotactic activities of human beta-defensin 3. Proc Natl Acad Sci USA 100 (2003) 8880-8885
57. Yang Y.S., Mitta G., Chavanieu A., Calas B., Sanchez J.F., Roch P., et al. Solution structure and activity of the synthetic four-disulfide bond Mediterranean mussel defensin (MGD-1). Biochemistry 39 (2000) 14436-14447