Absence of an interaction between the Rf-1 and Rf-5 QTLs influencing susceptibility to renal damage in rats

Nephron - Experimental Nephrology

Volumn 104, Issue 3, 2006, Pages

  Van Dijk, Sabine J ^a   Specht, Patricia A C ^a   Lazar, Jozef ^b   Jacob, Howard J ^b   Provoost, Abraham P ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

Chronic kidney disease; Double congenic rats; Rats, renal susceptibility; Renal damage in rats; Renal failure 1 (Rf 1) through Rf 5; Rf 1 and Rf 5 QTLs

Indexed keywords

N(G) NITROARGININE METHYL ESTER;

ALBUMINURIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOREGULATION; CHROMOSOME 1; CHROMOSOME 14; CHROMOSOME 17; CONGENIC STRAIN; CONTROLLED STUDY; FOLLOW UP; GENE MAPPING; GENETIC SUSCEPTIBILITY; GLOMERULOSCLEROSIS; HYPERTENSION; KIDNEY BLOOD FLOW; KIDNEY INJURY; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; RAT; STATISTICAL ANALYSIS; SURVIVAL TIME; SYSTOLIC BLOOD PRESSURE; UNINEPHRECTOMY;

ALBUMINURIA; ANIMALS; ANIMALS, CONGENIC; BLOOD PRESSURE; ENZYME INHIBITORS; EPISTASIS, GENETIC; GENETIC PREDISPOSITION TO DISEASE; GLOMERULOSCLEROSIS, FOCAL SEGMENTAL; HOMEOSTASIS; HYPERTENSION; KIDNEY FAILURE; NEPHRECTOMY; NG-NITROARGININE METHYL ESTER; QUANTITATIVE TRAIT LOCI; RATS; RATS, INBRED STRAINS; RENAL CIRCULATION; SURVIVAL ANALYSIS;

EID: 33750038004     PISSN: 16602129     EISSN: None     Source Type: Journal    
DOI: 10.1159/000094548     Document Type: Article

References (17)

1. Bowden DW: Genetics of kidney disease. Kidney Int 2003;63(suppl 83):S8-S12.
2. Williams SM, Haines JL, Moore JH: The use of animal models in the study of complex disease: all else is never equal or why do so many human studies fail to replicate animal findings. Bioessays 2004;26:170-179.
3. Lander ES, Schork NJ: Genetic dissection of complex traits. Science 1994;265:2037-2048.
4. Glazier AM, Nadeau JH, Aitman TJ: Finding genes that underlie complex traits. Science 2002;298:2345-2349.
5. Provoost AP: Spontaneous glomerulosclerosis: insights from the Fawn-hooded rat. Kidney Int 1994;45(suppl 45):S2-S5.
6. Brown DM, Provoost AP, Daly MJ, Lander ES, Jacob HJ: Renal disease susceptibility and hypertension are under independent genetic control in the Fawn-hooded rat. Nat Genet 1996;12:44-51.
7. Shiozawa M, Provoost AP, Van Dokkum RPE, Majewski RR, Jacob HJ: Evidence of gene-gene interactions in the genetic susceptibility to renal impairment after unilateral nephrectomy. J Am Soc Nephrol 2000;11:2068-2078.
8. Van Dijk SJ, Specht PAC, Lazar J, Jacob HJ, Provoost AP: Renal damage susceptibility and autoregulation in Rf-1 and Rf-5 congenic rats. Nephron Exp Nephrol 2005;101:e59-e66.
9. Van Dijk SJ, Specht PAC, Lutz MM Lazar J, Jacob HJ, Provoost AP: Interaction between Rf-1 and Rf-4 quantitative trait loci increases susceptibility to renal damage in double congenic rats. Kidney Int 2005;68:2462-2472.
10. Van Dijk SJ, Specht PAC, Lazar J, Jacob HJ, Provoost AP: Synergistic QTL interactions between Rf-1 and Rf-3 increase renal damage susceptibility in double congenic rats. Kidney Int 2006;69:1369-1376.
11. Nicklas W: Microbiological standardization of laboratory animals. Berl Münch Tierärtzl Wochenschr 1999;112:201-210.
12. Provoost AP, Shiozawa M, Van Dokkum RPE, Jacob HJ: Transfer of a single genomic region from the Fawn-hooded hypertensive rat onto the ACI background increases susceptibility to renal impairment. Physiol Genomics 2002;8:123-129.
13. Van Dokkum RPE, Alonso-Galicia M, Provoost AP, Jacob HJ, Roman RJ: Impaired autoregulation of renal blood flow in the Fawnhooded rat. Am J Physiol 1999;276:R189-R196.
14. Semple SJG, de Wardener HE: Effect of increased renal venous pressure on circulatory 'autoregulation' of isolated dog kidneys. Circ Res 1959;7:643-648.
15. Doumas BT, Watson WA, Biggs HG: Albumin standards and the measurement of serum albumin with bromocresol green. Clin Chim Acta 1971;31:87-96.
16. Rangel-Filho A, Sharma M, Datta YH, Moreno C, Roman RJ, Iwamoto Y, Provoost AP, Lazar J, Jacob HJ: Rf-2 gene modulates proteinuria and albuminuria independently of changes in glomerular permeability in the Fawn-hooded hypertensive rat. J Am Soc Nephrol 2005;16:852-856.
17. Yagil C, Sapojnikov M, Katni G, Ilan Z, Weskler Zangen S, Rosenmann E, Yagil Y: Proteinuria and glomerulosclerosis in the Sabra genetic rat model of salt susceptibility. Physiol Genomics 2002;9:167-178.